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The map label for this gene is pepC [H]

Identifier: 116495781

GI number: 116495781

Start: 2325926

End: 2327272

Strand: Direct

Name: pepC [H]

Synonym: LSEI_2329

Alternate gene names: 116495781

Gene position: 2325926-2327272 (Clockwise)

Preceding gene: 116495780

Following gene: 116495782

Centisome position: 80.34

GC content: 46.7

Gene sequence:

>1347_bases
ATGTCTGCAGAAATTACCACTGGCGATCTGGCTCAATTCAAACAAGATCTCCAAGCCACACCCGGTGCCTCCGCTCTTCA
AAAAGCGGTCATGAACAACGGTATCAACGCAACTGCTGAGAACACCGACAGCAAAGTTGCCATGACCCCGACTTTTTCTA
TTGAACTTGATACCGGCAGCGTTGCTAACCAAAAGCAAAGTGGCCGTTGCTGGATGTTTGCCGCCCTCAACACGATGCGT
CACGGCATTCAAGCACAATTTAAAATCAAAGACTTCGAACTTTCTCAGAATTACACCTTCTTCTGGGACAAATTTGAAAA
ATCCAATTATTTTTATGAAAATGTTCTAAAAACCGCCGATCAACCACTCGACAGCCGTAAAGTTGCTTTTTTGATGACCA
CACCACAACAGGATGGTGGTCAGTGGGATATGTTGTCTGCTTTGATCGAAAAATACGGGATCGTTCCTAAGTCCGTGATG
CCGGAAACTTACAGCTCAAGTAAAAGTAGCGAGTTGAACGGTTTGTTGAACTTGAAGTTACGCAAGGACGCTGTTGCGCT
TCGCAAACTGGTTGCTGATAAAGCAAGCGATGCTGATATTGAGGCAGCTAAACAGAAAATGTTAGCTGAAGATTATCGGA
TTTTGGCTTACACCTTAGGCAACCCGCCGACGAAGTTCGACTTCGAATATCGCGATGATGATAAGCAGTATCATATTGAC
CGCGAACTCACCCCGCAGACCTTCTTCAAGAAGTACGTTGCATGGAACCTTGATGATTACCAAAGTATCATCAATGCGCC
AACTGACGACAAGCCATACAACCATTTATACACGGTTGAAATGCTCGGCAACGTTGTCGGTGGCCGCGAAGTTCGGCACT
TGAACCTCGATATCGATACTTTCAAAGCCTTGGCCGTTAAGCAGCTCAAGGCAGGCGAATCAGTTTGGTTCGGTTCTGAT
GTTGGTCAGAGTTCTGATCGGCAATTGGGCATCATGGATACCAACATCTATAAGAAGGATGATCTTTTCAACACCGACTT
CACCATGACCAAGGCGGAACGCCTCGATTACGGCGAAAGCCTCATGACCCACGCAATGGTCCTCACCGGCGTTGACATTG
TCGACGGCAAGCCAACCAAGTGGAAGGTTGAAAACTCTTGGGGCGACAAGGTCGGTGACAAAGGCTATTTTGTGGCCAGT
GATTCTTGGTTTGACGAGTTCGTTTACCAAGTTGTCATCTCCAAAAAGTACCTGTCAGCTGACTTGCAAGACGTCATCAA
GAACGAATACGACAAACCAACCGTTCTGGCCCCATGGGATCCAATGGGTGCTTTAGCTTCCAAATAA

Upstream 100 bases:

>100_bases
ACCCCAGATGCAATGGCCAAAACCCCATCACATCTGGCGCCGCTTACACTCCGGTTTCTAACCGGGCTGGCTCGCGCTCA
CAAAAAAGGAGTGTCTTTTA

Downstream 100 bases:

>100_bases
GTCCATACGAATTGGTAAGCTGTCATATTGCAAAGCCTCACGGTCAATGATCGTGAGGCTTTTTGCTGTTCGCAAACCCC
TTGCGAAACCATCAAAAAAT

Product: aminopeptidase C

Products: NA

Alternate protein names: Bleomycin hydrolase [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSAEITTGDLAQFKQDLQATPGASALQKAVMNNGINATAENTDSKVAMTPTFSIELDTGSVANQKQSGRCWMFAALNTMR
HGIQAQFKIKDFELSQNYTFFWDKFEKSNYFYENVLKTADQPLDSRKVAFLMTTPQQDGGQWDMLSALIEKYGIVPKSVM
PETYSSSKSSELNGLLNLKLRKDAVALRKLVADKASDADIEAAKQKMLAEDYRILAYTLGNPPTKFDFEYRDDDKQYHID
RELTPQTFFKKYVAWNLDDYQSIINAPTDDKPYNHLYTVEMLGNVVGGREVRHLNLDIDTFKALAVKQLKAGESVWFGSD
VGQSSDRQLGIMDTNIYKKDDLFNTDFTMTKAERLDYGESLMTHAMVLTGVDIVDGKPTKWKVENSWGDKVGDKGYFVAS
DSWFDEFVYQVVISKKYLSADLQDVIKNEYDKPTVLAPWDPMGALASK

Sequences:

>Translated_448_residues
MSAEITTGDLAQFKQDLQATPGASALQKAVMNNGINATAENTDSKVAMTPTFSIELDTGSVANQKQSGRCWMFAALNTMR
HGIQAQFKIKDFELSQNYTFFWDKFEKSNYFYENVLKTADQPLDSRKVAFLMTTPQQDGGQWDMLSALIEKYGIVPKSVM
PETYSSSKSSELNGLLNLKLRKDAVALRKLVADKASDADIEAAKQKMLAEDYRILAYTLGNPPTKFDFEYRDDDKQYHID
RELTPQTFFKKYVAWNLDDYQSIINAPTDDKPYNHLYTVEMLGNVVGGREVRHLNLDIDTFKALAVKQLKAGESVWFGSD
VGQSSDRQLGIMDTNIYKKDDLFNTDFTMTKAERLDYGESLMTHAMVLTGVDIVDGKPTKWKVENSWGDKVGDKGYFVAS
DSWFDEFVYQVVISKKYLSADLQDVIKNEYDKPTVLAPWDPMGALASK
>Mature_447_residues
SAEITTGDLAQFKQDLQATPGASALQKAVMNNGINATAENTDSKVAMTPTFSIELDTGSVANQKQSGRCWMFAALNTMRH
GIQAQFKIKDFELSQNYTFFWDKFEKSNYFYENVLKTADQPLDSRKVAFLMTTPQQDGGQWDMLSALIEKYGIVPKSVMP
ETYSSSKSSELNGLLNLKLRKDAVALRKLVADKASDADIEAAKQKMLAEDYRILAYTLGNPPTKFDFEYRDDDKQYHIDR
ELTPQTFFKKYVAWNLDDYQSIINAPTDDKPYNHLYTVEMLGNVVGGREVRHLNLDIDTFKALAVKQLKAGESVWFGSDV
GQSSDRQLGIMDTNIYKKDDLFNTDFTMTKAERLDYGESLMTHAMVLTGVDIVDGKPTKWKVENSWGDKVGDKGYFVASD
SWFDEFVYQVVISKKYLSADLQDVIKNEYDKPTVLAPWDPMGALASK

Specific function: Unknown

COG id: COG3579

COG function: function code E; Aminopeptidase C

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C1 family [H]

Homologues:

Organism=Homo sapiens, GI4557367, Length=394, Percent_Identity=44.4162436548223, Blast_Score=369, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6324090, Length=401, Percent_Identity=38.9027431421446, Blast_Score=294, Evalue=2e-80,
Organism=Drosophila melanogaster, GI161077632, Length=402, Percent_Identity=41.7910447761194, Blast_Score=331, Evalue=7e-91,
Organism=Drosophila melanogaster, GI24640588, Length=402, Percent_Identity=41.7910447761194, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI161077630, Length=367, Percent_Identity=41.6893732970027, Blast_Score=294, Evalue=1e-79,
Organism=Drosophila melanogaster, GI20130175, Length=477, Percent_Identity=25.5765199161426, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000169
- InterPro:   IPR004134 [H]

Pfam domain/function: PF03051 Peptidase_C1_2 [H]

EC number: =3.4.22.40 [H]

Molecular weight: Translated: 50601; Mature: 50470

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00139 THIOL_PROTEASE_CYS ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAEITTGDLAQFKQDLQATPGASALQKAVMNNGINATAENTDSKVAMTPTFSIELDTGS
CCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCEEEEEECCCC
VANQKQSGRCWMFAALNTMRHGIQAQFKIKDFELSQNYTFFWDKFEKSNYFYENVLKTAD
CCCCCCCCCEEEEHHHHHHHCCCEEEEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHC
QPLDSRKVAFLMTTPQQDGGQWDMLSALIEKYGIVPKSVMPETYSSSKSSELNGLLNLKL
CCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCEEEEEE
RKDAVALRKLVADKASDADIEAAKQKMLAEDYRILAYTLGNPPTKFDFEYRDDDKQYHID
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCEECCEECCCCCEEEEC
RELTPQTFFKKYVAWNLDDYQSIINAPTDDKPYNHLYTVEMLGNVVGGREVRHLNLDIDT
CCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHCCCEEEEEECCHHH
FKALAVKQLKAGESVWFGSDVGQSSDRQLGIMDTNIYKKDDLFNTDFTMTKAERLDYGES
HHHHHHHHHHCCCCEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEHHHHHCCCHHH
LMTHAMVLTGVDIVDGKPTKWKVENSWGDKVGDKGYFVASDSWFDEFVYQVVISKKYLSA
HHHHHHHHHCCEEECCCCCEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHH
DLQDVIKNEYDKPTVLAPWDPMGALASK
HHHHHHHCCCCCCEEECCCCCCHHHCCC
>Mature Secondary Structure 
SAEITTGDLAQFKQDLQATPGASALQKAVMNNGINATAENTDSKVAMTPTFSIELDTGS
CCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCEEEEEECCCC
VANQKQSGRCWMFAALNTMRHGIQAQFKIKDFELSQNYTFFWDKFEKSNYFYENVLKTAD
CCCCCCCCCEEEEHHHHHHHCCCEEEEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHC
QPLDSRKVAFLMTTPQQDGGQWDMLSALIEKYGIVPKSVMPETYSSSKSSELNGLLNLKL
CCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCEEEEEE
RKDAVALRKLVADKASDADIEAAKQKMLAEDYRILAYTLGNPPTKFDFEYRDDDKQYHID
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCEECCEECCCCCEEEEC
RELTPQTFFKKYVAWNLDDYQSIINAPTDDKPYNHLYTVEMLGNVVGGREVRHLNLDIDT
CCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHCCCEEEEEECCHHH
FKALAVKQLKAGESVWFGSDVGQSSDRQLGIMDTNIYKKDDLFNTDFTMTKAERLDYGES
HHHHHHHHHHCCCCEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEHHHHHCCCHHH
LMTHAMVLTGVDIVDGKPTKWKVENSWGDKVGDKGYFVASDSWFDEFVYQVVISKKYLSA
HHHHHHHHHCCEEECCCCCEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHH
DLQDVIKNEYDKPTVLAPWDPMGALASK
HHHHHHHCCCCCCEEECCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7851736 [H]