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The map label for this gene is ygcM [C]

Identifier: 116620683

GI number: 116620683

Start: 1921247

End: 1921672

Strand: Direct

Name: ygcM [C]

Synonym: Acid_1563

Alternate gene names: 116620683

Gene position: 1921247-1921672 (Clockwise)

Preceding gene: 116620679

Following gene: 116620684

Centisome position: 19.28

GC content: 57.98

Gene sequence:

>426_bases
ATGTTGATCACCCGCAAAGTAGAGTTTTCCGCCTCCCACATTTGCAGGAGTCCGCTGCTTTCCGATGAGGAAAATCGGCG
GATTTTCGGCCTGGCGGCGAATCCCCATGGACACGGCCACAACTACCTGGTGGAAGTCAGCCTCCGCGGAGAACCCGACC
CCGTGACCGGTATGGTCCTGGATCTGAAGGAGTTGAAAGAGATTCTGACGCGCGAGATTGTCGAGCCCTACGACCACAGA
TTTCTTAATTACGAGGTGCAGCCGTTCGACCGTGAAATTCCCACCACGGAAAATATCGCGCGCGATATCTGGCGGCGCCT
CGAGCCGCGCTTGAGCGACCCGCGGCACAGATTGTTCTCGGTCCGCGTGTACGAGACCGCCGACCTGTACGTCGATTATT
TCGGAGAGCAGCCGTGTTCCGCGTGA

Upstream 100 bases:

>100_bases
AATTCCCGCTCGCAGCAGCCGGTCAGTCTTGGGGTTCTGCATGACGTTCTATAATTTAATTGTATCTCCCGAGATCCTCG
CGGCGTCGAAAAATTACTCA

Downstream 100 bases:

>100_bases
CCCGCCGTTACCAGTTTGCCGCTTCTCATCGCCTGCATTCGGACCAATTGAGCGCGGAGGAGAACCGGAGCTTGTACGGC
AAGTGCAACAATCCGTACGG

Product: putative 6-pyruvoyl tetrahydropterin synthase

Products: 6-pyruvoyl-5,6,7,8-tetrahydropterin; triphosphate

Alternate protein names: 6-Pyruvoyl-Tetrahydropterin Synthase; 6-Pyruvoyltetrahydropterin Synthase; 6-Pyruvoyl-Tetrahydropterin Synthase-Like Protein; 6-Pyruvoyl Tetrahydrobiopterin Synthase; Queuosine Biosynthesis Protein QueD; 6-Pyruvoyl Tetrahydropterin Synthase Family; 6-Pyruvoyl Tetrahydropterin Synthase Family Protein; Tetrahydrobiopterin Biosynthesis-Like Protein; 6-Pyruvoyltetrahydrobiopterin Synthase; 6-Pyruvoyltetrahydropterin Synthase Synthase

Number of amino acids: Translated: 141; Mature: 141

Protein sequence:

>141_residues
MLITRKVEFSASHICRSPLLSDEENRRIFGLAANPHGHGHNYLVEVSLRGEPDPVTGMVLDLKELKEILTREIVEPYDHR
FLNYEVQPFDREIPTTENIARDIWRRLEPRLSDPRHRLFSVRVYETADLYVDYFGEQPCSA

Sequences:

>Translated_141_residues
MLITRKVEFSASHICRSPLLSDEENRRIFGLAANPHGHGHNYLVEVSLRGEPDPVTGMVLDLKELKEILTREIVEPYDHR
FLNYEVQPFDREIPTTENIARDIWRRLEPRLSDPRHRLFSVRVYETADLYVDYFGEQPCSA
>Mature_141_residues
MLITRKVEFSASHICRSPLLSDEENRRIFGLAANPHGHGHNYLVEVSLRGEPDPVTGMVLDLKELKEILTREIVEPYDHR
FLNYEVQPFDREIPTTENIARDIWRRLEPRLSDPRHRLFSVRVYETADLYVDYFGEQPCSA

Specific function: Tetrahydrobiopterin biosynthesis; second step. [C]

COG id: COG0720

COG function: function code H; 6-pyruvoyl-tetrahydropterin synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506331, Length=134, Percent_Identity=47.0149253731343, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI115532226, Length=127, Percent_Identity=40.9448818897638, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI115532224, Length=127, Percent_Identity=40.9448818897638, Blast_Score=98, Evalue=1e-21,
Organism=Drosophila melanogaster, GI19550074, Length=140, Percent_Identity=42.1428571428571, Blast_Score=109, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24585378, Length=140, Percent_Identity=42.1428571428571, Blast_Score=109, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.2.3.12

Molecular weight: Translated: 16522; Mature: 16522

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLITRKVEFSASHICRSPLLSDEENRRIFGLAANPHGHGHNYLVEVSLRGEPDPVTGMVL
CEEEEECCCCHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCHHEE
DLKELKEILTREIVEPYDHRFLNYEVQPFDREIPTTENIARDIWRRLEPRLSDPRHRLFS
CHHHHHHHHHHHHHCHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEE
VRVYETADLYVDYFGEQPCSA
EEEEECCEEEEEECCCCCCCC
>Mature Secondary Structure
MLITRKVEFSASHICRSPLLSDEENRRIFGLAANPHGHGHNYLVEVSLRGEPDPVTGMVL
CEEEEECCCCHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCHHEE
DLKELKEILTREIVEPYDHRFLNYEVQPFDREIPTTENIARDIWRRLEPRLSDPRHRLFS
CHHHHHHHHHHHHHCHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEE
VRVYETADLYVDYFGEQPCSA
EEEEECCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Mg2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 17.7 {6-(L-erythro-1,2-dihydroxypropyl} 5 {6-(L-erythro-1,2-dihydroxypropyl} 0.0091 {6-(L-erythro-1,2-dihydroxypropyl} 0.008 {6-(L-erythro-1,2-dihydroxypropyl} [C]

Substrates: 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin

Specific reaction: 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate

General reaction: Intramolecular redox reaction; P-O bond cleavage; Triphosphate elimination [C]

Inhibitor: (NH4)2SO4 [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA