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The map label for this gene is nqo13 [H]

Identifier: 116619263

GI number: 116619263

Start: 158355

End: 159911

Strand: Direct

Name: nqo13 [H]

Synonym: Acid_0119

Alternate gene names: 116619263

Gene position: 158355-159911 (Clockwise)

Preceding gene: 116619262

Following gene: 116619264

Centisome position: 1.59

GC content: 61.91

Gene sequence:

>1557_bases
ATGAACCTCCTCACCCTGGTCCTTTTCCTGCCGCTTGCCGGCTTCCTGGTCGCGCTCGCGATTCCGCGTTCGGTCTCCGC
GCAGGGCAGTCGCATGTGGGCGCTCCTCTGTTCCCTCGGCATCTTCGCCGCCTCGCTCGGCCTGCTGGCATGGTTTGATC
GGGGCCTCTCCGGCGAGCAGTTCGCCATCGACGTGCCGTGGATCTCCAGCCCGAATATTCACTTCGCGATCTCCGCCAAC
GGCGTCAGCATCTGGCTGGTCCTGCTCTCCACCCTGCTCACGCCGCTCTGCGTCCTGGTCTCCTGGAATTCCATCCACGA
CCGCACCAAGGAGTTTTACGCCTTCCTGCTCCTCCTCGAGTTCGGCCTGGTCGGCGTCTTCCTGGCGCAGGACCTCTTCC
TCTTCTACGTGTTCTGGGAAATCGCCCTGGTGCCCATGTACTTCATGATCGGCATCTGGGGGCACGACCGCCGCATTTAT
GCCGCGGTCAAATTCTTCCTGTACACGATGGCCGGCAGCGTCCTCATGCTCGCCGCCATCATCTACATCTACAACAAGAC
TCAGACCTTCAGCTATCCGGCGATCCTGGAGATGCTCTCCAACGGCCGCCTCTCCTTCCCGCCTGGCGAGCAGATGCTGC
TCTTCCTGGCCTTCTTCCTCGCCTTCGCGATCAAGGTGCCGCTCTTCCCGCTGCACACCTGGCTGCCTGACGCCCACGTG
GAAGCGCCCACCGCCGGTTCCATCATGCTGGCCAGCGTCATGCTGAAAATGGGCACGTACGGAATCCTGCACTTCTGCCT
CCCGATGTTCCCCAGCGCCGCGCGCGCGTGCGCCCCGTGGATTACGGTGCTCGCTATCATCGGCATCATCTACGGCGCAC
TGGTCGCGATGGTGCAACCAAATATGAAGAAGCTGGTGGCCTACTCTTCGGTCAGCCACCTCGGCTTCGTCGTCCTCGGA
ATTTTCACCTTCACGCAGCCCGGCCTGGATGGCGCCGTCTATCAGATGCTCAATCACGGCATCTCCACCGGCGCGCTCTT
CCTGGTTGTCGGCCTGCTCTACGAGCGCAACCATTCGCTCGAAATCAATTCCTATGGCGGCGTCGCCACGGTCGCTCCGT
GGCTCTCCGTCGCCTTCCTGATCACCACACTCGCCAGCGTCGGCCTGCCGACGCTCAACAATTTCGTCGGCGAGTTCCTG
GTGCTGCAGGGCGCCGCCATCGCCAATTTCCCCTGGGCAGTCTGGGCCTCTATCGGCGTCATCCTCTCCGCCTGCTACAT
GCTGTGGATGTATCAGCGCGTGTTCTACGGCGAGGTCAACCCGCACGTCCGCGAGCACACTCCCGATCTGAACCTGCGCG
AATGGGCGGCCATCCTCCCGCTGATCGCAATGATGGTGTGGATGGGCGTCTTCTCCCAAAGCTTCCTGCCGCCGGTCAGC
CAAAACACGGCACGCATTTTGAAACAGACCAACGTGAACGTTTCTTACCGAGTTCAGGCGCTTCCATTGCAACAATCGGG
CAAGCCGCAGACCGTGGAGGTCGCCCATGCCCGTTAG

Upstream 100 bases:

>100_bases
GTCTCCTCCAATCCGGCAGCATTCGCAGTTACGCCACCTGGGTGCTCTTCGGCTCCGTGGCCCTGATCGTCGCGATTACT
CTCGCGGGAGGTCTTCCCCG

Downstream 100 bases:

>100_bases
TCCCGCCTTCAACCCGCAGGACGCCCTGCGCTTCCTGCCCGAAATCATTTTGACCGTGATGGGCACGCTGCTCATGGTGC
TCGATCCGGTAATCCACAAG

Product: proton-translocating NADH-quinone oxidoreductase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 13; NDH-1, chain 13 [H]

Number of amino acids: Translated: 518; Mature: 518

Protein sequence:

>518_residues
MNLLTLVLFLPLAGFLVALAIPRSVSAQGSRMWALLCSLGIFAASLGLLAWFDRGLSGEQFAIDVPWISSPNIHFAISAN
GVSIWLVLLSTLLTPLCVLVSWNSIHDRTKEFYAFLLLLEFGLVGVFLAQDLFLFYVFWEIALVPMYFMIGIWGHDRRIY
AAVKFFLYTMAGSVLMLAAIIYIYNKTQTFSYPAILEMLSNGRLSFPPGEQMLLFLAFFLAFAIKVPLFPLHTWLPDAHV
EAPTAGSIMLASVMLKMGTYGILHFCLPMFPSAARACAPWITVLAIIGIIYGALVAMVQPNMKKLVAYSSVSHLGFVVLG
IFTFTQPGLDGAVYQMLNHGISTGALFLVVGLLYERNHSLEINSYGGVATVAPWLSVAFLITTLASVGLPTLNNFVGEFL
VLQGAAIANFPWAVWASIGVILSACYMLWMYQRVFYGEVNPHVREHTPDLNLREWAAILPLIAMMVWMGVFSQSFLPPVS
QNTARILKQTNVNVSYRVQALPLQQSGKPQTVEVAHAR

Sequences:

>Translated_518_residues
MNLLTLVLFLPLAGFLVALAIPRSVSAQGSRMWALLCSLGIFAASLGLLAWFDRGLSGEQFAIDVPWISSPNIHFAISAN
GVSIWLVLLSTLLTPLCVLVSWNSIHDRTKEFYAFLLLLEFGLVGVFLAQDLFLFYVFWEIALVPMYFMIGIWGHDRRIY
AAVKFFLYTMAGSVLMLAAIIYIYNKTQTFSYPAILEMLSNGRLSFPPGEQMLLFLAFFLAFAIKVPLFPLHTWLPDAHV
EAPTAGSIMLASVMLKMGTYGILHFCLPMFPSAARACAPWITVLAIIGIIYGALVAMVQPNMKKLVAYSSVSHLGFVVLG
IFTFTQPGLDGAVYQMLNHGISTGALFLVVGLLYERNHSLEINSYGGVATVAPWLSVAFLITTLASVGLPTLNNFVGEFL
VLQGAAIANFPWAVWASIGVILSACYMLWMYQRVFYGEVNPHVREHTPDLNLREWAAILPLIAMMVWMGVFSQSFLPPVS
QNTARILKQTNVNVSYRVQALPLQQSGKPQTVEVAHAR
>Mature_518_residues
MNLLTLVLFLPLAGFLVALAIPRSVSAQGSRMWALLCSLGIFAASLGLLAWFDRGLSGEQFAIDVPWISSPNIHFAISAN
GVSIWLVLLSTLLTPLCVLVSWNSIHDRTKEFYAFLLLLEFGLVGVFLAQDLFLFYVFWEIALVPMYFMIGIWGHDRRIY
AAVKFFLYTMAGSVLMLAAIIYIYNKTQTFSYPAILEMLSNGRLSFPPGEQMLLFLAFFLAFAIKVPLFPLHTWLPDAHV
EAPTAGSIMLASVMLKMGTYGILHFCLPMFPSAARACAPWITVLAIIGIIYGALVAMVQPNMKKLVAYSSVSHLGFVVLG
IFTFTQPGLDGAVYQMLNHGISTGALFLVVGLLYERNHSLEINSYGGVATVAPWLSVAFLITTLASVGLPTLNNFVGEFL
VLQGAAIANFPWAVWASIGVILSACYMLWMYQRVFYGEVNPHVREHTPDLNLREWAAILPLIAMMVWMGVFSQSFLPPVS
QNTARILKQTNVNVSYRVQALPLQQSGKPQTVEVAHAR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=353, Percent_Identity=33.9943342776204, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI251831117, Length=392, Percent_Identity=24.7448979591837, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1788613, Length=481, Percent_Identity=40.5405405405405, Blast_Score=313, Evalue=2e-86,
Organism=Escherichia coli, GI1788827, Length=294, Percent_Identity=30.2721088435374, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1788831, Length=409, Percent_Identity=25.1833740831296, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI1788614, Length=535, Percent_Identity=25.4205607476636, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI145693160, Length=414, Percent_Identity=27.536231884058, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1788829, Length=412, Percent_Identity=26.6990291262136, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI2367154, Length=446, Percent_Identity=25.3363228699552, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 57237; Mature: 57237

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLTLVLFLPLAGFLVALAIPRSVSAQGSRMWALLCSLGIFAASLGLLAWFDRGLSGEQ
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
FAIDVPWISSPNIHFAISANGVSIWLVLLSTLLTPLCVLVSWNSIHDRTKEFYAFLLLLE
EEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
FGLVGVFLAQDLFLFYVFWEIALVPMYFMIGIWGHDRRIYAAVKFFLYTMAGSVLMLAAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IYIYNKTQTFSYPAILEMLSNGRLSFPPGEQMLLFLAFFLAFAIKVPLFPLHTWLPDAHV
HHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCC
EAPTAGSIMLASVMLKMGTYGILHFCLPMFPSAARACAPWITVLAIIGIIYGALVAMVQP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NMKKLVAYSSVSHLGFVVLGIFTFTQPGLDGAVYQMLNHGISTGALFLVVGLLYERNHSL
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCE
EINSYGGVATVAPWLSVAFLITTLASVGLPTLNNFVGEFLVLQGAAIANFPWAVWASIGV
EEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHCCCHHHHHHHHHH
ILSACYMLWMYQRVFYGEVNPHVREHTPDLNLREWAAILPLIAMMVWMGVFSQSFLPPVS
HHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
QNTARILKQTNVNVSYRVQALPLQQSGKPQTVEVAHAR
CHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEECCCC
>Mature Secondary Structure
MNLLTLVLFLPLAGFLVALAIPRSVSAQGSRMWALLCSLGIFAASLGLLAWFDRGLSGEQ
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
FAIDVPWISSPNIHFAISANGVSIWLVLLSTLLTPLCVLVSWNSIHDRTKEFYAFLLLLE
EEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
FGLVGVFLAQDLFLFYVFWEIALVPMYFMIGIWGHDRRIYAAVKFFLYTMAGSVLMLAAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IYIYNKTQTFSYPAILEMLSNGRLSFPPGEQMLLFLAFFLAFAIKVPLFPLHTWLPDAHV
HHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCC
EAPTAGSIMLASVMLKMGTYGILHFCLPMFPSAARACAPWITVLAIIGIIYGALVAMVQP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NMKKLVAYSSVSHLGFVVLGIFTFTQPGLDGAVYQMLNHGISTGALFLVVGLLYERNHSL
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCE
EINSYGGVATVAPWLSVAFLITTLASVGLPTLNNFVGEFLVLQGAAIANFPWAVWASIGV
EEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHCCCHHHHHHHHHH
ILSACYMLWMYQRVFYGEVNPHVREHTPDLNLREWAAILPLIAMMVWMGVFSQSFLPPVS
HHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
QNTARILKQTNVNVSYRVQALPLQQSGKPQTVEVAHAR
CHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8422400 [H]