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The map label for this gene is nuoL [H]

Identifier: 116329145

GI number: 116329145

Start: 3048055

End: 3050001

Strand: Reverse

Name: nuoL [H]

Synonym: LBL_2569

Alternate gene names: 116329145

Gene position: 3050001-3048055 (Counterclockwise)

Preceding gene: 116329146

Following gene: 116329144

Centisome position: 84.38

GC content: 45.97

Gene sequence:

>1947_bases
ATGGAAATTGCAAATCTTATCCCTGCGTTAGTCGCCCTTCCTTTGATCGGATTTTTGATCTCCGGGCTTTTCGGCAAATG
GCTGAAAGGATTTACGGGGATTTTTTCGACCGGAGTCGTGTTTTTGTCCTTTGGTTTGGCTCTTGTGTCCTTCGTTCTAT
TTCATCCGATGGAAAGGACGATCCCGGAAATCGTCGCCGTACTTCCTTGGATTGAAACGGGGGGAATTCAGGTTTCTCTC
GCCTATCAAGTAGATCAACTTTCGCTTTATATGACTTTGATCATCACCGGAATCGGATCCCTCATCCATCTTTACAGCAT
TGGATATATGAAGGATGATCCCGGTTTTGCTCGTTATTTCGCTTACTTGAATTTGTTCATCTTTGCGATGCTCAATCTGG
TGCTTGCAGAAAATCTAATACTTCTATTTCTAGGATGGGAAGGGGTAGGACTTTGTTCGTATCTCTTGATCGGTTTCGAC
TATCACAAGGAATCCGCGGCCAACGCGGGAATGAAAGCCTTTATCGTAAACCGGATCGGAGATTTAGGAATGCTTTTGGG
GATTGCGCTTGTTTTCTGGTATACGGGTTCCGTGTCCTTTACGACGATCGAAGGGGCGATTCTGGAAATACCGTCTTTTC
GTTATATATTACCGGTAACAGCGGTTTGTTTTTTTATCGGGGCGATCGGAAAGTCCGCGCAACTTCCGTTGCACGTATGG
CTTCCGGACGCGATGGCCGGGCCGACTCCCGTATCCGCATTGATCCATGCTGCGACGATGGTGACCGCGGGAGTTTTTTT
GATCGCAAGATTAAATCCTATTTTTTTATCCGCGCCTCAAGTCGGACACTGGATCGTAGTTATAGGATCGATGACAGCTT
TCTTTGCCGCGACGATCGGGCTCTTTCAAAACGATATCAAAAAGGTACTCGCGTATTCCACCGTATCCCAACTCGGATAT
ATGTTCGTTGCGATGGGAGCGGGCGCTTATGTCGCAGGGCTCTTTCACTTGATGACGCATGCGTTCTTTAAGGCGCTCCT
CTTTTTGGGATCGGGTTCCGTGATTTATGCGCTTCATCACGAACAGGATCTTCGCAACATGGGCGGACTCAAAAAACGGA
TGAAAATCACCTGGATCACGTTTCTCGTCGGGTCGCTCGCGATCTCGGGAATCCCTCCTTTCAGCGGATTCTTTTCCAAA
GATCTAATATTAGAAAAAAGTTATACTTATGGAGCGCTCTTTTACGGGCTCGGAATTATAACTGCCCTTCTGACCGCATT
TTACATGTTTCGAATGACCTATCTCGCGTTTTACGGAGAATCCCGTGTGTCTTCCGATAAGGCGTTGCATTTGCATGAAT
CACCTCTTGTAATGACGATTCCCCTCGTAATTTTATCTATCGGAGCAACGGTCACCGGATTTTTGGAAGTGCCTCATTTT
TTGTTCGGAGGGGTGCACATACTTACAAATTATTTCAGTCCGGTTTTCATCCGAGGAATCGAAATTTCGGAACAAATCAT
AAAACAACCGTTAGACGTTCGCGAAGTCGGGACAACAAATGCGATTGAGTTTAGTTTAGTAGCCGTATCGATTGCCGTCG
CGATTTCCGGAATTTTTATCGCGAGGACGCTCTTTTTAACCGGAAAAAATGTTCCTGACGACGAGGGATCACACACGGGT
GTGAAACGAATTCTTTCTCGGAAATACTACATCGACGAGTTTTACAGAAACTTTATTGTGGATCCGATTCTACTACTCGG
GAAATTTTTAGCGGGATACGTGGAAAGAAATTTCTTGGATCTGATACTTCGAGGGACGGGAAGGTTCGCGGTCGCGATCT
CGCTGGTTTTAAGACGGGTTCAAACCGGAATTGTAGTCGACTACGCGATTTTGATCGTGCTTGGAACGGTAGTAATACTT
TCCTTTTTTCTAATGAGGGGGTTGTAA

Upstream 100 bases:

>100_bases
AAGCCGCGATCGGACTTGCGATTGTGATCGCGATCCACCGAATCAAAAAGACGAGTTACGTGGACGAAATGAATCTGATG
AAATGGTAGGAATAGGAAGA

Downstream 100 bases:

>100_bases
CTTGGATTTCCCGCCGTATATACTCAGTATCTTTTTATTTTTACCTCTGATCGGAGTGCCGTTTTTGTTTTTGTCCAATC
AGGTTTATTGGCTCCGATTC

Product: NADH dehydrogenase (ubiquinone), L chain

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 648; Mature: 648

Protein sequence:

>648_residues
MEIANLIPALVALPLIGFLISGLFGKWLKGFTGIFSTGVVFLSFGLALVSFVLFHPMERTIPEIVAVLPWIETGGIQVSL
AYQVDQLSLYMTLIITGIGSLIHLYSIGYMKDDPGFARYFAYLNLFIFAMLNLVLAENLILLFLGWEGVGLCSYLLIGFD
YHKESAANAGMKAFIVNRIGDLGMLLGIALVFWYTGSVSFTTIEGAILEIPSFRYILPVTAVCFFIGAIGKSAQLPLHVW
LPDAMAGPTPVSALIHAATMVTAGVFLIARLNPIFLSAPQVGHWIVVIGSMTAFFAATIGLFQNDIKKVLAYSTVSQLGY
MFVAMGAGAYVAGLFHLMTHAFFKALLFLGSGSVIYALHHEQDLRNMGGLKKRMKITWITFLVGSLAISGIPPFSGFFSK
DLILEKSYTYGALFYGLGIITALLTAFYMFRMTYLAFYGESRVSSDKALHLHESPLVMTIPLVILSIGATVTGFLEVPHF
LFGGVHILTNYFSPVFIRGIEISEQIIKQPLDVREVGTTNAIEFSLVAVSIAVAISGIFIARTLFLTGKNVPDDEGSHTG
VKRILSRKYYIDEFYRNFIVDPILLLGKFLAGYVERNFLDLILRGTGRFAVAISLVLRRVQTGIVVDYAILIVLGTVVIL
SFFLMRGL

Sequences:

>Translated_648_residues
MEIANLIPALVALPLIGFLISGLFGKWLKGFTGIFSTGVVFLSFGLALVSFVLFHPMERTIPEIVAVLPWIETGGIQVSL
AYQVDQLSLYMTLIITGIGSLIHLYSIGYMKDDPGFARYFAYLNLFIFAMLNLVLAENLILLFLGWEGVGLCSYLLIGFD
YHKESAANAGMKAFIVNRIGDLGMLLGIALVFWYTGSVSFTTIEGAILEIPSFRYILPVTAVCFFIGAIGKSAQLPLHVW
LPDAMAGPTPVSALIHAATMVTAGVFLIARLNPIFLSAPQVGHWIVVIGSMTAFFAATIGLFQNDIKKVLAYSTVSQLGY
MFVAMGAGAYVAGLFHLMTHAFFKALLFLGSGSVIYALHHEQDLRNMGGLKKRMKITWITFLVGSLAISGIPPFSGFFSK
DLILEKSYTYGALFYGLGIITALLTAFYMFRMTYLAFYGESRVSSDKALHLHESPLVMTIPLVILSIGATVTGFLEVPHF
LFGGVHILTNYFSPVFIRGIEISEQIIKQPLDVREVGTTNAIEFSLVAVSIAVAISGIFIARTLFLTGKNVPDDEGSHTG
VKRILSRKYYIDEFYRNFIVDPILLLGKFLAGYVERNFLDLILRGTGRFAVAISLVLRRVQTGIVVDYAILIVLGTVVIL
SFFLMRGL
>Mature_648_residues
MEIANLIPALVALPLIGFLISGLFGKWLKGFTGIFSTGVVFLSFGLALVSFVLFHPMERTIPEIVAVLPWIETGGIQVSL
AYQVDQLSLYMTLIITGIGSLIHLYSIGYMKDDPGFARYFAYLNLFIFAMLNLVLAENLILLFLGWEGVGLCSYLLIGFD
YHKESAANAGMKAFIVNRIGDLGMLLGIALVFWYTGSVSFTTIEGAILEIPSFRYILPVTAVCFFIGAIGKSAQLPLHVW
LPDAMAGPTPVSALIHAATMVTAGVFLIARLNPIFLSAPQVGHWIVVIGSMTAFFAATIGLFQNDIKKVLAYSTVSQLGY
MFVAMGAGAYVAGLFHLMTHAFFKALLFLGSGSVIYALHHEQDLRNMGGLKKRMKITWITFLVGSLAISGIPPFSGFFSK
DLILEKSYTYGALFYGLGIITALLTAFYMFRMTYLAFYGESRVSSDKALHLHESPLVMTIPLVILSIGATVTGFLEVPHF
LFGGVHILTNYFSPVFIRGIEISEQIIKQPLDVREVGTTNAIEFSLVAVSIAVAISGIFIARTLFLTGKNVPDDEGSHTG
VKRILSRKYYIDEFYRNFIVDPILLLGKFLAGYVERNFLDLILRGTGRFAVAISLVLRRVQTGIVVDYAILIVLGTVVIL
SFFLMRGL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=443, Percent_Identity=39.2776523702032, Blast_Score=288, Evalue=1e-77,
Organism=Escherichia coli, GI1788614, Length=590, Percent_Identity=40.3389830508475, Blast_Score=377, Evalue=1e-105,
Organism=Escherichia coli, GI1788829, Length=333, Percent_Identity=35.4354354354354, Blast_Score=176, Evalue=4e-45,
Organism=Escherichia coli, GI1788827, Length=359, Percent_Identity=32.033426183844, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1788831, Length=342, Percent_Identity=32.7485380116959, Blast_Score=131, Evalue=2e-31,
Organism=Escherichia coli, GI1788613, Length=393, Percent_Identity=30.0254452926209, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI2367154, Length=426, Percent_Identity=26.2910798122066, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI145693160, Length=365, Percent_Identity=27.3972602739726, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 71065; Mature: 71065

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIANLIPALVALPLIGFLISGLFGKWLKGFTGIFSTGVVFLSFGLALVSFVLFHPMERT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
IPEIVAVLPWIETGGIQVSLAYQVDQLSLYMTLIITGIGSLIHLYSIGYMKDDPGFARYF
HHHHHHHHCCEECCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
AYLNLFIFAMLNLVLAENLILLFLGWEGVGLCSYLLIGFDYHKESAANAGMKAFIVNRIG
HHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHH
DLGMLLGIALVFWYTGSVSFTTIEGAILEIPSFRYILPVTAVCFFIGAIGKSAQLPLHVW
HHHHHHHHHHHHHHCCCEEEEEECCHHEECCCCHHHHHHHHHHHHHHHCCCCCCCCEEEE
LPDAMAGPTPVSALIHAATMVTAGVFLIARLNPIFLSAPQVGHWIVVIGSMTAFFAATIG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCEEEEHHHHHHHHHHHHH
LFQNDIKKVLAYSTVSQLGYMFVAMGAGAYVAGLFHLMTHAFFKALLFLGSGSVIYALHH
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
EQDLRNMGGLKKRMKITWITFLVGSLAISGIPPFSGFFSKDLILEKSYTYGALFYGLGII
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCHHEECCCCHHHHHHHHHHH
TALLTAFYMFRMTYLAFYGESRVSSDKALHLHESPLVMTIPLVILSIGATVTGFLEVPHF
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHH
LFGGVHILTNYFSPVFIRGIEISEQIIKQPLDVREVGTTNAIEFSLVAVSIAVAISGIFI
HHHHHHHHHHHCCHHHEECCHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHH
ARTLFLTGKNVPDDEGSHTGVKRILSRKYYIDEFYRNFIVDPILLLGKFLAGYVERNFLD
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LILRGTGRFAVAISLVLRRVQTGIVVDYAILIVLGTVVILSFFLMRGL
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEIANLIPALVALPLIGFLISGLFGKWLKGFTGIFSTGVVFLSFGLALVSFVLFHPMERT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
IPEIVAVLPWIETGGIQVSLAYQVDQLSLYMTLIITGIGSLIHLYSIGYMKDDPGFARYF
HHHHHHHHCCEECCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
AYLNLFIFAMLNLVLAENLILLFLGWEGVGLCSYLLIGFDYHKESAANAGMKAFIVNRIG
HHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHH
DLGMLLGIALVFWYTGSVSFTTIEGAILEIPSFRYILPVTAVCFFIGAIGKSAQLPLHVW
HHHHHHHHHHHHHHCCCEEEEEECCHHEECCCCHHHHHHHHHHHHHHHCCCCCCCCEEEE
LPDAMAGPTPVSALIHAATMVTAGVFLIARLNPIFLSAPQVGHWIVVIGSMTAFFAATIG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCEEEEHHHHHHHHHHHHH
LFQNDIKKVLAYSTVSQLGYMFVAMGAGAYVAGLFHLMTHAFFKALLFLGSGSVIYALHH
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
EQDLRNMGGLKKRMKITWITFLVGSLAISGIPPFSGFFSKDLILEKSYTYGALFYGLGII
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCHHEECCCCHHHHHHHHHHH
TALLTAFYMFRMTYLAFYGESRVSSDKALHLHESPLVMTIPLVILSIGATVTGFLEVPHF
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHH
LFGGVHILTNYFSPVFIRGIEISEQIIKQPLDVREVGTTNAIEFSLVAVSIAVAISGIFI
HHHHHHHHHHHCCHHHEECCHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHH
ARTLFLTGKNVPDDEGSHTGVKRILSRKYYIDEFYRNFIVDPILLLGKFLAGYVERNFLD
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LILRGTGRFAVAISLVLRRVQTGIVVDYAILIVLGTVVILSFFLMRGL
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]