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The map label for this gene is nuoN1

Identifier: 116619264

GI number: 116619264

Start: 159901

End: 161361

Strand: Direct

Name: nuoN1

Synonym: Acid_0120

Alternate gene names: 116619264

Gene position: 159901-161361 (Clockwise)

Preceding gene: 116619263

Following gene: 116619266

Centisome position: 1.6

GC content: 63.24

Gene sequence:

>1461_bases
ATGCCCGTTAGTCCCGCCTTCAACCCGCAGGACGCCCTGCGCTTCCTGCCCGAAATCATTTTGACCGTGATGGGCACGCT
GCTCATGGTGCTCGATCCGGTAATCCACAAGCGTTCTTCCAACGCATTCGGCCACATCAGCCTGATCGCGCTGGTCATGG
CTCTCGGCGCCAGCATCTACGCTTACGGCATCGCGGGGCCGGCCTTCGGCGGCATGCTGATGGTCGATGGCTTCGCGACC
TTCTTCCGAGTGGTCGTCATCACGGTTGGCATCCTTACCGTTTTTCCTTCCTACCGATTCCTCGCGCGCCAGGACGCCGA
GACTTCCGAGTACCACGCCCTCCTGCTTTTCTCGATCGCCGGCCAGTGCCTCATGGCCGCCTCGAACGACCTGATCATGG
TCTTCATCGGACTGGAAATTTCTTCCATCGCCAGCTATGTGCTCGCCGGCTATCTGCGCGACGATAAGCGCGCCAATGAG
GCCGCGCTCAAGTATTTCCTGCTCGGCTCCTTTGCCACCGGCTTCTTCCTCTACGGTGTCGCGTGGATTTACGGCCTCAC
CCGCAGCGTGAATCTCTCCGTGGTCCGCGGCGTCTTCCAGCACCAGCCGGTAGACCCGACCTTCGTCGGCATCGCCGCCG
CGCTCATGTTTGTCGGACTGGCGTTCAAGGTGTCCGCCGCGCCCTTCCAGATCTGGGCGCCCGACGTCTACCAGGGCGCG
CCCACTCCCGTCTCCGCTTTCCTCTCCGCGGGTCCCAAGGCCGCCGCTTTCGCCATCTTCCTGCGGATCTTCATGACTGC
CTTCGAGCCCATCAGCGATAAGTGGCAGCCGCTGGTCTGGACCGCCGCGCTCGCCTCCATGTGCATCGGCAACTTCGCGG
CCATCCTGCAGACCAACATCAAGCGCATGCTGGCCTACAGCTCCATCGCCCATGCGGGGTATGTGCTGGTGGCGCTCACC
GCGCACAGCGAAACCGGCGTGGCCGCCGCCATGTTCTATCTCGCAGGCTACGCCTTCATGAACGTCGGCGCCTTCGCCGC
GGTCAGTGTGCTTACCGGCAAAGGCGAGCGCTACCAGAACATCGACGACTTCAAGGGCATGGGCCGCAAGCAGCCGCTCG
CAGCCGCCATGTTCACCATTTTCCTGCTCTCGCTGCTCGGCGTGCCGCTCACCGGAGGCTTCTTCGGCAAGTTCTATATC
TTCAAGGCCGCCCTGGATAGCCACCTGATCTGGCTCACCGTTCTCGGCCTGTTGAACAGCGCTGTGGGCGCCTACTACTA
CCTGCGCATTCTGGTGGTGATGTACATGTACGAGCCCGGCGAAGCCGCCGACGCCGCGGAGCCCCTGGCTCCCAGCCTCG
CGTTCGCCCTGATTCTGCCGGCCCTCGGCACTCTTGCGCTCGGCATCTTCCCCGGCTGGGTCCTCGAGTTCGCCACAAAG
TCCGCCGCGAACCTCAAGTAG

Upstream 100 bases:

>100_bases
ACGGCACGCATTTTGAAACAGACCAACGTGAACGTTTCTTACCGAGTTCAGGCGCTTCCATTGCAACAATCGGGCAAGCC
GCAGACCGTGGAGGTCGCCC

Downstream 100 bases:

>100_bases
GACAGGCCTCCAGGCCTCGGATGCGCGGGTCTTGGAGACCTTCTTTTCTCGCAAAGCTGCAAAGCCGCAAAGTTTCGCCA
AGAACAAGAATTGTCTTGCC

Product: proton-translocating NADH-quinone oxidoreductase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N 1; NDH-1 subunit N 1

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MPVSPAFNPQDALRFLPEIILTVMGTLLMVLDPVIHKRSSNAFGHISLIALVMALGASIYAYGIAGPAFGGMLMVDGFAT
FFRVVVITVGILTVFPSYRFLARQDAETSEYHALLLFSIAGQCLMAASNDLIMVFIGLEISSIASYVLAGYLRDDKRANE
AALKYFLLGSFATGFFLYGVAWIYGLTRSVNLSVVRGVFQHQPVDPTFVGIAAALMFVGLAFKVSAAPFQIWAPDVYQGA
PTPVSAFLSAGPKAAAFAIFLRIFMTAFEPISDKWQPLVWTAALASMCIGNFAAILQTNIKRMLAYSSIAHAGYVLVALT
AHSETGVAAAMFYLAGYAFMNVGAFAAVSVLTGKGERYQNIDDFKGMGRKQPLAAAMFTIFLLSLLGVPLTGGFFGKFYI
FKAALDSHLIWLTVLGLLNSAVGAYYYLRILVVMYMYEPGEAADAAEPLAPSLAFALILPALGTLALGIFPGWVLEFATK
SAANLK

Sequences:

>Translated_486_residues
MPVSPAFNPQDALRFLPEIILTVMGTLLMVLDPVIHKRSSNAFGHISLIALVMALGASIYAYGIAGPAFGGMLMVDGFAT
FFRVVVITVGILTVFPSYRFLARQDAETSEYHALLLFSIAGQCLMAASNDLIMVFIGLEISSIASYVLAGYLRDDKRANE
AALKYFLLGSFATGFFLYGVAWIYGLTRSVNLSVVRGVFQHQPVDPTFVGIAAALMFVGLAFKVSAAPFQIWAPDVYQGA
PTPVSAFLSAGPKAAAFAIFLRIFMTAFEPISDKWQPLVWTAALASMCIGNFAAILQTNIKRMLAYSSIAHAGYVLVALT
AHSETGVAAAMFYLAGYAFMNVGAFAAVSVLTGKGERYQNIDDFKGMGRKQPLAAAMFTIFLLSLLGVPLTGGFFGKFYI
FKAALDSHLIWLTVLGLLNSAVGAYYYLRILVVMYMYEPGEAADAAEPLAPSLAFALILPALGTLALGIFPGWVLEFATK
SAANLK
>Mature_485_residues
PVSPAFNPQDALRFLPEIILTVMGTLLMVLDPVIHKRSSNAFGHISLIALVMALGASIYAYGIAGPAFGGMLMVDGFATF
FRVVVITVGILTVFPSYRFLARQDAETSEYHALLLFSIAGQCLMAASNDLIMVFIGLEISSIASYVLAGYLRDDKRANEA
ALKYFLLGSFATGFFLYGVAWIYGLTRSVNLSVVRGVFQHQPVDPTFVGIAAALMFVGLAFKVSAAPFQIWAPDVYQGAP
TPVSAFLSAGPKAAAFAIFLRIFMTAFEPISDKWQPLVWTAALASMCIGNFAAILQTNIKRMLAYSSIAHAGYVLVALTA
HSETGVAAAMFYLAGYAFMNVGAFAAVSVLTGKGERYQNIDDFKGMGRKQPLAAAMFTIFLLSLLGVPLTGGFFGKFYIF
KAALDSHLIWLTVLGLLNSAVGAYYYLRILVVMYMYEPGEAADAAEPLAPSLAFALILPALGTLALGIFPGWVLEFATKS
AANLK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family

Homologues:

Organism=Homo sapiens, GI251831117, Length=345, Percent_Identity=24.6376811594203, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI145693160, Length=471, Percent_Identity=35.4564755838641, Blast_Score=255, Evalue=4e-69,
Organism=Escherichia coli, GI1788831, Length=353, Percent_Identity=27.1954674220963, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1788614, Length=389, Percent_Identity=26.9922879177378, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1788829, Length=410, Percent_Identity=26.5853658536585, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788613, Length=340, Percent_Identity=25.2941176470588, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788827, Length=287, Percent_Identity=24.7386759581882, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUON1_SOLUE (Q02CT1)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_821420.1
- STRING:   Q02CT1
- GeneID:   4424102
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_0120
- NMPDR:   fig|234267.9.peg.114
- HOGENOM:   HBG747830
- OMA:   FESVSIM
- PhylomeDB:   Q02CT1
- GO:   GO:0006810
- HAMAP:   MF_00445
- InterPro:   IPR010096
- InterPro:   IPR001750
- TIGRFAMs:   TIGR01770

Pfam domain/function: PF00361 Oxidored_q1

EC number: =1.6.99.5

Molecular weight: Translated: 52210; Mature: 52079

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x12de8f20)-; HASH(0x139d0780)-; HASH(0x139de400)-; HASH(0x13c91f18)-; HASH(0x13814908)-; HASH(0x12e3a43c)-; HASH(0x13c94ca0)-; HASH(0x138b3e90)-; HASH(0x13a63768)-; HASH(0x139e6bec)-; HASH(0x130c0f10)-; HASH(0x139f3e68)-; HASH(0x14230930)-; HASH(0x13c91ce4)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVSPAFNPQDALRFLPEIILTVMGTLLMVLDPVIHKRSSNAFGHISLIALVMALGASIY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHH
AYGIAGPAFGGMLMVDGFATFFRVVVITVGILTVFPSYRFLARQDAETSEYHALLLFSIA
HHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHH
GQCLMAASNDLIMVFIGLEISSIASYVLAGYLRDDKRANEAALKYFLLGSFATGFFLYGV
HHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
AWIYGLTRSVNLSVVRGVFQHQPVDPTFVGIAAALMFVGLAFKVSAAPFQIWAPDVYQGA
HHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHCCCC
PTPVSAFLSAGPKAAAFAIFLRIFMTAFEPISDKWQPLVWTAALASMCIGNFAAILQTNI
CCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KRMLAYSSIAHAGYVLVALTAHSETGVAAAMFYLAGYAFMNVGAFAAVSVLTGKGERYQN
HHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
IDDFKGMGRKQPLAAAMFTIFLLSLLGVPLTGGFFGKFYIFKAALDSHLIWLTVLGLLNS
CHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVGAYYYLRILVVMYMYEPGEAADAAEPLAPSLAFALILPALGTLALGIFPGWVLEFATK
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAANLK
HCCCCH
>Mature Secondary Structure 
PVSPAFNPQDALRFLPEIILTVMGTLLMVLDPVIHKRSSNAFGHISLIALVMALGASIY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHH
AYGIAGPAFGGMLMVDGFATFFRVVVITVGILTVFPSYRFLARQDAETSEYHALLLFSIA
HHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHH
GQCLMAASNDLIMVFIGLEISSIASYVLAGYLRDDKRANEAALKYFLLGSFATGFFLYGV
HHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
AWIYGLTRSVNLSVVRGVFQHQPVDPTFVGIAAALMFVGLAFKVSAAPFQIWAPDVYQGA
HHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHCCCC
PTPVSAFLSAGPKAAAFAIFLRIFMTAFEPISDKWQPLVWTAALASMCIGNFAAILQTNI
CCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KRMLAYSSIAHAGYVLVALTAHSETGVAAAMFYLAGYAFMNVGAFAAVSVLTGKGERYQN
HHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
IDDFKGMGRKQPLAAAMFTIFLLSLLGVPLTGGFFGKFYIFKAALDSHLIWLTVLGLLNS
CHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVGAYYYLRILVVMYMYEPGEAADAAEPLAPSLAFALILPALGTLALGIFPGWVLEFATK
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAANLK
HCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA