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The map label for this gene is gnd [H]

Identifier: 116492481

GI number: 116492481

Start: 750429

End: 751847

Strand: Direct

Name: gnd [H]

Synonym: PEPE_0713

Alternate gene names: 116492481

Gene position: 750429-751847 (Clockwise)

Preceding gene: 116492480

Following gene: 116492482

Centisome position: 40.95

GC content: 39.25

Gene sequence:

>1419_bases
ATGGATCAACCACAAATTGGTGTAGTGGGAATGGCCGTAATGGGTAAAAATCTCGCTTTAAACATCGAAAGCAGGGGATA
TACAGTTGCGATCTACAACCGTACTGCCTCAAAAACTGAAAAAGTAATGCAAGATCATTCTGAAAAGAAATTAGTTCCTG
CATATTCTATTGAAGAATTCGTAAATTCACTAGAAAAGCCTCGTCGAATTATGATGATGGTTAAGGCTGGTAAACCAACT
GATGCTGTTATTGCTGAATTACTTCCTTTACTTGACAAAGGAGATGTCTTAATCGACGGTGGTAACACTAACTTTGAAGA
CACTATGCGTCGTAATAAAGAATTGGATGAATCTGGAATTAACTTCATTGGTACAGGTGTTTCAGGTGGTGAATTAGGTG
CGTTACAAGGTCCTTCAATGATGCCAGGTGGACAAAAAGAAGCTTATGACTTAGTTGCACCAATCTTCGAACAAATCTCT
GCTAAGGCTAAAGACGGCGATCCATGTGTGACCTATATTGGACCTAACGGAGCTGGTCATTACGTTAAAATGGTTCATAA
CGGAATTGAATATGGTGATGAACAATTAATCGATGAAAGTTACGACCTAATGCGTAAGTTATTGGGTCTCCCAGTTAAAG
AAATTGCTGATATTTTTGCTGACTGGAATCAAGGTGAACTTGACAGTTATCTAATCGATATTACTGCTGATATTCTAACA
AGAACGGACGATCTTGGTTCAGATAAACCAATCGTTGATCTTATTATGGATAAAGGTGGCAATAAAGGAACAGGTAAGTG
GAGTTCACAAAATGCACTTGAATTAGGGGTTCCACAATCGCTCATCACTGAATCTGTATATGCTCGTTATATTTCCGTGC
TTAAGGACGAACGTGTCGCAGCAAGTAAAGTGCTTGCAGGTCCAGAAAAGAAAATTGACGTTGACAAGGATGAAGTCATC
GAAAAAATTCGTCGCGCACTATACTTCAGTAAGATTATGAGTTACGCTCAAGGATTTGAACAAATGCGTGTAGCTTCTGA
AAATTATGACTGGAACTTGAATTTTGGTGAAATTGCCAAGATCTGGCGTGCTGGATGTATCATCCGTGCTCAATTCCTTC
AAAATATTACAGATGCTTTCGATAAGAATCCTGAACTAAATAACCTTTTGATGGATTCATACTTCCAAGAAATTGCTGCT
AAGTATCAAGAAGCCGTTCGTGACGTAGTTGCACTTGCTGTTAAAGCTGGAATTCCAGTTCCCGCACTATCAGCAGCGGT
AGCATACTATGATTCATATCGTTCAGCTGTTTTACCAGCAAATCTTCTTCAAGCACAACGTGATTACTTTGGTGCTCACA
CCTACGAACGTGTTGATCGCGAAGGTATTTACCATTTTCCATGGTATGAAGAACAATAA

Upstream 100 bases:

>100_bases
TTTACTTATCTGTTAAAATATAATATATTGCTACACAAAGTTTCGAGTATTTTAAAATCAATGTCTTGGAACAATTGTTA
GATATAGAGGAGGAATCACG

Downstream 100 bases:

>100_bases
AAATTAGTTTAAATAGAAAAGCGATAACCGTTACGGCTACCGCTTTTTTTATATGGATTATTAAGGATATCACTTTGAGA
CTAGGTCAAATTAAGTGAGC

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MDQPQIGVVGMAVMGKNLALNIESRGYTVAIYNRTASKTEKVMQDHSEKKLVPAYSIEEFVNSLEKPRRIMMMVKAGKPT
DAVIAELLPLLDKGDVLIDGGNTNFEDTMRRNKELDESGINFIGTGVSGGELGALQGPSMMPGGQKEAYDLVAPIFEQIS
AKAKDGDPCVTYIGPNGAGHYVKMVHNGIEYGDEQLIDESYDLMRKLLGLPVKEIADIFADWNQGELDSYLIDITADILT
RTDDLGSDKPIVDLIMDKGGNKGTGKWSSQNALELGVPQSLITESVYARYISVLKDERVAASKVLAGPEKKIDVDKDEVI
EKIRRALYFSKIMSYAQGFEQMRVASENYDWNLNFGEIAKIWRAGCIIRAQFLQNITDAFDKNPELNNLLMDSYFQEIAA
KYQEAVRDVVALAVKAGIPVPALSAAVAYYDSYRSAVLPANLLQAQRDYFGAHTYERVDREGIYHFPWYEEQ

Sequences:

>Translated_472_residues
MDQPQIGVVGMAVMGKNLALNIESRGYTVAIYNRTASKTEKVMQDHSEKKLVPAYSIEEFVNSLEKPRRIMMMVKAGKPT
DAVIAELLPLLDKGDVLIDGGNTNFEDTMRRNKELDESGINFIGTGVSGGELGALQGPSMMPGGQKEAYDLVAPIFEQIS
AKAKDGDPCVTYIGPNGAGHYVKMVHNGIEYGDEQLIDESYDLMRKLLGLPVKEIADIFADWNQGELDSYLIDITADILT
RTDDLGSDKPIVDLIMDKGGNKGTGKWSSQNALELGVPQSLITESVYARYISVLKDERVAASKVLAGPEKKIDVDKDEVI
EKIRRALYFSKIMSYAQGFEQMRVASENYDWNLNFGEIAKIWRAGCIIRAQFLQNITDAFDKNPELNNLLMDSYFQEIAA
KYQEAVRDVVALAVKAGIPVPALSAAVAYYDSYRSAVLPANLLQAQRDYFGAHTYERVDREGIYHFPWYEEQ
>Mature_472_residues
MDQPQIGVVGMAVMGKNLALNIESRGYTVAIYNRTASKTEKVMQDHSEKKLVPAYSIEEFVNSLEKPRRIMMMVKAGKPT
DAVIAELLPLLDKGDVLIDGGNTNFEDTMRRNKELDESGINFIGTGVSGGELGALQGPSMMPGGQKEAYDLVAPIFEQIS
AKAKDGDPCVTYIGPNGAGHYVKMVHNGIEYGDEQLIDESYDLMRKLLGLPVKEIADIFADWNQGELDSYLIDITADILT
RTDDLGSDKPIVDLIMDKGGNKGTGKWSSQNALELGVPQSLITESVYARYISVLKDERVAASKVLAGPEKKIDVDKDEVI
EKIRRALYFSKIMSYAQGFEQMRVASENYDWNLNFGEIAKIWRAGCIIRAQFLQNITDAFDKNPELNNLLMDSYFQEIAA
KYQEAVRDVVALAVKAGIPVPALSAAVAYYDSYRSAVLPANLLQAQRDYFGAHTYERVDREGIYHFPWYEEQ

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=471, Percent_Identity=52.4416135881104, Blast_Score=490, Evalue=1e-138,
Organism=Escherichia coli, GI1788341, Length=468, Percent_Identity=68.3760683760684, Blast_Score=674, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17542558, Length=473, Percent_Identity=50.9513742071882, Blast_Score=492, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6321695, Length=465, Percent_Identity=52.9032258064516, Blast_Score=499, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6321977, Length=454, Percent_Identity=54.1850220264317, Blast_Score=489, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24639279, Length=465, Percent_Identity=52.4731182795699, Blast_Score=479, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 52476; Mature: 52476

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQPQIGVVGMAVMGKNLALNIESRGYTVAIYNRTASKTEKVMQDHSEKKLVPAYSIEEF
CCCCCCCCEEHHHHCCCEEEEEECCCEEEEEECCCHHHHHHHHHCCCCCCCCCHHHHHHH
VNSLEKPRRIMMMVKAGKPTDAVIAELLPLLDKGDVLIDGGNTNFEDTMRRNKELDESGI
HHHHHCCHHEEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHCCCCCCCCC
NFIGTGVSGGELGALQGPSMMPGGQKEAYDLVAPIFEQISAKAKDGDPCVTYIGPNGAGH
CEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCH
YVKMVHNGIEYGDEQLIDESYDLMRKLLGLPVKEIADIFADWNQGELDSYLIDITADILT
HHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
RTDDLGSDKPIVDLIMDKGGNKGTGKWSSQNALELGVPQSLITESVYARYISVLKDERVA
CCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHH
ASKVLAGPEKKIDVDKDEVIEKIRRALYFSKIMSYAQGFEQMRVASENYDWNLNFGEIAK
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
IWRAGCIIRAQFLQNITDAFDKNPELNNLLMDSYFQEIAAKYQEAVRDVVALAVKAGIPV
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PALSAAVAYYDSYRSAVLPANLLQAQRDYFGAHTYERVDREGIYHFPWYEEQ
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHCCCEECCCCCCC
>Mature Secondary Structure
MDQPQIGVVGMAVMGKNLALNIESRGYTVAIYNRTASKTEKVMQDHSEKKLVPAYSIEEF
CCCCCCCCEEHHHHCCCEEEEEECCCEEEEEECCCHHHHHHHHHCCCCCCCCCHHHHHHH
VNSLEKPRRIMMMVKAGKPTDAVIAELLPLLDKGDVLIDGGNTNFEDTMRRNKELDESGI
HHHHHCCHHEEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHCCCCCCCCC
NFIGTGVSGGELGALQGPSMMPGGQKEAYDLVAPIFEQISAKAKDGDPCVTYIGPNGAGH
CEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCH
YVKMVHNGIEYGDEQLIDESYDLMRKLLGLPVKEIADIFADWNQGELDSYLIDITADILT
HHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
RTDDLGSDKPIVDLIMDKGGNKGTGKWSSQNALELGVPQSLITESVYARYISVLKDERVA
CCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHH
ASKVLAGPEKKIDVDKDEVIEKIRRALYFSKIMSYAQGFEQMRVASENYDWNLNFGEIAK
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
IWRAGCIIRAQFLQNITDAFDKNPELNNLLMDSYFQEIAAKYQEAVRDVVALAVKAGIPV
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PALSAAVAYYDSYRSAVLPANLLQAQRDYFGAHTYERVDREGIYHFPWYEEQ
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]