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The map label for this gene is nuoL [H]

Identifier: 116619262

GI number: 116619262

Start: 156484

End: 158358

Strand: Direct

Name: nuoL [H]

Synonym: Acid_0118

Alternate gene names: 116619262

Gene position: 156484-158358 (Clockwise)

Preceding gene: 116619261

Following gene: 116619263

Centisome position: 1.57

GC content: 61.01

Gene sequence:

>1875_bases
ATGCAACTCTGGCTCATACCAATCTTCCCGCTGGCCGGTTTCCTGATCAACGGCCTCTTCGGCCGCAAGTTCTCCAAGAG
CCTGGTCAGCACCGTTGCTGTCGGCAGCGTGGTTCTCTCTTTTCTCTGGGTGCTGAAAACCATCTCCGCCATGGGAGATC
TGAATACCCCCCACCTGGAGCATTACTTCACGTGGATTCAGAGCGGTTTTCCCGGCAGCCCCAACTTCGTCAACATCGGC
TGCGATTTCCTGGTCGATCGCCTCACCATCGTCATGCTGCTGGTGGTCACCGGCATCGGCTCACTGATCCACATCTATTC
CATCGGGTACATGGCGCACGAGCACGGCCCCAATTTCGGCGGCTTTTACCGCTTCTTCGCCTACCTGAATCTCTTCATGT
TTTTCATGCTGGTGCTGGTGCTCGGAGCCAACTACCTGCTGCTCTTCGTGGGCTGGGAAGGCGTGGGCTTGTGCAGCTAC
CTGCTGATCGGCTTCTACTTCGATAAGAAATTCGCCACCAACGCCGGCAACAAGGCATTCATCGTCAATCGCATCGGCGA
TTTCGGCTTCTCGCTGGCGATGTTCCTGATCTTCCATCATTTCGGCTCGCTGGATTTCGCCGAGGTCTTCCACAAGGCGC
CCGGCGGCACCGAAGCCACCCTGACCACCATCTGTCTCCTGCTGCTGGTCGGCGCCTGCGGCAAGAGCGCGCAGATTCCG
CTCTACGTCTGGCTCCCCGACGCCATGGCCGGCCCCACGCCCGTCTCCGCCCTCATCCACGCCGCCACCATGGTGACTGC
CGGCGTCTATATGACCGCCCGCTCCTGGGTGCTCTTCACCCACGCGCCCGGCGCCATGGACGTGATGGCCATCATCGGCA
TCGCGACCGCGTTCATGGCCGCGACCATCGGCCTGGCGCAGAACGATATCAAGAAAGTCTTCGCCTACTCCACCGTCTCG
CAACTCGGCTATATGTTCGTCGGCGTGGGCAGCGGAGCGTTCTCCGCGGGCGTCTGGCACCTGGTGACCCATGCGTTCTT
CAAGGCGCTGCTCTTCCTTGGCGCCGGCAGCGTGATCCACTCCCTCTCCGGCGAACAGGACATGCGCAACATGGGCGGCC
TGCGCAAGAAGATCCCGATCACCTTCTGGACCATGGCTTGCGCCTGGGTCGCGATCTCCGGCATCCCACCCTTCTCGGGC
TTCTTCAGCAAGGACGCGATCCTGGTGGCCGCCTACCAGCACTCGCACGCCATCTACTGGATCGGCGTGATAACGGCCGA
ACTCACGGCCTTCTACGTCTCCCGCGCCATGTTCATGACCTTCTTCGGCGAGTACCGCGGCAAGGCGCATCCGCACGAAT
CGCCTGCCGTGATGTGGGCCCCCCTGGCCGTGCTCGCGGTGCTCTCGCTGATCGGCGGCATGGTTTTCAATATCCCCGAA
TTCCTCAAAGCCATGTTCCCGGCGATGGAAGAAGTCGATAATCCGATGCTCATGTACATCTCCATCGCGTTTGGCTTCCT
CGGCATCGCGCTGGCCTGGTTGATGTATGTGGTGAAGCCCGGCCTGGCCGATTCCCTCGCCAACATGTTCAAGGCGCCCT
ATCAATTGATCTACAACAAATATTTCGTGGACGAGATTTACGATGCGACCGTGGTCAAGCCCGTTGTCGCCGGTTCGCGC
GTGGTCCTCTGGAAGGGCGTGGACGCGGGCCTCATCGATGGCATAGTCAACGGCGTGGGAGCGCGCTCCCGCGATGTGGG
CAGCGTGCTGCGTCTCCTCCAATCCGGCAGCATTCGCAGTTACGCCACCTGGGTGCTCTTCGGCTCCGTGGCCCTGATCG
TCGCGATTACTCTCGCGGGAGGTCTTCCCCGATGA

Upstream 100 bases:

>100_bases
CCGAAGCGGCGGTGGGACTGGCCATCATCCTGACAGTGTTCAAGAACCGCTCGACACTCAATATCGATGATGTCAATTCG
ATGAAGAACTAACCGAACCG

Downstream 100 bases:

>100_bases
ACCTCCTCACCCTGGTCCTTTTCCTGCCGCTTGCCGGCTTCCTGGTCGCGCTCGCGATTCCGCGTTCGGTCTCCGCGCAG
GGCAGTCGCATGTGGGCGCT

Product: proton-translocating NADH-quinone oxidoreductase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 624; Mature: 624

Protein sequence:

>624_residues
MQLWLIPIFPLAGFLINGLFGRKFSKSLVSTVAVGSVVLSFLWVLKTISAMGDLNTPHLEHYFTWIQSGFPGSPNFVNIG
CDFLVDRLTIVMLLVVTGIGSLIHIYSIGYMAHEHGPNFGGFYRFFAYLNLFMFFMLVLVLGANYLLLFVGWEGVGLCSY
LLIGFYFDKKFATNAGNKAFIVNRIGDFGFSLAMFLIFHHFGSLDFAEVFHKAPGGTEATLTTICLLLLVGACGKSAQIP
LYVWLPDAMAGPTPVSALIHAATMVTAGVYMTARSWVLFTHAPGAMDVMAIIGIATAFMAATIGLAQNDIKKVFAYSTVS
QLGYMFVGVGSGAFSAGVWHLVTHAFFKALLFLGAGSVIHSLSGEQDMRNMGGLRKKIPITFWTMACAWVAISGIPPFSG
FFSKDAILVAAYQHSHAIYWIGVITAELTAFYVSRAMFMTFFGEYRGKAHPHESPAVMWAPLAVLAVLSLIGGMVFNIPE
FLKAMFPAMEEVDNPMLMYISIAFGFLGIALAWLMYVVKPGLADSLANMFKAPYQLIYNKYFVDEIYDATVVKPVVAGSR
VVLWKGVDAGLIDGIVNGVGARSRDVGSVLRLLQSGSIRSYATWVLFGSVALIVAITLAGGLPR

Sequences:

>Translated_624_residues
MQLWLIPIFPLAGFLINGLFGRKFSKSLVSTVAVGSVVLSFLWVLKTISAMGDLNTPHLEHYFTWIQSGFPGSPNFVNIG
CDFLVDRLTIVMLLVVTGIGSLIHIYSIGYMAHEHGPNFGGFYRFFAYLNLFMFFMLVLVLGANYLLLFVGWEGVGLCSY
LLIGFYFDKKFATNAGNKAFIVNRIGDFGFSLAMFLIFHHFGSLDFAEVFHKAPGGTEATLTTICLLLLVGACGKSAQIP
LYVWLPDAMAGPTPVSALIHAATMVTAGVYMTARSWVLFTHAPGAMDVMAIIGIATAFMAATIGLAQNDIKKVFAYSTVS
QLGYMFVGVGSGAFSAGVWHLVTHAFFKALLFLGAGSVIHSLSGEQDMRNMGGLRKKIPITFWTMACAWVAISGIPPFSG
FFSKDAILVAAYQHSHAIYWIGVITAELTAFYVSRAMFMTFFGEYRGKAHPHESPAVMWAPLAVLAVLSLIGGMVFNIPE
FLKAMFPAMEEVDNPMLMYISIAFGFLGIALAWLMYVVKPGLADSLANMFKAPYQLIYNKYFVDEIYDATVVKPVVAGSR
VVLWKGVDAGLIDGIVNGVGARSRDVGSVLRLLQSGSIRSYATWVLFGSVALIVAITLAGGLPR
>Mature_624_residues
MQLWLIPIFPLAGFLINGLFGRKFSKSLVSTVAVGSVVLSFLWVLKTISAMGDLNTPHLEHYFTWIQSGFPGSPNFVNIG
CDFLVDRLTIVMLLVVTGIGSLIHIYSIGYMAHEHGPNFGGFYRFFAYLNLFMFFMLVLVLGANYLLLFVGWEGVGLCSY
LLIGFYFDKKFATNAGNKAFIVNRIGDFGFSLAMFLIFHHFGSLDFAEVFHKAPGGTEATLTTICLLLLVGACGKSAQIP
LYVWLPDAMAGPTPVSALIHAATMVTAGVYMTARSWVLFTHAPGAMDVMAIIGIATAFMAATIGLAQNDIKKVFAYSTVS
QLGYMFVGVGSGAFSAGVWHLVTHAFFKALLFLGAGSVIHSLSGEQDMRNMGGLRKKIPITFWTMACAWVAISGIPPFSG
FFSKDAILVAAYQHSHAIYWIGVITAELTAFYVSRAMFMTFFGEYRGKAHPHESPAVMWAPLAVLAVLSLIGGMVFNIPE
FLKAMFPAMEEVDNPMLMYISIAFGFLGIALAWLMYVVKPGLADSLANMFKAPYQLIYNKYFVDEIYDATVVKPVVAGSR
VVLWKGVDAGLIDGIVNGVGARSRDVGSVLRLLQSGSIRSYATWVLFGSVALIVAITLAGGLPR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=404, Percent_Identity=37.6237623762376, Blast_Score=244, Evalue=2e-64,
Organism=Escherichia coli, GI1788614, Length=611, Percent_Identity=40.4255319148936, Blast_Score=370, Evalue=1e-103,
Organism=Escherichia coli, GI1788829, Length=427, Percent_Identity=33.7236533957845, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1788831, Length=354, Percent_Identity=29.6610169491525, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1788827, Length=367, Percent_Identity=30.7901907356948, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI2367154, Length=463, Percent_Identity=23.9740820734341, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1788613, Length=478, Percent_Identity=24.8953974895398, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI145693160, Length=307, Percent_Identity=28.0130293159609, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 67861; Mature: 67861

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLWLIPIFPLAGFLINGLFGRKFSKSLVSTVAVGSVVLSFLWVLKTISAMGDLNTPHLE
CEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
HYFTWIQSGFPGSPNFVNIGCDFLVDRLTIVMLLVVTGIGSLIHIYSIGYMAHEHGPNFG
HHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
GFYRFFAYLNLFMFFMLVLVLGANYLLLFVGWEGVGLCSYLLIGFYFDKKFATNAGNKAF
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEE
IVNRIGDFGFSLAMFLIFHHFGSLDFAEVFHKAPGGTEATLTTICLLLLVGACGKSAQIP
EEECHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
LYVWLPDAMAGPTPVSALIHAATMVTAGVYMTARSWVLFTHAPGAMDVMAIIGIATAFMA
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHH
ATIGLAQNDIKKVFAYSTVSQLGYMFVGVGSGAFSAGVWHLVTHAFFKALLFLGAGSVIH
HHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHH
SLSGEQDMRNMGGLRKKIPITFWTMACAWVAISGIPPFSGFFSKDAILVAAYQHSHAIYW
HCCCCHHHHHHCCCHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCEEEE
IGVITAELTAFYVSRAMFMTFFGEYRGKAHPHESPAVMWAPLAVLAVLSLIGGMVFNIPE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHH
FLKAMFPAMEEVDNPMLMYISIAFGFLGIALAWLMYVVKPGLADSLANMFKAPYQLIYNK
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
YFVDEIYDATVVKPVVAGSRVVLWKGVDAGLIDGIVNGVGARSRDVGSVLRLLQSGSIRS
HHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHH
YATWVLFGSVALIVAITLAGGLPR
HHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQLWLIPIFPLAGFLINGLFGRKFSKSLVSTVAVGSVVLSFLWVLKTISAMGDLNTPHLE
CEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
HYFTWIQSGFPGSPNFVNIGCDFLVDRLTIVMLLVVTGIGSLIHIYSIGYMAHEHGPNFG
HHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
GFYRFFAYLNLFMFFMLVLVLGANYLLLFVGWEGVGLCSYLLIGFYFDKKFATNAGNKAF
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEE
IVNRIGDFGFSLAMFLIFHHFGSLDFAEVFHKAPGGTEATLTTICLLLLVGACGKSAQIP
EEECHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
LYVWLPDAMAGPTPVSALIHAATMVTAGVYMTARSWVLFTHAPGAMDVMAIIGIATAFMA
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHH
ATIGLAQNDIKKVFAYSTVSQLGYMFVGVGSGAFSAGVWHLVTHAFFKALLFLGAGSVIH
HHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHH
SLSGEQDMRNMGGLRKKIPITFWTMACAWVAISGIPPFSGFFSKDAILVAAYQHSHAIYW
HCCCCHHHHHHCCCHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCEEEE
IGVITAELTAFYVSRAMFMTFFGEYRGKAHPHESPAVMWAPLAVLAVLSLIGGMVFNIPE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHH
FLKAMFPAMEEVDNPMLMYISIAFGFLGIALAWLMYVVKPGLADSLANMFKAPYQLIYNK
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
YFVDEIYDATVVKPVVAGSRVVLWKGVDAGLIDGIVNGVGARSRDVGSVLRLLQSGSIRS
HHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHH
YATWVLFGSVALIVAITLAGGLPR
HHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]