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The map label for this gene is nuoD

Identifier: 116329151

GI number: 116329151

Start: 3053892

End: 3055109

Strand: Reverse

Name: nuoD

Synonym: LBL_2575

Alternate gene names: 116329151

Gene position: 3055109-3053892 (Counterclockwise)

Preceding gene: 116329152

Following gene: 116329150

Centisome position: 84.52

GC content: 49.01

Gene sequence:

>1218_bases
ATGATGTACGAAAAAACGGCGGAACATTTCGAGCAGAAATATAAAAATCTTCCCGAAGGACATCTTCTCGTAAATTTAGG
GCCTTCCCATCCGGCGACACACGGAATTTTGCAAAACGTGATCCAGATTGACGGGGAAAGAATCGTGGAAGCCGAGTCCG
TAATCGGATACGTACACCGTTGTTTTGAAAAATTAGGGGAACGTTATACGTACAATCAATTTCTGGTCTGCACGGATCGG
ATGAACTACGTTTCCACTCCGCTGAACAATATAGGTTGGATTCTCGCGGTGGAAAAGATGATGCAGGTGGAAGTGCCTGA
TCGCGTAACGTATGTCAGAATGATTATTTCCGAACTTTCCCGGATCATGGATCATATCATTTGTCTCGGAATTTTGGGAG
TGGATCTCGGAGCCTTCTCCGGGATGTTGCACCTCTTTCATCATAGAGAAAACATCTATCAGATCATCGAAAAGCTCACC
GGTGCAAGATTGACTACGACTTTCTGCAGAATTGGAGGACTCGAAAGAGACATCTATCCCGAGTTCGAAAAGGAAGTGAA
ACTCGTGTGCAAGGGATTAAAACCCGCGATCGAAGAGTTCAACAGCCTTCTTCTGAAAAACAAAATCTTTCTGGGTCGCA
CCGAAGGCATCGGCGGAATCTCCGCGGAAAACGCAATCGCCTACGGATTCAGCGGACCGAATCTCCGCGCCGCGGGCGTG
GATTGGGACGTCCGCAAAGACAAACCGTATATGCTGTACGACAAGGTGGACTTCGACGTTCCGATCGGAGAGGACGGAAG
TGTTCTGCACCGCAGTCTTGTGAGAATGGAAGAGATGCGTCAGTCGATCCGGATTATCGAACAGCTCGTGGACGGAATTC
CTTCCGGAGCTTGGCACGCGGATCTACCGCACGCCTATCTTCCCGAAAAGAACAAAGTCTACAACAACATGGAAGAATTG
ATCTATCACTTCAAGATCATCATGCACGGGGTCAAGGTTCCTCCGGGAGAACATTACATGGCGACCGAAGCGGCCAACGG
AGAACTCGGATTTTACATCATTTCCGAAGGGGAAAAATCTCCCTGGAGAGTTCACGTTAGACGTCCTTGTTTCTGGTATT
ATCAATCGTTTGCGGAACTCGTGCGCGGAGGACTTCTCGCGGATTCGGTCGCGACCATGAGTTCTTTGAACGTGATTGCG
GGGGAGCTGGACTGCTGA

Upstream 100 bases:

>100_bases
AAGGATTTTCCATTGGAAGGGTTCGGACAGGATTATCTGATCGAGGATCTGCTTCATATCCACGTAAACGAAGATATAAC
CAAAAAAGGAGGGAAGTAGT

Downstream 100 bases:

>100_bases
TGAGTTACAAGTTTAGTGAAGCCTCCGAAAAAAGATTCCGGAAGATGTTGGAAGTATTTCCGGACAAACGTTCTCTCGTT
CTGCCTTGTTTGTACATTCT

Product: NADH dehydrogenase (ubiquinone), D chain

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MMYEKTAEHFEQKYKNLPEGHLLVNLGPSHPATHGILQNVIQIDGERIVEAESVIGYVHRCFEKLGERYTYNQFLVCTDR
MNYVSTPLNNIGWILAVEKMMQVEVPDRVTYVRMIISELSRIMDHIICLGILGVDLGAFSGMLHLFHHRENIYQIIEKLT
GARLTTTFCRIGGLERDIYPEFEKEVKLVCKGLKPAIEEFNSLLLKNKIFLGRTEGIGGISAENAIAYGFSGPNLRAAGV
DWDVRKDKPYMLYDKVDFDVPIGEDGSVLHRSLVRMEEMRQSIRIIEQLVDGIPSGAWHADLPHAYLPEKNKVYNNMEEL
IYHFKIIMHGVKVPPGEHYMATEAANGELGFYIISEGEKSPWRVHVRRPCFWYYQSFAELVRGGLLADSVATMSSLNVIA
GELDC

Sequences:

>Translated_405_residues
MMYEKTAEHFEQKYKNLPEGHLLVNLGPSHPATHGILQNVIQIDGERIVEAESVIGYVHRCFEKLGERYTYNQFLVCTDR
MNYVSTPLNNIGWILAVEKMMQVEVPDRVTYVRMIISELSRIMDHIICLGILGVDLGAFSGMLHLFHHRENIYQIIEKLT
GARLTTTFCRIGGLERDIYPEFEKEVKLVCKGLKPAIEEFNSLLLKNKIFLGRTEGIGGISAENAIAYGFSGPNLRAAGV
DWDVRKDKPYMLYDKVDFDVPIGEDGSVLHRSLVRMEEMRQSIRIIEQLVDGIPSGAWHADLPHAYLPEKNKVYNNMEEL
IYHFKIIMHGVKVPPGEHYMATEAANGELGFYIISEGEKSPWRVHVRRPCFWYYQSFAELVRGGLLADSVATMSSLNVIA
GELDC
>Mature_405_residues
MMYEKTAEHFEQKYKNLPEGHLLVNLGPSHPATHGILQNVIQIDGERIVEAESVIGYVHRCFEKLGERYTYNQFLVCTDR
MNYVSTPLNNIGWILAVEKMMQVEVPDRVTYVRMIISELSRIMDHIICLGILGVDLGAFSGMLHLFHHRENIYQIIEKLT
GARLTTTFCRIGGLERDIYPEFEKEVKLVCKGLKPAIEEFNSLLLKNKIFLGRTEGIGGISAENAIAYGFSGPNLRAAGV
DWDVRKDKPYMLYDKVDFDVPIGEDGSVLHRSLVRMEEMRQSIRIIEQLVDGIPSGAWHADLPHAYLPEKNKVYNNMEEL
IYHFKIIMHGVKVPPGEHYMATEAANGELGFYIISEGEKSPWRVHVRRPCFWYYQSFAELVRGGLLADSVATMSSLNVIA
GELDC

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=384, Percent_Identity=38.0208333333333, Blast_Score=298, Evalue=8e-81,
Organism=Homo sapiens, GI260898743, Length=379, Percent_Identity=37.7308707124011, Blast_Score=290, Evalue=1e-78,
Organism=Escherichia coli, GI145693162, Length=387, Percent_Identity=34.625322997416, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI1789076, Length=289, Percent_Identity=29.4117647058824, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788832, Length=289, Percent_Identity=27.681660899654, Blast_Score=112, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17568379, Length=394, Percent_Identity=37.3096446700508, Blast_Score=298, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI17555284, Length=398, Percent_Identity=36.1809045226131, Blast_Score=295, Evalue=3e-80,
Organism=Drosophila melanogaster, GI24638644, Length=384, Percent_Identity=39.84375, Blast_Score=318, Evalue=6e-87,
Organism=Drosophila melanogaster, GI221459469, Length=382, Percent_Identity=40.5759162303665, Blast_Score=315, Evalue=4e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_LEPBL (Q04YA7)

Other databases:

- EMBL:   CP000348
- RefSeq:   YP_798871.1
- ProteinModelPortal:   Q04YA7
- SMR:   Q04YA7
- STRING:   Q04YA7
- GeneID:   4407906
- GenomeReviews:   CP000348_GR
- KEGG:   lbl:LBL_2575
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   THPATHG
- ProtClustDB:   CLSK814139
- BioCyc:   LBOR355276:LBL_2575-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR001135
- InterPro:   IPR022885

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 46084; Mature: 46084

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMYEKTAEHFEQKYKNLPEGHLLVNLGPSHPATHGILQNVIQIDGERIVEAESVIGYVHR
CCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
CFEKLGERYTYNQFLVCTDRMNYVSTPLNNIGWILAVEKMMQVEVPDRVTYVRMIISELS
HHHHHCCCCCCCEEEEEECCCHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
RIMDHIICLGILGVDLGAFSGMLHLFHHRENIYQIIEKLTGARLTTTFCRIGGLERDIYP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCC
EFEKEVKLVCKGLKPAIEEFNSLLLKNKIFLGRTEGIGGISAENAIAYGFSGPNLRAAGV
HHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEECCCCCCCEECCC
DWDVRKDKPYMLYDKVDFDVPIGEDGSVLHRSLVRMEEMRQSIRIIEQLVDGIPSGAWHA
CCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
DLPHAYLPEKNKVYNNMEELIYHFKIIMHGVKVPPGEHYMATEAANGELGFYIISEGEKS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEEEEEECCCCC
PWRVHVRRPCFWYYQSFAELVRGGLLADSVATMSSLNVIAGELDC
CEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MMYEKTAEHFEQKYKNLPEGHLLVNLGPSHPATHGILQNVIQIDGERIVEAESVIGYVHR
CCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
CFEKLGERYTYNQFLVCTDRMNYVSTPLNNIGWILAVEKMMQVEVPDRVTYVRMIISELS
HHHHHCCCCCCCEEEEEECCCHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
RIMDHIICLGILGVDLGAFSGMLHLFHHRENIYQIIEKLTGARLTTTFCRIGGLERDIYP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCC
EFEKEVKLVCKGLKPAIEEFNSLLLKNKIFLGRTEGIGGISAENAIAYGFSGPNLRAAGV
HHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEECCCCCCCEECCC
DWDVRKDKPYMLYDKVDFDVPIGEDGSVLHRSLVRMEEMRQSIRIIEQLVDGIPSGAWHA
CCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
DLPHAYLPEKNKVYNNMEELIYHFKIIMHGVKVPPGEHYMATEAANGELGFYIISEGEKS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEEEEEECCCCC
PWRVHVRRPCFWYYQSFAELVRGGLLADSVATMSSLNVIAGELDC
CEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA