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The map label for this gene is typA [H]

Identifier: 116492917

GI number: 116492917

Start: 1154622

End: 1156466

Strand: Reverse

Name: typA [H]

Synonym: PEPE_1156

Alternate gene names: 116492917

Gene position: 1156466-1154622 (Counterclockwise)

Preceding gene: 116492918

Following gene: 116492916

Centisome position: 63.11

GC content: 38.81

Gene sequence:

>1845_bases
TTGAATTTAAGAGACGATATTAGAAATATTGCAATCATTGCCCACGTTGACCACGGAAAGACTACCTTGGTTAATGAATT
ATTGAAACAATCAGATACATTAGACGAACACGTTCAAATTGAAGACCGTGCTTTGGACTCAAATGCGATTGAACGTGAAC
GTGGAATCACAATTCTTTCAAAAAACACTGCTGTACGTTATGCAGATAAACAAATTAACATTTTAGATACTCCAGGACAT
GCTGACTTCGGTGGTGAAGTTGAACGTATCATGCGCATGGTTGATGGTGTTTTGCTTGTTGTTGATGCTTTTGAAGGAAC
AATGCCCCAAACACGCTTTGTTTTGAAAAAAGCTTTGGAACAACATTTAACACCAATCGTGGTTGTTAACAAGATTGACC
GCCCAGGCGCACGTCCAGAAGAAGTTGTTGACGAAGTTCTTGATCTATTCATTGAACTTGGTGCTGATGAAGACCAACTT
GAGTTCCCAGTTGTATATGCTTCAGCTATCAATGGAACTTCTAGTTTTTCTTCAGACCCAGCTGACCAAGAACACACAAT
GAAACCAATTTTTGATACAATTGTAGATACAATTCCAGCTCCTGAAGATTCTTCAGCTGAACCACTTCAATTCCAAGTTG
CTTTACTTGATTACAACGACTTCGTTGGACGGATTGGTATTGGACGTGTATTCCGCGGTCGGATCAAGGTTGGAGACAAC
GTTTCCGTGCTTAAACTTGATGGTTCAAAGAAAAACTTCCGAGTTACTAAGTTGTTTGGTTACTTTGGTTTGAAACGTTT
GGAAATCAACGAAGCCAAAGCAGGGGACTTGATTGCTATCTCAGGTATGGAAGACATTTTCGTTGGTGAAACAGTTGCCG
ATGCAGAACATCCAGAAGCATTACCAGTGTTACGAATTGACGAACCTACACTACAAATGACATTTAGAACAAATGATTCA
CCATTTGCTGGTCGCGAAGGTAAGTTCGTTACATCACGTCAGTTGGAACAACGTTTGAAGACTGAACTTCATACTGATGT
TTCACTTCGAGTTGATGATACTGATGATCCTGGTGCATGGATTGTTTCAGGTCGTGGTGAACTTCATCTTTCAATTTTAA
TTGAAACACTTCGTCGCGAAGGTTACGAACTTCAAGCATCACGTCCAGAAGTTATCATCAAGGAAATCGATGGCAAGCTA
TGTGAACCTTATGAAATGGTTCAAATTGATACACCTGATGAATATACTGGTTCTGTAATTGATTCACTTTCACAACGTAA
GGGTGAAATGAAGAATATGGAAACTACTGATAATGGTCAAACTCGTTTGACTTTCTTGGCTCCTTCACGTGGATTGATTG
GTTACTCTACAGAATTCCTATCAATGACTCGTGGATATGGTATTATGAACCATACTTTCCAAGAATACTTACCACAAATT
AAGAACTGGAATCCAGGTCGTCGTAATGGTACTTTAGTATCAATTAATTCTGGTAAAGTTACCACTTACGCTATCATGGC
TGTTCAAGATCGTGGAGTTATCTTTACAGATGCTGGTACTGAAGTATATGAAGGTATGATTGTTGGTCAAAACAGTCGTG
AAAATGATATTTCAGTTAACATTACTCGTGGACGTAACCAAACTAACGTGCGTGCTGCTGGTTCTGAAGATATCGCTAAG
GTTAAAACACCAGTTCATATGTCACTCGAAGAATCACTTGAATTTTTGAATGAAGATGAATACTGTGAAATTACACCTGA
TCACATTCGTTTGCGTAAGCAAATCTTGAATACAAATGAACGTGAAAAAGCTGCTAAGAAACGTAAAATGGCTGCTAAAA
AATAA

Upstream 100 bases:

>100_bases
CTGCTATAATGAGTATAGTGAAATAGCATTATGCTGTGACGAATTAGACGTCACAGGTTTTTTTATGTTAAGCCATTGAA
AAACGAAAGGGAGAAACATA

Downstream 100 bases:

>100_bases
TTAAGAAAAGACGAAAATTTAATTTTCGTCTTTTTTTATTTTTAAGGAGCGTAGTACGATATAATAGATTAGGTATTATG
CAGGATAAGGGTGAAATATT

Product: stress response membrane GTPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MNLRDDIRNIAIIAHVDHGKTTLVNELLKQSDTLDEHVQIEDRALDSNAIERERGITILSKNTAVRYADKQINILDTPGH
ADFGGEVERIMRMVDGVLLVVDAFEGTMPQTRFVLKKALEQHLTPIVVVNKIDRPGARPEEVVDEVLDLFIELGADEDQL
EFPVVYASAINGTSSFSSDPADQEHTMKPIFDTIVDTIPAPEDSSAEPLQFQVALLDYNDFVGRIGIGRVFRGRIKVGDN
VSVLKLDGSKKNFRVTKLFGYFGLKRLEINEAKAGDLIAISGMEDIFVGETVADAEHPEALPVLRIDEPTLQMTFRTNDS
PFAGREGKFVTSRQLEQRLKTELHTDVSLRVDDTDDPGAWIVSGRGELHLSILIETLRREGYELQASRPEVIIKEIDGKL
CEPYEMVQIDTPDEYTGSVIDSLSQRKGEMKNMETTDNGQTRLTFLAPSRGLIGYSTEFLSMTRGYGIMNHTFQEYLPQI
KNWNPGRRNGTLVSINSGKVTTYAIMAVQDRGVIFTDAGTEVYEGMIVGQNSRENDISVNITRGRNQTNVRAAGSEDIAK
VKTPVHMSLEESLEFLNEDEYCEITPDHIRLRKQILNTNEREKAAKKRKMAAKK

Sequences:

>Translated_614_residues
MNLRDDIRNIAIIAHVDHGKTTLVNELLKQSDTLDEHVQIEDRALDSNAIERERGITILSKNTAVRYADKQINILDTPGH
ADFGGEVERIMRMVDGVLLVVDAFEGTMPQTRFVLKKALEQHLTPIVVVNKIDRPGARPEEVVDEVLDLFIELGADEDQL
EFPVVYASAINGTSSFSSDPADQEHTMKPIFDTIVDTIPAPEDSSAEPLQFQVALLDYNDFVGRIGIGRVFRGRIKVGDN
VSVLKLDGSKKNFRVTKLFGYFGLKRLEINEAKAGDLIAISGMEDIFVGETVADAEHPEALPVLRIDEPTLQMTFRTNDS
PFAGREGKFVTSRQLEQRLKTELHTDVSLRVDDTDDPGAWIVSGRGELHLSILIETLRREGYELQASRPEVIIKEIDGKL
CEPYEMVQIDTPDEYTGSVIDSLSQRKGEMKNMETTDNGQTRLTFLAPSRGLIGYSTEFLSMTRGYGIMNHTFQEYLPQI
KNWNPGRRNGTLVSINSGKVTTYAIMAVQDRGVIFTDAGTEVYEGMIVGQNSRENDISVNITRGRNQTNVRAAGSEDIAK
VKTPVHMSLEESLEFLNEDEYCEITPDHIRLRKQILNTNEREKAAKKRKMAAKK
>Mature_614_residues
MNLRDDIRNIAIIAHVDHGKTTLVNELLKQSDTLDEHVQIEDRALDSNAIERERGITILSKNTAVRYADKQINILDTPGH
ADFGGEVERIMRMVDGVLLVVDAFEGTMPQTRFVLKKALEQHLTPIVVVNKIDRPGARPEEVVDEVLDLFIELGADEDQL
EFPVVYASAINGTSSFSSDPADQEHTMKPIFDTIVDTIPAPEDSSAEPLQFQVALLDYNDFVGRIGIGRVFRGRIKVGDN
VSVLKLDGSKKNFRVTKLFGYFGLKRLEINEAKAGDLIAISGMEDIFVGETVADAEHPEALPVLRIDEPTLQMTFRTNDS
PFAGREGKFVTSRQLEQRLKTELHTDVSLRVDDTDDPGAWIVSGRGELHLSILIETLRREGYELQASRPEVIIKEIDGKL
CEPYEMVQIDTPDEYTGSVIDSLSQRKGEMKNMETTDNGQTRLTFLAPSRGLIGYSTEFLSMTRGYGIMNHTFQEYLPQI
KNWNPGRRNGTLVSINSGKVTTYAIMAVQDRGVIFTDAGTEVYEGMIVGQNSRENDISVNITRGRNQTNVRAAGSEDIAK
VKTPVHMSLEESLEFLNEDEYCEITPDHIRLRKQILNTNEREKAAKKRKMAAKK

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=511, Percent_Identity=27.9843444227006, Blast_Score=150, Evalue=5e-36,
Organism=Homo sapiens, GI94966754, Length=133, Percent_Identity=43.609022556391, Blast_Score=121, Evalue=3e-27,
Organism=Homo sapiens, GI18390331, Length=195, Percent_Identity=33.3333333333333, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI25306287, Length=470, Percent_Identity=26.5957446808511, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI4503483, Length=150, Percent_Identity=36.6666666666667, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI310132016, Length=111, Percent_Identity=42.3423423423423, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI310110807, Length=111, Percent_Identity=42.3423423423423, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI310123363, Length=111, Percent_Identity=42.3423423423423, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI25306283, Length=168, Percent_Identity=36.3095238095238, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI19923640, Length=168, Percent_Identity=36.3095238095238, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI217272892, Length=194, Percent_Identity=33.5051546391753, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI217272894, Length=194, Percent_Identity=33.5051546391753, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI34147630, Length=251, Percent_Identity=31.0756972111554, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI94966752, Length=129, Percent_Identity=33.3333333333333, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI53729339, Length=138, Percent_Identity=34.7826086956522, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI53729337, Length=138, Percent_Identity=34.7826086956522, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI48994988, Length=607, Percent_Identity=52.0593080724876, Blast_Score=659, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=507, Percent_Identity=28.4023668639053, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI1789738, Length=167, Percent_Identity=38.9221556886228, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1790835, Length=145, Percent_Identity=33.1034482758621, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1790412, Length=283, Percent_Identity=28.9752650176678, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1789737, Length=283, Percent_Identity=28.9752650176678, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17557151, Length=542, Percent_Identity=24.9077490774908, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17556745, Length=485, Percent_Identity=27.8350515463918, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17533571, Length=172, Percent_Identity=37.7906976744186, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17506493, Length=164, Percent_Identity=34.1463414634146, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71988811, Length=130, Percent_Identity=36.1538461538462, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71988819, Length=128, Percent_Identity=36.71875, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17552882, Length=197, Percent_Identity=34.010152284264, Blast_Score=93, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17556456, Length=281, Percent_Identity=29.1814946619217, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71994658, Length=155, Percent_Identity=32.258064516129, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323320, Length=519, Percent_Identity=28.3236994219653, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324707, Length=152, Percent_Identity=40.7894736842105, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320593, Length=152, Percent_Identity=40.7894736842105, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324761, Length=276, Percent_Identity=31.5217391304348, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6323098, Length=177, Percent_Identity=32.7683615819209, Blast_Score=95, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324166, Length=142, Percent_Identity=38.0281690140845, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6322359, Length=149, Percent_Identity=36.241610738255, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324550, Length=148, Percent_Identity=33.1081081081081, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI78706572, Length=518, Percent_Identity=25.8687258687259, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24582462, Length=220, Percent_Identity=32.7272727272727, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28574573, Length=140, Percent_Identity=42.1428571428571, Blast_Score=110, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24585711, Length=154, Percent_Identity=35.0649350649351, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24585713, Length=154, Percent_Identity=35.0649350649351, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24585709, Length=154, Percent_Identity=35.0649350649351, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21357743, Length=213, Percent_Identity=34.7417840375587, Blast_Score=100, Evalue=5e-21,
Organism=Drosophila melanogaster, GI221458488, Length=161, Percent_Identity=40.9937888198758, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281363316, Length=237, Percent_Identity=32.0675105485232, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17864358, Length=237, Percent_Identity=32.0675105485232, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19921738, Length=299, Percent_Identity=26.4214046822742, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28572034, Length=166, Percent_Identity=34.3373493975904, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137380, Length=325, Percent_Identity=25.5384615384615, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 68783; Mature: 68783

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLRDDIRNIAIIAHVDHGKTTLVNELLKQSDTLDEHVQIEDRALDSNAIERERGITILS
CCCHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCHHHEEEHHHHCCCCHHHHHCCEEEEE
KNTAVRYADKQINILDTPGHADFGGEVERIMRMVDGVLLVVDAFEGTMPQTRFVLKKALE
CCCEEEEECCEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHH
QHLTPIVVVNKIDRPGARPEEVVDEVLDLFIELGADEDQLEFPVVYASAINGTSSFSSDP
HHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCC
ADQEHTMKPIFDTIVDTIPAPEDSSAEPLQFQVALLDYNDFVGRIGIGRVFRGRIKVGDN
CCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCHHHCCCCCCCEEECEEEECCC
VSVLKLDGSKKNFRVTKLFGYFGLKRLEINEAKAGDLIAISGMEDIFVGETVADAEHPEA
EEEEEECCCCCCEEEEEEHHHHCEEEEEECCCCCCCEEEECCCCHHCCCCCCCCCCCCCC
LPVLRIDEPTLQMTFRTNDSPFAGREGKFVTSRQLEQRLKTELHTDVSLRVDDTDDPGAW
CEEEEECCCCEEEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHCCCEEEEECCCCCCCEE
IVSGRGELHLSILIETLRREGYELQASRPEVIIKEIDGKLCEPYEMVQIDTPDEYTGSVI
EEECCCCEEHHHHHHHHHHCCCEEECCCCCEEEEECCCCCCCCEEEEEECCCCCHHHHHH
DSLSQRKGEMKNMETTDNGQTRLTFLAPSRGLIGYSTEFLSMTRGYGIMNHTFQEYLPQI
HHHHHHCCHHCCCCCCCCCCEEEEEECCCCCCEECCHHHHHHHCCCCHHHHHHHHHHHHH
KNWNPGRRNGTLVSINSGKVTTYAIMAVQDRGVIFTDAGTEVYEGMIVGQNSRENDISVN
CCCCCCCCCCEEEEECCCCEEEEEEEEEECCCEEEECCCCHHHCCEEEECCCCCCCEEEE
ITRGRNQTNVRAAGSEDIAKVKTPVHMSLEESLEFLNEDEYCEITPDHIRLRKQILNTNE
EECCCCCCCEEECCCCCHHHHCCCCEECHHHHHHHHCCCCCEEECHHHHHHHHHHHCCCH
REKAAKKRKMAAKK
HHHHHHHHHHCCCC
>Mature Secondary Structure
MNLRDDIRNIAIIAHVDHGKTTLVNELLKQSDTLDEHVQIEDRALDSNAIERERGITILS
CCCHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCHHHEEEHHHHCCCCHHHHHCCEEEEE
KNTAVRYADKQINILDTPGHADFGGEVERIMRMVDGVLLVVDAFEGTMPQTRFVLKKALE
CCCEEEEECCEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHH
QHLTPIVVVNKIDRPGARPEEVVDEVLDLFIELGADEDQLEFPVVYASAINGTSSFSSDP
HHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCC
ADQEHTMKPIFDTIVDTIPAPEDSSAEPLQFQVALLDYNDFVGRIGIGRVFRGRIKVGDN
CCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCHHHCCCCCCCEEECEEEECCC
VSVLKLDGSKKNFRVTKLFGYFGLKRLEINEAKAGDLIAISGMEDIFVGETVADAEHPEA
EEEEEECCCCCCEEEEEEHHHHCEEEEEECCCCCCCEEEECCCCHHCCCCCCCCCCCCCC
LPVLRIDEPTLQMTFRTNDSPFAGREGKFVTSRQLEQRLKTELHTDVSLRVDDTDDPGAW
CEEEEECCCCEEEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHCCCEEEEECCCCCCCEE
IVSGRGELHLSILIETLRREGYELQASRPEVIIKEIDGKLCEPYEMVQIDTPDEYTGSVI
EEECCCCEEHHHHHHHHHHCCCEEECCCCCEEEEECCCCCCCCEEEEEECCCCCHHHHHH
DSLSQRKGEMKNMETTDNGQTRLTFLAPSRGLIGYSTEFLSMTRGYGIMNHTFQEYLPQI
HHHHHHCCHHCCCCCCCCCCEEEEEECCCCCCEECCHHHHHHHCCCCHHHHHHHHHHHHH
KNWNPGRRNGTLVSINSGKVTTYAIMAVQDRGVIFTDAGTEVYEGMIVGQNSRENDISVN
CCCCCCCCCCEEEEECCCCEEEEEEEEEECCCEEEECCCCHHHCCEEEECCCCCCCEEEE
ITRGRNQTNVRAAGSEDIAKVKTPVHMSLEESLEFLNEDEYCEITPDHIRLRKQILNTNE
EECCCCCCCEEECCCCCHHHHCCCCEECHHHHHHHHCCCCCEEECHHHHHHHHHHHCCCH
REKAAKKRKMAAKK
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]