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The map label for this gene is tktC [C]

Identifier: 116328513

GI number: 116328513

Start: 2170585

End: 2171547

Strand: Reverse

Name: tktC [C]

Synonym: LBL_1863

Alternate gene names: 116328513

Gene position: 2171547-2170585 (Counterclockwise)

Preceding gene: 116328514

Following gene: 116328512

Centisome position: 60.08

GC content: 45.07

Gene sequence:

>963_bases
ATGGGAGCTCCAAGCACATCGACTGCGACAGAAAAAGCGACTCGTGACGGTTATGGAGATGCACTGCATGAGCTGGGAGT
TTCCCGTCAGGATGTAGTCGTCTTGGACGCAGATCTTTCCGGTTCCACAAAAACCAATAAGTTTGCAAAGAGCTATCCGG
ATCGTTTTTTCAACGTGGGTGTTGCCGAACAAAATTTAGTTGGTCATGCCGCGGGGCTTGCGCTTTCCGGACTCGTTCCG
TTTGCTTCTTCCTTTGCAATGTTTCTTTCCGGAAGAGCCTGGGAAGTCGTTCGTAATAGCGTAGTTTATCCGTTTTTGAA
CGTGAAGCTCGTGGCCTCTCACGGTGGAGTGACTGTAGGGGAAGACGGGGCCTCTCATCAATGTATCGAAGACTTTGCAA
TCATGAGAGCCATTCCGGAAATGACTGTGATTTGTCCTTCCGATTACGACGAATGTAAGCAGGTAATTCACACAATTGCG
GATTATAAAGGCCCGGTTTATGTTCGAGTGGGTCGTCCTAATGTTCCGGTGATTGAAAGAGAGAATTACAAATTTCAGAT
TGGCAAAGCCGAAGTGATGAGAGAAGGCAAAGACATTCTCATCATTGCGAATGGGGTTCTTGTCAGCGAAGCTATGAAAG
CTGTGGAGGAACTTTCCAAGGAAGGGATTCATGCGACGCTTCTGAACATGGCAACAATCAAACCGATTGATAAAGAAATA
ATTTTAAAATATGCGAAAAAATGCGGCGCTGTAGTGACTTGTGAAGAGCACAATGTAATCGGCGGGCTTGGTTCCGCGGT
CAGCGAGTTTCTATCCGAAGAGTATCCGATTCACGTTTTGAAAGTAGGAATGAAAGATCAGTTCGGAAAATCGGGAACTT
GGAAAGAACTTTTGGATTATTTTGGGCTTCGTTCTAAAACTATCATAGAAACCGCAAAAAAAGCGATTGTTCTCAAAAAA
TAA

Upstream 100 bases:

>100_bases
GTATAGAGAGACTGCATCGTATGGACATTTCGGAAGAAAAGGGTCCACATTCACTTGGGAAAAAACCGATAAAACGGTAG
CTTTAAAAGGATAAGAAAAA

Downstream 100 bases:

>100_bases
AATTATTGATAATTTAAAAGAATTTCATATGTTTTTTTCTTTTTTTGATAGAGGGAAGAATTTTGTGAAGGTTCTTTTAG
AGAGAAATTTTTTTATTCCT

Product: transketolase, C-terminal subunit

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MGAPSTSTATEKATRDGYGDALHELGVSRQDVVVLDADLSGSTKTNKFAKSYPDRFFNVGVAEQNLVGHAAGLALSGLVP
FASSFAMFLSGRAWEVVRNSVVYPFLNVKLVASHGGVTVGEDGASHQCIEDFAIMRAIPEMTVICPSDYDECKQVIHTIA
DYKGPVYVRVGRPNVPVIERENYKFQIGKAEVMREGKDILIIANGVLVSEAMKAVEELSKEGIHATLLNMATIKPIDKEI
ILKYAKKCGAVVTCEEHNVIGGLGSAVSEFLSEEYPIHVLKVGMKDQFGKSGTWKELLDYFGLRSKTIIETAKKAIVLKK

Sequences:

>Translated_320_residues
MGAPSTSTATEKATRDGYGDALHELGVSRQDVVVLDADLSGSTKTNKFAKSYPDRFFNVGVAEQNLVGHAAGLALSGLVP
FASSFAMFLSGRAWEVVRNSVVYPFLNVKLVASHGGVTVGEDGASHQCIEDFAIMRAIPEMTVICPSDYDECKQVIHTIA
DYKGPVYVRVGRPNVPVIERENYKFQIGKAEVMREGKDILIIANGVLVSEAMKAVEELSKEGIHATLLNMATIKPIDKEI
ILKYAKKCGAVVTCEEHNVIGGLGSAVSEFLSEEYPIHVLKVGMKDQFGKSGTWKELLDYFGLRSKTIIETAKKAIVLKK
>Mature_319_residues
GAPSTSTATEKATRDGYGDALHELGVSRQDVVVLDADLSGSTKTNKFAKSYPDRFFNVGVAEQNLVGHAAGLALSGLVPF
ASSFAMFLSGRAWEVVRNSVVYPFLNVKLVASHGGVTVGEDGASHQCIEDFAIMRAIPEMTVICPSDYDECKQVIHTIAD
YKGPVYVRVGRPNVPVIERENYKFQIGKAEVMREGKDILIIANGVLVSEAMKAVEELSKEGIHATLLNMATIKPIDKEII
LKYAKKCGAVVTCEEHNVIGGLGSAVSEFLSEEYPIHVLKVGMKDQFGKSGTWKELLDYFGLRSKTIIETAKKAIVLKK

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=318, Percent_Identity=37.1069182389937, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI4507521, Length=318, Percent_Identity=37.1069182389937, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI225637461, Length=316, Percent_Identity=37.9746835443038, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI225637463, Length=316, Percent_Identity=37.9746835443038, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI225637459, Length=316, Percent_Identity=37.9746835443038, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI133778974, Length=311, Percent_Identity=36.6559485530547, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI291084858, Length=281, Percent_Identity=25.2669039145907, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI156564403, Length=288, Percent_Identity=25.6944444444444, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI4557353, Length=245, Percent_Identity=25.7142857142857, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI34101272, Length=245, Percent_Identity=25.7142857142857, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1786622, Length=289, Percent_Identity=36.3321799307958, Blast_Score=171, Evalue=6e-44,
Organism=Escherichia coli, GI48994911, Length=326, Percent_Identity=25.1533742331288, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788808, Length=332, Percent_Identity=24.0963855421687, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17539652, Length=317, Percent_Identity=40.3785488958991, Blast_Score=219, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17538422, Length=287, Percent_Identity=24.0418118466899, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6325331, Length=282, Percent_Identity=25.177304964539, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319593, Length=277, Percent_Identity=24.5487364620939, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319698, Length=346, Percent_Identity=25.1445086705202, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45551847, Length=311, Percent_Identity=35.3697749196142, Blast_Score=177, Evalue=6e-45,
Organism=Drosophila melanogaster, GI45550715, Length=311, Percent_Identity=35.3697749196142, Blast_Score=177, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24645119, Length=317, Percent_Identity=34.7003154574132, Blast_Score=177, Evalue=7e-45,
Organism=Drosophila melanogaster, GI24666278, Length=313, Percent_Identity=33.8658146964856, Blast_Score=167, Evalue=8e-42,
Organism=Drosophila melanogaster, GI21358145, Length=287, Percent_Identity=27.1777003484321, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24650940, Length=287, Percent_Identity=27.1777003484321, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI160714832, Length=278, Percent_Identity=25.8992805755396, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI160714828, Length=278, Percent_Identity=25.8992805755396, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 34771; Mature: 34640

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAPSTSTATEKATRDGYGDALHELGVSRQDVVVLDADLSGSTKTNKFAKSYPDRFFNVG
CCCCCCCCHHHHHHCCCHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHCCHHHHCCC
VAEQNLVGHAAGLALSGLVPFASSFAMFLSGRAWEVVRNSVVYPFLNVKLVASHGGVTVG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCEEEEEEEEEEEECCCCEEEC
EDGASHQCIEDFAIMRAIPEMTVICPSDYDECKQVIHTIADYKGPVYVRVGRPNVPVIER
CCCCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEC
ENYKFQIGKAEVMREGKDILIIANGVLVSEAMKAVEELSKEGIHATLLNMATIKPIDKEI
CCCEEEECHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHH
ILKYAKKCGAVVTCEEHNVIGGLGSAVSEFLSEEYPIHVLKVGMKDQFGKSGTWKELLDY
HHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEECCHHCCCCCCCHHHHHHH
FGLRSKTIIETAKKAIVLKK
HCCCCHHHHHHHHHHHEECC
>Mature Secondary Structure 
GAPSTSTATEKATRDGYGDALHELGVSRQDVVVLDADLSGSTKTNKFAKSYPDRFFNVG
CCCCCCCHHHHHHCCCHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHCCHHHHCCC
VAEQNLVGHAAGLALSGLVPFASSFAMFLSGRAWEVVRNSVVYPFLNVKLVASHGGVTVG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCEEEEEEEEEEEECCCCEEEC
EDGASHQCIEDFAIMRAIPEMTVICPSDYDECKQVIHTIADYKGPVYVRVGRPNVPVIER
CCCCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEC
ENYKFQIGKAEVMREGKDILIIANGVLVSEAMKAVEELSKEGIHATLLNMATIKPIDKEI
CCCEEEECHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHH
ILKYAKKCGAVVTCEEHNVIGGLGSAVSEFLSEEYPIHVLKVGMKDQFGKSGTWKELLDY
HHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEECCHHCCCCCCCHHHHHHH
FGLRSKTIIETAKKAIVLKK
HCCCCHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]