Click here to switch to the map view.

The map label for this gene is sbm [H]

Identifier: 116332561

GI number: 116332561

Start: 146240

End: 148120

Strand: Reverse

Name: sbm [H]

Synonym: LBJ_4127

Alternate gene names: 116332561

Gene position: 148120-146240 (Counterclockwise)

Preceding gene: 116332562

Following gene: 116332560

Centisome position: 49.41

GC content: 45.08

Gene sequence:

>1881_bases
ATGGCCGATCAAAAACTATTTACGGACTTTCCTCCCATTACTCGGGAAGCCTGGATTGCACTCATTCAAAAAGATCTCAA
GGGAGCGGACTTTGAAAAGAAACTAGTTTGGGAAACGGCAGAAGGATTTAAGATCCAACCTGTTTATACGAAAGACGATA
TCGACGATAAACAATGGCTGACTTCCAATCTTCCCGGAACGATTCCCTTTGCCAGATCCACTCGAAAACTCGTTCAAGAC
TGGAGTATTCGCCAAGATTTCGATTCATCTTCGATAGCCGAAGCCAATCGATTGGCAAAAGAAGCGGCAGCTAACGGTGT
GACAGCGATCGGGTTTATCATCGAAAATAAAACATCTTCCCAAGCAGGAATTCCGATACATTCTTCCAAAGATTTGGAAA
ACCTCATCGAAGGACTTCCTTTCGACCAAGTAACTCTTCACTTCATTGCGGAAGAAAGATCCCCCGAAATTTTTTCTTGG
CTTCCCAAAGACAGAGTGTTTGTCGGAGGACTCGGATACGATCCGTATCGGATTCTTCTCAAACAAGGAAAATCGGGAAA
ACATTCGATCACGGGGCTCAAAGAAATTTTGGAAACGATCGCTTCTTCTTGGCCGTATTACAGAGGTTTGTCGGTAACGT
CATCCACGTTCCGGGACGGAGGTTCTACGATCTCCGAAGAACTCGCGTTTACATTAGCCGCCGCCGCCGAGTATGTGCAG
CAGCTGCGGGAAGCGGGAATGGACGTGGATACAATCTCTTCCCAGTTGATGTTCGAGTTTTCCATCGGTCCGGATTACTT
TTTGGAAATCGCAAAGTTACGCGCCGCGAGAATTCTTTGGGCCGCGATTCTCAAAGAATTTTCCCCCAAGAAGGAAAGTT
CTCTCCACGCTTTTTTAAGCGCACAAACTTGTAGATACAATTACAGCGTCTATGATCCGAATGTGAATATGCTTCGCGCA
ACAACCGAAGCCATGTCCGCCGCAATCGGTGGTTGTGAGGTCATCGCCGTTTCTCCGTACGACAACGTTTTAAAAACTTC
CGATTCGTTCTCCTTGAGAATCGCCCGAAACATCCAACTGTTGATGAAACACGAATCGCATTTGGATAAGGTAGTGGATC
CTTCTGCAGGTTCCTATTATCTCGAGTCGCTCACGGATTCACTCACAAAAAAAGCTTGGGAAATTTTCTGTGAGATCGAA
TCCGTCGGAGGATTTTTAGAGGCCGTTCGAAAAGGAATCATCCAAAAAAGAATCGTTGAGTCTAGAAAAAAGAAAGAAAA
GAATCTTGCCGACCGCAAGGAGATTCTTCTTGGAACCAACCAATACCCGAACGGAGAAGATAGAGTCCCTACTCTCAATC
AAAACAAAGCGTTAGGCGATATTGATAGCGTTGTAGGTGAAATTACTTGCGAAAGGATCTCCGAATTCAGAGCCGGAGCC
GGAATCGAAGAGATTCGGCTGAAAACGGAAAGTTTTTCGAGCAAAAACGGGAAGGTTCCGACTGTTCTTCTTCTCCCGAT
GGGAGATCTCAAAATGAAAAAAGCGCGCGCCATTTTTTCACAAAATTTTTTGGCTTGTGCGGGCTATAAGGTGATTGATC
CGGGAAGTTATTCCACCCCCGAAGAAGCGCTTCAAGGTTTGAGAGAAACAAAGGCGGACATCGTCGTATTCTGTACGAGC
GACGAAGAAATAACCGGTTTTGTGGATTCTACTTTTGCGGTTTTGAAAAAACAAAATCACCATCTGGTCGGAATCGTAGC
GGGAAATCCAACAGAACAAATCGATTCTCTGGGATCCAAAGGAATTGAATTTTTCATTCATGTCAGATCCCAACATTTAG
AAACACTGAAACTCATTCAGAAAAGGCTGGGCATCCGATGA

Upstream 100 bases:

>100_bases
CGGAACTTAAAAGTGGGTTTTTGGCTTTACACCGGAGTCTTGCAAGGTTCCCTAGAAAGGGAACCTTGTAAAAGTTTTCC
CAAAAAAGAGAAAAATCAAA

Downstream 100 bases:

>100_bases
AACGTCCGAATTTCGACCCGAAACGTTATGTGTCACATGGAAGCGAAAATATTTCCAAATCCGACTGGGAAAAAGCCGCT
CTTGGAGATTTAGGCCTTAA

Product: methylmalonyl-COA mutase

Products: NA

Alternate protein names: MCM-beta [H]

Number of amino acids: Translated: 626; Mature: 625

Protein sequence:

>626_residues
MADQKLFTDFPPITREAWIALIQKDLKGADFEKKLVWETAEGFKIQPVYTKDDIDDKQWLTSNLPGTIPFARSTRKLVQD
WSIRQDFDSSSIAEANRLAKEAAANGVTAIGFIIENKTSSQAGIPIHSSKDLENLIEGLPFDQVTLHFIAEERSPEIFSW
LPKDRVFVGGLGYDPYRILLKQGKSGKHSITGLKEILETIASSWPYYRGLSVTSSTFRDGGSTISEELAFTLAAAAEYVQ
QLREAGMDVDTISSQLMFEFSIGPDYFLEIAKLRAARILWAAILKEFSPKKESSLHAFLSAQTCRYNYSVYDPNVNMLRA
TTEAMSAAIGGCEVIAVSPYDNVLKTSDSFSLRIARNIQLLMKHESHLDKVVDPSAGSYYLESLTDSLTKKAWEIFCEIE
SVGGFLEAVRKGIIQKRIVESRKKKEKNLADRKEILLGTNQYPNGEDRVPTLNQNKALGDIDSVVGEITCERISEFRAGA
GIEEIRLKTESFSSKNGKVPTVLLLPMGDLKMKKARAIFSQNFLACAGYKVIDPGSYSTPEEALQGLRETKADIVVFCTS
DEEITGFVDSTFAVLKKQNHHLVGIVAGNPTEQIDSLGSKGIEFFIHVRSQHLETLKLIQKRLGIR

Sequences:

>Translated_626_residues
MADQKLFTDFPPITREAWIALIQKDLKGADFEKKLVWETAEGFKIQPVYTKDDIDDKQWLTSNLPGTIPFARSTRKLVQD
WSIRQDFDSSSIAEANRLAKEAAANGVTAIGFIIENKTSSQAGIPIHSSKDLENLIEGLPFDQVTLHFIAEERSPEIFSW
LPKDRVFVGGLGYDPYRILLKQGKSGKHSITGLKEILETIASSWPYYRGLSVTSSTFRDGGSTISEELAFTLAAAAEYVQ
QLREAGMDVDTISSQLMFEFSIGPDYFLEIAKLRAARILWAAILKEFSPKKESSLHAFLSAQTCRYNYSVYDPNVNMLRA
TTEAMSAAIGGCEVIAVSPYDNVLKTSDSFSLRIARNIQLLMKHESHLDKVVDPSAGSYYLESLTDSLTKKAWEIFCEIE
SVGGFLEAVRKGIIQKRIVESRKKKEKNLADRKEILLGTNQYPNGEDRVPTLNQNKALGDIDSVVGEITCERISEFRAGA
GIEEIRLKTESFSSKNGKVPTVLLLPMGDLKMKKARAIFSQNFLACAGYKVIDPGSYSTPEEALQGLRETKADIVVFCTS
DEEITGFVDSTFAVLKKQNHHLVGIVAGNPTEQIDSLGSKGIEFFIHVRSQHLETLKLIQKRLGIR
>Mature_625_residues
ADQKLFTDFPPITREAWIALIQKDLKGADFEKKLVWETAEGFKIQPVYTKDDIDDKQWLTSNLPGTIPFARSTRKLVQDW
SIRQDFDSSSIAEANRLAKEAAANGVTAIGFIIENKTSSQAGIPIHSSKDLENLIEGLPFDQVTLHFIAEERSPEIFSWL
PKDRVFVGGLGYDPYRILLKQGKSGKHSITGLKEILETIASSWPYYRGLSVTSSTFRDGGSTISEELAFTLAAAAEYVQQ
LREAGMDVDTISSQLMFEFSIGPDYFLEIAKLRAARILWAAILKEFSPKKESSLHAFLSAQTCRYNYSVYDPNVNMLRAT
TEAMSAAIGGCEVIAVSPYDNVLKTSDSFSLRIARNIQLLMKHESHLDKVVDPSAGSYYLESLTDSLTKKAWEIFCEIES
VGGFLEAVRKGIIQKRIVESRKKKEKNLADRKEILLGTNQYPNGEDRVPTLNQNKALGDIDSVVGEITCERISEFRAGAG
IEEIRLKTESFSSKNGKVPTVLLLPMGDLKMKKARAIFSQNFLACAGYKVIDPGSYSTPEEALQGLRETKADIVVFCTSD
EEITGFVDSTFAVLKKQNHHLVGIVAGNPTEQIDSLGSKGIEFFIHVRSQHLETLKLIQKRLGIR

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=472, Percent_Identity=29.6610169491525, Blast_Score=214, Evalue=3e-55,
Organism=Escherichia coli, GI1789284, Length=463, Percent_Identity=30.0215982721382, Blast_Score=213, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI25144500, Length=492, Percent_Identity=27.6422764227642, Blast_Score=215, Evalue=7e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 69711; Mature: 69580

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADQKLFTDFPPITREAWIALIQKDLKGADFEKKLVWETAEGFKIQPVYTKDDIDDKQWL
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHEECCCCCEEEEEECCCCCCCHHHH
TSNLPGTIPFARSTRKLVQDWSIRQDFDSSSIAEANRLAKEAAANGVTAIGFIIENKTSS
HCCCCCCCCCHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCC
QAGIPIHSSKDLENLIEGLPFDQVTLHFIAEERSPEIFSWLPKDRVFVGGLGYDPYRILL
CCCCCCCCCCHHHHHHHCCCCCHHHEEEECCCCCCHHHHCCCCCCEEECCCCCCHHHHHH
KQGKSGKHSITGLKEILETIASSWPYYRGLSVTSSTFRDGGSTISEELAFTLAAAAEYVQ
HCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHH
QLREAGMDVDTISSQLMFEFSIGPDYFLEIAKLRAARILWAAILKEFSPKKESSLHAFLS
HHHHCCCCHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AQTCRYNYSVYDPNVNMLRATTEAMSAAIGGCEVIAVSPYDNVLKTSDSFSLRIARNIQL
HHHEEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHCCCCCEEEEEHHHHH
LMKHESHLDKVVDPSAGSYYLESLTDSLTKKAWEIFCEIESVGGFLEAVRKGIIQKRIVE
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRKKKEKNLADRKEILLGTNQYPNGEDRVPTLNQNKALGDIDSVVGEITCERISEFRAGA
HHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
GIEEIRLKTESFSSKNGKVPTVLLLPMGDLKMKKARAIFSQNFLACAGYKVIDPGSYSTP
CHHHHEEEHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHCCEEEECCCCCCCH
EEALQGLRETKADIVVFCTSDEEITGFVDSTFAVLKKQNHHLVGIVAGNPTEQIDSLGSK
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHCCC
GIEFFIHVRSQHLETLKLIQKRLGIR
CEEEEEEEHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADQKLFTDFPPITREAWIALIQKDLKGADFEKKLVWETAEGFKIQPVYTKDDIDDKQWL
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHEECCCCCEEEEEECCCCCCCHHHH
TSNLPGTIPFARSTRKLVQDWSIRQDFDSSSIAEANRLAKEAAANGVTAIGFIIENKTSS
HCCCCCCCCCHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCC
QAGIPIHSSKDLENLIEGLPFDQVTLHFIAEERSPEIFSWLPKDRVFVGGLGYDPYRILL
CCCCCCCCCCHHHHHHHCCCCCHHHEEEECCCCCCHHHHCCCCCCEEECCCCCCHHHHHH
KQGKSGKHSITGLKEILETIASSWPYYRGLSVTSSTFRDGGSTISEELAFTLAAAAEYVQ
HCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHH
QLREAGMDVDTISSQLMFEFSIGPDYFLEIAKLRAARILWAAILKEFSPKKESSLHAFLS
HHHHCCCCHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AQTCRYNYSVYDPNVNMLRATTEAMSAAIGGCEVIAVSPYDNVLKTSDSFSLRIARNIQL
HHHEEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHCCCCCEEEEEHHHHH
LMKHESHLDKVVDPSAGSYYLESLTDSLTKKAWEIFCEIESVGGFLEAVRKGIIQKRIVE
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRKKKEKNLADRKEILLGTNQYPNGEDRVPTLNQNKALGDIDSVVGEITCERISEFRAGA
HHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
GIEEIRLKTESFSSKNGKVPTVLLLPMGDLKMKKARAIFSQNFLACAGYKVIDPGSYSTP
CHHHHEEEHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHCCEEEECCCCCCCH
EEALQGLRETKADIVVFCTSDEEITGFVDSTFAVLKKQNHHLVGIVAGNPTEQIDSLGSK
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHCCC
GIEFFIHVRSQHLETLKLIQKRLGIR
CEEEEEEEHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8566763; 12949112 [H]