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The map label for this gene is cobH [H]

Identifier: 116332608

GI number: 116332608

Start: 210381

End: 211052

Strand: Direct

Name: cobH [H]

Synonym: LBJ_4181

Alternate gene names: 116332608

Gene position: 210381-211052 (Clockwise)

Preceding gene: 116332607

Following gene: 116332609

Centisome position: 70.18

GC content: 43.6

Gene sequence:

>672_bases
ATGAATGATATGAGGCAAATGACGTTCCTCGGCAGAGAAATCGAAGACAAATCCTTTTCGATCATAGACGAAGAAGCGGG
TCCACATCCTTTTTCCAAGGAAGAATGGGAAGTGGTTCGTAGAATCATACACGCAACGGCCGACTTTGAATACAAAGATA
TTACCAAAATACATTATCAAGCGATCGATTCTGGAATCCAGGCCCTAAAGAAAGGATGTCCGATCGTTTGCGACGTTCAG
ATGATACTCGCCGGCCTTAATCAGGACAGGCTCAAAGCTTACGGCTGTAAAACGTTCTGTTTTATCTCGGACAAAGACGT
GATCACAAAAGCGAAAGAAAAAAATTCCACACGAGCGATCGAAGCGATTCAAAAAGCGAAGGCATCCAATCTTTTGAACG
GAGCGGTGATCATCGTCGGGAACGCCCCCACGGCATTACTCGAGATTGAAAGACTGATCCGTTTAGAAGGAATCAAACCG
GCTCTGATTATCGGAGTTCCGGTCGGTTTTGTTTCGGCAGTCGAATCCAAAGAAGTTATTCTAAAATTAGAATATTCTAA
TGTATTTTCGGTGCCGTATATTCTCACGAAAGGACGAAAAGGAGGAAGTACGATCGCCGTTGCGATTCTTCACACTCTTC
TTCTTTTATCTTCCAAAAGAGGGGAAAAATGA

Upstream 100 bases:

>100_bases
TATGTCGATTTCCTGTTATATGGTGGACTTTGACGGAACACTCTTGGGCAAATTCGAAAATTTCTCGCAAAAATCGAAAC
TACGAAAGGGAATTTGACAC

Downstream 100 bases:

>100_bases
AAGCGGTTACCGTGATTGGAATGGGCGACGAAGGTTGCCTTGGGCTATCAAGCATTGCCGCAAACGCCGTCTCCAATGCA
CAAGTCCTTGCGGGAGGGAA

Product: precorrin-8X methylmutase or isomerase

Products: hydrogenobyrinate

Alternate protein names: Cobalt-precorrin isomerase; HBA synthase [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MNDMRQMTFLGREIEDKSFSIIDEEAGPHPFSKEEWEVVRRIIHATADFEYKDITKIHYQAIDSGIQALKKGCPIVCDVQ
MILAGLNQDRLKAYGCKTFCFISDKDVITKAKEKNSTRAIEAIQKAKASNLLNGAVIIVGNAPTALLEIERLIRLEGIKP
ALIIGVPVGFVSAVESKEVILKLEYSNVFSVPYILTKGRKGGSTIAVAILHTLLLLSSKRGEK

Sequences:

>Translated_223_residues
MNDMRQMTFLGREIEDKSFSIIDEEAGPHPFSKEEWEVVRRIIHATADFEYKDITKIHYQAIDSGIQALKKGCPIVCDVQ
MILAGLNQDRLKAYGCKTFCFISDKDVITKAKEKNSTRAIEAIQKAKASNLLNGAVIIVGNAPTALLEIERLIRLEGIKP
ALIIGVPVGFVSAVESKEVILKLEYSNVFSVPYILTKGRKGGSTIAVAILHTLLLLSSKRGEK
>Mature_223_residues
MNDMRQMTFLGREIEDKSFSIIDEEAGPHPFSKEEWEVVRRIIHATADFEYKDITKIHYQAIDSGIQALKKGCPIVCDVQ
MILAGLNQDRLKAYGCKTFCFISDKDVITKAKEKNSTRAIEAIQKAKASNLLNGAVIIVGNAPTALLEIERLIRLEGIKP
ALIIGVPVGFVSAVESKEVILKLEYSNVFSVPYILTKGRKGGSTIAVAILHTLLLLSSKRGEK

Specific function: Catalyzes the conversion of cobalt-precorrin-8X to cobyrinic acid; a methyl migration reaction during the transformation of cobalt-precorrin-3 to form cobyrinic acid [H]

COG id: COG2082

COG function: function code H; Precorrin isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003722 [H]

Pfam domain/function: PF02570 CbiC [H]

EC number: 5.4.1.2

Molecular weight: Translated: 24659; Mature: 24659

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDMRQMTFLGREIEDKSFSIIDEEAGPHPFSKEEWEVVRRIIHATADFEYKDITKIHYQ
CCCHHHHHHHCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
AIDSGIQALKKGCPIVCDVQMILAGLNQDRLKAYGCKTFCFISDKDVITKAKEKNSTRAI
HHHHHHHHHHHCCCEEEEHHHHHHCCCHHHHHHHCCCEEEEECCCHHHHHHHHCCHHHHH
EAIQKAKASNLLNGAVIIVGNAPTALLEIERLIRLEGIKPALIIGVPVGFVSAVESKEVI
HHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHCCCEEE
LKLEYSNVFSVPYILTKGRKGGSTIAVAILHTLLLLSSKRGEK
EEEECCCEECCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNDMRQMTFLGREIEDKSFSIIDEEAGPHPFSKEEWEVVRRIIHATADFEYKDITKIHYQ
CCCHHHHHHHCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
AIDSGIQALKKGCPIVCDVQMILAGLNQDRLKAYGCKTFCFISDKDVITKAKEKNSTRAI
HHHHHHHHHHHCCCEEEEHHHHHHCCCHHHHHHHCCCEEEEECCCHHHHHHHHCCHHHHH
EAIQKAKASNLLNGAVIIVGNAPTALLEIERLIRLEGIKPALIIGVPVGFVSAVESKEVI
HHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHCCCEEE
LKLEYSNVFSVPYILTKGRKGGSTIAVAILHTLLLLSSKRGEK
EEEECCCEECCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Precorrin 8X

Specific reaction: precorrin-8X = hydrogenobyrinate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]