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The map label for this gene is arlS [H]

Identifier: 116492483

GI number: 116492483

Start: 752970

End: 754451

Strand: Direct

Name: arlS [H]

Synonym: PEPE_0715

Alternate gene names: 116492483

Gene position: 752970-754451 (Clockwise)

Preceding gene: 116492482

Following gene: 116492486

Centisome position: 41.09

GC content: 33.6

Gene sequence:

>1482_bases
ATGGAAAATAAAGTAATTAAAAAAAAAAGAATGTCGCTAAAATGGAAATGGGCTATCGGTACTGGTGTTGGAGTCCTATT
AATTTTTGCACTTTTCTCTTTTTTTGTTTTTAAAATTGTAACAGATTCATTATATGCTGAAGAACATCGAGATGTGGAAT
CAACAGTAACCCAAGTAAGAAGTCGTCTTCAAAATGCGAATGAGATTAATTATAAAACTACGGATATATTCAGACCTGAT
TTAAACCAAAAATCGGCGGTTAATAATAACCAAGGTGGTTTTAATGATTCATTGTTAGCGAGTTTAACCAGGCGAGATTT
AGTAGTTTCAGTTTATAACTTAGAAAAAGAATCAGTTTTTTCGAATCAAAGAATTAGTATGAAGACTACTCTCTCCGAGC
GAAAGTCAATTAAACGGAGTAAATTTCATCATAAAGATATTATTGTGGGACAAGCACCGATTATTAATAAAGATAATCAA
GTAATCGGGTATGTACGAGTTGTTGATTTACTGGTGAAATATAATAACAGATATCAGCGCTTGATCTGGCTATTTACCTT
AACGTCGCTTTTAATTTTTATGGTAATCTCCATTTTCGGTTATGGATTAACGGCATACTTATTAAAACCAATGAATTTAA
TTAATCAGTCGATGCGTAATTTAGAGGAAGATCCTCAAACCGATTTAAGAGTTCCTGAAATTGATACAAATGACGAGTTA
TCGGACTTGGCTCATGAATTTAATGATATGATTGATCGAATGCAACGCTATATTGATCAACAGAGACAGTTCGTTGAAGA
TGTATCACATGAATTGCGAACGCCAGTGGCAGTTGTGGAAGGTCACCTAAAGATGCTTGACCGTTGGGGAAAGGATGATC
CACAAGTTTTGGATGAATCAATTAAAGCGTCCTTAGAAGAAACGCAACGAATGAAAAGTTTAGTTAGTGAAATGCTAGAT
CTAACACGAGCTGATCAAATTGAGATTAATTATGCCGATGAAAAAACGAACGTCGTTCAATTAGTAAATCAAGTATTCAA
TGATTTTAAGATGATTCATCCAGAATTTAATTTCGTAATGGATGACGATATTACTGGTGAACCCATTGTTCCTATATATC
GGAATCATTTAGAACAAATTCTCGTAATCCTGCTTGATAATGCCATCAAGTACTCAAAAGATCGCAAAGAAATTCATATT
TCAACTGCTAATACCAAAAAGACCGTTGAAATTGCTGTACAAGATTTTGGTGAGGGGATTGCTGAAGAAAATCTGAAACA
GGTATTTAATCGTTTCTATCGAATCGACAAAGCTCGCAGTCGAGATCAAGGTGGGAACGGTTTAGGTTTATCCATTGCTA
AGAAATTAACTGAAGAATATCATGGAAATATTTCGCTAGAAAGTTCAGTTGGTTCAGGTTCAATATTTAGAATTAAATTA
CCGATTATTGAAGATCAACAGATAGAAATTAGTGAAAAATAA

Upstream 100 bases:

>100_bases
GATGTGTACATTAGATACCTCCGAAATAAAATTGATGTTAAGGGACGTCCTAGCTACATTCAAACCGTACGTGGTACTGG
ATATGTAATGAGGACCTAGT

Downstream 100 bases:

>100_bases
AAAATCCTTGGAAAATGAGTTTTACTCAAAATTTTCCAAGGATTTTTTTGGTATTTAATTTTAGTCACGATGATGATTTT
GTTTACCTGCATTACGACGA

Product: Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MENKVIKKKRMSLKWKWAIGTGVGVLLIFALFSFFVFKIVTDSLYAEEHRDVESTVTQVRSRLQNANEINYKTTDIFRPD
LNQKSAVNNNQGGFNDSLLASLTRRDLVVSVYNLEKESVFSNQRISMKTTLSERKSIKRSKFHHKDIIVGQAPIINKDNQ
VIGYVRVVDLLVKYNNRYQRLIWLFTLTSLLIFMVISIFGYGLTAYLLKPMNLINQSMRNLEEDPQTDLRVPEIDTNDEL
SDLAHEFNDMIDRMQRYIDQQRQFVEDVSHELRTPVAVVEGHLKMLDRWGKDDPQVLDESIKASLEETQRMKSLVSEMLD
LTRADQIEINYADEKTNVVQLVNQVFNDFKMIHPEFNFVMDDDITGEPIVPIYRNHLEQILVILLDNAIKYSKDRKEIHI
STANTKKTVEIAVQDFGEGIAEENLKQVFNRFYRIDKARSRDQGGNGLGLSIAKKLTEEYHGNISLESSVGSGSIFRIKL
PIIEDQQIEISEK

Sequences:

>Translated_493_residues
MENKVIKKKRMSLKWKWAIGTGVGVLLIFALFSFFVFKIVTDSLYAEEHRDVESTVTQVRSRLQNANEINYKTTDIFRPD
LNQKSAVNNNQGGFNDSLLASLTRRDLVVSVYNLEKESVFSNQRISMKTTLSERKSIKRSKFHHKDIIVGQAPIINKDNQ
VIGYVRVVDLLVKYNNRYQRLIWLFTLTSLLIFMVISIFGYGLTAYLLKPMNLINQSMRNLEEDPQTDLRVPEIDTNDEL
SDLAHEFNDMIDRMQRYIDQQRQFVEDVSHELRTPVAVVEGHLKMLDRWGKDDPQVLDESIKASLEETQRMKSLVSEMLD
LTRADQIEINYADEKTNVVQLVNQVFNDFKMIHPEFNFVMDDDITGEPIVPIYRNHLEQILVILLDNAIKYSKDRKEIHI
STANTKKTVEIAVQDFGEGIAEENLKQVFNRFYRIDKARSRDQGGNGLGLSIAKKLTEEYHGNISLESSVGSGSIFRIKL
PIIEDQQIEISEK
>Mature_493_residues
MENKVIKKKRMSLKWKWAIGTGVGVLLIFALFSFFVFKIVTDSLYAEEHRDVESTVTQVRSRLQNANEINYKTTDIFRPD
LNQKSAVNNNQGGFNDSLLASLTRRDLVVSVYNLEKESVFSNQRISMKTTLSERKSIKRSKFHHKDIIVGQAPIINKDNQ
VIGYVRVVDLLVKYNNRYQRLIWLFTLTSLLIFMVISIFGYGLTAYLLKPMNLINQSMRNLEEDPQTDLRVPEIDTNDEL
SDLAHEFNDMIDRMQRYIDQQRQFVEDVSHELRTPVAVVEGHLKMLDRWGKDDPQVLDESIKASLEETQRMKSLVSEMLD
LTRADQIEINYADEKTNVVQLVNQVFNDFKMIHPEFNFVMDDDITGEPIVPIYRNHLEQILVILLDNAIKYSKDRKEIHI
STANTKKTVEIAVQDFGEGIAEENLKQVFNRFYRIDKARSRDQGGNGLGLSIAKKLTEEYHGNISLESSVGSGSIFRIKL
PIIEDQQIEISEK

Specific function: Member of the two-component regulatory system ArlS/ArlR. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=279, Percent_Identity=29.7491039426523, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1788393, Length=260, Percent_Identity=29.6153846153846, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1786783, Length=329, Percent_Identity=28.2674772036474, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1790346, Length=261, Percent_Identity=29.5019157088123, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1788713, Length=239, Percent_Identity=27.6150627615063, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1787894, Length=250, Percent_Identity=25.2, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI145693157, Length=248, Percent_Identity=25.8064516129032, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790436, Length=349, Percent_Identity=24.6418338108883, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1787374, Length=323, Percent_Identity=26.0061919504644, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790861, Length=502, Percent_Identity=22.1115537848606, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789149, Length=250, Percent_Identity=28.4, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788279, Length=248, Percent_Identity=27.0161290322581, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790551, Length=306, Percent_Identity=26.797385620915, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786912, Length=235, Percent_Identity=27.2340425531915, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI87082128, Length=306, Percent_Identity=25.1633986928105, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1788549, Length=263, Percent_Identity=25.4752851711027, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1789403, Length=306, Percent_Identity=24.1830065359477, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1789808, Length=247, Percent_Identity=24.2914979757085, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87081816, Length=259, Percent_Identity=22.7799227799228, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI48994928, Length=248, Percent_Identity=20.9677419354839, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=84, Percent_Identity=40.4761904761905, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56976; Mature: 56976

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENKVIKKKRMSLKWKWAIGTGVGVLLIFALFSFFVFKIVTDSLYAEEHRDVESTVTQVR
CCCCHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
SRLQNANEINYKTTDIFRPDLNQKSAVNNNQGGFNDSLLASLTRRDLVVSVYNLEKESVF
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEHHHHCCHHHHH
SNQRISMKTTLSERKSIKRSKFHHKDIIVGQAPIINKDNQVIGYVRVVDLLVKYNNRYQR
CCCCEEHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCHHHH
LIWLFTLTSLLIFMVISIFGYGLTAYLLKPMNLINQSMRNLEEDPQTDLRVPEIDTNDEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHH
SDLAHEFNDMIDRMQRYIDQQRQFVEDVSHELRTPVAVVEGHLKMLDRWGKDDPQVLDES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHH
IKASLEETQRMKSLVSEMLDLTRADQIEINYADEKTNVVQLVNQVFNDFKMIHPEFNFVM
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHEECCCCCEEE
DDDITGEPIVPIYRNHLEQILVILLDNAIKYSKDRKEIHISTANTKKTVEIAVQDFGEGI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCH
AEENLKQVFNRFYRIDKARSRDQGGNGLGLSIAKKLTEEYHGNISLESSVGSGSIFRIKL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEE
PIIEDQQIEISEK
CCCCCCCCCCCCC
>Mature Secondary Structure
MENKVIKKKRMSLKWKWAIGTGVGVLLIFALFSFFVFKIVTDSLYAEEHRDVESTVTQVR
CCCCHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
SRLQNANEINYKTTDIFRPDLNQKSAVNNNQGGFNDSLLASLTRRDLVVSVYNLEKESVF
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEHHHHCCHHHHH
SNQRISMKTTLSERKSIKRSKFHHKDIIVGQAPIINKDNQVIGYVRVVDLLVKYNNRYQR
CCCCEEHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCHHHH
LIWLFTLTSLLIFMVISIFGYGLTAYLLKPMNLINQSMRNLEEDPQTDLRVPEIDTNDEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHH
SDLAHEFNDMIDRMQRYIDQQRQFVEDVSHELRTPVAVVEGHLKMLDRWGKDDPQVLDES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHH
IKASLEETQRMKSLVSEMLDLTRADQIEINYADEKTNVVQLVNQVFNDFKMIHPEFNFVM
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHEECCCCCEEE
DDDITGEPIVPIYRNHLEQILVILLDNAIKYSKDRKEIHISTANTKKTVEIAVQDFGEGI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCH
AEENLKQVFNRFYRIDKARSRDQGGNGLGLSIAKKLTEEYHGNISLESSVGSGSIFRIKL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEE
PIIEDQQIEISEK
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA