Click here to switch to the map view.

The map label for this gene is malR [H]

Identifier: 116496287

GI number: 116496287

Start: 2852270

End: 2852959

Strand: Direct

Name: malR [H]

Synonym: LSEI_2869

Alternate gene names: 116496287

Gene position: 2852270-2852959 (Clockwise)

Preceding gene: 116496286

Following gene: 116496291

Centisome position: 98.52

GC content: 44.78

Gene sequence:

>690_bases
ATGACGAACATTCTAATCGTTGAAGATGATCCAATGGTGCAATTTATCCACCGCAATTATTTAGAAAAAATCGGTACTTT
TGACACCATCTACTCTTCAGAAACCATCGCTGAAGCCAAAAAACTCTTGTCCAGCCGATCCATCCAACTCGTTTTACTCG
ACATTCGCCTCAAAGACGGGAACGGCATTGATTTTTTAACCGACCTGCGCCGCACCAAACAAACCGTTGATGTCATCCTC
ATCACCGCGGCAAACGAGGTCAACATTGTCAATGATGCCTTGCACTTAGGCGTGATTGACTACCTCATCAAACCCTTCAC
GTTGGAACGCTTCGAAAAAAGTATTCAACGTTACAGAACCAAGCATCAAGCATTGGTAACTGATCAGCTTGATCAAAGTC
AACTCGACACGTATTTCGAACCGCAAACAACCATCGCTCCGACAGTCGATCTAGACAAAGGCCTGAGCAAAGCCACGTTG
CAACTCATTCAAGGCGCCATTAAACAACTCCCGCAACCATTTACCGTCGCACAATTAACGACAGAAACCGGTCTCTCGCA
TGTTTCTGTCCGGAAATATTTAAGTTTTCTAGAGGATCATCATTTTCTGAAAGGCGATACGATTTATCGCAAGACAGGCC
GACCTTATAAAACTTATCAGATGGTCACGGCACCACATGCGCTGTCGTAA

Upstream 100 bases:

>100_bases
TTCCAACAACTGCTGACGGAGTTGAACGGCTCAGTCACCGTTAGCTCAACCGATCCGCTGACACTAACATTAACTGTGGA
CTACCACGAGGAGGCTCAAA

Downstream 100 bases:

>100_bases
ACATCATTCAAATCTTTAAAAAGGCAGTGATCTTAAATACTAAGATCACTGCCTTTTTGTTGTTAATGATTGAGGTTGCT
TACATACAATGAACGCTAAT

Product: response regulator of citrate/malate metabolism

Products: NA

Alternate protein names: Malate response regulator [H]

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MTNILIVEDDPMVQFIHRNYLEKIGTFDTIYSSETIAEAKKLLSSRSIQLVLLDIRLKDGNGIDFLTDLRRTKQTVDVIL
ITAANEVNIVNDALHLGVIDYLIKPFTLERFEKSIQRYRTKHQALVTDQLDQSQLDTYFEPQTTIAPTVDLDKGLSKATL
QLIQGAIKQLPQPFTVAQLTTETGLSHVSVRKYLSFLEDHHFLKGDTIYRKTGRPYKTYQMVTAPHALS

Sequences:

>Translated_229_residues
MTNILIVEDDPMVQFIHRNYLEKIGTFDTIYSSETIAEAKKLLSSRSIQLVLLDIRLKDGNGIDFLTDLRRTKQTVDVIL
ITAANEVNIVNDALHLGVIDYLIKPFTLERFEKSIQRYRTKHQALVTDQLDQSQLDTYFEPQTTIAPTVDLDKGLSKATL
QLIQGAIKQLPQPFTVAQLTTETGLSHVSVRKYLSFLEDHHFLKGDTIYRKTGRPYKTYQMVTAPHALS
>Mature_228_residues
TNILIVEDDPMVQFIHRNYLEKIGTFDTIYSSETIAEAKKLLSSRSIQLVLLDIRLKDGNGIDFLTDLRRTKQTVDVILI
TAANEVNIVNDALHLGVIDYLIKPFTLERFEKSIQRYRTKHQALVTDQLDQSQLDTYFEPQTTIAPTVDLDKGLSKATLQ
LIQGAIKQLPQPFTVAQLTTETGLSHVSVRKYLSFLEDHHFLKGDTIYRKTGRPYKTYQMVTAPHALS

Specific function: Member of a two-component regulatory system malK/malR. Activates transcription of maeA, maeN and yflS in presence of malate by binding to their promoter region [H]

COG id: COG4565

COG function: function code KT; Response regulator of citrate/malate metabolism

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790566, Length=233, Percent_Identity=36.0515021459227, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1786838, Length=218, Percent_Identity=30.2752293577982, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1786911, Length=124, Percent_Identity=34.6774193548387, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 26094; Mature: 25963

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNILIVEDDPMVQFIHRNYLEKIGTFDTIYSSETIAEAKKLLSSRSIQLVLLDIRLKDG
CCCEEEECCCHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHCCCEEEEEEEEEEECC
NGIDFLTDLRRTKQTVDVILITAANEVNIVNDALHLGVIDYLIKPFTLERFEKSIQRYRT
CCCHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
KHQALVTDQLDQSQLDTYFEPQTTIAPTVDLDKGLSKATLQLIQGAIKQLPQPFTVAQLT
HHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHCCCCCCHHHHH
TETGLSHVSVRKYLSFLEDHHFLKGDTIYRKTGRPYKTYQMVTAPHALS
HHHCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEEEECCCCCC
>Mature Secondary Structure 
TNILIVEDDPMVQFIHRNYLEKIGTFDTIYSSETIAEAKKLLSSRSIQLVLLDIRLKDG
CCEEEECCCHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHCCCEEEEEEEEEEECC
NGIDFLTDLRRTKQTVDVILITAANEVNIVNDALHLGVIDYLIKPFTLERFEKSIQRYRT
CCCHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
KHQALVTDQLDQSQLDTYFEPQTTIAPTVDLDKGLSKATLQLIQGAIKQLPQPFTVAQLT
HHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHCCCCCCHHHHH
TETGLSHVSVRKYLSFLEDHHFLKGDTIYRKTGRPYKTYQMVTAPHALS
HHHCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377; 12949159; 12949160 [H]