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The map label for this gene is cobA/cobO [H]

Identifier: 116332614

GI number: 116332614

Start: 216418

End: 216954

Strand: Direct

Name: cobA/cobO [H]

Synonym: LBJ_4187

Alternate gene names: 116332614

Gene position: 216418-216954 (Clockwise)

Preceding gene: 116332613

Following gene: 116332615

Centisome position: 72.2

GC content: 45.07

Gene sequence:

>537_bases
ATGAACTCAGACTCAAAAAGAACGAAAGGACTCGTGATCGTTCATACCGGAAACGGTAAAGGAAAAACCACTGCCGCACT
TGGAATCTTATTTCGCGCGTTAGGAAGAGGGTTGAAATGCGGAGTCGTCCAATTTCTAAAAGGAAAATGGGAAACGGGTG
AAAGAATGTTTGCAAGGACCATTCCGGGACTCGACTTCCACGTCATGGGATCCGGCTTTACCTGGGATAGCGACGATCTG
GACAAAGATAAAGCCGCCGCACAGTCCGCATGGTCCGTCTCTCGTCGAATGATATTAAAAGGAAATTATAATATCATAAT
ACTTGATGAGATTACCTACGCATTTCATTACGGCTGGTTAAATACCGAAGACGTTATCCGGATCCTAGCCAAAAGACCAA
AAAACGTACACGTAGTAATCACGGGAAGAAACTGTCCGGAAACTCTGATGAACTACGCCGATTTAGTCAGCGTGACCGAA
GCCAAAAAACATCCGTATCGAGACGGAATTCCCGCACAACAAGGAATCGATTTTTAG

Upstream 100 bases:

>100_bases
TTATTTTTGTCGGCCCAGTTTTAAACTGCCGCGACTTTGCCGACTCCAAACTTTACTCGGCCGATTTTTCGCACAAATTC
AGAAAAGTAAAAAAGAATTT

Downstream 100 bases:

>100_bases
TGAACGTTTTATATACAGAAATCAAAATTCCAAGAATCGTAATCGCAGGAACAGGAAGCGGCGTCGGAAAAACCACGGTA
GTTCTTGCACTCACGCAAGC

Product: Cob(I)yrinic acid a,c-diamide adenosyltransferase

Products: NA

Alternate protein names: Cob(I)alamin adenosyltransferase; Corrinoid adenosyltransferase [H]

Number of amino acids: Translated: 178; Mature: 178

Protein sequence:

>178_residues
MNSDSKRTKGLVIVHTGNGKGKTTAALGILFRALGRGLKCGVVQFLKGKWETGERMFARTIPGLDFHVMGSGFTWDSDDL
DKDKAAAQSAWSVSRRMILKGNYNIIILDEITYAFHYGWLNTEDVIRILAKRPKNVHVVITGRNCPETLMNYADLVSVTE
AKKHPYRDGIPAQQGIDF

Sequences:

>Translated_178_residues
MNSDSKRTKGLVIVHTGNGKGKTTAALGILFRALGRGLKCGVVQFLKGKWETGERMFARTIPGLDFHVMGSGFTWDSDDL
DKDKAAAQSAWSVSRRMILKGNYNIIILDEITYAFHYGWLNTEDVIRILAKRPKNVHVVITGRNCPETLMNYADLVSVTE
AKKHPYRDGIPAQQGIDF
>Mature_178_residues
MNSDSKRTKGLVIVHTGNGKGKTTAALGILFRALGRGLKCGVVQFLKGKWETGERMFARTIPGLDFHVMGSGFTWDSDDL
DKDKAAAQSAWSVSRRMILKGNYNIIILDEITYAFHYGWLNTEDVIRILAKRPKNVHVVITGRNCPETLMNYADLVSVTE
AKKHPYRDGIPAQQGIDF

Specific function: Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids [H]

COG id: COG2109

COG function: function code H; ATP:corrinoid adenosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Cob(I)alamin adenosyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1787525, Length=176, Percent_Identity=43.1818181818182, Blast_Score=160, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003724 [H]

Pfam domain/function: PF02572 CobA_CobO_BtuR [H]

EC number: =2.5.1.17 [H]

Molecular weight: Translated: 19842; Mature: 19842

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSDSKRTKGLVIVHTGNGKGKTTAALGILFRALGRGLKCGVVQFLKGKWETGERMFART
CCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHH
IPGLDFHVMGSGFTWDSDDLDKDKAAAQSAWSVSRRMILKGNYNIIILDEITYAFHYGWL
CCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCCEEEEECEEEEEEECCC
NTEDVIRILAKRPKNVHVVITGRNCPETLMNYADLVSVTEAKKHPYRDGIPAQQGIDF
CHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCC
>Mature Secondary Structure
MNSDSKRTKGLVIVHTGNGKGKTTAALGILFRALGRGLKCGVVQFLKGKWETGERMFART
CCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHH
IPGLDFHVMGSGFTWDSDDLDKDKAAAQSAWSVSRRMILKGNYNIIILDEITYAFHYGWL
CCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCCEEEEECEEEEEEECCC
NTEDVIRILAKRPKNVHVVITGRNCPETLMNYADLVSVTEAKKHPYRDGIPAQQGIDF
CHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1655697; 1917862 [H]