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The map label for this gene is ggt [H]

Identifier: 116328083

GI number: 116328083

Start: 1613661

End: 1615394

Strand: Direct

Name: ggt [H]

Synonym: LBL_1380

Alternate gene names: 116328083

Gene position: 1613661-1615394 (Clockwise)

Preceding gene: 116328082

Following gene: 116328084

Centisome position: 44.64

GC content: 43.83

Gene sequence:

>1734_bases
ATGAAACAAATCACAATTCGTATCATTCTGATACTTTTACTCTTCTCGTGTAGGGAAACTTCTCTTACCATCGAAGGAAA
AAGGATTTCGACGGATTTACTCGTAACTCCTTCTCATGGAAAAACACACGTCGATTACTTCAGCGAAAGTAAGAATCTTA
TGATCGCAACTGATTCTCCCGAGGCCACCCAAGCGGGGATCGAAGTCGGGTTGTTAGGTGGAAACGTAGTGGACGTAGCC
GTTGCAACTTCGTTTGCGATTTCGGTTACAAGACCACATTCGACCGGACTGGGTGGAGGAGGTTTTCTTATTCTTTACTT
GAAAGAATTTTCGGAACCGATCGCTTTTGATTTTCGGGAAAGAGCTCCTAACGCGGCATCTAGGGACATGTATAAGAAAA
AACCGAAAGAAGATTCTTTGCTTGGGTTCCGGGCCGTAGGTGTTCCGGGTAATGTAGCGGGTCTTGTTCAGATCCAAAAA
CGTTACGGAAAACTTTCTCTCAAAACGGTAATTTCTCCCGCGATTCGATTGGCAGAAAAGGGATTTCCGATGTATCCTGA
TTTACAGTCTGCGATTCAGAAGTCTTCGAAGGATATGGATCAGGAAATGAAAGGGATTTTTCTTCCAGGGGGAAGGGTTC
CCGAATTAAAAAGTATTCTGGTTCAAAAGGATTTGGCAAATTCTTTGAAGTTGATTTCCGAAACGGGTGAGAAGGAATTT
TATCATGGAAAAATCGCGGATGCGATCACGACCGCGATGAAAGCCAACGGTGGGTTGATAACTTCTCAAGATTTAAGCGA
TTTTAAGGTGATTGAAAAGAAAACTTTAAAGACGAAGTATCGCGATTATACGATTTATACAATGCCTCCGCCTTCTTCCG
GAATTCATCTCCTCACGATGTTATCGATGTTGGAAAAAGAACCTCTCAAAGAAATGTATGAAAAAGATTCGGCTTTGTAT
TATCATTTCGTTACGGAGGTGATGAGGAGAGGGTATGCGGACCGTGCGGTTTTTGGCGGTGATTCCGCGTTTACGAGAAT
ACCCGTGGACCGTCTTCTTTCTAAGAAATATGCAGAGGAAAAGATTTCCGACTTCGATCCGAAAATCGCCTCTAGTAGTT
CTTCTTTTCTAAAAACTCTTAACTTCGGTGTGGAATCTCCGCAGACTACTCATATTTCGGTAATGGATCGAGAGGGAAAC
TCCATATCTACGACTCAGTCCATCAATTTTCGTTTTGGGGCCTCGGTTGTGGCTCCCGGAACCGGAATTGTTTTGAACGA
TACAATGGATGATTTTAGCAGGGCTCCCGGAGAACCGAACGTATACGGTTTGATTGGTGCGGAGGCAAATTCTATTCTTC
CTAAAAAAACGCCTTTGAGCAGTATGTCTCCGACCATCGTTTTTAAGGGAAAAGAGCCCTTTTTAACCACAGGGGCGCCG
GGAGGAGCTTACATCATCAACGCGGTTTTGCAATCTCTTGTCTACAATTTGGATTTCAATTTAACCCTGTATGAATCCGT
CGCAAGGGGAAGAATTCATCATCAGCTTTTTCCTGACGCAGTGTTTATCGAAAAATCCGTGAATGAAAGAAACGTATTCG
ATGGTCTTTCGTCGAAAAAACACGATATCCGAATTGCTCCGAACTTTGCAAAACTGTTCTCGGTCAAAAGAGAGAACGGA
ATGCTCTATGGAGCTTCCGATCCACGTGGGGAAGGAGCCACGGGCGGACTTTGA

Upstream 100 bases:

>100_bases
TGAAGTCCGGAGGTAAAGTGAAACTGATTTCCGGCCAAGAGGGAATTGAAATGAAATTCACGTCCGGAAAAAAATCCTGA
AACTCAAATACCAGGATCCA

Downstream 100 bases:

>100_bases
AAACTAAGGAACTCACTCAATCGAAGATAGAAGAAGTATCCCTCGAAATTCTTTTGAGACATGCCGTAAAGGCGAAACAC
GGCTTGGAAAAGGAAAGTAT

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 577; Mature: 577

Protein sequence:

>577_residues
MKQITIRIILILLLFSCRETSLTIEGKRISTDLLVTPSHGKTHVDYFSESKNLMIATDSPEATQAGIEVGLLGGNVVDVA
VATSFAISVTRPHSTGLGGGGFLILYLKEFSEPIAFDFRERAPNAASRDMYKKKPKEDSLLGFRAVGVPGNVAGLVQIQK
RYGKLSLKTVISPAIRLAEKGFPMYPDLQSAIQKSSKDMDQEMKGIFLPGGRVPELKSILVQKDLANSLKLISETGEKEF
YHGKIADAITTAMKANGGLITSQDLSDFKVIEKKTLKTKYRDYTIYTMPPPSSGIHLLTMLSMLEKEPLKEMYEKDSALY
YHFVTEVMRRGYADRAVFGGDSAFTRIPVDRLLSKKYAEEKISDFDPKIASSSSSFLKTLNFGVESPQTTHISVMDREGN
SISTTQSINFRFGASVVAPGTGIVLNDTMDDFSRAPGEPNVYGLIGAEANSILPKKTPLSSMSPTIVFKGKEPFLTTGAP
GGAYIINAVLQSLVYNLDFNLTLYESVARGRIHHQLFPDAVFIEKSVNERNVFDGLSSKKHDIRIAPNFAKLFSVKRENG
MLYGASDPRGEGATGGL

Sequences:

>Translated_577_residues
MKQITIRIILILLLFSCRETSLTIEGKRISTDLLVTPSHGKTHVDYFSESKNLMIATDSPEATQAGIEVGLLGGNVVDVA
VATSFAISVTRPHSTGLGGGGFLILYLKEFSEPIAFDFRERAPNAASRDMYKKKPKEDSLLGFRAVGVPGNVAGLVQIQK
RYGKLSLKTVISPAIRLAEKGFPMYPDLQSAIQKSSKDMDQEMKGIFLPGGRVPELKSILVQKDLANSLKLISETGEKEF
YHGKIADAITTAMKANGGLITSQDLSDFKVIEKKTLKTKYRDYTIYTMPPPSSGIHLLTMLSMLEKEPLKEMYEKDSALY
YHFVTEVMRRGYADRAVFGGDSAFTRIPVDRLLSKKYAEEKISDFDPKIASSSSSFLKTLNFGVESPQTTHISVMDREGN
SISTTQSINFRFGASVVAPGTGIVLNDTMDDFSRAPGEPNVYGLIGAEANSILPKKTPLSSMSPTIVFKGKEPFLTTGAP
GGAYIINAVLQSLVYNLDFNLTLYESVARGRIHHQLFPDAVFIEKSVNERNVFDGLSSKKHDIRIAPNFAKLFSVKRENG
MLYGASDPRGEGATGGL
>Mature_577_residues
MKQITIRIILILLLFSCRETSLTIEGKRISTDLLVTPSHGKTHVDYFSESKNLMIATDSPEATQAGIEVGLLGGNVVDVA
VATSFAISVTRPHSTGLGGGGFLILYLKEFSEPIAFDFRERAPNAASRDMYKKKPKEDSLLGFRAVGVPGNVAGLVQIQK
RYGKLSLKTVISPAIRLAEKGFPMYPDLQSAIQKSSKDMDQEMKGIFLPGGRVPELKSILVQKDLANSLKLISETGEKEF
YHGKIADAITTAMKANGGLITSQDLSDFKVIEKKTLKTKYRDYTIYTMPPPSSGIHLLTMLSMLEKEPLKEMYEKDSALY
YHFVTEVMRRGYADRAVFGGDSAFTRIPVDRLLSKKYAEEKISDFDPKIASSSSSFLKTLNFGVESPQTTHISVMDREGN
SISTTQSINFRFGASVVAPGTGIVLNDTMDDFSRAPGEPNVYGLIGAEANSILPKKTPLSSMSPTIVFKGKEPFLTTGAP
GGAYIINAVLQSLVYNLDFNLTLYESVARGRIHHQLFPDAVFIEKSVNERNVFDGLSSKKHDIRIAPNFAKLFSVKRENG
MLYGASDPRGEGATGGL

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=535, Percent_Identity=29.5327102803738, Blast_Score=228, Evalue=2e-59,
Organism=Homo sapiens, GI73915090, Length=535, Percent_Identity=29.5327102803738, Blast_Score=228, Evalue=2e-59,
Organism=Homo sapiens, GI73915096, Length=535, Percent_Identity=29.5327102803738, Blast_Score=228, Evalue=2e-59,
Organism=Homo sapiens, GI73915094, Length=535, Percent_Identity=29.5327102803738, Blast_Score=228, Evalue=2e-59,
Organism=Homo sapiens, GI113429324, Length=537, Percent_Identity=27.9329608938547, Blast_Score=196, Evalue=6e-50,
Organism=Homo sapiens, GI113429326, Length=542, Percent_Identity=27.859778597786, Blast_Score=195, Evalue=9e-50,
Organism=Homo sapiens, GI109148539, Length=535, Percent_Identity=29.5327102803738, Blast_Score=187, Evalue=3e-47,
Organism=Homo sapiens, GI153266901, Length=526, Percent_Identity=25.8555133079848, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI153266885, Length=525, Percent_Identity=25.5238095238095, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI153266907, Length=524, Percent_Identity=24.8091603053435, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI30581157, Length=190, Percent_Identity=36.3157894736842, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI30581155, Length=190, Percent_Identity=36.3157894736842, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI218505805, Length=189, Percent_Identity=35.4497354497354, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI310124095, Length=189, Percent_Identity=31.7460317460317, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1789856, Length=529, Percent_Identity=40.0756143667297, Blast_Score=370, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17542894, Length=586, Percent_Identity=30.5460750853242, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17506189, Length=546, Percent_Identity=31.3186813186813, Blast_Score=228, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI212646519, Length=510, Percent_Identity=31.1764705882353, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI193208247, Length=563, Percent_Identity=29.8401420959147, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI72000294, Length=510, Percent_Identity=31.1764705882353, Blast_Score=226, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI193208245, Length=567, Percent_Identity=29.9823633156966, Blast_Score=226, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI72001497, Length=223, Percent_Identity=29.5964125560538, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI72001495, Length=223, Percent_Identity=29.5964125560538, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17564448, Length=440, Percent_Identity=26.5909090909091, Blast_Score=90, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6323330, Length=492, Percent_Identity=29.0650406504065, Blast_Score=156, Evalue=1e-38,
Organism=Drosophila melanogaster, GI18859893, Length=490, Percent_Identity=32.0408163265306, Blast_Score=219, Evalue=5e-57,
Organism=Drosophila melanogaster, GI161077496, Length=522, Percent_Identity=30.2681992337165, Blast_Score=205, Evalue=6e-53,
Organism=Drosophila melanogaster, GI161077878, Length=541, Percent_Identity=27.3567467652495, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI45551474, Length=541, Percent_Identity=27.3567467652495, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI161077880, Length=541, Percent_Identity=27.3567467652495, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24642670, Length=541, Percent_Identity=27.3567467652495, Blast_Score=186, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24642666, Length=541, Percent_Identity=27.3567467652495, Blast_Score=186, Evalue=5e-47,
Organism=Drosophila melanogaster, GI18859741, Length=544, Percent_Identity=26.4705882352941, Blast_Score=155, Evalue=9e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 63192; Mature: 63192

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQITIRIILILLLFSCRETSLTIEGKRISTDLLVTPSHGKTHVDYFSESKNLMIATDSP
CCEEHHHHHHHHHHHHCCCCEEEEECCEECEEEEEECCCCCEEEHEECCCCCEEEEECCC
EATQAGIEVGLLGGNVVDVAVATSFAISVTRPHSTGLGGGGFLILYLKEFSEPIAFDFRE
CHHHCCCEEEEECCCEEEEEEEEEEEEEEECCCCCCCCCCCEEEEEEHHCCCCCEECHHH
RAPNAASRDMYKKKPKEDSLLGFRAVGVPGNVAGLVQIQKRYGKLSLKTVISPAIRLAEK
CCCCCHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
GFPMYPDLQSAIQKSSKDMDQEMKGIFLPGGRVPELKSILVQKDLANSLKLISETGEKEF
CCCCCCCHHHHHHHHHHHHHHHHCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
YHGKIADAITTAMKANGGLITSQDLSDFKVIEKKTLKTKYRDYTIYTMPPPSSGIHLLTM
HCCHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHH
LSMLEKEPLKEMYEKDSALYYHFVTEVMRRGYADRAVFGGDSAFTRIPVDRLLSKKYAEE
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEECCCCCEEECCHHHHHHHHHHHH
KISDFDPKIASSSSSFLKTLNFGVESPQTTHISVMDREGNSISTTQSINFRFGASVVAPG
HHHCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCEECEEEEEEEECCEEECCC
TGIVLNDTMDDFSRAPGEPNVYGLIGAEANSILPKKTPLSSMSPTIVFKGKEPFLTTGAP
CCEEEECCHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCEEECCCC
GGAYIINAVLQSLVYNLDFNLTLYESVARGRIHHQLFPDAVFIEKSVNERNVFDGLSSKK
CHHHHHHHHHHHHHHHCCCCEEHHHHHHHCCHHHHHCCCEEEEECCCCCHHHHCCCCCCC
HDIRIAPNFAKLFSVKRENGMLYGASDPRGEGATGGL
CCEEECCCHHHHHHHHHHCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKQITIRIILILLLFSCRETSLTIEGKRISTDLLVTPSHGKTHVDYFSESKNLMIATDSP
CCEEHHHHHHHHHHHHCCCCEEEEECCEECEEEEEECCCCCEEEHEECCCCCEEEEECCC
EATQAGIEVGLLGGNVVDVAVATSFAISVTRPHSTGLGGGGFLILYLKEFSEPIAFDFRE
CHHHCCCEEEEECCCEEEEEEEEEEEEEEECCCCCCCCCCCEEEEEEHHCCCCCEECHHH
RAPNAASRDMYKKKPKEDSLLGFRAVGVPGNVAGLVQIQKRYGKLSLKTVISPAIRLAEK
CCCCCHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
GFPMYPDLQSAIQKSSKDMDQEMKGIFLPGGRVPELKSILVQKDLANSLKLISETGEKEF
CCCCCCCHHHHHHHHHHHHHHHHCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
YHGKIADAITTAMKANGGLITSQDLSDFKVIEKKTLKTKYRDYTIYTMPPPSSGIHLLTM
HCCHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHH
LSMLEKEPLKEMYEKDSALYYHFVTEVMRRGYADRAVFGGDSAFTRIPVDRLLSKKYAEE
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEECCCCCEEECCHHHHHHHHHHHH
KISDFDPKIASSSSSFLKTLNFGVESPQTTHISVMDREGNSISTTQSINFRFGASVVAPG
HHHCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCEECEEEEEEEECCEEECCC
TGIVLNDTMDDFSRAPGEPNVYGLIGAEANSILPKKTPLSSMSPTIVFKGKEPFLTTGAP
CCEEEECCHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCEEECCCC
GGAYIINAVLQSLVYNLDFNLTLYESVARGRIHHQLFPDAVFIEKSVNERNVFDGLSSKK
CHHHHHHHHHHHHHHHCCCCEEHHHHHHHCCHHHHHCCCEEEEECCCCCHHHHCCCCCCC
HDIRIAPNFAKLFSVKRENGMLYGASDPRGEGATGGL
CCEEECCCHHHHHHHHHHCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]