| Definition | Leptospira borgpetersenii serovar Hardjo-bovis L550 chromosome 1, complete sequence. |
|---|---|
| Accession | NC_008508 |
| Length | 3,614,446 |
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The map label for this gene is sdhA [H]
Identifier: 116328391
GI number: 116328391
Start: 2012927
End: 2014840
Strand: Direct
Name: sdhA [H]
Synonym: LBL_1728
Alternate gene names: 116328391
Gene position: 2012927-2014840 (Clockwise)
Preceding gene: 116328390
Following gene: 116328392
Centisome position: 55.69
GC content: 45.82
Gene sequence:
>1914_bases ATGAGTTTAGATTCTAAAATTCCAAACGGCCCGATTGAGAAAAAATGGTCTAATCACAAGGCTAATATCAAGTTAGTCAA CCCAGCCAACAAAAGAAAATTCAACATCATCGTAGTCGGTTCCGGTTTGGCAGGAGCTTCCGCATCGGCAACTCTCGCAG AACTCGGTTACAACGTAAAAACATTCTGTTTTCAAGACAGTCCTCGTCGTGCGCATAGTATCGCGGCTCAAGGTGGGATC AACGCCGCTAAAAACTACCAAAACGACGGTGATTCAGTTTATCGTTTATTCTACGATACAGTGAAAGGCGGCGACTTTCG CGCAAGAGAAGCGAATGTGCATCGCCTTGCGGAAGTTTCCGTTAACATCATCGATCAGTGTGTCGCCCAAGGAGTTCCTT TCGCGAGAGAATACGGAGGGCATCTTTCCAACCGTTCTTTCGGCGGGGCTCAAGTTTCCAGAACCTTCTACGCAAAAGGT CAAACCGGACAACAGCTTCTCTTAGGAGCTTACTCCGCTCTCTCTCGTCAAATCGGGTTGGGTGCGGTAAAGATGTATCC TAGAACCGAGATGGTGGAACTAATCGTGATTGACGGTCATGCAAAAGGAATCATAGTTCGTGATCTTGTCACCGGAGAAC TTTCCACTCACATGGCGGATGCAATTGTGCTTGGAACCGGAGGTTACGGAAACGTATTCTTTCTTTCCACGAATGCAAAA GGTTGTAACGTAACTGCAACTTGGAAAGCTCATAAAAAAGGAGCATACTTTGCTAACCCGTGTTATACGCAAATTCACCC GACGTGTATTCCTGTTTCCGGAGATCATCAATCCAAACTGACTTTGATGTCCGAGTCCCTTAGAAACGACGGAAGAATCT GGGTTCCGAAAAATAAAGGAGACAAACGGAGTCCCGCGGACATACCCGAATCGGAAAGAGATTATTATTTGGAAAGAAAA TACCCAAGTTACGGAAATCTTTCTCCAAGGGACATTGCATCCCGCGCGGCCAAAGAAGCTTGCGACGCAGGACTCGGTGT GGGAGAATCCGGACAAGGAGTATATTTGGATTTTGCAGACTCGATCAAACGCCTTGGTGAAGACAAAATCCGGGATCGTT ACGAAAATCTCTTCCAAATGTATGAACAAATCACCGGTGAAAATCCTTACAAACAACCGATGAGAATTTACCCTGCTGTC CACTATACAATGGGTGGACTTTGGGTGGATTACAATCTAATGAGCAACTTACCCGGTCTGTTTGTAATCGGAGAAGCAAA CTTTTCCGATCACGGAGCAAACCGCCTCGGAGCGTCCGCTTTGATGCAGGGACTTGCGGACGGATATTTCATTCTTCCTT ATACGATCGGAAATTATCTCGCAGGAGTGGGATTTAATTCTCATCCCAAAGAAGATCACGCAGAAGCCAAAAAAGCTCTT TCCGATGCGAAAGAGACCACGAAAAAACTTCTTTCCATCCAAGGAAAAAGAACCGTGGATTCTTTCCATAAGCAACTCGG GAAACTGATGTGGGACAAATGCGGAATGGCGCGTAATGATAAAGGTCTTAAAGAAGCGTTATCCGAAATTCCTAATATCC GGGAAGAGTTCTGGAAAAACGTAAATGTTCCCGGAAGTGGAGCCGAGCTCAATCAGTCTCTCGAAAAAGCGGGAAGAGTC GCGGACTTCCTCGAATTCGCCGAACTTCTTTGTTTAGATGCATTGACTCGGGAAGAATCCTGTGGAGGACATTTCCGAGA AGAGCACCAAGAAGAAGGAGAAGCGAAACGAAACGACGATAAATTCTGCCACGCAACCGCTTGGGAATTCAACGGAATCG GTAAAAAACCGACAGAACACAGGGAAAAACTGGAATTCGAAAACGTTCACCTCGCTACAAGGAGTTATAAATAA
Upstream 100 bases:
>100_bases AGCGATTCTTTTTGCTTTGATCATTTTTATTGGAAACACTTCTATCCCGCTTTCGATTTTGGCGGGATACGTTCACCCGT AATTCTTTGGAGAAACTTTT
Downstream 100 bases:
>100_bases TGGATCTGAAGCTCAAAGTTTGGAGACAAAAAAACGGAGAAACAAAGGGAAAGATTGCAGACTATGATGCAAAAGATATT TCCCCGAACATGTCCTTTTT
Product: succinate dehydrogenase flavoprotein subunit
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 637; Mature: 636
Protein sequence:
>637_residues MSLDSKIPNGPIEKKWSNHKANIKLVNPANKRKFNIIVVGSGLAGASASATLAELGYNVKTFCFQDSPRRAHSIAAQGGI NAAKNYQNDGDSVYRLFYDTVKGGDFRAREANVHRLAEVSVNIIDQCVAQGVPFAREYGGHLSNRSFGGAQVSRTFYAKG QTGQQLLLGAYSALSRQIGLGAVKMYPRTEMVELIVIDGHAKGIIVRDLVTGELSTHMADAIVLGTGGYGNVFFLSTNAK GCNVTATWKAHKKGAYFANPCYTQIHPTCIPVSGDHQSKLTLMSESLRNDGRIWVPKNKGDKRSPADIPESERDYYLERK YPSYGNLSPRDIASRAAKEACDAGLGVGESGQGVYLDFADSIKRLGEDKIRDRYENLFQMYEQITGENPYKQPMRIYPAV HYTMGGLWVDYNLMSNLPGLFVIGEANFSDHGANRLGASALMQGLADGYFILPYTIGNYLAGVGFNSHPKEDHAEAKKAL SDAKETTKKLLSIQGKRTVDSFHKQLGKLMWDKCGMARNDKGLKEALSEIPNIREEFWKNVNVPGSGAELNQSLEKAGRV ADFLEFAELLCLDALTREESCGGHFREEHQEEGEAKRNDDKFCHATAWEFNGIGKKPTEHREKLEFENVHLATRSYK
Sequences:
>Translated_637_residues MSLDSKIPNGPIEKKWSNHKANIKLVNPANKRKFNIIVVGSGLAGASASATLAELGYNVKTFCFQDSPRRAHSIAAQGGI NAAKNYQNDGDSVYRLFYDTVKGGDFRAREANVHRLAEVSVNIIDQCVAQGVPFAREYGGHLSNRSFGGAQVSRTFYAKG QTGQQLLLGAYSALSRQIGLGAVKMYPRTEMVELIVIDGHAKGIIVRDLVTGELSTHMADAIVLGTGGYGNVFFLSTNAK GCNVTATWKAHKKGAYFANPCYTQIHPTCIPVSGDHQSKLTLMSESLRNDGRIWVPKNKGDKRSPADIPESERDYYLERK YPSYGNLSPRDIASRAAKEACDAGLGVGESGQGVYLDFADSIKRLGEDKIRDRYENLFQMYEQITGENPYKQPMRIYPAV HYTMGGLWVDYNLMSNLPGLFVIGEANFSDHGANRLGASALMQGLADGYFILPYTIGNYLAGVGFNSHPKEDHAEAKKAL SDAKETTKKLLSIQGKRTVDSFHKQLGKLMWDKCGMARNDKGLKEALSEIPNIREEFWKNVNVPGSGAELNQSLEKAGRV ADFLEFAELLCLDALTREESCGGHFREEHQEEGEAKRNDDKFCHATAWEFNGIGKKPTEHREKLEFENVHLATRSYK >Mature_636_residues SLDSKIPNGPIEKKWSNHKANIKLVNPANKRKFNIIVVGSGLAGASASATLAELGYNVKTFCFQDSPRRAHSIAAQGGIN AAKNYQNDGDSVYRLFYDTVKGGDFRAREANVHRLAEVSVNIIDQCVAQGVPFAREYGGHLSNRSFGGAQVSRTFYAKGQ TGQQLLLGAYSALSRQIGLGAVKMYPRTEMVELIVIDGHAKGIIVRDLVTGELSTHMADAIVLGTGGYGNVFFLSTNAKG CNVTATWKAHKKGAYFANPCYTQIHPTCIPVSGDHQSKLTLMSESLRNDGRIWVPKNKGDKRSPADIPESERDYYLERKY PSYGNLSPRDIASRAAKEACDAGLGVGESGQGVYLDFADSIKRLGEDKIRDRYENLFQMYEQITGENPYKQPMRIYPAVH YTMGGLWVDYNLMSNLPGLFVIGEANFSDHGANRLGASALMQGLADGYFILPYTIGNYLAGVGFNSHPKEDHAEAKKALS DAKETTKKLLSIQGKRTVDSFHKQLGKLMWDKCGMARNDKGLKEALSEIPNIREEFWKNVNVPGSGAELNQSLEKAGRVA DFLEFAELLCLDALTREESCGGHFREEHQEEGEAKRNDDKFCHATAWEFNGIGKKPTEHREKLEFENVHLATRSYK
Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]
COG id: COG1053
COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
Gene ontology:
Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]
Homologues:
Organism=Homo sapiens, GI156416003, Length=559, Percent_Identity=25.9391771019678, Blast_Score=146, Evalue=6e-35, Organism=Escherichia coli, GI1790597, Length=571, Percent_Identity=27.6707530647986, Blast_Score=198, Evalue=1e-51, Organism=Escherichia coli, GI1788928, Length=589, Percent_Identity=25.2971137521222, Blast_Score=128, Evalue=1e-30, Organism=Escherichia coli, GI1786942, Length=603, Percent_Identity=26.0364842454395, Blast_Score=127, Evalue=3e-30, Organism=Caenorhabditis elegans, GI17550100, Length=540, Percent_Identity=28.8888888888889, Blast_Score=171, Evalue=8e-43, Organism=Caenorhabditis elegans, GI17505833, Length=543, Percent_Identity=27.8084714548803, Blast_Score=170, Evalue=2e-42, Organism=Saccharomyces cerevisiae, GI6322701, Length=600, Percent_Identity=27.3333333333333, Blast_Score=179, Evalue=8e-46, Organism=Saccharomyces cerevisiae, GI6322416, Length=620, Percent_Identity=26.7741935483871, Blast_Score=170, Evalue=8e-43, Organism=Drosophila melanogaster, GI17137288, Length=654, Percent_Identity=27.0642201834862, Blast_Score=170, Evalue=2e-42, Organism=Drosophila melanogaster, GI24655642, Length=654, Percent_Identity=27.0642201834862, Blast_Score=170, Evalue=2e-42, Organism=Drosophila melanogaster, GI24655647, Length=654, Percent_Identity=27.0642201834862, Blast_Score=170, Evalue=2e-42, Organism=Drosophila melanogaster, GI24663005, Length=575, Percent_Identity=25.9130434782609, Blast_Score=151, Evalue=1e-36,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003953 - InterPro: IPR013027 - InterPro: IPR003952 - InterPro: IPR015939 - InterPro: IPR004112 - InterPro: IPR011280 [H]
Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]
EC number: =1.3.99.1 [H]
Molecular weight: Translated: 70377; Mature: 70246
Theoretical pI: Translated: 8.37; Mature: 8.37
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.6 %Cys (Translated Protein) 1.9 %Met (Translated Protein) 3.5 %Cys+Met (Translated Protein) 1.6 %Cys (Mature Protein) 1.7 %Met (Mature Protein) 3.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSLDSKIPNGPIEKKWSNHKANIKLVNPANKRKFNIIVVGSGLAGASASATLAELGYNVK CCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHCCCEE TFCFQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTVKGGDFRAREANVHRLAEVS EEEECCCCHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH VNIIDQCVAQGVPFAREYGGHLSNRSFGGAQVSRTFYAKGQTGQQLLLGAYSALSRQIGL HHHHHHHHHCCCCHHHHHCCCCCCCCCCCCHHEEEEEECCCCCHHHHHHHHHHHHHHHCC GAVKMYPRTEMVELIVIDGHAKGIIVRDLVTGELSTHMADAIVLGTGGYGNVFFLSTNAK CEEEECCCCCEEEEEEECCCCCCEEEEEHHHHHHHHHHCCEEEEECCCCCCEEEEECCCC GCNVTATWKAHKKGAYFANPCYTQIHPTCIPVSGDHQSKLTLMSESLRNDGRIWVPKNKG CCEEEEEECCCCCCCEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCC DKRSPADIPESERDYYLERKYPSYGNLSPRDIASRAAKEACDAGLGVGESGQGVYLDFAD CCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHH SIKRLGEDKIRDRYENLFQMYEQITGENPYKQPMRIYPAVHYTMGGLWVDYNLMSNLPGL HHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEECCCEEEEEEHHHCCCCE FVIGEANFSDHGANRLGASALMQGLADGYFILPYTIGNYLAGVGFNSHPKEDHAEAKKAL EEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHCCCCCCCCCHHHHHHHHHH SDAKETTKKLLSIQGKRTVDSFHKQLGKLMWDKCGMARNDKGLKEALSEIPNIREEFWKN HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHC VNVPGSGAELNQSLEKAGRVADFLEFAELLCLDALTREESCGGHFREEHQEEGEAKRNDD CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCC KFCHATAWEFNGIGKKPTEHREKLEFENVHLATRSYK CEEEEEEEECCCCCCCCHHHHHHCCCCCEEEEECCCC >Mature Secondary Structure SLDSKIPNGPIEKKWSNHKANIKLVNPANKRKFNIIVVGSGLAGASASATLAELGYNVK CCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHCCCEE TFCFQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTVKGGDFRAREANVHRLAEVS EEEECCCCHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH VNIIDQCVAQGVPFAREYGGHLSNRSFGGAQVSRTFYAKGQTGQQLLLGAYSALSRQIGL HHHHHHHHHCCCCHHHHHCCCCCCCCCCCCHHEEEEEECCCCCHHHHHHHHHHHHHHHCC GAVKMYPRTEMVELIVIDGHAKGIIVRDLVTGELSTHMADAIVLGTGGYGNVFFLSTNAK CEEEECCCCCEEEEEEECCCCCCEEEEEHHHHHHHHHHCCEEEEECCCCCCEEEEECCCC GCNVTATWKAHKKGAYFANPCYTQIHPTCIPVSGDHQSKLTLMSESLRNDGRIWVPKNKG CCEEEEEECCCCCCCEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCC DKRSPADIPESERDYYLERKYPSYGNLSPRDIASRAAKEACDAGLGVGESGQGVYLDFAD CCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHH SIKRLGEDKIRDRYENLFQMYEQITGENPYKQPMRIYPAVHYTMGGLWVDYNLMSNLPGL HHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCEEECCCEEEEEEHHHCCCCE FVIGEANFSDHGANRLGASALMQGLADGYFILPYTIGNYLAGVGFNSHPKEDHAEAKKAL EEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHCCCCCCCCCHHHHHHHHHH SDAKETTKKLLSIQGKRTVDSFHKQLGKLMWDKCGMARNDKGLKEALSEIPNIREEFWKN HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHC VNVPGSGAELNQSLEKAGRVADFLEFAELLCLDALTREESCGGHFREEHQEEGEAKRNDD CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCC KFCHATAWEFNGIGKKPTEHREKLEFENVHLATRSYK CEEEEEEEECCCCCCCCHHHHHHCCCCCEEEEECCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]