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The map label for this gene is ezrA [H]

Identifier: 116494739

GI number: 116494739

Start: 1223194

End: 1224897

Strand: Direct

Name: ezrA [H]

Synonym: LSEI_1246

Alternate gene names: 116494739

Gene position: 1223194-1224897 (Clockwise)

Preceding gene: 116494735

Following gene: 116494740

Centisome position: 42.25

GC content: 46.48

Gene sequence:

>1704_bases
ATGATCTGGTTCTTTGTTATCGTAGTGATCATAGTTGTCGCTGCCGGCGGTGTCTGGTGGCTGCAGCATTATTTTCAGAC
TCGAATCAAGAACTTGGACGCGCAAGTCGAAGCGATCGACGTTGGTGCGCTGTCGAGTCAGATTCGCAGCATCGAGCAGT
TAAAGTTAACTGGCGATAGTCTGGCAACGTTCAGCAAGTGGGAACGGGCCTTTGATCAGTTGAATGATGACGACTTGGCT
GACCTACAGAAGATTCTGCTTGATCTGGAGGACCAGGCCAAGCGTTTTCGCTTTGATCATGCCCAGAAAATTGCTAAGGT
GCTGGAAGCAAAAATTGACACAGCCCGCCAACAATATGACTTGATCAGCCAAGCCTTACAAGACATTCGGCATGACGAGG
CGGATAATCGCAGTAAGATGTTGCAGCTACGTGATGATTATCAAGTGTCGCGTAAAACGATCCTCGCCAAAAGTTTTGTC
TTCGGGGATGCCCAGCCGGCTTTGGAGCAGCAGTTGCAACAACTGGCTGAACTTTTTCAAAAAATTGACCAGATTAATAA
TGATGGCGATCATCAAGCTGCTAAGAGCGAGATTAAGCAGTTAAGCGATGAGATGGCGGCATTGCGGCGTCAAGTTAAAG
AATTGCCACCGCTTGTCAATGAACAGGTGAACGAATTCCCGGCGCAGATTAATGAAATCGAGCATGGCTATCGGCAGTTG
ACAACGGCTCATTATGTTTTCACTGATGATATTCCGGGCATGGTCGAGGATGTTAACGAAAAGATGGCTGACGCTAACAC
CGCGCTTAAGTCGCTTGATGTGGACGCCACAGAAGCGGCTAACAGCGAAATTGAAGCTGAGATTGATAAGATGTACGCGA
TTATGGAAAAGGAAATGCAGGCTAGAAAGCGCGTCGATGCTGCTGCGCCAGACCTGCGCCAATTTATTGATCACGCCTTG
CGTCAAAATCGCGAGTTGCAGACAGAACTGGATCATTTGAATCAGAGCTACACGTTGAATCACGATGAAATCAAAATTGC
CAAAGATTTAAAGACGCAGCTTGATTCGATCAATGCCAACTATATTAAGGATACGGATGCGATTGAAGCTGGTAAGGCCG
TGTATTCTGATGTGATTGAGCGGTTTGATGCCACCAAAGATGAGTTGACAGCGATTGAGAAGCAGCAGGTTCAAATTAAT
CAAGCGGTCGCAGGCTTAAAGAAAGGCGAGATTGTCGCCAACAAGCAGGCAGAGAATTTTGAACTGGATATGCGTAACAT
CAAACACGAAATTTTACGGCATCACCTACCTGGTCTGCCACAAGATTATGTGAGCCAGGTCAAGCACGTCACTGCCGAGA
TCGAGCAATTAAACCATGATCTTGATCAAGTGAAAATTAACATGGATGCGATTGCTAAGTTTCTGATTAAAATTGCCAGC
GATATTGATGCGTTGAAAAAAGCTACCAGCGCTTTGATTGACGCTGCGGGTTTGACAGAAGAACTGATGCAGTATGCCAA
CCGCTATAAAACAACAGTGAAACCAGTCGCCGAAGCAGTGCATCAGGCTACTGAGTCGTATATGCAATTTGATTATAAGC
AAGCCGCGGATACCTTAGCGACGGCATTGGAGCAAACCGAAGCCGGAAGCTATAAGAAGGTTGAGGATGCGTACCTTGCG
CGGAAGAAAGCTTCATTATATTAG

Upstream 100 bases:

>100_bases
TACTTAGGATATTCTCACATTTTGATGCTTAACGGCATTTTAGCCGCGAAGCTGTCAAAATGCAATTGAAATGATAATAG
GTAAAGCAGAGGGTGTAGGG

Downstream 100 bases:

>100_bases
TGATTCGGATTTGGGAAAACCAGCCGGTGGTGGCTGGTTTTTTGTTTGGAGGTTGTTGTTGTGCGAATTTGTGGGTAATT
TTCGTAGGACTTGTTGTACG

Product: septation ring formation regulator EzrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 567; Mature: 567

Protein sequence:

>567_residues
MIWFFVIVVIIVVAAGGVWWLQHYFQTRIKNLDAQVEAIDVGALSSQIRSIEQLKLTGDSLATFSKWERAFDQLNDDDLA
DLQKILLDLEDQAKRFRFDHAQKIAKVLEAKIDTARQQYDLISQALQDIRHDEADNRSKMLQLRDDYQVSRKTILAKSFV
FGDAQPALEQQLQQLAELFQKIDQINNDGDHQAAKSEIKQLSDEMAALRRQVKELPPLVNEQVNEFPAQINEIEHGYRQL
TTAHYVFTDDIPGMVEDVNEKMADANTALKSLDVDATEAANSEIEAEIDKMYAIMEKEMQARKRVDAAAPDLRQFIDHAL
RQNRELQTELDHLNQSYTLNHDEIKIAKDLKTQLDSINANYIKDTDAIEAGKAVYSDVIERFDATKDELTAIEKQQVQIN
QAVAGLKKGEIVANKQAENFELDMRNIKHEILRHHLPGLPQDYVSQVKHVTAEIEQLNHDLDQVKINMDAIAKFLIKIAS
DIDALKKATSALIDAAGLTEELMQYANRYKTTVKPVAEAVHQATESYMQFDYKQAADTLATALEQTEAGSYKKVEDAYLA
RKKASLY

Sequences:

>Translated_567_residues
MIWFFVIVVIIVVAAGGVWWLQHYFQTRIKNLDAQVEAIDVGALSSQIRSIEQLKLTGDSLATFSKWERAFDQLNDDDLA
DLQKILLDLEDQAKRFRFDHAQKIAKVLEAKIDTARQQYDLISQALQDIRHDEADNRSKMLQLRDDYQVSRKTILAKSFV
FGDAQPALEQQLQQLAELFQKIDQINNDGDHQAAKSEIKQLSDEMAALRRQVKELPPLVNEQVNEFPAQINEIEHGYRQL
TTAHYVFTDDIPGMVEDVNEKMADANTALKSLDVDATEAANSEIEAEIDKMYAIMEKEMQARKRVDAAAPDLRQFIDHAL
RQNRELQTELDHLNQSYTLNHDEIKIAKDLKTQLDSINANYIKDTDAIEAGKAVYSDVIERFDATKDELTAIEKQQVQIN
QAVAGLKKGEIVANKQAENFELDMRNIKHEILRHHLPGLPQDYVSQVKHVTAEIEQLNHDLDQVKINMDAIAKFLIKIAS
DIDALKKATSALIDAAGLTEELMQYANRYKTTVKPVAEAVHQATESYMQFDYKQAADTLATALEQTEAGSYKKVEDAYLA
RKKASLY
>Mature_567_residues
MIWFFVIVVIIVVAAGGVWWLQHYFQTRIKNLDAQVEAIDVGALSSQIRSIEQLKLTGDSLATFSKWERAFDQLNDDDLA
DLQKILLDLEDQAKRFRFDHAQKIAKVLEAKIDTARQQYDLISQALQDIRHDEADNRSKMLQLRDDYQVSRKTILAKSFV
FGDAQPALEQQLQQLAELFQKIDQINNDGDHQAAKSEIKQLSDEMAALRRQVKELPPLVNEQVNEFPAQINEIEHGYRQL
TTAHYVFTDDIPGMVEDVNEKMADANTALKSLDVDATEAANSEIEAEIDKMYAIMEKEMQARKRVDAAAPDLRQFIDHAL
RQNRELQTELDHLNQSYTLNHDEIKIAKDLKTQLDSINANYIKDTDAIEAGKAVYSDVIERFDATKDELTAIEKQQVQIN
QAVAGLKKGEIVANKQAENFELDMRNIKHEILRHHLPGLPQDYVSQVKHVTAEIEQLNHDLDQVKINMDAIAKFLIKIAS
DIDALKKATSALIDAAGLTEELMQYANRYKTTVKPVAEAVHQATESYMQFDYKQAADTLATALEQTEAGSYKKVEDAYLA
RKKASLY

Specific function: Negative regulator of ftsZ ring formation; modulates the frequency and position of ftsZ ring formation. Inhibits ftsZ ring formation at polar sites. Interacts either with ftsZ or with one of its binding partners to promote depolymerization [H]

COG id: COG4477

COG function: function code D; Negative regulator of septation ring formation

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein. Note=Colocalized with ftsZ to the nascent septal site [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ezrA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010379 [H]

Pfam domain/function: PF06160 EzrA [H]

EC number: NA

Molecular weight: Translated: 64456; Mature: 64456

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIWFFVIVVIIVVAAGGVWWLQHYFQTRIKNLDAQVEAIDVGALSSQIRSIEQLKLTGDS
CHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHH
LATFSKWERAFDQLNDDDLADLQKILLDLEDQAKRFRFDHAQKIAKVLEAKIDTARQQYD
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LISQALQDIRHDEADNRSKMLQLRDDYQVSRKTILAKSFVFGDAQPALEQQLQQLAELFQ
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
KIDQINNDGDHQAAKSEIKQLSDEMAALRRQVKELPPLVNEQVNEFPAQINEIEHGYRQL
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
TTAHYVFTDDIPGMVEDVNEKMADANTALKSLDVDATEAANSEIEAEIDKMYAIMEKEMQ
HHHHEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHH
ARKRVDAAAPDLRQFIDHALRQNRELQTELDHLNQSYTLNHDEIKIAKDLKTQLDSINAN
HHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCC
YIKDTDAIEAGKAVYSDVIERFDATKDELTAIEKQQVQINQAVAGLKKGEIVANKQAENF
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCH
ELDMRNIKHEILRHHLPGLPQDYVSQVKHVTAEIEQLNHDLDQVKINMDAIAKFLIKIAS
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHEECHHHHHHHHHHHHH
DIDALKKATSALIDAAGLTEELMQYANRYKTTVKPVAEAVHQATESYMQFDYKQAADTLA
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TALEQTEAGSYKKVEDAYLARKKASLY
HHHHHHCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12566566 [H]