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The map label for this gene is groEL [H]

Identifier: 116514960

GI number: 116514960

Start: 11102

End: 12754

Strand: Direct

Name: groEL [H]

Synonym: BCc_011

Alternate gene names: 116514960

Gene position: 11102-12754 (Clockwise)

Preceding gene: 116514959

Following gene: 116514961

Centisome position: 2.67

GC content: 33.15

Gene sequence:

>1653_bases
ATGGCTGCAAAAGATGTGAAATTTGGTAATGAAGCTCGAATTAAAATGTTACATGGAGTAAATGTTTTAGCAGATGCTGT
AAAAGTAACATTAGGTCCTAAAGGAAGAAATGTAGTTTTAGATAAATCATTTGGACCACCAAGTATTACTAAGGATGGCG
TATCAGTAGCTCGAGAAATTGAATTAGAAGATAAATTTGAAAATATGGGTGCGCAAATGGTCAAGGAAGTAGCTTCTAAG
GCAAATGATGCCGCAGGTGATGGAACAACAACAGCTACATTATTAGCGCAATCTATTGTAAATGAAGGTTTAAAAGCAGT
AGCTGCTGGAATGAATCCTATGGATTTAAAAAGAGGAATTGATAAAGCAGTAATAGATGCTGTAGATGAATTAAAAAAAT
TATCCGTACCTTGTGCAGATTCTAAAGCAATTACTCAGGTTGGTACTATTTCAGCTAATGCAGATGAAAAGGTTGGTTCA
TTAATTGCAGAAGCTATGGAAAAAGTAGGAAATGATGGTGTTATAACTGTTGAAGAAGGGACAGGATTACAAAATGAATT
AGAAGTAGTAAAAGGTATGCAATTTGATAGAGGTTATTTATCTCCATACTTTATTAATCAACCTGAAACAGGATTAGTAG
AATTAGAAAATCCGTATATTTTAATGGTAGATAAAAAAATTTCTAATATTCGTGAATTATTACCTATTTTAGAAGCTGTT
GCTAAATCTAGTAAACCATTATTAATTATTTCAGAAGATTTAGAAGGTGAAGCTTTAGCTACTTTAGTAGTAAATTCTAT
GAGAGGAATAGTAAAAGTTGCAGCTGTTAAAGCTCCAGGTTTTGGAGATCGTAGAAAAGCAATGTTACAAGATATTTCTA
TTTTAACTGGTGGTTCTGTAATTTCTGAAGAATTAGCTATGGATTTAGAAAAATCTTCTTTAGAAGATTTAGGGCAAGCT
AAACGTGTTGTCATTAATAAAGATACAACAACAATTATTGATGGTAATGGAAATAAAGAAGCTATTAAAAGTCGTATTAG
TCAAATTAGACAAGAAATAAATGAAGCTACATCAGATTATGATAAAGAAAAATTAAATGAACGTTTAGCAAAATTATCTG
GTGGTGTAGCAGTATTAAAAGTAGGTGCAGCAACTGAAGTAGAAATGAAAGAAAAAAAAGCTCGTGTTGAAGATGCTTTA
CATGCTACTAGAGCTGCAGTAGAAGAAGGTGTTGTTCCTGGTGGTGGTGTTGCTTTAGTTCGTGTTGCAGAAAAAATTTC
CCGTATTAATGGTCAAAATGAAGATCAAAATGTTGGAATTCGTGTTGCTTTACGTGCTATGGAAGCTCCTTTACGTCAGA
TTGTAGCTAATTCTGGAGAAGAACCTTCAGTAGTAACAAATAATGTGAAAGATGGTCATGGTAATTATGGTTATAATGCA
GCTACAGATGAGTATGGTGATATGATATCTTTTGGTATTTTAGATCCTACAAAAGTTACTAGATCTGCATTACAATATGC
TGCTTCTGTTGCTGGATTAATGATAACAACAGAATGTATGGTAACAGATTTGCCTAAAGATGAAAAATCTTCATCTGAAC
TAAATTCAGCTCCTGGAAATGGAATGGGTGGCGGAATGGGTGGAATGATGTAA

Upstream 100 bases:

>100_bases
ATTAATTCTTACAGAAAATGATATTTTAGCAATTGTTGAAAAATAAAATTATATAAAAATTTATTTTTAATTATTTATTA
AATACTGTGAGGATATTAAC

Downstream 100 bases:

>100_bases
TTTTTTGTTTTTATGTTATATGTCAATATATAAAAAGAGTTATTATACTTTATTTAGTATACTTCATAATTTCCTTGTTC
TCTTTTTCGTTCTTTGAGAA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 550; Mature: 549

Protein sequence:

>550_residues
MAAKDVKFGNEARIKMLHGVNVLADAVKVTLGPKGRNVVLDKSFGPPSITKDGVSVAREIELEDKFENMGAQMVKEVASK
ANDAAGDGTTTATLLAQSIVNEGLKAVAAGMNPMDLKRGIDKAVIDAVDELKKLSVPCADSKAITQVGTISANADEKVGS
LIAEAMEKVGNDGVITVEEGTGLQNELEVVKGMQFDRGYLSPYFINQPETGLVELENPYILMVDKKISNIRELLPILEAV
AKSSKPLLIISEDLEGEALATLVVNSMRGIVKVAAVKAPGFGDRRKAMLQDISILTGGSVISEELAMDLEKSSLEDLGQA
KRVVINKDTTTIIDGNGNKEAIKSRISQIRQEINEATSDYDKEKLNERLAKLSGGVAVLKVGAATEVEMKEKKARVEDAL
HATRAAVEEGVVPGGGVALVRVAEKISRINGQNEDQNVGIRVALRAMEAPLRQIVANSGEEPSVVTNNVKDGHGNYGYNA
ATDEYGDMISFGILDPTKVTRSALQYAASVAGLMITTECMVTDLPKDEKSSSELNSAPGNGMGGGMGGMM

Sequences:

>Translated_550_residues
MAAKDVKFGNEARIKMLHGVNVLADAVKVTLGPKGRNVVLDKSFGPPSITKDGVSVAREIELEDKFENMGAQMVKEVASK
ANDAAGDGTTTATLLAQSIVNEGLKAVAAGMNPMDLKRGIDKAVIDAVDELKKLSVPCADSKAITQVGTISANADEKVGS
LIAEAMEKVGNDGVITVEEGTGLQNELEVVKGMQFDRGYLSPYFINQPETGLVELENPYILMVDKKISNIRELLPILEAV
AKSSKPLLIISEDLEGEALATLVVNSMRGIVKVAAVKAPGFGDRRKAMLQDISILTGGSVISEELAMDLEKSSLEDLGQA
KRVVINKDTTTIIDGNGNKEAIKSRISQIRQEINEATSDYDKEKLNERLAKLSGGVAVLKVGAATEVEMKEKKARVEDAL
HATRAAVEEGVVPGGGVALVRVAEKISRINGQNEDQNVGIRVALRAMEAPLRQIVANSGEEPSVVTNNVKDGHGNYGYNA
ATDEYGDMISFGILDPTKVTRSALQYAASVAGLMITTECMVTDLPKDEKSSSELNSAPGNGMGGGMGGMM
>Mature_549_residues
AAKDVKFGNEARIKMLHGVNVLADAVKVTLGPKGRNVVLDKSFGPPSITKDGVSVAREIELEDKFENMGAQMVKEVASKA
NDAAGDGTTTATLLAQSIVNEGLKAVAAGMNPMDLKRGIDKAVIDAVDELKKLSVPCADSKAITQVGTISANADEKVGSL
IAEAMEKVGNDGVITVEEGTGLQNELEVVKGMQFDRGYLSPYFINQPETGLVELENPYILMVDKKISNIRELLPILEAVA
KSSKPLLIISEDLEGEALATLVVNSMRGIVKVAAVKAPGFGDRRKAMLQDISILTGGSVISEELAMDLEKSSLEDLGQAK
RVVINKDTTTIIDGNGNKEAIKSRISQIRQEINEATSDYDKEKLNERLAKLSGGVAVLKVGAATEVEMKEKKARVEDALH
ATRAAVEEGVVPGGGVALVRVAEKISRINGQNEDQNVGIRVALRAMEAPLRQIVANSGEEPSVVTNNVKDGHGNYGYNAA
TDEYGDMISFGILDPTKVTRSALQYAASVAGLMITTECMVTDLPKDEKSSSELNSAPGNGMGGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=50.3787878787879, Blast_Score=530, Evalue=1e-150,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=50.3787878787879, Blast_Score=530, Evalue=1e-150,
Organism=Homo sapiens, GI63162572, Length=563, Percent_Identity=21.6696269982238, Blast_Score=76, Evalue=9e-14,
Organism=Escherichia coli, GI1790586, Length=528, Percent_Identity=84.469696969697, Blast_Score=908, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=51.5151515151515, Blast_Score=538, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI193210679, Length=210, Percent_Identity=52.8571428571429, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17564182, Length=539, Percent_Identity=22.0779220779221, Blast_Score=69, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=53.2442748091603, Blast_Score=551, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6322350, Length=567, Percent_Identity=22.9276895943563, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6322524, Length=162, Percent_Identity=27.1604938271605, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=51.8026565464896, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=51.8026565464896, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=51.6129032258064, Blast_Score=541, Evalue=1e-154,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=51.6129032258064, Blast_Score=541, Evalue=1e-154,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=51.6129032258064, Blast_Score=541, Evalue=1e-154,
Organism=Drosophila melanogaster, GI17864606, Length=554, Percent_Identity=42.2382671480144, Blast_Score=448, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24584129, Length=533, Percent_Identity=38.4615384615385, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI19921262, Length=533, Percent_Identity=38.4615384615385, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI24583944, Length=234, Percent_Identity=23.9316239316239, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 58280; Mature: 58149

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVKFGNEARIKMLHGVNVLADAVKVTLGPKGRNVVLDKSFGPPSITKDGVSVAREI
CCCCCCCCCCHHHEEHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCHHHHHHHHHH
ELEDKFENMGAQMVKEVASKANDAAGDGTTTATLLAQSIVNEGLKAVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCH
DKAVIDAVDELKKLSVPCADSKAITQVGTISANADEKVGSLIAEAMEKVGNDGVITVEEG
HHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECC
TGLQNELEVVKGMQFDRGYLSPYFINQPETGLVELENPYILMVDKKISNIRELLPILEAV
CCCHHHHHHHHCCCCCCCCCCCEECCCCCCCEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKSSKPLLIISEDLEGEALATLVVNSMRGIVKVAAVKAPGFGDRRKAMLQDISILTGGSV
HCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHCCCHH
ISEELAMDLEKSSLEDLGQAKRVVINKDTTTIIDGNGNKEAIKSRISQIRQEINEATSDY
HHHHHHHHHHHHHHHHHHHHCEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCH
DKEKLNERLAKLSGGVAVLKVGAATEVEMKEKKARVEDALHATRAAVEEGVVPGGGVALV
HHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RVAEKISRINGQNEDQNVGIRVALRAMEAPLRQIVANSGEEPSVVTNNVKDGHGNYGYNA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCC
ATDEYGDMISFGILDPTKVTRSALQYAASVAGLMITTECMVTDLPKDEKSSSELNSAPGN
CCCHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCC
GMGGGMGGMM
CCCCCCCCCC
>Mature Secondary Structure 
AAKDVKFGNEARIKMLHGVNVLADAVKVTLGPKGRNVVLDKSFGPPSITKDGVSVAREI
CCCCCCCCCHHHEEHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCHHHHHHHHHH
ELEDKFENMGAQMVKEVASKANDAAGDGTTTATLLAQSIVNEGLKAVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCH
DKAVIDAVDELKKLSVPCADSKAITQVGTISANADEKVGSLIAEAMEKVGNDGVITVEEG
HHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECC
TGLQNELEVVKGMQFDRGYLSPYFINQPETGLVELENPYILMVDKKISNIRELLPILEAV
CCCHHHHHHHHCCCCCCCCCCCEECCCCCCCEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKSSKPLLIISEDLEGEALATLVVNSMRGIVKVAAVKAPGFGDRRKAMLQDISILTGGSV
HCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHCCCHH
ISEELAMDLEKSSLEDLGQAKRVVINKDTTTIIDGNGNKEAIKSRISQIRQEINEATSDY
HHHHHHHHHHHHHHHHHHHHCEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCH
DKEKLNERLAKLSGGVAVLKVGAATEVEMKEKKARVEDALHATRAAVEEGVVPGGGVALV
HHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RVAEKISRINGQNEDQNVGIRVALRAMEAPLRQIVANSGEEPSVVTNNVKDGHGNYGYNA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCC
ATDEYGDMISFGILDPTKVTRSALQYAASVAGLMITTECMVTDLPKDEKSSSELNSAPGN
CCCHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCC
GMGGGMGGMM
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12522265 [H]