BacMap

Definition	Leptospira borgpetersenii serovar Hardjo-bovis JB197 chromosome 2, complete sequence.
Accession	NC_008511
Length	299,762

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The map label for this gene is fabG [C]

Identifier: 116332473

GI number: 116332473

Start: 31892

End: 32638

Strand: Direct

Name: fabG [C]

Synonym: LBJ_4029

Alternate gene names: 116332473

Gene position: 31892-32638 (Clockwise)

Preceding gene: 116332472

Following gene: 116332474

Centisome position: 10.64

GC content: 42.57

Gene sequence:

>747_bases
ATGAAAAATGTACTTATCACTGGGGCAAGTTCGGGTATTGGAAAAGAATTAGCAAGGCTTTATGCGGAGGCGGGAGCCAA
CGTAGCGTTGACTGCAAGAAGAAGGGATTCTCTTAAAAAAATTGCCGACGAACTGAAATCTTCCGGTGCAAAAGGTAAAA
TTTTATTTGCTTCTTTGGACGTTTCCGACACGGATCAGAATTTTAAAGTCATTCCCAAGTTGGCAAAGGAGCTCGGAGGT
TTGGATTTGATCGTTTTAAATGCCGGGATCTCAACTACTGCTTCGTTCGGAGGCAGAAGTTTTGAAGCCGATCGTGCGGT
GATTGAAACTAATTTGATCGGAGCGATGGCAGGTGTAGAGGCGGCCTTGCCTATTTTTCAAAAACAAAAATCGGGACAAA
TTGCTGCGATTTCTTCGGTAGCTTCTTTTAGAGGTCTTCCCGGTTCTGCAAGTTATTCTTCCTCGAAAGCGGGACTTTCC
ACCTATATGGAAGCTCTTCGAGGAGAAGTGCAACGATATGGGGTTTCGGTAACGGTAATTCATCCCGGATTTATAGATAC
TCCAATCAACAATCAAATGAAATCTCGTCCGTTTGTAGTTCCGGTGGAAAAAGGCGCTCGGAAAATATATAAAAGAATTG
AAAACAAAGTTTTATCAGCTACAGTTCCTTGGTTCCCATGGGTTTTCCTTGGTTATTTTATGAAACGAATTCCCGAGTTT
TTATGGTCGAAGATCGGTCTGAAATAG

Upstream 100 bases:

>100_bases
AGAAAAGCGGAAATGAAAGGTGAAGGTGGATTTGAAATAAATTGGATTTTCTTGAAATTAATGTTTGAAGTAAGTTATAA
TTTGCATTCAATTGTTTCGT

Downstream 100 bases:

>100_bases
AATTACCTTTTGAAAAACAAAACCGAAAAGGGAAACAGTCGATTCGGGTTTTGTTTGTTTGCCTCGGAAATATTTGTAGA
TCTCCTGCAGCGGAAGGAGC

Product: Short chain dehydrogenase

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MKNVLITGASSGIGKELARLYAEAGANVALTARRRDSLKKIADELKSSGAKGKILFASLDVSDTDQNFKVIPKLAKELGG
LDLIVLNAGISTTASFGGRSFEADRAVIETNLIGAMAGVEAALPIFQKQKSGQIAAISSVASFRGLPGSASYSSSKAGLS
TYMEALRGEVQRYGVSVTVIHPGFIDTPINNQMKSRPFVVPVEKGARKIYKRIENKVLSATVPWFPWVFLGYFMKRIPEF
LWSKIGLK

Sequences:

>Translated_248_residues
MKNVLITGASSGIGKELARLYAEAGANVALTARRRDSLKKIADELKSSGAKGKILFASLDVSDTDQNFKVIPKLAKELGG
LDLIVLNAGISTTASFGGRSFEADRAVIETNLIGAMAGVEAALPIFQKQKSGQIAAISSVASFRGLPGSASYSSSKAGLS
TYMEALRGEVQRYGVSVTVIHPGFIDTPINNQMKSRPFVVPVEKGARKIYKRIENKVLSATVPWFPWVFLGYFMKRIPEF
LWSKIGLK
>Mature_248_residues
MKNVLITGASSGIGKELARLYAEAGANVALTARRRDSLKKIADELKSSGAKGKILFASLDVSDTDQNFKVIPKLAKELGG
LDLIVLNAGISTTASFGGRSFEADRAVIETNLIGAMAGVEAALPIFQKQKSGQIAAISSVASFRGLPGSASYSSSKAGLS
TYMEALRGEVQRYGVSVTVIHPGFIDTPINNQMKSRPFVVPVEKGARKIYKRIENKVLSATVPWFPWVFLGYFMKRIPEF
LWSKIGLK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI20149619, Length=191, Percent_Identity=34.0314136125654, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI32455239, Length=254, Percent_Identity=31.496062992126, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI5031765, Length=254, Percent_Identity=31.496062992126, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI7706318, Length=256, Percent_Identity=26.953125, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI157739938, Length=191, Percent_Identity=29.8429319371728, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI4503817, Length=189, Percent_Identity=34.3915343915344, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI40254992, Length=193, Percent_Identity=31.0880829015544, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI7657478, Length=188, Percent_Identity=32.9787234042553, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI310128830, Length=253, Percent_Identity=28.8537549407115, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI310115468, Length=253, Percent_Identity=28.8537549407115, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI40807363, Length=248, Percent_Identity=26.2096774193548, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI38348362, Length=185, Percent_Identity=31.3513513513514, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI38424085, Length=185, Percent_Identity=31.3513513513514, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI31543615, Length=229, Percent_Identity=27.9475982532751, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI210032110, Length=240, Percent_Identity=24.5833333333333, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI31542939, Length=193, Percent_Identity=29.0155440414508, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI142976729, Length=187, Percent_Identity=27.807486631016, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI109715829, Length=189, Percent_Identity=26.4550264550265, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI19743808, Length=205, Percent_Identity=29.2682926829268, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI223718074, Length=206, Percent_Identity=27.6699029126214, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI40254986, Length=198, Percent_Identity=30.3030303030303, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI19923817, Length=184, Percent_Identity=24.4565217391304, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI32483357, Length=196, Percent_Identity=24.4897959183673, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI4504505, Length=188, Percent_Identity=29.2553191489362, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI44680136, Length=186, Percent_Identity=29.5698924731183, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI44680133, Length=186, Percent_Identity=29.5698924731183, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI17738292, Length=186, Percent_Identity=29.5698924731183, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI150247226, Length=199, Percent_Identity=29.6482412060301, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1787335, Length=188, Percent_Identity=36.7021276595745, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1788459, Length=188, Percent_Identity=31.3829787234043, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI87082100, Length=189, Percent_Identity=32.8042328042328, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082160, Length=199, Percent_Identity=28.643216080402, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787820, Length=183, Percent_Identity=29.5081967213115, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786701, Length=209, Percent_Identity=31.1004784688995, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI2367175, Length=222, Percent_Identity=28.3783783783784, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1789378, Length=193, Percent_Identity=30.5699481865285, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI2367365, Length=205, Percent_Identity=33.1707317073171, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787526, Length=182, Percent_Identity=26.3736263736264, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1786812, Length=194, Percent_Identity=28.3505154639175, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17567345, Length=229, Percent_Identity=27.0742358078603, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71997402, Length=189, Percent_Identity=32.8042328042328, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI32563809, Length=204, Percent_Identity=30.8823529411765, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17507613, Length=204, Percent_Identity=30.8823529411765, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17570069, Length=189, Percent_Identity=33.3333333333333, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17564282, Length=213, Percent_Identity=30.0469483568075, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17508895, Length=240, Percent_Identity=27.5, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17562904, Length=198, Percent_Identity=29.2929292929293, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17560220, Length=207, Percent_Identity=28.9855072463768, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI115534660, Length=195, Percent_Identity=29.7435897435897, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17557780, Length=205, Percent_Identity=30.2439024390244, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=198, Percent_Identity=28.7878787878788, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=196, Percent_Identity=29.0816326530612, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71994600, Length=192, Percent_Identity=29.6875, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=198, Percent_Identity=27.7777777777778, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193203117, Length=235, Percent_Identity=24.6808510638298, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=198, Percent_Identity=28.2828282828283, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=235, Percent_Identity=24.6808510638298, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=194, Percent_Identity=28.3505154639175, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17551412, Length=195, Percent_Identity=28.2051282051282, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17536025, Length=189, Percent_Identity=29.1005291005291, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115534694, Length=197, Percent_Identity=29.4416243654822, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71982365, Length=190, Percent_Identity=26.3157894736842, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=246, Percent_Identity=26.4227642276423, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=190, Percent_Identity=32.1052631578947, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322861, Length=188, Percent_Identity=32.4468085106383, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6322227, Length=201, Percent_Identity=26.3681592039801, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI21358495, Length=191, Percent_Identity=31.9371727748691, Blast_Score=104, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24580925, Length=190, Percent_Identity=32.6315789473684, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI23397609, Length=192, Percent_Identity=36.4583333333333, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24644339, Length=189, Percent_Identity=33.8624338624339, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI116007236, Length=195, Percent_Identity=29.7435897435897, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24584752, Length=192, Percent_Identity=32.8125, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24663911, Length=198, Percent_Identity=30.8080808080808, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24640492, Length=190, Percent_Identity=30.5263157894737, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281364892, Length=229, Percent_Identity=26.6375545851528, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356301, Length=200, Percent_Identity=30.5, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28571526, Length=191, Percent_Identity=31.413612565445, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21357041, Length=188, Percent_Identity=31.9148936170213, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI116007234, Length=195, Percent_Identity=30.7692307692308, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI28571387, Length=196, Percent_Identity=32.1428571428571, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI116007238, Length=183, Percent_Identity=28.4153005464481, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24581726, Length=220, Percent_Identity=25.9090909090909, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24651139, Length=198, Percent_Identity=26.2626262626263, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574402, Length=191, Percent_Identity=27.7486910994764, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24584744, Length=191, Percent_Identity=27.7486910994764, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI116007232, Length=183, Percent_Identity=28.9617486338798, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24641232, Length=195, Percent_Identity=27.1794871794872, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI161076933, Length=190, Percent_Identity=26.3157894736842, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24639444, Length=191, Percent_Identity=30.8900523560209, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24584748, Length=190, Percent_Identity=26.3157894736842, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17737361, Length=197, Percent_Identity=29.4416243654822, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI21355631, Length=171, Percent_Identity=29.2397660818713, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24641388, Length=198, Percent_Identity=30.8080808080808, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI18859837, Length=188, Percent_Identity=30.3191489361702, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24649181, Length=190, Percent_Identity=26.3157894736842, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281364494, Length=195, Percent_Identity=29.2307692307692, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24647946, Length=247, Percent_Identity=24.6963562753036, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24640442, Length=201, Percent_Identity=27.363184079602, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI45553409, Length=248, Percent_Identity=24.5967741935484, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24647948, Length=248, Percent_Identity=24.5967741935484, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 26716; Mature: 26716

Theoretical pI: Translated: 10.61; Mature: 10.61

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNVLITGASSGIGKELARLYAEAGANVALTARRRDSLKKIADELKSSGAKGKILFASLD
CCCEEEECCCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCCCCEEEEEEEC
VSDTDQNFKVIPKLAKELGGLDLIVLNAGISTTASFGGRSFEADRAVIETNLIGAMAGVE
CCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHH
AALPIFQKQKSGQIAAISSVASFRGLPGSASYSSSKAGLSTYMEALRGEVQRYGVSVTVI
HHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEE
HPGFIDTPINNQMKSRPFVVPVEKGARKIYKRIENKVLSATVPWFPWVFLGYFMKRIPEF
CCCCCCCCCCCHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LWSKIGLK
HHHHHCCC
>Mature Secondary Structure
MKNVLITGASSGIGKELARLYAEAGANVALTARRRDSLKKIADELKSSGAKGKILFASLD
CCCEEEECCCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCCCCEEEEEEEC
VSDTDQNFKVIPKLAKELGGLDLIVLNAGISTTASFGGRSFEADRAVIETNLIGAMAGVE
CCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHH
AALPIFQKQKSGQIAAISSVASFRGLPGSASYSSSKAGLSTYMEALRGEVQRYGVSVTVI
HHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEE
HPGFIDTPINNQMKSRPFVVPVEKGARKIYKRIENKVLSATVPWFPWVFLGYFMKRIPEF
CCCCCCCCCCCHHCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LWSKIGLK
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]