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The map label for this gene is arlR [H]

Identifier: 116492482

GI number: 116492482

Start: 752282

End: 752968

Strand: Direct

Name: arlR [H]

Synonym: PEPE_0714

Alternate gene names: 116492482

Gene position: 752282-752968 (Clockwise)

Preceding gene: 116492481

Following gene: 116492483

Centisome position: 41.05

GC content: 36.1

Gene sequence:

>687_bases
ATGAGTCGTATTTTGATAATCGAAGATGAAAAAAGTCTTGCACGTTTTGTTCAACTTGAATTACAGCATGAAGGATATGA
AGTTGAAGTTCAATCTAACGGACGCACAGGTTTAGAAGCAGCATTATCAGAAGATTTTGATGCTATCTTACTTGATTTAA
TGTTGCCAGAAATTAATGGAATTGAAGTATGTCGGCGTATTAGAAGAGAAAAAATAACTCCTATTATTATGATGACAGCT
CGCGATTCAATCATTGATCGTGTTTCAGGTCTTGATCACGGAGCAGATGATTATATTGTAAAACCTTTTGCTATTGAGGA
GTTACTTGCTCGTTTACGCGCAGTTCTTCGCCGAGTGGATTTAGAAACACAAGATTCCACTTTCCACCAAACAACGGTTG
AATTTCAAGATATTGTTATTGAAAAGGAAAATCGAGTTGTACGTCGTAATAACGAAGTAATCAATTTAACTAAACGTGAA
TATGAGTTGCTATTGTTATTAATGGAAAATATTAACGTGGTTCAGTCTCGAGAAACTTTATTGAATAAGGTATGGGGTGT
AGACGATGGTGTAGAAACTAACGTTGTCGATGTGTACATTAGATACCTCCGAAATAAAATTGATGTTAAGGGACGTCCTA
GCTACATTCAAACCGTACGTGGTACTGGATATGTAATGAGGACCTAG

Upstream 100 bases:

>100_bases
TTTGTTTGCAACATAATATTGGAAGCGCTAGGCAAAGCAACCGGATAATGTTAGAATTTACTACAGTAGGGTTAAAATAA
TTTAATTTTGGGGTAAAAAA

Downstream 100 bases:

>100_bases
TATGGAAAATAAAGTAATTAAAAAAAAAAGAATGTCGCTAAAATGGAAATGGGCTATCGGTACTGGTGTTGGAGTCCTAT
TAATTTTTGCACTTTTCTCT

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MSRILIIEDEKSLARFVQLELQHEGYEVEVQSNGRTGLEAALSEDFDAILLDLMLPEINGIEVCRRIRREKITPIIMMTA
RDSIIDRVSGLDHGADDYIVKPFAIEELLARLRAVLRRVDLETQDSTFHQTTVEFQDIVIEKENRVVRRNNEVINLTKRE
YELLLLLMENINVVQSRETLLNKVWGVDDGVETNVVDVYIRYLRNKIDVKGRPSYIQTVRGTGYVMRT

Sequences:

>Translated_228_residues
MSRILIIEDEKSLARFVQLELQHEGYEVEVQSNGRTGLEAALSEDFDAILLDLMLPEINGIEVCRRIRREKITPIIMMTA
RDSIIDRVSGLDHGADDYIVKPFAIEELLARLRAVLRRVDLETQDSTFHQTTVEFQDIVIEKENRVVRRNNEVINLTKRE
YELLLLLMENINVVQSRETLLNKVWGVDDGVETNVVDVYIRYLRNKIDVKGRPSYIQTVRGTGYVMRT
>Mature_227_residues
SRILIIEDEKSLARFVQLELQHEGYEVEVQSNGRTGLEAALSEDFDAILLDLMLPEINGIEVCRRIRREKITPIIMMTAR
DSIIDRVSGLDHGADDYIVKPFAIEELLARLRAVLRRVDLETQDSTFHQTTVEFQDIVIEKENRVVRRNNEVINLTKREY
ELLLLLMENINVVQSRETLLNKVWGVDDGVETNVVDVYIRYLRNKIDVKGRPSYIQTVRGTGYVMRT

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=40.990990990991, Blast_Score=169, Evalue=1e-43,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=39.1111111111111, Blast_Score=163, Evalue=8e-42,
Organism=Escherichia coli, GI1786599, Length=230, Percent_Identity=38.695652173913, Blast_Score=151, Evalue=4e-38,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=36.8888888888889, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=35.1111111111111, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=37.3333333333333, Blast_Score=138, Evalue=2e-34,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=36.1233480176211, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=34.9344978165939, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=36.6071428571429, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=33.1858407079646, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1787375, Length=226, Percent_Identity=32.3008849557522, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=34.2222222222222, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=32.6271186440678, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=31.5789473684211, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1788550, Length=132, Percent_Identity=32.5757575757576, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1790437, Length=131, Percent_Identity=32.824427480916, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=31.4814814814815, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26432; Mature: 26301

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRILIIEDEKSLARFVQLELQHEGYEVEVQSNGRTGLEAALSEDFDAILLDLMLPEING
CCEEEEEECCHHHHHHHHHHEECCCEEEEECCCCCCHHHHHHHCCHHHHHHHHHCCCCCH
IEVCRRIRREKITPIIMMTARDSIIDRVSGLDHGADDYIVKPFAIEELLARLRAVLRRVD
HHHHHHHHHHCCCEEEEEECHHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHHHC
LETQDSTFHQTTVEFQDIVIEKENRVVRRNNEVINLTKREYELLLLLMENINVVQSRETL
CCCCCCCHHHHHHHHHHEEEECCCCEEECCCCEEEEHHHHHHHHHHHHHCCCHHHHHHHH
LNKVWGVDDGVETNVVDVYIRYLRNKIDVKGRPSYIQTVRGTGYVMRT
HHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHEECCCEEEEEC
>Mature Secondary Structure 
SRILIIEDEKSLARFVQLELQHEGYEVEVQSNGRTGLEAALSEDFDAILLDLMLPEING
CEEEEEECCHHHHHHHHHHEECCCEEEEECCCCCCHHHHHHHCCHHHHHHHHHCCCCCH
IEVCRRIRREKITPIIMMTARDSIIDRVSGLDHGADDYIVKPFAIEELLARLRAVLRRVD
HHHHHHHHHHCCCEEEEEECHHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHHHC
LETQDSTFHQTTVEFQDIVIEKENRVVRRNNEVINLTKREYELLLLLMENINVVQSRETL
CCCCCCCHHHHHHHHHHEEEECCCCEEECCCCEEEEHHHHHHHHHHHHHCCCHHHHHHHH
LNKVWGVDDGVETNVVDVYIRYLRNKIDVKGRPSYIQTVRGTGYVMRT
HHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHEECCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA