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The map label for this gene is guaB [H]

Identifier: 116493788

GI number: 116493788

Start: 211588

End: 213075

Strand: Direct

Name: guaB [H]

Synonym: LSEI_0217

Alternate gene names: 116493788

Gene position: 211588-213075 (Clockwise)

Preceding gene: 116493787

Following gene: 116493790

Centisome position: 7.31

GC content: 50.47

Gene sequence:

>1488_bases
ATGAGTCTTTGGGATACAAAGTTTGCCCGGCGCGGTTTTACGTTTGATGATGTGTTGTTGATACCTGCAGAAAGTCATGT
TTTACCTCACGATGTCGATCTGTCTGTACAACTGGCGGACAACTTGAAGCTGAATATCCCAATCATCTCGGCGGGGATGG
ATACCGTTACCGAGAGTGCTATGGCAATTGCAATGGCACGCCAAGGCGGGTTGGGCGTGATTCATAAGAACATGAGCATC
GAAGCACAAGCAGATGAAGTGCTGAAGGTGAAGCGCAGTGAAAATGGTGTCATTGTCGATCCATTCTTCCTGACGGCCGA
TAAACCGGTTAGTGATGCTGAAGATTTAATGAAAAAATATCGGATTAGCGGCGTCCCAATTGTTAATAACACCACAGATC
GCAAGTTGACCGGCATCATCACCAACCGTGATCTGCGTTATGTTGATGATAAAAGTGTGCTGATTGACACGGTTATGACC
AAGGAAGGGCTTGTGACCGCGCCGGCTGGCACTTCAATCGAAGATGCCGAAGCTATTTTACAGTCTCGTAAAATTGAAAA
ATTACCGTTGATCGATAAGGAAGGCCGCCTTAGTGGGCTGATTACGATCAAGGATATTGAAAAAGTGGTTGAATTCCCGC
ATGCTGCTAAAGATGCGCATGGCCGTTTGTTGGTTGCAGCAGCGGTTGGCGTTACCTCTGACACCTTTGATCGGGCGCAA
GCTTTGCTTGATGCGGGTGCCGATGCGATTGTGATCGACACGGCCCATGGGCATAGTGCTGGCGTGATTCGGAAAATCAA
AGAGATTCGGGAACAGTTCCCATTAGCAACTCTGATTGCCGGTAATGTGGCCACGGCTGAAGCAACGGAAGCGTTGTATG
ATGCTGGTGTCGATGTTGTCAAAGTTGGCATTGGCCCCGGTTCAATCTGCACAACCCGGATCGTTGCCGGTGTCGGTGTG
CCACAACTGACTGCCATCTATGATGCCGCCAGTGTTGCTCGTAAGCGCGGCAAGACAATTATCGCTGACGGTGGGATCAA
GTATTCCGGTGATATCGTAAAGGCTTTGGCAGCTGGCGGCAATGCCGTTATGCTCGGTTCCCTTTTGGCCGGCACTGATG
AGGCACCTGGCCAGTTCGAAATTTATCAAGGCCGCCGCTTCAAGACTTATCGCGGCATGGGCTCACTTGGCGCGATGGCG
CAGGCCCACGGTTCTAGTGATCGTTATTTCCAGAGCGGGGTTAACGAAGCAAACAAACTGGTTCCTGAAGGCATCGAAGG
CCGCGTGGCTTACAAGGGCAGTCTCGGCGATGTGATTTTCCAAATGCTCGGTGGTATTGAATCCGGCATGGGTTATGTCG
GTGCACCGAATCTTCAAGAACTCCAAGATAATGCGCAGTTCATTCAAATTACCGGTGCCGGTTTACGCGAGAGCCATCCG
CATGATGTGCAGATCACGCGGGAAGCACCTAACTATTCCGTTCAATAA

Upstream 100 bases:

>100_bases
TGATACCGGCGTTTCGAAAAAAATGGTTAGACTTGTTTGACGTGCCTAAATTCCGGTAGTACATTAGTCAACAACTAAAA
ATTGAAAGAGGGATTACGCT

Downstream 100 bases:

>100_bases
AAGATTGGTGTCACAAAAAGGCTCGTACTGCCATTGGTTGCAGTGCGGGCCTTTTTTTGGTGAACGCGCTATGATTAAGA
GGCTACATTCGTGCCCGATG

Product: IMP dehydrogenase/GMP reductase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MSLWDTKFARRGFTFDDVLLIPAESHVLPHDVDLSVQLADNLKLNIPIISAGMDTVTESAMAIAMARQGGLGVIHKNMSI
EAQADEVLKVKRSENGVIVDPFFLTADKPVSDAEDLMKKYRISGVPIVNNTTDRKLTGIITNRDLRYVDDKSVLIDTVMT
KEGLVTAPAGTSIEDAEAILQSRKIEKLPLIDKEGRLSGLITIKDIEKVVEFPHAAKDAHGRLLVAAAVGVTSDTFDRAQ
ALLDAGADAIVIDTAHGHSAGVIRKIKEIREQFPLATLIAGNVATAEATEALYDAGVDVVKVGIGPGSICTTRIVAGVGV
PQLTAIYDAASVARKRGKTIIADGGIKYSGDIVKALAAGGNAVMLGSLLAGTDEAPGQFEIYQGRRFKTYRGMGSLGAMA
QAHGSSDRYFQSGVNEANKLVPEGIEGRVAYKGSLGDVIFQMLGGIESGMGYVGAPNLQELQDNAQFIQITGAGLRESHP
HDVQITREAPNYSVQ

Sequences:

>Translated_495_residues
MSLWDTKFARRGFTFDDVLLIPAESHVLPHDVDLSVQLADNLKLNIPIISAGMDTVTESAMAIAMARQGGLGVIHKNMSI
EAQADEVLKVKRSENGVIVDPFFLTADKPVSDAEDLMKKYRISGVPIVNNTTDRKLTGIITNRDLRYVDDKSVLIDTVMT
KEGLVTAPAGTSIEDAEAILQSRKIEKLPLIDKEGRLSGLITIKDIEKVVEFPHAAKDAHGRLLVAAAVGVTSDTFDRAQ
ALLDAGADAIVIDTAHGHSAGVIRKIKEIREQFPLATLIAGNVATAEATEALYDAGVDVVKVGIGPGSICTTRIVAGVGV
PQLTAIYDAASVARKRGKTIIADGGIKYSGDIVKALAAGGNAVMLGSLLAGTDEAPGQFEIYQGRRFKTYRGMGSLGAMA
QAHGSSDRYFQSGVNEANKLVPEGIEGRVAYKGSLGDVIFQMLGGIESGMGYVGAPNLQELQDNAQFIQITGAGLRESHP
HDVQITREAPNYSVQ
>Mature_494_residues
SLWDTKFARRGFTFDDVLLIPAESHVLPHDVDLSVQLADNLKLNIPIISAGMDTVTESAMAIAMARQGGLGVIHKNMSIE
AQADEVLKVKRSENGVIVDPFFLTADKPVSDAEDLMKKYRISGVPIVNNTTDRKLTGIITNRDLRYVDDKSVLIDTVMTK
EGLVTAPAGTSIEDAEAILQSRKIEKLPLIDKEGRLSGLITIKDIEKVVEFPHAAKDAHGRLLVAAAVGVTSDTFDRAQA
LLDAGADAIVIDTAHGHSAGVIRKIKEIREQFPLATLIAGNVATAEATEALYDAGVDVVKVGIGPGSICTTRIVAGVGVP
QLTAIYDAASVARKRGKTIIADGGIKYSGDIVKALAAGGNAVMLGSLLAGTDEAPGQFEIYQGRRFKTYRGMGSLGAMAQ
AHGSSDRYFQSGVNEANKLVPEGIEGRVAYKGSLGDVIFQMLGGIESGMGYVGAPNLQELQDNAQFIQITGAGLRESHPH
DVQITREAPNYSVQ

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=456, Percent_Identity=42.3245614035088, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI34328928, Length=456, Percent_Identity=42.3245614035088, Blast_Score=336, Evalue=3e-92,
Organism=Homo sapiens, GI156616279, Length=456, Percent_Identity=42.3245614035088, Blast_Score=336, Evalue=3e-92,
Organism=Homo sapiens, GI34328930, Length=456, Percent_Identity=42.3245614035088, Blast_Score=336, Evalue=3e-92,
Organism=Homo sapiens, GI66933016, Length=456, Percent_Identity=41.2280701754386, Blast_Score=335, Evalue=6e-92,
Organism=Homo sapiens, GI217035152, Length=451, Percent_Identity=42.350332594235, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI217035148, Length=456, Percent_Identity=41.4473684210526, Blast_Score=324, Evalue=1e-88,
Organism=Homo sapiens, GI217035150, Length=456, Percent_Identity=39.2543859649123, Blast_Score=296, Evalue=2e-80,
Organism=Homo sapiens, GI50541956, Length=249, Percent_Identity=39.7590361445783, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI50541954, Length=249, Percent_Identity=39.7590361445783, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI50541952, Length=249, Percent_Identity=39.7590361445783, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI50541948, Length=249, Percent_Identity=39.7590361445783, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI156104880, Length=249, Percent_Identity=38.5542168674699, Blast_Score=168, Evalue=1e-41,
Organism=Escherichia coli, GI1788855, Length=489, Percent_Identity=52.9652351738241, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI1786293, Length=248, Percent_Identity=36.2903225806452, Blast_Score=161, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI71994385, Length=477, Percent_Identity=36.6876310272537, Blast_Score=282, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI71994389, Length=427, Percent_Identity=38.6416861826698, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17560440, Length=222, Percent_Identity=41.4414414414414, Blast_Score=175, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6322012, Length=470, Percent_Identity=37.8723404255319, Blast_Score=318, Evalue=1e-87,
Organism=Saccharomyces cerevisiae, GI6323464, Length=470, Percent_Identity=38.7234042553192, Blast_Score=308, Evalue=1e-84,
Organism=Saccharomyces cerevisiae, GI6323585, Length=464, Percent_Identity=37.5, Blast_Score=306, Evalue=5e-84,
Organism=Saccharomyces cerevisiae, GI6319352, Length=347, Percent_Identity=37.7521613832853, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6319353, Length=119, Percent_Identity=38.655462184874, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24641071, Length=481, Percent_Identity=40.7484407484407, Blast_Score=333, Evalue=2e-91,
Organism=Drosophila melanogaster, GI24641073, Length=481, Percent_Identity=40.7484407484407, Blast_Score=333, Evalue=2e-91,
Organism=Drosophila melanogaster, GI28571163, Length=440, Percent_Identity=41.3636363636364, Blast_Score=304, Evalue=1e-82,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52642; Mature: 52511

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLWDTKFARRGFTFDDVLLIPAESHVLPHDVDLSVQLADNLKLNIPIISAGMDTVTESA
CCCCCCHHHHCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCEEEEEEEECCHHHHHHHH
MAIAMARQGGLGVIHKNMSIEAQADEVLKVKRSENGVIVDPFFLTADKPVSDAEDLMKKY
HHHHHHCCCCCEEEEECCEEECCHHHHHHHEECCCCEEEEEEEEECCCCCCCHHHHHHHH
RISGVPIVNNTTDRKLTGIITNRDLRYVDDKSVLIDTVMTKEGLVTAPAGTSIEDAEAIL
HCCCCEEECCCCCCEEEEEEECCCEEEECCCCEEEHHHHCCCCEEECCCCCCHHHHHHHH
QSRKIEKLPLIDKEGRLSGLITIKDIEKVVEFPHAAKDAHGRLLVAAAVGVTSDTFDRAQ
HHCCCCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHH
ALLDAGADAIVIDTAHGHSAGVIRKIKEIREQFPLATLIAGNVATAEATEALYDAGVDVV
HHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHCCCEEE
KVGIGPGSICTTRIVAGVGVPQLTAIYDAASVARKRGKTIIADGGIKYSGDIVKALAAGG
EEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEECCCEEECCHHHHHHHCCC
NAVMLGSLLAGTDEAPGQFEIYQGRRFKTYRGMGSLGAMAQAHGSSDRYFQSGVNEANKL
CEEEEEHHHCCCCCCCCEEEEECCCEEEECCCCCCHHHHHHCCCCCCHHHHHHCCHHHHC
VPEGIEGRVAYKGSLGDVIFQMLGGIESGMGYVGAPNLQELQDNAQFIQITGAGLRESHP
CCCCCCCEEEECCCHHHHHHHHHCCHHHCCCCCCCCCHHHHHCCCEEEEEECCCCCCCCC
HDVQITREAPNYSVQ
CCEEEEECCCCCCCC
>Mature Secondary Structure 
SLWDTKFARRGFTFDDVLLIPAESHVLPHDVDLSVQLADNLKLNIPIISAGMDTVTESA
CCCCCHHHHCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCEEEEEEEECCHHHHHHHH
MAIAMARQGGLGVIHKNMSIEAQADEVLKVKRSENGVIVDPFFLTADKPVSDAEDLMKKY
HHHHHHCCCCCEEEEECCEEECCHHHHHHHEECCCCEEEEEEEEECCCCCCCHHHHHHHH
RISGVPIVNNTTDRKLTGIITNRDLRYVDDKSVLIDTVMTKEGLVTAPAGTSIEDAEAIL
HCCCCEEECCCCCCEEEEEEECCCEEEECCCCEEEHHHHCCCCEEECCCCCCHHHHHHHH
QSRKIEKLPLIDKEGRLSGLITIKDIEKVVEFPHAAKDAHGRLLVAAAVGVTSDTFDRAQ
HHCCCCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHH
ALLDAGADAIVIDTAHGHSAGVIRKIKEIREQFPLATLIAGNVATAEATEALYDAGVDVV
HHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHCCCEEE
KVGIGPGSICTTRIVAGVGVPQLTAIYDAASVARKRGKTIIADGGIKYSGDIVKALAAGG
EEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEECCCEEECCHHHHHHHCCC
NAVMLGSLLAGTDEAPGQFEIYQGRRFKTYRGMGSLGAMAQAHGSSDRYFQSGVNEANKL
CEEEEEHHHCCCCCCCCEEEEECCCEEEECCCCCCHHHHHHCCCCCCHHHHHHCCHHHHC
VPEGIEGRVAYKGSLGDVIFQMLGGIESGMGYVGAPNLQELQDNAQFIQITGAGLRESHP
CCCCCCCEEEECCCHHHHHHHHHCCHHHCCCCCCCCCHHHHHCCCEEEEEECCCCCCCCC
HDVQITREAPNYSVQ
CCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]