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The map label for this gene is nuoM [H]

Identifier: 116329144

GI number: 116329144

Start: 3046356

End: 3048053

Strand: Reverse

Name: nuoM [H]

Synonym: LBL_2568

Alternate gene names: 116329144

Gene position: 3048053-3046356 (Counterclockwise)

Preceding gene: 116329145

Following gene: 116329143

Centisome position: 84.33

GC content: 44.82

Gene sequence:

>1698_bases
TTGGATTTCCCGCCGTATATACTCAGTATCTTTTTATTTTTACCTCTGATCGGAGTGCCGTTTTTGTTTTTGTCCAATCA
GGTTTATTGGCTCCGATTCATCGCGGGATCGTTTACTCTCGTTCCGTTTCTGATCATCGTCGGATTGTATTTCCAATACG
ATTCTTCCAACTCGGCTCTTCAGTTTGTGGATCGTATCTGGGGAATCGTAGTGTCCGGAAATTTGAAAGTGGATTATCAT
ATCGGACTCGACGGATTTAGTCTTCTTCTCTGCGGAATGTCTTCTTTGTTGTTCTTTCTTTCCACGCTCGCCACTTGGTC
GAGCATCACGAATCGTATTCGCGAATTTTATGTTTATCTAATGATTGTGGAAATGAGCGTTCACGGAGTATTTTTATCCG
GAAATCTCGTGTTGTTCTATATCTTCTGGGAAGCGATGGTTTCTCCCATGGTGCTCATGGTCGGGATTTGGGGAGAGGAT
CAACGAGTCAAAGCGGCGATCAAGTATCTGATTTTTTCGTTTACCGGATCGGTGTTGATGCTTGCAGGAATTCTAATACT
CTATTTTAAAACCGGGACAATCGTTATCGAAGAATTGTCGACGGGACTTTTACCCGAAATTCCGAAAAACATCCGTTTAT
TTATATTTTTTGCATTTGTGTTGGCGTTTGCAATTAAGGTGCCCTTATTTCCGCTTCATACCTGGATGCCGGACGTTCAC
TCGCAGGCGCCTACGGTGGGTTCCGTAGATCTTTCCGGAATTTTATTGAAAATCGGGCTCTACGGTTTTGTACGATTGGC
GATCCCTTTATTTCCGGAGGAGATGTTGGAATATAGGGAACTCCTCGGAGGACTTTGTATCGCGGGAATCATCTACGGCG
CCGTGATTGCGATGGCTCAGGAAAACTCGAAACGAGTCGTTGCATTTTCTTCTCTTTCACACATGAGTTTTTGTATGCTT
GGAATATTGAGTTTTACGGAAGAGGGAATGGCGGGCGGAATGCTACAGATGTTGAACCACGGGTTTACCGCGGGGATGCT
TTTCTTTATGCTCGGAATGTTGCATGAAAGGATCGGAAATAACGACATTGCCAAAGCCGGAGGATTGTCTAAATTGCTTC
CGGTATTTTCGGTTTTTTTTGCGATTGCGATTTTTTCCTCCTTGGGAGTTCCCGGAACCAACAGTTTTATCGGGGAATTT
CTGATCATCCTCGGAAGTATCAAAGCAAACGTGGTATATGGAGCGTTAGCCGTAACCGGCGTCGTATTCGCGGCCGGTTA
TCTTTTGTTGTTCGCAAAAAGAATGATTTTTGGAGAACCTTCCAAAAATCTGATCGAGCACCACGACCTCAGCTTGAAAG
AGTGGATCATCCTCATCCCTACGGTCGTGATGATTTTTTGGATCGGAATTTATCCGAAACCTTTTCTAAAAGTGTTGGAG
CCGTCCGTCAAAGTCGCATTGAATTCCGCGTCCGCTAAAACGATCCAAGATCGTACTGCGAGCTCGTTTAAAGAAACGGA
TCTGAACGGAAAAACCGTGGATAACGCAAGAAAGTATATCTCTTACCGATCGCTCGGCGAAGAACCCGGTCGTTACGAAG
AGCGTCTCAAAGGATTTCAAAGTAAATATGCTTTACCTGGGTCGATCCGAAAAGGAAAAGAAACCACTCCCGAGGGAGAC
GAGGAGGCTCTGAAATGA

Upstream 100 bases:

>100_bases
TTAAGACGGGTTCAAACCGGAATTGTAGTCGACTACGCGATTTTGATCGTGCTTGGAACGGTAGTAATACTTTCCTTTTT
TCTAATGAGGGGGTTGTAAC

Downstream 100 bases:

>100_bases
ATTTTATCCCGGATGGTTTCGATTTATTTTCTATTCTTCCTGCATTGATTTTGGCAACAGGAGGAGTGTTTCTGATTTGT
CTTTCCGTACTTTTTAAAAC

Product: NADH dehydrogenase (ubiquinone), M chain

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MDFPPYILSIFLFLPLIGVPFLFLSNQVYWLRFIAGSFTLVPFLIIVGLYFQYDSSNSALQFVDRIWGIVVSGNLKVDYH
IGLDGFSLLLCGMSSLLFFLSTLATWSSITNRIREFYVYLMIVEMSVHGVFLSGNLVLFYIFWEAMVSPMVLMVGIWGED
QRVKAAIKYLIFSFTGSVLMLAGILILYFKTGTIVIEELSTGLLPEIPKNIRLFIFFAFVLAFAIKVPLFPLHTWMPDVH
SQAPTVGSVDLSGILLKIGLYGFVRLAIPLFPEEMLEYRELLGGLCIAGIIYGAVIAMAQENSKRVVAFSSLSHMSFCML
GILSFTEEGMAGGMLQMLNHGFTAGMLFFMLGMLHERIGNNDIAKAGGLSKLLPVFSVFFAIAIFSSLGVPGTNSFIGEF
LIILGSIKANVVYGALAVTGVVFAAGYLLLFAKRMIFGEPSKNLIEHHDLSLKEWIILIPTVVMIFWIGIYPKPFLKVLE
PSVKVALNSASAKTIQDRTASSFKETDLNGKTVDNARKYISYRSLGEEPGRYEERLKGFQSKYALPGSIRKGKETTPEGD
EEALK

Sequences:

>Translated_565_residues
MDFPPYILSIFLFLPLIGVPFLFLSNQVYWLRFIAGSFTLVPFLIIVGLYFQYDSSNSALQFVDRIWGIVVSGNLKVDYH
IGLDGFSLLLCGMSSLLFFLSTLATWSSITNRIREFYVYLMIVEMSVHGVFLSGNLVLFYIFWEAMVSPMVLMVGIWGED
QRVKAAIKYLIFSFTGSVLMLAGILILYFKTGTIVIEELSTGLLPEIPKNIRLFIFFAFVLAFAIKVPLFPLHTWMPDVH
SQAPTVGSVDLSGILLKIGLYGFVRLAIPLFPEEMLEYRELLGGLCIAGIIYGAVIAMAQENSKRVVAFSSLSHMSFCML
GILSFTEEGMAGGMLQMLNHGFTAGMLFFMLGMLHERIGNNDIAKAGGLSKLLPVFSVFFAIAIFSSLGVPGTNSFIGEF
LIILGSIKANVVYGALAVTGVVFAAGYLLLFAKRMIFGEPSKNLIEHHDLSLKEWIILIPTVVMIFWIGIYPKPFLKVLE
PSVKVALNSASAKTIQDRTASSFKETDLNGKTVDNARKYISYRSLGEEPGRYEERLKGFQSKYALPGSIRKGKETTPEGD
EEALK
>Mature_565_residues
MDFPPYILSIFLFLPLIGVPFLFLSNQVYWLRFIAGSFTLVPFLIIVGLYFQYDSSNSALQFVDRIWGIVVSGNLKVDYH
IGLDGFSLLLCGMSSLLFFLSTLATWSSITNRIREFYVYLMIVEMSVHGVFLSGNLVLFYIFWEAMVSPMVLMVGIWGED
QRVKAAIKYLIFSFTGSVLMLAGILILYFKTGTIVIEELSTGLLPEIPKNIRLFIFFAFVLAFAIKVPLFPLHTWMPDVH
SQAPTVGSVDLSGILLKIGLYGFVRLAIPLFPEEMLEYRELLGGLCIAGIIYGAVIAMAQENSKRVVAFSSLSHMSFCML
GILSFTEEGMAGGMLQMLNHGFTAGMLFFMLGMLHERIGNNDIAKAGGLSKLLPVFSVFFAIAIFSSLGVPGTNSFIGEF
LIILGSIKANVVYGALAVTGVVFAAGYLLLFAKRMIFGEPSKNLIEHHDLSLKEWIILIPTVVMIFWIGIYPKPFLKVLE
PSVKVALNSASAKTIQDRTASSFKETDLNGKTVDNARKYISYRSLGEEPGRYEERLKGFQSKYALPGSIRKGKETTPEGD
EEALK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=303, Percent_Identity=28.7128712871287, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI251831117, Length=340, Percent_Identity=24.1176470588235, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1788613, Length=424, Percent_Identity=38.2075471698113, Blast_Score=269, Evalue=4e-73,
Organism=Escherichia coli, GI1788831, Length=390, Percent_Identity=26.9230769230769, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1788827, Length=259, Percent_Identity=27.027027027027, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI145693160, Length=450, Percent_Identity=23.5555555555556, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788829, Length=478, Percent_Identity=23.2217573221757, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788614, Length=339, Percent_Identity=23.3038348082596, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI2367154, Length=241, Percent_Identity=25.3112033195021, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 62742; Mature: 62742

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFPPYILSIFLFLPLIGVPFLFLSNQVYWLRFIAGSFTLVPFLIIVGLYFQYDSSNSAL
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHH
QFVDRIWGIVVSGNLKVDYHIGLDGFSLLLCGMSSLLFFLSTLATWSSITNRIREFYVYL
HHHHHHHCEEEECCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MIVEMSVHGVFLSGNLVLFYIFWEAMVSPMVLMVGIWGEDQRVKAAIKYLIFSFTGSVLM
HHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LAGILILYFKTGTIVIEELSTGLLPEIPKNIRLFIFFAFVLAFAIKVPLFPLHTWMPDVH
HHHHHHHHHCCCCEEHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHH
SQAPTVGSVDLSGILLKIGLYGFVRLAIPLFPEEMLEYRELLGGLCIAGIIYGAVIAMAQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENSKRVVAFSSLSHMSFCMLGILSFTEEGMAGGMLQMLNHGFTAGMLFFMLGMLHERIGN
CCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCC
NDIAKAGGLSKLLPVFSVFFAIAIFSSLGVPGTNSFIGEFLIILGSIKANVVYGALAVTG
CCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVFAAGYLLLFAKRMIFGEPSKNLIEHHDLSLKEWIILIPTVVMIFWIGIYPKPFLKVLE
HHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
PSVKVALNSASAKTIQDRTASSFKETDLNGKTVDNARKYISYRSLGEEPGRYEERLKGFQ
CHHHEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
SKYALPGSIRKGKETTPEGDEEALK
HCCCCCCCCCCCCCCCCCCCHHHCC
>Mature Secondary Structure
MDFPPYILSIFLFLPLIGVPFLFLSNQVYWLRFIAGSFTLVPFLIIVGLYFQYDSSNSAL
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHH
QFVDRIWGIVVSGNLKVDYHIGLDGFSLLLCGMSSLLFFLSTLATWSSITNRIREFYVYL
HHHHHHHCEEEECCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MIVEMSVHGVFLSGNLVLFYIFWEAMVSPMVLMVGIWGEDQRVKAAIKYLIFSFTGSVLM
HHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LAGILILYFKTGTIVIEELSTGLLPEIPKNIRLFIFFAFVLAFAIKVPLFPLHTWMPDVH
HHHHHHHHHCCCCEEHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHH
SQAPTVGSVDLSGILLKIGLYGFVRLAIPLFPEEMLEYRELLGGLCIAGIIYGAVIAMAQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENSKRVVAFSSLSHMSFCMLGILSFTEEGMAGGMLQMLNHGFTAGMLFFMLGMLHERIGN
CCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCC
NDIAKAGGLSKLLPVFSVFFAIAIFSSLGVPGTNSFIGEFLIILGSIKANVVYGALAVTG
CCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVFAAGYLLLFAKRMIFGEPSKNLIEHHDLSLKEWIILIPTVVMIFWIGIYPKPFLKVLE
HHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
PSVKVALNSASAKTIQDRTASSFKETDLNGKTVDNARKYISYRSLGEEPGRYEERLKGFQ
CHHHEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
SKYALPGSIRKGKETTPEGDEEALK
HCCCCCCCCCCCCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA