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The map label for this gene is wzb [C]

Identifier: 116332474

GI number: 116332474

Start: 32614

End: 33165

Strand: Direct

Name: wzb [C]

Synonym: LBJ_4030

Alternate gene names: 116332474

Gene position: 32614-33165 (Clockwise)

Preceding gene: 116332473

Following gene: 116332475

Centisome position: 10.88

GC content: 39.67

Gene sequence:

>552_bases
ATGGTCGAAGATCGGTCTGAAATAGAATTACCTTTTGAAAAACAAAACCGAAAAGGGAAACAGTCGATTCGGGTTTTGTT
TGTTTGCCTCGGAAATATTTGTAGATCTCCTGCAGCGGAAGGAGCCTTTCTGGATTTGATCCAGAAAAGAAATTTGGAAT
CTTCCTTTTTCGTGGATTCGTGCGGAACGTCCAGGTATCATATCGGGGAACTTCCGGATCCCAGGACTAGGCAAGCCGCA
CGTAAAAGAGGGATCGAACTTACCCACAAGGCGAGGCAATTTCGAAAAGAAGATTTTAGGGATTTCGATTACATCCTTAC
GATGGATAAATCGAATCAGAAAGATGTTTTGTATCTTGCTTTTTCAGACGAAGAAAGGAAAAAAGTGCAATTGTTTCGGT
TTTTTCAAAAAGATTCCAAAAAAGACTTCGAAGTTCCCGACCCATATTATGGTACTTTAAAAGACTTTGACGAAGTGCAA
AATATCGTCTCTGAGGCCGCGGAAGACTTTCTTGATTTTCTTCTCTCTAAAAAACTGGATTTAAAAACTTAA

Upstream 100 bases:

>100_bases
AAATATATAAAAGAATTGAAAACAAAGTTTTATCAGCTACAGTTCCTTGGTTCCCATGGGTTTTCCTTGGTTATTTTATG
AAACGAATTCCCGAGTTTTT

Downstream 100 bases:

>100_bases
TCTGGGAGGAAATTCCTCACAAATGAGTGAAACCAGGAAAAGAAAAATAGTAGTCGTCGGCGCAGGGTTTGGGGGTTTAC
AAGTCATTAAAAAACTTTCC

Product: protein-tyrosine-phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MVEDRSEIELPFEKQNRKGKQSIRVLFVCLGNICRSPAAEGAFLDLIQKRNLESSFFVDSCGTSRYHIGELPDPRTRQAA
RKRGIELTHKARQFRKEDFRDFDYILTMDKSNQKDVLYLAFSDEERKKVQLFRFFQKDSKKDFEVPDPYYGTLKDFDEVQ
NIVSEAAEDFLDFLLSKKLDLKT

Sequences:

>Translated_183_residues
MVEDRSEIELPFEKQNRKGKQSIRVLFVCLGNICRSPAAEGAFLDLIQKRNLESSFFVDSCGTSRYHIGELPDPRTRQAA
RKRGIELTHKARQFRKEDFRDFDYILTMDKSNQKDVLYLAFSDEERKKVQLFRFFQKDSKKDFEVPDPYYGTLKDFDEVQ
NIVSEAAEDFLDFLLSKKLDLKT
>Mature_183_residues
MVEDRSEIELPFEKQNRKGKQSIRVLFVCLGNICRSPAAEGAFLDLIQKRNLESSFFVDSCGTSRYHIGELPDPRTRQAA
RKRGIELTHKARQFRKEDFRDFDYILTMDKSNQKDVLYLAFSDEERKKVQLFRFFQKDSKKDFEVPDPYYGTLKDFDEVQ
NIVSEAAEDFLDFLLSKKLDLKT

Specific function: Dephosphorylates Wzc. Required For The Extracellular Polysaccharide Colanic Acid Synthesis. Probably Involved In The Export Of Colanic Acid From The Cell To Medium. [C]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI6005988, Length=149, Percent_Identity=42.2818791946309, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI4757714, Length=149, Percent_Identity=42.9530201342282, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI96304457, Length=76, Percent_Identity=47.3684210526316, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI1788375, Length=156, Percent_Identity=32.0512820512821, Blast_Score=72, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6325330, Length=140, Percent_Identity=40, Blast_Score=112, Evalue=2e-26,
Organism=Drosophila melanogaster, GI78706766, Length=127, Percent_Identity=40.1574803149606, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI78706768, Length=127, Percent_Identity=40.1574803149606, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI78706764, Length=127, Percent_Identity=40.1574803149606, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI78711846, Length=152, Percent_Identity=35.5263157894737, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI78706770, Length=155, Percent_Identity=36.7741935483871, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI78706772, Length=155, Percent_Identity=36.7741935483871, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24648069, Length=161, Percent_Identity=32.9192546583851, Blast_Score=78, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 21525; Mature: 21525

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEDRSEIELPFEKQNRKGKQSIRVLFVCLGNICRSPAAEGAFLDLIQKRNLESSFFVDS
CCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEC
CGTSRYHIGELPDPRTRQAARKRGIELTHKARQFRKEDFRDFDYILTMDKSNQKDVLYLA
CCCCCEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEE
FSDEERKKVQLFRFFQKDSKKDFEVPDPYYGTLKDFDEVQNIVSEAAEDFLDFLLSKKLD
ECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LKT
CCC
>Mature Secondary Structure
MVEDRSEIELPFEKQNRKGKQSIRVLFVCLGNICRSPAAEGAFLDLIQKRNLESSFFVDS
CCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEC
CGTSRYHIGELPDPRTRQAARKRGIELTHKARQFRKEDFRDFDYILTMDKSNQKDVLYLA
CCCCCEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEE
FSDEERKKVQLFRFFQKDSKKDFEVPDPYYGTLKDFDEVQNIVSEAAEDFLDFLLSKKLD
ECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LKT
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]