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The map label for this gene is vanR [H]

Identifier: 116493790

GI number: 116493790

Start: 213993

End: 214679

Strand: Direct

Name: vanR [H]

Synonym: LSEI_0219

Alternate gene names: 116493790

Gene position: 213993-214679 (Clockwise)

Preceding gene: 116493788

Following gene: 116493791

Centisome position: 7.39

GC content: 44.98

Gene sequence:

>687_bases
ATGAAAATTTTAATTGTTGACGACGATAAAGAAATCGTCGAATTACTAAGTATTTACGTTAAAAACGAAGGTTACGAACC
GATTCAGGCGTATTCCGGTAAGGAAGCCATTACTAAGCTTGTGACCAATCCTGATATTGCTTTGATGATCCTCGATATTA
TGATGCCTAATATGTCTGGGATGGATGTTGTCAAAGAAGTCCGCAAAGATTCACAGATTCCAATCATTATCGTCTCGGCT
AAAACAGCAGATATGGACAAGATTCAAGGCCTTATTACTGGAGCAGACGATTATGTCACCAAGCCATTCAATCCGCTAGA
GGTCATGGCGCGCGTCAAGAGTTTGTTGCGCCGAAGTCAAAATGAGGTGACCAATACAGAACCGGATGTGCTTGAAGGCG
GTCCGCTAACGATCAAAAAAGATAGTCATGAAGTCACCACCCTTACCGGCAAGCAAATTCAGCTAACCGCGCTGGAATTC
GGCATTCTGTACTTGCTGGCTAGCCATCCGAATCGTGTTTTCTCGGCTGATGAGATTTTTGAACGCGTTTGGCAACAGGA
ATCAATCGTCTCAGCGAAAACCGTTATGGTGCATGTCTCGCATCTGCGTGACAAGATTGAAGAAGCGACCGATGGCGAGA
AGGTGATCGAAACAGTTTGGGGCGTCGGCTATAAGGTTGAGGCCTAA

Upstream 100 bases:

>100_bases
TTTTCTTAGGCTTTTCGTAAAGAATTCCCCGGTCAACTTTGGTACAATGGACTTTGATGTAACAGACCCTACAGTTCTTC
TCATAAACGGAGCCAATACA

Downstream 100 bases:

>100_bases
CGATCATGAGCGAAAAAGTCAAACTAACTGGTAAGGAAAAATCCGAACTTTGGATTGAAGGCATCGTAACGGTGATTCTG
CTGTTAATGCTTAATTTTGC

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MKILIVDDDKEIVELLSIYVKNEGYEPIQAYSGKEAITKLVTNPDIALMILDIMMPNMSGMDVVKEVRKDSQIPIIIVSA
KTADMDKIQGLITGADDYVTKPFNPLEVMARVKSLLRRSQNEVTNTEPDVLEGGPLTIKKDSHEVTTLTGKQIQLTALEF
GILYLLASHPNRVFSADEIFERVWQQESIVSAKTVMVHVSHLRDKIEEATDGEKVIETVWGVGYKVEA

Sequences:

>Translated_228_residues
MKILIVDDDKEIVELLSIYVKNEGYEPIQAYSGKEAITKLVTNPDIALMILDIMMPNMSGMDVVKEVRKDSQIPIIIVSA
KTADMDKIQGLITGADDYVTKPFNPLEVMARVKSLLRRSQNEVTNTEPDVLEGGPLTIKKDSHEVTTLTGKQIQLTALEF
GILYLLASHPNRVFSADEIFERVWQQESIVSAKTVMVHVSHLRDKIEEATDGEKVIETVWGVGYKVEA
>Mature_228_residues
MKILIVDDDKEIVELLSIYVKNEGYEPIQAYSGKEAITKLVTNPDIALMILDIMMPNMSGMDVVKEVRKDSQIPIIIVSA
KTADMDKIQGLITGADDYVTKPFNPLEVMARVKSLLRRSQNEVTNTEPDVLEGGPLTIKKDSHEVTTLTGKQIQLTALEF
GILYLLASHPNRVFSADEIFERVWQQESIVSAKTVMVHVSHLRDKIEEATDGEKVIETVWGVGYKVEA

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=35.2422907488987, Blast_Score=151, Evalue=4e-38,
Organism=Escherichia coli, GI1788394, Length=228, Percent_Identity=35.0877192982456, Blast_Score=150, Evalue=9e-38,
Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=32.4561403508772, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=35.6828193832599, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=33.3333333333333, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI87082012, Length=228, Percent_Identity=33.3333333333333, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=30.4347826086957, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=34.2105263157895, Blast_Score=112, Evalue=1e-26,
Organism=Escherichia coli, GI1786911, Length=230, Percent_Identity=28.695652173913, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=29.3859649122807, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1787375, Length=229, Percent_Identity=31.8777292576419, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1790552, Length=229, Percent_Identity=31.4410480349345, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=28.1385281385281, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI1788550, Length=105, Percent_Identity=36.1904761904762, Blast_Score=68, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25486; Mature: 25486

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILIVDDDKEIVELLSIYVKNEGYEPIQAYSGKEAITKLVTNPDIALMILDIMMPNMSG
CEEEEECCCHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCCCC
MDVVKEVRKDSQIPIIIVSAKTADMDKIQGLITGADDYVTKPFNPLEVMARVKSLLRRSQ
HHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHHHH
NEVTNTEPDVLEGGPLTIKKDSHEVTTLTGKQIQLTALEFGILYLLASHPNRVFSADEIF
HHCCCCCCCCCCCCCEEEECCCCEEEEECCCEEEEHHHHHHHHHHHHCCCCCCCCHHHHH
ERVWQQESIVSAKTVMVHVSHLRDKIEEATDGEKVIETVWGVGYKVEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEECC
>Mature Secondary Structure
MKILIVDDDKEIVELLSIYVKNEGYEPIQAYSGKEAITKLVTNPDIALMILDIMMPNMSG
CEEEEECCCHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCCCC
MDVVKEVRKDSQIPIIIVSAKTADMDKIQGLITGADDYVTKPFNPLEVMARVKSLLRRSQ
HHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHHHH
NEVTNTEPDVLEGGPLTIKKDSHEVTTLTGKQIQLTALEFGILYLLASHPNRVFSADEIF
HHCCCCCCCCCCCCCEEEECCCCEEEEECCCEEEEHHHHHHHHHHHHCCCCCCCCHHHHH
ERVWQQESIVSAKTVMVHVSHLRDKIEEATDGEKVIETVWGVGYKVEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]