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The map label for this gene is gpo [H]

Identifier: 116494401

GI number: 116494401

Start: 869567

End: 870040

Strand: Direct

Name: gpo [H]

Synonym: LSEI_0893

Alternate gene names: 116494401

Gene position: 869567-870040 (Clockwise)

Preceding gene: 116494400

Following gene: 116494402

Centisome position: 30.03

GC content: 44.73

Gene sequence:

>474_bases
ATGTCAATTTATGATTATGAGGTCACATTAGAAGATGGCTCGCAATATGCTTTGAGCAAATACAAGGGTCGACCAATGTT
GATCGTGAACACTGCCACTAAATGCGGCTTCGCGCCTCAGTTTGATGGTTTGGAGAAATTGTATGACAAGTTCAAGGATC
AAGGTTTGGTAGTGCTAGGTTTTCCTTCTGATCAATTTAAACAGGAACTGGCTGATGGTCATGCAGCGGCCGAGGCTTGC
CGGTTGAAATACGGTGTGAGTTTTCCAATGCATGCTTTGATTAAGGTGAACGGCAAAGAAGCAGCTCCGCTGTTTCAATA
CCTTAAAACCCAAGCCCCTGGTGAACTAGGCAAGTCCATCAAATGGAACTTTACGAAGTTTTTGGTTGATCGTGATGGTC
AAGTTGTCGCCCGCTTTGCACCAAAAACAAAACCAGAAGCGATTGAACCAGCAGTGGAGAAGCTTCTTGGCTAA

Upstream 100 bases:

>100_bases
TTAGGCACCGGTCATGGCAATGAGTGGCGTTTTTACTGACAACTGTTCAAAAAATGGTAGGATGAGGCGTAAGCTTTTAC
CAAGAAATGGAGGCTAACCA

Downstream 100 bases:

>100_bases
CTTTTGTCAGTTGCACGTGGGGCTGGTTCACGCTCTGTTTTAAACGCGTTTGCCAGCCCAGAGACCTGCGTGTAAGGACC
TTGGGTGCAATAGCCAAAGC

Product: glutathione peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 157; Mature: 156

Protein sequence:

>157_residues
MSIYDYEVTLEDGSQYALSKYKGRPMLIVNTATKCGFAPQFDGLEKLYDKFKDQGLVVLGFPSDQFKQELADGHAAAEAC
RLKYGVSFPMHALIKVNGKEAAPLFQYLKTQAPGELGKSIKWNFTKFLVDRDGQVVARFAPKTKPEAIEPAVEKLLG

Sequences:

>Translated_157_residues
MSIYDYEVTLEDGSQYALSKYKGRPMLIVNTATKCGFAPQFDGLEKLYDKFKDQGLVVLGFPSDQFKQELADGHAAAEAC
RLKYGVSFPMHALIKVNGKEAAPLFQYLKTQAPGELGKSIKWNFTKFLVDRDGQVVARFAPKTKPEAIEPAVEKLLG
>Mature_156_residues
SIYDYEVTLEDGSQYALSKYKGRPMLIVNTATKCGFAPQFDGLEKLYDKFKDQGLVVLGFPSDQFKQELADGHAAAEACR
LKYGVSFPMHALIKVNGKEAAPLFQYLKTQAPGELGKSIKWNFTKFLVDRDGQVVARFAPKTKPEAIEPAVEKLLG

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI75709200, Length=151, Percent_Identity=35.0993377483444, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI90903240, Length=151, Percent_Identity=35.0993377483444, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI15618997, Length=155, Percent_Identity=36.7741935483871, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI192455698, Length=157, Percent_Identity=35.031847133758, Blast_Score=92, Evalue=1e-19,
Organism=Homo sapiens, GI4557629, Length=175, Percent_Identity=34.2857142857143, Blast_Score=80, Evalue=7e-16,
Organism=Homo sapiens, GI90903238, Length=129, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI6006001, Length=166, Percent_Identity=33.7349397590361, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI33186887, Length=162, Percent_Identity=32.7160493827161, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI32967607, Length=181, Percent_Identity=28.7292817679558, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1788003, Length=156, Percent_Identity=39.1025641025641, Blast_Score=115, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17506887, Length=158, Percent_Identity=38.6075949367089, Blast_Score=117, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI193210707, Length=163, Percent_Identity=38.6503067484663, Blast_Score=108, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17535473, Length=157, Percent_Identity=38.2165605095541, Blast_Score=106, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71993584, Length=158, Percent_Identity=31.0126582278481, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17550320, Length=181, Percent_Identity=31.4917127071823, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI193209493, Length=181, Percent_Identity=30.939226519337, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319721, Length=157, Percent_Identity=48.4076433121019, Blast_Score=155, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6322228, Length=146, Percent_Identity=45.2054794520548, Blast_Score=140, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6322826, Length=156, Percent_Identity=41.025641025641, Blast_Score=134, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24656772, Length=158, Percent_Identity=41.7721518987342, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24656767, Length=158, Percent_Identity=41.7721518987342, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24656777, Length=158, Percent_Identity=41.7721518987342, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI85726443, Length=160, Percent_Identity=34.375, Blast_Score=96, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 17440; Mature: 17309

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIYDYEVTLEDGSQYALSKYKGRPMLIVNTATKCGFAPQFDGLEKLYDKFKDQGLVVLG
CCEEEEEEEECCCCCCHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHCCCEEEEE
FPSDQFKQELADGHAAAEACRLKYGVSFPMHALIKVNGKEAAPLFQYLKTQAPGELGKSI
CCCHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHCCCHHHCCCC
KWNFTKFLVDRDGQVVARFAPKTKPEAIEPAVEKLLG
CCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SIYDYEVTLEDGSQYALSKYKGRPMLIVNTATKCGFAPQFDGLEKLYDKFKDQGLVVLG
CEEEEEEEECCCCCCHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHCCCEEEEE
FPSDQFKQELADGHAAAEACRLKYGVSFPMHALIKVNGKEAAPLFQYLKTQAPGELGKSI
CCCHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHCCCHHHCCCC
KWNFTKFLVDRDGQVVARFAPKTKPEAIEPAVEKLLG
CCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]