| Definition | Leptospira borgpetersenii serovar Hardjo-bovis JB197 chromosome 2, complete sequence. |
|---|---|
| Accession | NC_008511 |
| Length | 299,762 |
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The map label for this gene is mutB [H]
Identifier: 116332560
GI number: 116332560
Start: 144045
End: 146243
Strand: Reverse
Name: mutB [H]
Synonym: LBJ_4126
Alternate gene names: 116332560
Gene position: 146243-144045 (Counterclockwise)
Preceding gene: 116332561
Following gene: 116332559
Centisome position: 48.79
GC content: 47.98
Gene sequence:
>2199_bases ATGAAACGTCCGAATTTCGACCCGAAACGTTATGTGTCACATGGAAGCGAAAATATTTCCAAATCCGACTGGGAAAAAGC CGCTCTTGGAGATTTAGGCCTTAATTCCATGGAACAAATTCTGTGGAATACTCCCGAAAAAATTCCAGTCAAACCGGTTT ATACAGCGGAAGATTTGGAGCACATGGAACATCTCGATTTCGTAGCGGGAATTCCTCCGTACTTACGCGGACCGTATTCC ACGATGTATGTCCAACAACCTTGGACCATCCGTCAGTACGCCGGTTTTTCCACAGCGGAAGAATCAAACGCATTCTATCG TAGAAACTTAGCGGCCGGACAAAAAGGTCTTTCGGTCGCGTTCGACTTGGCGACTCACAGAGGATACGATTCCGATCACG AACGCGTCGTAGGCGACGTCGGAAAGGCCGGGGTTGCGATCGATTCGATTCTCGACATGAAAATTCTATTCGATCAGATT CCTCTGGATCAAATGTCCGTATCGATGACGATGAACGGTGCTGTAATTCCTATATTAGCGTTTTATATCGTCGCCGCGGA AGAACAAGGCGTAAGTGCGGACAAACTTTCAGGTACAATCCAAAACGACATCTTAAAAGAATTCATGGTGCGGAACACAT ATATCTATCCCCCCGCGCCTTCGATGAAGATCATCGCCGACATTTTTAAATACACTTCCGACTTTATGCCCAAGTTCAAT TCGATCTCGATTTCGGGGTATCACATGCAGGAAGCGGGAGCGACGGCGGACATCGAGCTCGCTTACACTCTCGCGGACGG TCTGGAATATTTAAGAACAGGAATCAAAGCGGGAATGGACGTGGATACGTTCGCGCCTCGTTTGTCTTTTTTCTGGGCGA TCGGGATGAATCACTTTATGGAAATCGCAAAGATGAGAGCCGGTCGTCTTCTCTGGGCGAAACTCGTAAAACAATTCCAT CCTAAGAATTTAAAGTCCCTCGCGCTCCGAACCCATTGCCAAACTTCCGGTTGGAGTTTAACCGAACAAGATCCGTTCAA CAACGTCGCACGAACCTGTATCGAAGCGTTGGCCGCGGTACTCGGTCATACACAATCCCTTCACACAAACGCACTTGACG AAGCGATCGCGCTTCCGACCGACTTTTCCGCGAGAATCGCCAGAAATACGCAGATCTTTTTGCAGGAAGAAACAAACATT CATCGTGTCGTGGATCCATGGGGGGGCTCGTATTACGTGGAATCTTTGACACATTCTCTTGCGCATCGCGCTTGGGAATT GATCGAAGAGGTGGAAAAGTTAGGCGGAATCGCAGAGGCGATCGAAACCGGAATTCCCAAAATGAGAATCGAGGAAGCCG CCGCTCGCAAACAGGCTAAGATCGATTCCGGGAAAGATGTGATCGTAGGAGTCAACCGCTACAAGGCGCAAGAAGAAAAA CCTTTAGACATATTAGATATCAATAATACTGCGGTGAGAGAGGCTCAGCTTCGCAGACTCGCCGAGTTAAAAAAGAATCG GAACGGCGCCGACGTTGCCACAGCGCTCGACGCGATCACAAAATGCGCCGGAGGCGAAGAGGGAAACCTTCTAGCGCTTG CGGTAAACGCTGCTCGCAAACGAGCGACTCTCGGGGAAATTTCCTACGCTATGGAAAAAGTATTTGGAAGATACCAAGCC ACAATTCGTTCTATCTCGGGTGTTTATTCCTCCGAGATAGAAGACGATCCGGATTTTAAAAGAGCAAGAGAACTTTCGGA CCGGTTTGCGATTTTAGAAGGACGTCGCCCTAGAATCATGGTGGCCAAGATGGGACAAGACGGACACGATCGAGGCGCGA AAGTGATTTCTACAAGTTTTGCAGACATGGGATTTGACGTCGATATAGGCCCCCTTTTCCAAACTCCTACGGAAGCCGCC AAACAAGCAGTGGAAAATGACGTACATATCCTAGGAATTTCTAGTTTGGCCGCAGGCCACAAAACCCTTGTCCCACAGGT CATCCAAGAATTGGAAAAACTTGAAAGAGAAGACATTATGGTTGTTGCGGGTGGAGTAATCCCCCAACAAGATTATGACA CCCTTTACAAAGCGGGAGTTACTGGGATTTTCGGACCGGGAACAAAAATCTCCAAAGCCGCCGTAGGTATTTTGGAACTT CTCATTAAAGATTTAGAAACTTCTAAAGTAAACGCCTAA
Upstream 100 bases:
>100_bases AAATCGATTCTCTGGGATCCAAAGGAATTGAATTTTTCATTCATGTCAGATCCCAACATTTAGAAACACTGAAACTCATT CAGAAAAGGCTGGGCATCCG
Downstream 100 bases:
>100_bases GGGAAGAATGAGTTCTGAAGAACAATCGGGGATTTCTTCTAACGCAAGCGGAGGAATCCGATCCACCGGGATTTCCAGAA AAGTTCTCCCTACGGTGGAA
Product: methylmalonyl-CoA mutase
Products: NA
Alternate protein names: MCM-alpha [H]
Number of amino acids: Translated: 732; Mature: 732
Protein sequence:
>732_residues MKRPNFDPKRYVSHGSENISKSDWEKAALGDLGLNSMEQILWNTPEKIPVKPVYTAEDLEHMEHLDFVAGIPPYLRGPYS TMYVQQPWTIRQYAGFSTAEESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHERVVGDVGKAGVAIDSILDMKILFDQI PLDQMSVSMTMNGAVIPILAFYIVAAEEQGVSADKLSGTIQNDILKEFMVRNTYIYPPAPSMKIIADIFKYTSDFMPKFN SISISGYHMQEAGATADIELAYTLADGLEYLRTGIKAGMDVDTFAPRLSFFWAIGMNHFMEIAKMRAGRLLWAKLVKQFH PKNLKSLALRTHCQTSGWSLTEQDPFNNVARTCIEALAAVLGHTQSLHTNALDEAIALPTDFSARIARNTQIFLQEETNI HRVVDPWGGSYYVESLTHSLAHRAWELIEEVEKLGGIAEAIETGIPKMRIEEAAARKQAKIDSGKDVIVGVNRYKAQEEK PLDILDINNTAVREAQLRRLAELKKNRNGADVATALDAITKCAGGEEGNLLALAVNAARKRATLGEISYAMEKVFGRYQA TIRSISGVYSSEIEDDPDFKRARELSDRFAILEGRRPRIMVAKMGQDGHDRGAKVISTSFADMGFDVDIGPLFQTPTEAA KQAVENDVHILGISSLAAGHKTLVPQVIQELEKLEREDIMVVAGGVIPQQDYDTLYKAGVTGIFGPGTKISKAAVGILEL LIKDLETSKVNA
Sequences:
>Translated_732_residues MKRPNFDPKRYVSHGSENISKSDWEKAALGDLGLNSMEQILWNTPEKIPVKPVYTAEDLEHMEHLDFVAGIPPYLRGPYS TMYVQQPWTIRQYAGFSTAEESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHERVVGDVGKAGVAIDSILDMKILFDQI PLDQMSVSMTMNGAVIPILAFYIVAAEEQGVSADKLSGTIQNDILKEFMVRNTYIYPPAPSMKIIADIFKYTSDFMPKFN SISISGYHMQEAGATADIELAYTLADGLEYLRTGIKAGMDVDTFAPRLSFFWAIGMNHFMEIAKMRAGRLLWAKLVKQFH PKNLKSLALRTHCQTSGWSLTEQDPFNNVARTCIEALAAVLGHTQSLHTNALDEAIALPTDFSARIARNTQIFLQEETNI HRVVDPWGGSYYVESLTHSLAHRAWELIEEVEKLGGIAEAIETGIPKMRIEEAAARKQAKIDSGKDVIVGVNRYKAQEEK PLDILDINNTAVREAQLRRLAELKKNRNGADVATALDAITKCAGGEEGNLLALAVNAARKRATLGEISYAMEKVFGRYQA TIRSISGVYSSEIEDDPDFKRARELSDRFAILEGRRPRIMVAKMGQDGHDRGAKVISTSFADMGFDVDIGPLFQTPTEAA KQAVENDVHILGISSLAAGHKTLVPQVIQELEKLEREDIMVVAGGVIPQQDYDTLYKAGVTGIFGPGTKISKAAVGILEL LIKDLETSKVNA >Mature_732_residues MKRPNFDPKRYVSHGSENISKSDWEKAALGDLGLNSMEQILWNTPEKIPVKPVYTAEDLEHMEHLDFVAGIPPYLRGPYS TMYVQQPWTIRQYAGFSTAEESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHERVVGDVGKAGVAIDSILDMKILFDQI PLDQMSVSMTMNGAVIPILAFYIVAAEEQGVSADKLSGTIQNDILKEFMVRNTYIYPPAPSMKIIADIFKYTSDFMPKFN SISISGYHMQEAGATADIELAYTLADGLEYLRTGIKAGMDVDTFAPRLSFFWAIGMNHFMEIAKMRAGRLLWAKLVKQFH PKNLKSLALRTHCQTSGWSLTEQDPFNNVARTCIEALAAVLGHTQSLHTNALDEAIALPTDFSARIARNTQIFLQEETNI HRVVDPWGGSYYVESLTHSLAHRAWELIEEVEKLGGIAEAIETGIPKMRIEEAAARKQAKIDSGKDVIVGVNRYKAQEEK PLDILDINNTAVREAQLRRLAELKKNRNGADVATALDAITKCAGGEEGNLLALAVNAARKRATLGEISYAMEKVFGRYQA TIRSISGVYSSEIEDDPDFKRARELSDRFAILEGRRPRIMVAKMGQDGHDRGAKVISTSFADMGFDVDIGPLFQTPTEAA KQAVENDVHILGISSLAAGHKTLVPQVIQELEKLEREDIMVVAGGVIPQQDYDTLYKAGVTGIFGPGTKISKAAVGILEL LIKDLETSKVNA
Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]
COG id: COG1884
COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 B12-binding domain [H]
Homologues:
Organism=Homo sapiens, GI156105689, Length=708, Percent_Identity=63.135593220339, Blast_Score=935, Evalue=0.0, Organism=Escherichia coli, GI1789284, Length=705, Percent_Identity=60.5673758865248, Blast_Score=857, Evalue=0.0, Organism=Caenorhabditis elegans, GI25144500, Length=720, Percent_Identity=61.9444444444444, Blast_Score=910, Evalue=0.0,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR006159 - InterPro: IPR016176 - InterPro: IPR014348 - InterPro: IPR006158 - InterPro: IPR006099 - InterPro: IPR006098 [H]
Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]
EC number: =5.4.99.2 [H]
Molecular weight: Translated: 80879; Mature: 80879
Theoretical pI: Translated: 5.88; Mature: 5.88
Prosite motif: PS00544 METMALONYL_COA_MUTASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 3.0 %Met (Translated Protein) 3.4 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 3.0 %Met (Mature Protein) 3.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKRPNFDPKRYVSHGSENISKSDWEKAALGDLGLNSMEQILWNTPEKIPVKPVYTAEDLE CCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCHHHHH HMEHLDFVAGIPPYLRGPYSTMYVQQPWTIRQYAGFSTAEESNAFYRRNLAAGQKGLSVA HHHHHHHHHCCCHHHCCCCCEEEEECCCCHHHHCCCCCCHHCCHHHHHHHHCCCCCCEEE FDLATHRGYDSDHERVVGDVGKAGVAIDSILDMKILFDQIPLDQMSVSMTMNGAVIPILA EEHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHEEEEEECCHHHHHHH FYIVAAEEQGVSADKLSGTIQNDILKEFMVRNTYIYPPAPSMKIIADIFKYTSDFMPKFN HHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHHHHHHHCCCCC SISISGYHMQEAGATADIELAYTLADGLEYLRTGIKAGMDVDTFAPRLSFFWAIGMNHFM CEEEECEEECCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH EIAKMRAGRLLWAKLVKQFHPKNLKSLALRTHCQTSGWSLTEQDPFNNVARTCIEALAAV HHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH LGHTQSLHTNALDEAIALPTDFSARIARNTQIFLQEETNIHRVVDPWGGSYYVESLTHSL HCCCHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHH AHRAWELIEEVEKLGGIAEAIETGIPKMRIEEAAARKQAKIDSGKDVIVGVNRYKAQEEK HHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECHHHCCCCCC PLDILDINNTAVREAQLRRLAELKKNRNGADVATALDAITKCAGGEEGNLLALAVNAARK CCEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECHHHH RATLGEISYAMEKVFGRYQATIRSISGVYSSEIEDDPDFKRARELSDRFAILEGRRPRIM HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEE VAKMGQDGHDRGAKVISTSFADMGFDVDIGPLFQTPTEAAKQAVENDVHILGISSLAAGH EEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEEHHHHCCH KTLVPQVIQELEKLEREDIMVVAGGVIPQQDYDTLYKAGVTGIFGPGTKISKAAVGILEL HHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH LIKDLETSKVNA HHHHHHHHCCCC >Mature Secondary Structure MKRPNFDPKRYVSHGSENISKSDWEKAALGDLGLNSMEQILWNTPEKIPVKPVYTAEDLE CCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCHHHHH HMEHLDFVAGIPPYLRGPYSTMYVQQPWTIRQYAGFSTAEESNAFYRRNLAAGQKGLSVA HHHHHHHHHCCCHHHCCCCCEEEEECCCCHHHHCCCCCCHHCCHHHHHHHHCCCCCCEEE FDLATHRGYDSDHERVVGDVGKAGVAIDSILDMKILFDQIPLDQMSVSMTMNGAVIPILA EEHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHEEEEEECCHHHHHHH FYIVAAEEQGVSADKLSGTIQNDILKEFMVRNTYIYPPAPSMKIIADIFKYTSDFMPKFN HHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHHHHHHHCCCCC SISISGYHMQEAGATADIELAYTLADGLEYLRTGIKAGMDVDTFAPRLSFFWAIGMNHFM CEEEECEEECCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH EIAKMRAGRLLWAKLVKQFHPKNLKSLALRTHCQTSGWSLTEQDPFNNVARTCIEALAAV HHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH LGHTQSLHTNALDEAIALPTDFSARIARNTQIFLQEETNIHRVVDPWGGSYYVESLTHSL HCCCHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHH AHRAWELIEEVEKLGGIAEAIETGIPKMRIEEAAARKQAKIDSGKDVIVGVNRYKAQEEK HHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECHHHCCCCCC PLDILDINNTAVREAQLRRLAELKKNRNGADVATALDAITKCAGGEEGNLLALAVNAARK CCEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECHHHH RATLGEISYAMEKVFGRYQATIRSISGVYSSEIEDDPDFKRARELSDRFAILEGRRPRIM HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEE VAKMGQDGHDRGAKVISTSFADMGFDVDIGPLFQTPTEAAKQAVENDVHILGISSLAAGH EEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEEHHHHCCH KTLVPQVIQELEKLEREDIMVVAGGVIPQQDYDTLYKAGVTGIFGPGTKISKAAVGILEL HHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH LIKDLETSKVNA HHHHHHHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8566763; 12949112 [H]