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The map label for this gene is purL [H]

Identifier: 116493200

GI number: 116493200

Start: 1436239

End: 1438443

Strand: Reverse

Name: purL [H]

Synonym: PEPE_1462

Alternate gene names: 116493200

Gene position: 1438443-1436239 (Counterclockwise)

Preceding gene: 116493201

Following gene: 116493199

Centisome position: 78.5

GC content: 41.18

Gene sequence:

>2205_bases
ATGAAGGAATTAACACCTACCGAAATTCGAGATCAAAAATTGTATTTGCAATGGGGGATAAGCGAAGACGAATATCAGAA
AATCAATGATGCTTTAGGGCGCCTACCTAATTTTACAGAAACGGGTTTGTTCGCTGCGATGTGGAGTGAGCATTGTGCAT
ATAAAAATTCTAAACCCCTCTTAAAACAATTTCCAACAACGGGTTCACAGATTTTACAAGGGCCCGGGGAAGGAGCTGGA
ATTGTTGATATTGGTAACAATCAAGCGGTGGTCTTTAAAGCAGAAAGTCATAATCACCCTACGGCAGTCGAGCCTTATCA
AGGAGCGGCTACTGGAGTTGGAGGAATTATTCGTGATATTTTTTCCATGGGAGCGCGTCCGATTGCATTAATGGACAGTT
TACATTTCGGTGAATTGAATGATGCCCATACTAAGTATCTTGTTGACCAGACAATAGCTGGAATCGGCGATTACGGTAAT
TGTATGGGAATACCTACAGTAGGAGGGGAAACGACCTTCGATACAATTTATCAAAACAATCCAGTCATGAACGCAATGTG
TGTGGGGTTATTGGATATCAACGACCAACAAAAAGGAGCGGCTGCTGGTGTAGGTAATGCCATTTACTACGTGGGGGCTA
AAACGGGACGTGATGGAATTCAAGGAGCCATTTTTGCTTCAACCAAATTTAGTGACGAACAAGAAACGCAACGTTCAGCC
GTCCAGGTTGGAGATCCTTTTGCTGAAAAACAACTAATGGAAGCGTGTCTAGAACTGATTCATAACCATTCCGAATATCT
AGTGGGAATTCAAGATATGGGAGCAGCGGGGTTGATTTCATCATCTGCAGAAATGGCTGCTAAAGCTGGATATGGAATGC
ATTTGAATTTGGATTTAGTTCCACAACGTGAAGAAGAAATGATCCCTTATGAATTAATGCTATCTGAATCTCAGGAACGG
ATGCTGCTCTGTGTCAAACAAGGATTTGAACCCGCAGTTGAAGCACTATTTGCTAAATACGAGAGCGAAGCAGTAAAAAT
TGGTGAAGTTACTGCAGGTGACCGCTATCAATTAACCTTTAAGGGCGTTCAAGTTGCTGATGTACCAGTGCATGCTTTGG
TGGATGAAGCCCCAGTTTACCATCAACCAAGTCAGAAACCTCAGCATATCAGTGAAACTAAAAAGCAACAGTATCAACCT
AAAATTGAAAATTTAACTAAAACCTTCCAAGCGATGTTGCAACAACCCACAATTGCGCATAAAGGTGCTATTTTTGAACG
GTATGACTCTCAAGTTCAAACTAATACAATTTCAACGACACAAAGTGATGCGGCAGTGGTTCGTATTCGAGGAACTCAGA
AAACTTTGGCGATGACGACCGATGCTAATCCGCGTTATTTGTATTTAGATCCCTATTATGGTGGACAAATCGCGGTCAGT
GAGGCCGCTCGAAACATAGTTGCTACAGGTGGAATACCATTGGCAATTACCGACTGTTTGAACTTTGGTAGCCCCGAAGA
CCCAGAAAGTTTCTATGAATTAGAACAGGCTACTAAAGGGATGACGGAGGCTTGTAAATTATTTGATACACCCGTCATTT
CAGGTAATGTCTCACTTTATAATGAATCCAACCAACAACCCATTTATCCAACACCAATGGTTGGAATGGTTGGTTTAATT
GAAAATCCAGCTTGGATAACAACCATAGATTTTAAAAAATCTGGTGATTTAATTTATATTTTGGGAGAAACAACAGCAGA
ACTTAATGGTAGTGAATTACAAAAAATGCAACTCGGACATGTTGAAGGTCCATTATTTAATTTCGATTTACGCTATGAAC
AGGAGCAACAAGAATTGTTGACTCAGTTAATTCACGCGGAACTTTTGAATAGTGCGCATGACTTAGCCGAAGGTGGCTTA
GCCGTTGGTTTAGCTGAATGCGTGTTCGCTAGTGAGTTAGGATGTGACGTCAAGACTAATTTAACAGCTACAGAACTATT
TGCCGAAAATCAGGCCCGCTTTATTGTGACGATTGCTCCAGATAAACAAAAGATTTTTGAAGCACAAGTGGCAAACAGAG
CAACTTTAATCGGCCAAGTTGGCGGTAAGCGGATCAAAATTGCAACGATGGATGATGTAATTGATGTTGATTTGAAAAAT
ACTAAGGAGAGTTGGAAGGGAGCCCTAGCATGGCAGCTGAATTAA

Upstream 100 bases:

>100_bases
CTAGTGAAGCCGTCCTAGGTGGCGAAGATGGCAAAATGCTGTTCCAAAGTTTAATTGAAAGCATGACGCAAAATGTTTAA
TTAAAGGAGTTTTCGCAATG

Downstream 100 bases:

>100_bases
AGGGTCTAAACGAAGAATGCGGTGTTTTTGGTATTTGGAATGATTCAGAAGCTGCCCAACGGACCTACTTCGGACTTCAC
AGCTTACAACATCGAGGCCA

Product: phosphoribosylformylglycinamidine synthase domain-containing protein

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 734; Mature: 734

Protein sequence:

>734_residues
MKELTPTEIRDQKLYLQWGISEDEYQKINDALGRLPNFTETGLFAAMWSEHCAYKNSKPLLKQFPTTGSQILQGPGEGAG
IVDIGNNQAVVFKAESHNHPTAVEPYQGAATGVGGIIRDIFSMGARPIALMDSLHFGELNDAHTKYLVDQTIAGIGDYGN
CMGIPTVGGETTFDTIYQNNPVMNAMCVGLLDINDQQKGAAAGVGNAIYYVGAKTGRDGIQGAIFASTKFSDEQETQRSA
VQVGDPFAEKQLMEACLELIHNHSEYLVGIQDMGAAGLISSSAEMAAKAGYGMHLNLDLVPQREEEMIPYELMLSESQER
MLLCVKQGFEPAVEALFAKYESEAVKIGEVTAGDRYQLTFKGVQVADVPVHALVDEAPVYHQPSQKPQHISETKKQQYQP
KIENLTKTFQAMLQQPTIAHKGAIFERYDSQVQTNTISTTQSDAAVVRIRGTQKTLAMTTDANPRYLYLDPYYGGQIAVS
EAARNIVATGGIPLAITDCLNFGSPEDPESFYELEQATKGMTEACKLFDTPVISGNVSLYNESNQQPIYPTPMVGMVGLI
ENPAWITTIDFKKSGDLIYILGETTAELNGSELQKMQLGHVEGPLFNFDLRYEQEQQELLTQLIHAELLNSAHDLAEGGL
AVGLAECVFASELGCDVKTNLTATELFAENQARFIVTIAPDKQKIFEAQVANRATLIGQVGGKRIKIATMDDVIDVDLKN
TKESWKGALAWQLN

Sequences:

>Translated_734_residues
MKELTPTEIRDQKLYLQWGISEDEYQKINDALGRLPNFTETGLFAAMWSEHCAYKNSKPLLKQFPTTGSQILQGPGEGAG
IVDIGNNQAVVFKAESHNHPTAVEPYQGAATGVGGIIRDIFSMGARPIALMDSLHFGELNDAHTKYLVDQTIAGIGDYGN
CMGIPTVGGETTFDTIYQNNPVMNAMCVGLLDINDQQKGAAAGVGNAIYYVGAKTGRDGIQGAIFASTKFSDEQETQRSA
VQVGDPFAEKQLMEACLELIHNHSEYLVGIQDMGAAGLISSSAEMAAKAGYGMHLNLDLVPQREEEMIPYELMLSESQER
MLLCVKQGFEPAVEALFAKYESEAVKIGEVTAGDRYQLTFKGVQVADVPVHALVDEAPVYHQPSQKPQHISETKKQQYQP
KIENLTKTFQAMLQQPTIAHKGAIFERYDSQVQTNTISTTQSDAAVVRIRGTQKTLAMTTDANPRYLYLDPYYGGQIAVS
EAARNIVATGGIPLAITDCLNFGSPEDPESFYELEQATKGMTEACKLFDTPVISGNVSLYNESNQQPIYPTPMVGMVGLI
ENPAWITTIDFKKSGDLIYILGETTAELNGSELQKMQLGHVEGPLFNFDLRYEQEQQELLTQLIHAELLNSAHDLAEGGL
AVGLAECVFASELGCDVKTNLTATELFAENQARFIVTIAPDKQKIFEAQVANRATLIGQVGGKRIKIATMDDVIDVDLKN
TKESWKGALAWQLN
>Mature_734_residues
MKELTPTEIRDQKLYLQWGISEDEYQKINDALGRLPNFTETGLFAAMWSEHCAYKNSKPLLKQFPTTGSQILQGPGEGAG
IVDIGNNQAVVFKAESHNHPTAVEPYQGAATGVGGIIRDIFSMGARPIALMDSLHFGELNDAHTKYLVDQTIAGIGDYGN
CMGIPTVGGETTFDTIYQNNPVMNAMCVGLLDINDQQKGAAAGVGNAIYYVGAKTGRDGIQGAIFASTKFSDEQETQRSA
VQVGDPFAEKQLMEACLELIHNHSEYLVGIQDMGAAGLISSSAEMAAKAGYGMHLNLDLVPQREEEMIPYELMLSESQER
MLLCVKQGFEPAVEALFAKYESEAVKIGEVTAGDRYQLTFKGVQVADVPVHALVDEAPVYHQPSQKPQHISETKKQQYQP
KIENLTKTFQAMLQQPTIAHKGAIFERYDSQVQTNTISTTQSDAAVVRIRGTQKTLAMTTDANPRYLYLDPYYGGQIAVS
EAARNIVATGGIPLAITDCLNFGSPEDPESFYELEQATKGMTEACKLFDTPVISGNVSLYNESNQQPIYPTPMVGMVGLI
ENPAWITTIDFKKSGDLIYILGETTAELNGSELQKMQLGHVEGPLFNFDLRYEQEQQELLTQLIHAELLNSAHDLAEGGL
AVGLAECVFASELGCDVKTNLTATELFAENQARFIVTIAPDKQKIFEAQVANRATLIGQVGGKRIKIATMDDVIDVDLKN
TKESWKGALAWQLN

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Escherichia coli, GI48994899, Length=832, Percent_Identity=24.1586538461538, Blast_Score=126, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17553022, Length=443, Percent_Identity=25.2821670428894, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24582111, Length=226, Percent_Identity=29.2035398230088, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24582109, Length=226, Percent_Identity=29.2035398230088, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17137292, Length=226, Percent_Identity=29.2035398230088, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 80241; Mature: 80241

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKELTPTEIRDQKLYLQWGISEDEYQKINDALGRLPNFTETGLFAAMWSEHCAYKNSKPL
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCH
LKQFPTTGSQILQGPGEGAGIVDIGNNQAVVFKAESHNHPTAVEPYQGAATGVGGIIRDI
HHHCCCCCHHHHCCCCCCCCEEEECCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHH
FSMGARPIALMDSLHFGELNDAHTKYLVDQTIAGIGDYGNCMGIPTVGGETTFDTIYQNN
HHCCCCCEEHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHCCCC
PVMNAMCVGLLDINDQQKGAAAGVGNAIYYVGAKTGRDGIQGAIFASTKFSDEQETQRSA
CCCHHHEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHH
VQVGDPFAEKQLMEACLELIHNHSEYLVGIQDMGAAGLISSSAEMAAKAGYGMHLNLDLV
HHCCCCHHHHHHHHHHHHHHHCCCCEEEEHHHCCCHHHHCCCHHHHHHCCCCEEEEEEEC
PQREEEMIPYELMLSESQERMLLCVKQGFEPAVEALFAKYESEAVKIGEVTAGDRYQLTF
CCCCHHCCCHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCEEEEEE
KGVQVADVPVHALVDEAPVYHQPSQKPQHISETKKQQYQPKIENLTKTFQAMLQQPTIAH
CCEEEECCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHH
KGAIFERYDSQVQTNTISTTQSDAAVVRIRGTQKTLAMTTDANPRYLYLDPYYGGQIAVS
CCCHHHHHCCCCCCCCCCCCCCCEEEEEEECCCEEEEEEECCCCCEEEECCCCCCEEEHH
EAARNIVATGGIPLAITDCLNFGSPEDPESFYELEQATKGMTEACKLFDTPVISGNVSLY
HHHCCEEECCCCCEEEEHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCEEECCEEEE
NESNQQPIYPTPMVGMVGLIENPAWITTIDFKKSGDLIYILGETTAELNGSELQKMQLGH
ECCCCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHCCC
VEGPLFNFDLRYEQEQQELLTQLIHAELLNSAHDLAEGGLAVGLAECVFASELGCDVKTN
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCC
LTATELFAENQARFIVTIAPDKQKIFEAQVANRATLIGQVGGKRIKIATMDDVIDVDLKN
CCHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCEEEECCCCCEEEEEEECCEEECCCCC
TKESWKGALAWQLN
CHHHHCCEEEEEEC
>Mature Secondary Structure
MKELTPTEIRDQKLYLQWGISEDEYQKINDALGRLPNFTETGLFAAMWSEHCAYKNSKPL
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCH
LKQFPTTGSQILQGPGEGAGIVDIGNNQAVVFKAESHNHPTAVEPYQGAATGVGGIIRDI
HHHCCCCCHHHHCCCCCCCCEEEECCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHH
FSMGARPIALMDSLHFGELNDAHTKYLVDQTIAGIGDYGNCMGIPTVGGETTFDTIYQNN
HHCCCCCEEHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHCCCC
PVMNAMCVGLLDINDQQKGAAAGVGNAIYYVGAKTGRDGIQGAIFASTKFSDEQETQRSA
CCCHHHEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHH
VQVGDPFAEKQLMEACLELIHNHSEYLVGIQDMGAAGLISSSAEMAAKAGYGMHLNLDLV
HHCCCCHHHHHHHHHHHHHHHCCCCEEEEHHHCCCHHHHCCCHHHHHHCCCCEEEEEEEC
PQREEEMIPYELMLSESQERMLLCVKQGFEPAVEALFAKYESEAVKIGEVTAGDRYQLTF
CCCCHHCCCHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCEEEEEE
KGVQVADVPVHALVDEAPVYHQPSQKPQHISETKKQQYQPKIENLTKTFQAMLQQPTIAH
CCEEEECCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHH
KGAIFERYDSQVQTNTISTTQSDAAVVRIRGTQKTLAMTTDANPRYLYLDPYYGGQIAVS
CCCHHHHHCCCCCCCCCCCCCCCEEEEEEECCCEEEEEEECCCCCEEEECCCCCCEEEHH
EAARNIVATGGIPLAITDCLNFGSPEDPESFYELEQATKGMTEACKLFDTPVISGNVSLY
HHHCCEEECCCCCEEEEHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCEEECCEEEE
NESNQQPIYPTPMVGMVGLIENPAWITTIDFKKSGDLIYILGETTAELNGSELQKMQLGH
ECCCCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHCCC
VEGPLFNFDLRYEQEQQELLTQLIHAELLNSAHDLAEGGLAVGLAECVFASELGCDVKTN
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCC
LTATELFAENQARFIVTIAPDKQKIFEAQVANRATLIGQVGGKRIKIATMDDVIDVDLKN
CCHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCEEEECCCCCEEEEEEECCEEECCCCC
TKESWKGALAWQLN
CHHHHCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12566566 [H]