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The map label for this gene is pepC [H]

Identifier: 116495780

GI number: 116495780

Start: 2324376

End: 2325695

Strand: Direct

Name: pepC [H]

Synonym: LSEI_2328

Alternate gene names: 116495780

Gene position: 2324376-2325695 (Clockwise)

Preceding gene: 116495778

Following gene: 116495781

Centisome position: 80.28

GC content: 47.2

Gene sequence:

>1320_bases
ATGTCAGAAATTACATTTGATCAAATTAAAGACTTTCAAGCCCAACTAGCCAAACAGCCGGCTGCCGGCGCCACAGCTCG
TGCGGTGCAAAACGTTGGCCCACAAGCTGCAAGTCGCGAACCCATTGACGGCGAAGATATGAAACCGGTCTTTTCTCTTG
ATCTTGATACCGGTACCGTTGCTAACCAAAAGAAAAGTGGCCGCTGTTGGCTCTTTGCCACCCTCAATACCGTTCGCCAC
GGCATTGCTGATGAATTCGGCATTAAGGACTTCGAGTTTTCACAAAACTACAACGCCTTCTTTGATCGTTTGGAAAAAGC
TAATTTATTTTATGAAAACATTTTAGCAACGGCCGATAAACCGCTTGATGCCCGCGAAGTTGCCGATTATCTGAGTGGCC
CGGATCAGGATGGCGGTCACTATGATCAGGCTGAAGCACTGATCGAAAAATACGGTCTAGTCCCTAAGTCAATCATGCCA
GAAACCTACAACAGCGAAAAAACGGTTGAACTCAACAGCGTTTTGAATGAGAAGCTGCGCAAAGATGCCAAAGTCTTGCG
TGAGTTGAAACAGGCCAACGCTGGCGATGACGCCATTGCCGCTAAAAAACGCGAATTTCTCAGCGTTGTTTACCGCATTC
TCGCATACACTTTTGGCAACCCGCCAACCCAATTTGACTTTGAATATCGCGATGATAAGAAGCAGTACCACCGCGACACC
AACCTGACACCGCAGTCTTTCTTCAAAAAATATGTGAAGTGGCATTTTGACGATTACGTTGTGGTTGCGAGTGATCCGGA
GCCGAACAAAAAATATCATCAGCTGTATACCATCGCTTCAGCGAACACCGTTGTCGGCGGTCATCCCCTGACCATTCTGA
ATCTACCACCTGACCAGTTGAAAAAACTGGCTTTAACCCAGCTACAGGCGGGTGAAGCCGTTTGGTTCGGCAATGATGTG
CTCGCTGATATGGATCGCAAATCTGGCACGCTTAAAGGCGGGCTGTATAACTACAGTGACTTATTCGATCTGGATCTTCA
TTTCGACAAAACTGATCGAATTGTGACTACCGAAGCAGAAATGTCGCATGCTATGACGCTGACCGGCGCTGATGTTGTTG
ACGGCGAGGTCACCAAATGGAAAGTCGAAAATTCTTGGGGCAAAGACAACGGTCACGATGGCTATTTTGTTGCTGATGCA
TCTTGGTTCGACCAATATGTTTATGAAGTGGTCGTTCGCAAAGATCTGCTCGATCCAGCTGATCAAGCAGCACTTAAAGC
AACGCCGATCAATGTACCTGTCTGGGATTTCCTGAATTAA

Upstream 100 bases:

>100_bases
TAACGAGCTTGTGCCACTCAATGATCCATTGATTTTCCATCTTTAAATTCAAATTAAAATGAGGTAAGGTTTCTTTAATG
CAATAAAAAGGAGATCGCCT

Downstream 100 bases:

>100_bases
ATTGGACTTGTATGCTAGACTAATGATGTTCGACAAAGGCAGCGCACCTACATGCTAGCTCATGCTTTCATGAACGCGCT
TGTCTTCGTCTTCATAACGC

Product: aminopeptidase C

Products: NA

Alternate protein names: Bleomycin hydrolase [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MSEITFDQIKDFQAQLAKQPAAGATARAVQNVGPQAASREPIDGEDMKPVFSLDLDTGTVANQKKSGRCWLFATLNTVRH
GIADEFGIKDFEFSQNYNAFFDRLEKANLFYENILATADKPLDAREVADYLSGPDQDGGHYDQAEALIEKYGLVPKSIMP
ETYNSEKTVELNSVLNEKLRKDAKVLRELKQANAGDDAIAAKKREFLSVVYRILAYTFGNPPTQFDFEYRDDKKQYHRDT
NLTPQSFFKKYVKWHFDDYVVVASDPEPNKKYHQLYTIASANTVVGGHPLTILNLPPDQLKKLALTQLQAGEAVWFGNDV
LADMDRKSGTLKGGLYNYSDLFDLDLHFDKTDRIVTTEAEMSHAMTLTGADVVDGEVTKWKVENSWGKDNGHDGYFVADA
SWFDQYVYEVVVRKDLLDPADQAALKATPINVPVWDFLN

Sequences:

>Translated_439_residues
MSEITFDQIKDFQAQLAKQPAAGATARAVQNVGPQAASREPIDGEDMKPVFSLDLDTGTVANQKKSGRCWLFATLNTVRH
GIADEFGIKDFEFSQNYNAFFDRLEKANLFYENILATADKPLDAREVADYLSGPDQDGGHYDQAEALIEKYGLVPKSIMP
ETYNSEKTVELNSVLNEKLRKDAKVLRELKQANAGDDAIAAKKREFLSVVYRILAYTFGNPPTQFDFEYRDDKKQYHRDT
NLTPQSFFKKYVKWHFDDYVVVASDPEPNKKYHQLYTIASANTVVGGHPLTILNLPPDQLKKLALTQLQAGEAVWFGNDV
LADMDRKSGTLKGGLYNYSDLFDLDLHFDKTDRIVTTEAEMSHAMTLTGADVVDGEVTKWKVENSWGKDNGHDGYFVADA
SWFDQYVYEVVVRKDLLDPADQAALKATPINVPVWDFLN
>Mature_438_residues
SEITFDQIKDFQAQLAKQPAAGATARAVQNVGPQAASREPIDGEDMKPVFSLDLDTGTVANQKKSGRCWLFATLNTVRHG
IADEFGIKDFEFSQNYNAFFDRLEKANLFYENILATADKPLDAREVADYLSGPDQDGGHYDQAEALIEKYGLVPKSIMPE
TYNSEKTVELNSVLNEKLRKDAKVLRELKQANAGDDAIAAKKREFLSVVYRILAYTFGNPPTQFDFEYRDDKKQYHRDTN
LTPQSFFKKYVKWHFDDYVVVASDPEPNKKYHQLYTIASANTVVGGHPLTILNLPPDQLKKLALTQLQAGEAVWFGNDVL
ADMDRKSGTLKGGLYNYSDLFDLDLHFDKTDRIVTTEAEMSHAMTLTGADVVDGEVTKWKVENSWGKDNGHDGYFVADAS
WFDQYVYEVVVRKDLLDPADQAALKATPINVPVWDFLN

Specific function: Unknown

COG id: COG3579

COG function: function code E; Aminopeptidase C

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C1 family [H]

Homologues:

Organism=Homo sapiens, GI4557367, Length=385, Percent_Identity=38.7012987012987, Blast_Score=299, Evalue=3e-81,
Organism=Saccharomyces cerevisiae, GI6324090, Length=441, Percent_Identity=35.1473922902494, Blast_Score=241, Evalue=1e-64,
Organism=Drosophila melanogaster, GI161077632, Length=444, Percent_Identity=34.009009009009, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24640588, Length=444, Percent_Identity=34.009009009009, Blast_Score=282, Evalue=3e-76,
Organism=Drosophila melanogaster, GI161077630, Length=358, Percent_Identity=36.0335195530726, Blast_Score=248, Evalue=8e-66,
Organism=Drosophila melanogaster, GI20130175, Length=387, Percent_Identity=24.031007751938, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000169
- InterPro:   IPR004134 [H]

Pfam domain/function: PF03051 Peptidase_C1_2 [H]

EC number: =3.4.22.40 [H]

Molecular weight: Translated: 49461; Mature: 49329

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00139 THIOL_PROTEASE_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEITFDQIKDFQAQLAKQPAAGATARAVQNVGPQAASREPIDGEDMKPVFSLDLDTGTV
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCC
ANQKKSGRCWLFATLNTVRHGIADEFGIKDFEFSQNYNAFFDRLEKANLFYENILATADK
CCCCCCCCEEEEEEHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
PLDAREVADYLSGPDQDGGHYDQAEALIEKYGLVPKSIMPETYNSEKTVELNSVLNEKLR
CCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHCCCCCCCCCEEEHHHHHHHHHH
KDAKVLRELKQANAGDDAIAAKKREFLSVVYRILAYTFGNPPTQFDFEYRDDKKQYHRDT
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCC
NLTPQSFFKKYVKWHFDDYVVVASDPEPNKKYHQLYTIASANTVVGGHPLTILNLPPDQL
CCCHHHHHHHHHHCCCCCEEEEECCCCCCCHHEEEEEEECCCEEECCCCEEEEECCHHHH
KKLALTQLQAGEAVWFGNDVLADMDRKSGTLKGGLYNYSDLFDLDLHFDKTDRIVTTEAE
HHHHHHHHCCCCEEEECCHHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEHHH
MSHAMTLTGADVVDGEVTKWKVENSWGKDNGHDGYFVADASWFDQYVYEVVVRKDLLDPA
HHHEEEECCCCCCCCCCEEEEEECCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCH
DQAALKATPINVPVWDFLN
HHHHEEECCCCCCHHHCCC
>Mature Secondary Structure 
SEITFDQIKDFQAQLAKQPAAGATARAVQNVGPQAASREPIDGEDMKPVFSLDLDTGTV
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCC
ANQKKSGRCWLFATLNTVRHGIADEFGIKDFEFSQNYNAFFDRLEKANLFYENILATADK
CCCCCCCCEEEEEEHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
PLDAREVADYLSGPDQDGGHYDQAEALIEKYGLVPKSIMPETYNSEKTVELNSVLNEKLR
CCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHCCCCCCCCCEEEHHHHHHHHHH
KDAKVLRELKQANAGDDAIAAKKREFLSVVYRILAYTFGNPPTQFDFEYRDDKKQYHRDT
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCC
NLTPQSFFKKYVKWHFDDYVVVASDPEPNKKYHQLYTIASANTVVGGHPLTILNLPPDQL
CCCHHHHHHHHHHCCCCCEEEEECCCCCCCHHEEEEEEECCCEEECCCCEEEEECCHHHH
KKLALTQLQAGEAVWFGNDVLADMDRKSGTLKGGLYNYSDLFDLDLHFDKTDRIVTTEAE
HHHHHHHHCCCCEEEECCHHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEHHH
MSHAMTLTGADVVDGEVTKWKVENSWGKDNGHDGYFVADASWFDQYVYEVVVRKDLLDPA
HHHEEEECCCCCCCCCCEEEEEECCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCH
DQAALKATPINVPVWDFLN
HHHHEEECCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7851736 [H]