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The map label for this gene is lysA [H]

Identifier: 116491950

GI number: 116491950

Start: 160674

End: 161966

Strand: Reverse

Name: lysA [H]

Synonym: PEPE_0136

Alternate gene names: 116491950

Gene position: 161966-160674 (Counterclockwise)

Preceding gene: 116491954

Following gene: 116491949

Centisome position: 8.84

GC content: 41.53

Gene sequence:

>1293_bases
ATGTCTTTATACACCGTAAATAACGTTAATCAGGTTACCATAGGCGGCCTAAGCGCTACTCAACTTGCCCGTCAATATGG
GACCCCACTCCAAGTTTTTGACGTCACCATGATTCGTAATCAAATTCAAGCCTTTCAAAAAGAATTTGAAGACCGTGGTA
TACGCGGCATCGTCAGCTATGCTTCCAAGGCTTTTAGTTGCAAAGCCATTTACCAAGTTGTTAAGCAAGAACATGCCCAT
TCCGATGTCGTTTCTGGAGGTGAGATTGCTACAGCTTTGGCCGCTGGTTTCCCCTCTACTAGTCTTAGCTTCCATGGCAA
TAACAAATCACTCGCCGAGTTGAATTTTGCCGTCCAAAAAGGAGTGGGAACTATCATTTTAGATAATTTTCATGAATTAG
AATTGCTCGATCAAGTTTTGAACGAAAATAATACTCAAATTGATGTGTTGCTCCGTGTTACACCAGGTGTTTCTGCTCAT
ACTCACAGCTATATTCAAACCGGTCAAACTGACAGTAAATTTGGATTTGATATTGATTCAGGACAAGCATTAAAAGCCAT
GCGCTTGTCCCAAAACAACCCTCGAATCCATCTACGAGGAATCCATGCCCACATTGGTTCACAAATTTTTGAAGTAACAG
GTTTTAAATTAGAGGTTAAAAAGTTAGTCAATTTATTAACAAATTGGTCTCAAAAATACCAATTTACAGCCGATATTTTA
AATATCGGTGGTGGATTTGGAATTAAGTATACCCATGCGGATGATCCTCTTGCCCCCGAGCTTCTTCTCGGTGAAATTTT
AGATGAACTTCAAGTCCAGTACTCTAAGCTTGGACAACCCATTCCCACCATTTGGATAGAGCCAGGTCGTTCCATTGTTG
GCCCAGCCGGTTTTTCACTTTACACAATCGGTTCACGAAAAGATGTCCCTGGTTTATCCCCTTACGTTGCTGTTGACGGC
GGAATGGGTGATAATATTCGGCCCGCACTTTACCAGGCTGACTATGAGGCGGTCCTTGCAGAAAATCCAAACCAGCCTCC
GATTGAAACCGTTCGTTTAGCTGGTAAATTCTGTGAATCTGGTGACATCTTAATCAACCACCTTCCATTACCTACTACTA
AGACCGGTGATGTACTCGTTATGTTGGCAACAGGTGCTTACGGGTATTCAATGGCTAGTAACTATAACCGTAATCCTCGT
CCAGCAGTTGTCTTTGCTGAAAATAGCCAAGCTCAATTAGTTATTCAAAGAGAAACATACGCAGATATGATACAAAATGA
TTTAGATTATTGA

Upstream 100 bases:

>100_bases
GAGCAACAATTTATGACATATACCCCCTTACTTTATGCTTGACGAAATTCATTTAGTATTATAAATTTGTGAAAATTAAA
TTAGAAAAGGGGGTAAACGA

Downstream 100 bases:

>100_bases
AAATTGAAAGGGGAATTACTATGAGTAATCTTGACACCCAGTCCATTATTAACACCATTTCAAACTCCAAAAAGCAGACC
CCCGTTCGAGTGTTTATTGC

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MSLYTVNNVNQVTIGGLSATQLARQYGTPLQVFDVTMIRNQIQAFQKEFEDRGIRGIVSYASKAFSCKAIYQVVKQEHAH
SDVVSGGEIATALAAGFPSTSLSFHGNNKSLAELNFAVQKGVGTIILDNFHELELLDQVLNENNTQIDVLLRVTPGVSAH
THSYIQTGQTDSKFGFDIDSGQALKAMRLSQNNPRIHLRGIHAHIGSQIFEVTGFKLEVKKLVNLLTNWSQKYQFTADIL
NIGGGFGIKYTHADDPLAPELLLGEILDELQVQYSKLGQPIPTIWIEPGRSIVGPAGFSLYTIGSRKDVPGLSPYVAVDG
GMGDNIRPALYQADYEAVLAENPNQPPIETVRLAGKFCESGDILINHLPLPTTKTGDVLVMLATGAYGYSMASNYNRNPR
PAVVFAENSQAQLVIQRETYADMIQNDLDY

Sequences:

>Translated_430_residues
MSLYTVNNVNQVTIGGLSATQLARQYGTPLQVFDVTMIRNQIQAFQKEFEDRGIRGIVSYASKAFSCKAIYQVVKQEHAH
SDVVSGGEIATALAAGFPSTSLSFHGNNKSLAELNFAVQKGVGTIILDNFHELELLDQVLNENNTQIDVLLRVTPGVSAH
THSYIQTGQTDSKFGFDIDSGQALKAMRLSQNNPRIHLRGIHAHIGSQIFEVTGFKLEVKKLVNLLTNWSQKYQFTADIL
NIGGGFGIKYTHADDPLAPELLLGEILDELQVQYSKLGQPIPTIWIEPGRSIVGPAGFSLYTIGSRKDVPGLSPYVAVDG
GMGDNIRPALYQADYEAVLAENPNQPPIETVRLAGKFCESGDILINHLPLPTTKTGDVLVMLATGAYGYSMASNYNRNPR
PAVVFAENSQAQLVIQRETYADMIQNDLDY
>Mature_429_residues
SLYTVNNVNQVTIGGLSATQLARQYGTPLQVFDVTMIRNQIQAFQKEFEDRGIRGIVSYASKAFSCKAIYQVVKQEHAHS
DVVSGGEIATALAAGFPSTSLSFHGNNKSLAELNFAVQKGVGTIILDNFHELELLDQVLNENNTQIDVLLRVTPGVSAHT
HSYIQTGQTDSKFGFDIDSGQALKAMRLSQNNPRIHLRGIHAHIGSQIFEVTGFKLEVKKLVNLLTNWSQKYQFTADILN
IGGGFGIKYTHADDPLAPELLLGEILDELQVQYSKLGQPIPTIWIEPGRSIVGPAGFSLYTIGSRKDVPGLSPYVAVDGG
MGDNIRPALYQADYEAVLAENPNQPPIETVRLAGKFCESGDILINHLPLPTTKTGDVLVMLATGAYGYSMASNYNRNPRP
AVVFAENSQAQLVIQRETYADMIQNDLDY

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=431, Percent_Identity=32.2505800464037, Blast_Score=150, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 47059; Mature: 46928

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLYTVNNVNQVTIGGLSATQLARQYGTPLQVFDVTMIRNQIQAFQKEFEDRGIRGIVSY
CCEEEECCCCEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
ASKAFSCKAIYQVVKQEHAHSDVVSGGEIATALAAGFPSTSLSFHGNNKSLAELNFAVQK
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHC
GVGTIILDNFHELELLDQVLNENNTQIDVLLRVTPGVSAHTHSYIQTGQTDSKFGFDIDS
CCCEEEECCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCC
GQALKAMRLSQNNPRIHLRGIHAHIGSQIFEVTGFKLEVKKLVNLLTNWSQKYQFTADIL
CCHHHHHHHCCCCCEEEEEEEHHHHCCCEEECCCCEEEHHHHHHHHHCCCHHEEEEEHHH
NIGGGFGIKYTHADDPLAPELLLGEILDELQVQYSKLGQPIPTIWIEPGRSIVGPAGFSL
CCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEECCCCEEE
YTIGSRKDVPGLSPYVAVDGGMGDNIRPALYQADYEAVLAENPNQPPIETVRLAGKFCES
EEECCCCCCCCCCCEEEEECCCCCCCCHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHCCC
GDILINHLPLPTTKTGDVLVMLATGAYGYSMASNYNRNPRPAVVFAENSQAQLVIQRETY
CCEEEEECCCCCCCCCCEEEEEECCCCCHHHHCCCCCCCCCEEEEECCCCEEEEEEHHHH
ADMIQNDLDY
HHHHHHCCCC
>Mature Secondary Structure 
SLYTVNNVNQVTIGGLSATQLARQYGTPLQVFDVTMIRNQIQAFQKEFEDRGIRGIVSY
CEEEECCCCEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
ASKAFSCKAIYQVVKQEHAHSDVVSGGEIATALAAGFPSTSLSFHGNNKSLAELNFAVQK
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHC
GVGTIILDNFHELELLDQVLNENNTQIDVLLRVTPGVSAHTHSYIQTGQTDSKFGFDIDS
CCCEEEECCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCC
GQALKAMRLSQNNPRIHLRGIHAHIGSQIFEVTGFKLEVKKLVNLLTNWSQKYQFTADIL
CCHHHHHHHCCCCCEEEEEEEHHHHCCCEEECCCCEEEHHHHHHHHHCCCHHEEEEEHHH
NIGGGFGIKYTHADDPLAPELLLGEILDELQVQYSKLGQPIPTIWIEPGRSIVGPAGFSL
CCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEECCCCEEE
YTIGSRKDVPGLSPYVAVDGGMGDNIRPALYQADYEAVLAENPNQPPIETVRLAGKFCES
EEECCCCCCCCCCCEEEEECCCCCCCCHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHCCC
GDILINHLPLPTTKTGDVLVMLATGAYGYSMASNYNRNPRPAVVFAENSQAQLVIQRETY
CCEEEEECCCCCCCCCCEEEEEECCCCCHHHHCCCCCCCCCEEEEECCCCEEEEEEHHHH
ADMIQNDLDY
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8215365 [H]