| Definition | Leptospira borgpetersenii serovar Hardjo-bovis L550 chromosome 1, complete sequence. |
|---|---|
| Accession | NC_008508 |
| Length | 3,614,446 |
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The map label for this gene is clpA-2 [H]
Identifier: 116328082
GI number: 116328082
Start: 1611409
End: 1613640
Strand: Direct
Name: clpA-2 [H]
Synonym: LBL_1379
Alternate gene names: 116328082
Gene position: 1611409-1613640 (Clockwise)
Preceding gene: 116328081
Following gene: 116328083
Centisome position: 44.58
GC content: 42.79
Gene sequence:
>2232_bases ATGATACTCACGGAAGAAATGGAACGTACCCTCAAAAAGGCTTGGGAAGAAGCCAAAAGAAGAAGAAACGAATTTATCAC TCTAGAGCACATCCTTTTCGCTCTTACTTATGATACGGTAGGAAAGGAGGTTCTGGAAGCCTGCGGAGCAGACATAGAAC GTCTGCGAAAGGATTTGATCGGTTATTTAGAAAGTGAGTTGGAGACTCTTCCGGAATCCTCCGACGATCCGATTTATACA ATCGGAGTGCAACATGTTCTTCAACTCGCGGAGTTTCACGTTCAGTCCACAAGAAATAAAAAAATGGACGGAGGAGACGT TCTTGCCGCTCTTTTTCGGGAAGATCAATCGAATGCGGTTTATTTTTTAGGATTACAGGATATTTCCAGACTCGACATCG TTCGTTATATCTCGCACGGAATCCGAAAGGATTCTAAAAATCCCAACAAGGAAATTCAGGGAGAAGAAAATGAGAAAATT TCAGATCCTTTACAAACTTTTTGTGTAGATCTCACTGCGAGAGCCAAAGAAGGAAAGCTCGATCCTATGGTTGGAAGGGA AGAAGAACTTGATCGTACCATTCATATTCTTTGTAGAAGAAGAAAGAACAATCCTATCTTTGTAGGCGAGGCAGGCGTCG GTAAAACCTCAATCGTGGAAGGACTTGCCCAAAGAGTTGTGGATGGAAAAGTTCCTGAACCATTAAAGAATTTGAAAGTA TATTCTCTCGATATGGGACTCTTACTTGCTGGAACCAAGTTTAGGGGAGAATTTGAAGAGAGATTGAAAAACGTAGTCAC TCAAATTACGGCACAGGATGATCATGTCCTATTTATCGACGAGATTCATACGATTATAGGTGCAGGAGCGGTTTCCGGCG GTTCTTTGGACGCTTCTAATCTTTTAAAACCTGCGCTTTCTAGCGGAGAACTTCGTTGTATAGGAACCACGACTTACAAG GAATTCAAATCCATATTCGAAAAAGATCATGCGCTTTCCAGAAGATTTCAAAAAGTGGAGGTAGGCGAACCTTCCGTTTT CGAGACGATAGAAATCTTAAAGGGTCTTTTGAAAAAATACGAATCTTTCCATAAGGTGAAATACTCTTCTTCCGCCGTAG AACAAGCGGCGGAGTTGTCCGCTCGTTATATTCTGGATCGAAAACTTCCGGATAAGGCGATCGATCTTTTGGACGAGGCA GGGGCGAGGGTTCGGCTCAGAGAAGGTGGTAAAAAAACGGTTACTGTTCGAGAGATCGAGGACCTCGTTTCCAAGATCGC AAAAGTTCCTTCGGTTACGGTAAAGGCTGACGATCGCGAAAAACTAAAGAACTTGGATGAAGAATTAAAAACTAAAATCT ACGGACAAGACGCTGCGATTGAACAGTTGGTTCAGTCGATTCGGCTTTCTATAAGTGGACTTTCCGAGCTTGGGAAACCC GTCGGATGTTTTCTTTTTGCAGGACCGACCGGCGTAGGCAAAACCGAACTTACTCGAAAGTTGGCAGAAATCCTGGGTGT GGAACTTGTTCGTTTTGATATGAGCGAGTATATGGAAAAACATACGGTATCTCGTTTAATAGGTTCTCCTCCGGGTTATG TCGGCTTTGAACAGGGAGGGCAACTTACGGATGCGATTTATAGAAACCCACATTGTGTACTTTTGCTCGATGAAATTGAA AAAGCGCACGAGGATATTTATAATATTCTATTACAGATTATGGATCACGCTACACTTACGGATAACAACGGAAGAAAATC AGATTTCCACCAAGTGATACTTGTGATGACGACCAATACGGGAGCGCGTGAGCGTTCTACCAATCCGGTAGGATTTGCCA ATGATCTTTTGGAAGACCGAAGTCTAAAAGCGATCGAAAAGCAGTTTTCTCCCGAGTTCAGAAACCGTTTGACTGCAGTG ATTGAATTCTCTTCTCTAAACCAGGAACATGTGGCTAAAGTGGTTGCAAAACAGCTTGCTCTATTACAGGAAAGATTGAA TTTTAAACAAATTGAACTAGAGTTTCAGGACGATGTGCTTGTCTATATTGCGGACAAAGCCTATACACCCGAGTTCGGCG CAAGACCCGTTCAAAGATGGATCGATACTCATATATCAAAACGGATCTCCGAAGAAATTCTTTTCGGAGCGCTGAAGTCC GGAGGTAAAGTGAAACTGATTTCCGGCCAAGAGGGAATTGAAATGAAATTCACGTCCGGAAAAAAATCCTGA
Upstream 100 bases:
>100_bases ACTCGCACGATGTCGCAAGGACTAAAGTTATACAAGTTCAACAATTGGCGGAACAACATGGATATCCGCTTCACTGTACG ATGGAAGTGGAGGAAGAATC
Downstream 100 bases:
>100_bases AACTCAAATACCAGGATCCAATGAAACAAATCACAATTCGTATCATTCTGATACTTTTACTCTTCTCGTGTAGGGAAACT TCTCTTACCATCGAAGGAAA
Product: ATP-dependent Clp protease ATP-binding subunit
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 743; Mature: 743
Protein sequence:
>743_residues MILTEEMERTLKKAWEEAKRRRNEFITLEHILFALTYDTVGKEVLEACGADIERLRKDLIGYLESELETLPESSDDPIYT IGVQHVLQLAEFHVQSTRNKKMDGGDVLAALFREDQSNAVYFLGLQDISRLDIVRYISHGIRKDSKNPNKEIQGEENEKI SDPLQTFCVDLTARAKEGKLDPMVGREEELDRTIHILCRRRKNNPIFVGEAGVGKTSIVEGLAQRVVDGKVPEPLKNLKV YSLDMGLLLAGTKFRGEFEERLKNVVTQITAQDDHVLFIDEIHTIIGAGAVSGGSLDASNLLKPALSSGELRCIGTTTYK EFKSIFEKDHALSRRFQKVEVGEPSVFETIEILKGLLKKYESFHKVKYSSSAVEQAAELSARYILDRKLPDKAIDLLDEA GARVRLREGGKKTVTVREIEDLVSKIAKVPSVTVKADDREKLKNLDEELKTKIYGQDAAIEQLVQSIRLSISGLSELGKP VGCFLFAGPTGVGKTELTRKLAEILGVELVRFDMSEYMEKHTVSRLIGSPPGYVGFEQGGQLTDAIYRNPHCVLLLDEIE KAHEDIYNILLQIMDHATLTDNNGRKSDFHQVILVMTTNTGARERSTNPVGFANDLLEDRSLKAIEKQFSPEFRNRLTAV IEFSSLNQEHVAKVVAKQLALLQERLNFKQIELEFQDDVLVYIADKAYTPEFGARPVQRWIDTHISKRISEEILFGALKS GGKVKLISGQEGIEMKFTSGKKS
Sequences:
>Translated_743_residues MILTEEMERTLKKAWEEAKRRRNEFITLEHILFALTYDTVGKEVLEACGADIERLRKDLIGYLESELETLPESSDDPIYT IGVQHVLQLAEFHVQSTRNKKMDGGDVLAALFREDQSNAVYFLGLQDISRLDIVRYISHGIRKDSKNPNKEIQGEENEKI SDPLQTFCVDLTARAKEGKLDPMVGREEELDRTIHILCRRRKNNPIFVGEAGVGKTSIVEGLAQRVVDGKVPEPLKNLKV YSLDMGLLLAGTKFRGEFEERLKNVVTQITAQDDHVLFIDEIHTIIGAGAVSGGSLDASNLLKPALSSGELRCIGTTTYK EFKSIFEKDHALSRRFQKVEVGEPSVFETIEILKGLLKKYESFHKVKYSSSAVEQAAELSARYILDRKLPDKAIDLLDEA GARVRLREGGKKTVTVREIEDLVSKIAKVPSVTVKADDREKLKNLDEELKTKIYGQDAAIEQLVQSIRLSISGLSELGKP VGCFLFAGPTGVGKTELTRKLAEILGVELVRFDMSEYMEKHTVSRLIGSPPGYVGFEQGGQLTDAIYRNPHCVLLLDEIE KAHEDIYNILLQIMDHATLTDNNGRKSDFHQVILVMTTNTGARERSTNPVGFANDLLEDRSLKAIEKQFSPEFRNRLTAV IEFSSLNQEHVAKVVAKQLALLQERLNFKQIELEFQDDVLVYIADKAYTPEFGARPVQRWIDTHISKRISEEILFGALKS GGKVKLISGQEGIEMKFTSGKKS >Mature_743_residues MILTEEMERTLKKAWEEAKRRRNEFITLEHILFALTYDTVGKEVLEACGADIERLRKDLIGYLESELETLPESSDDPIYT IGVQHVLQLAEFHVQSTRNKKMDGGDVLAALFREDQSNAVYFLGLQDISRLDIVRYISHGIRKDSKNPNKEIQGEENEKI SDPLQTFCVDLTARAKEGKLDPMVGREEELDRTIHILCRRRKNNPIFVGEAGVGKTSIVEGLAQRVVDGKVPEPLKNLKV YSLDMGLLLAGTKFRGEFEERLKNVVTQITAQDDHVLFIDEIHTIIGAGAVSGGSLDASNLLKPALSSGELRCIGTTTYK EFKSIFEKDHALSRRFQKVEVGEPSVFETIEILKGLLKKYESFHKVKYSSSAVEQAAELSARYILDRKLPDKAIDLLDEA GARVRLREGGKKTVTVREIEDLVSKIAKVPSVTVKADDREKLKNLDEELKTKIYGQDAAIEQLVQSIRLSISGLSELGKP VGCFLFAGPTGVGKTELTRKLAEILGVELVRFDMSEYMEKHTVSRLIGSPPGYVGFEQGGQLTDAIYRNPHCVLLLDEIE KAHEDIYNILLQIMDHATLTDNNGRKSDFHQVILVMTTNTGARERSTNPVGFANDLLEDRSLKAIEKQFSPEFRNRLTAV IEFSSLNQEHVAKVVAKQLALLQERLNFKQIELEFQDDVLVYIADKAYTPEFGARPVQRWIDTHISKRISEEILFGALKS GGKVKLISGQEGIEMKFTSGKKS
Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]
COG id: COG0542
COG function: function code O; ATPases with chaperone activity, ATP-binding subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the clpA/clpB family [H]
Homologues:
Organism=Homo sapiens, GI13540606, Length=299, Percent_Identity=30.7692307692308, Blast_Score=144, Evalue=2e-34, Organism=Escherichia coli, GI1787109, Length=744, Percent_Identity=50.9408602150538, Blast_Score=775, Evalue=0.0, Organism=Escherichia coli, GI1788943, Length=413, Percent_Identity=44.0677966101695, Blast_Score=302, Evalue=7e-83, Organism=Saccharomyces cerevisiae, GI6320464, Length=281, Percent_Identity=51.6014234875445, Blast_Score=268, Evalue=2e-72, Organism=Saccharomyces cerevisiae, GI6323002, Length=249, Percent_Identity=50.2008032128514, Blast_Score=251, Evalue=4e-67,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003593 - InterPro: IPR013093 - InterPro: IPR003959 - InterPro: IPR018368 - InterPro: IPR001270 - InterPro: IPR019489 - InterPro: IPR004176 - InterPro: IPR013461 - InterPro: IPR023150 [H]
Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]
EC number: NA
Molecular weight: Translated: 83434; Mature: 83434
Theoretical pI: Translated: 6.14; Mature: 6.14
Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 1.3 %Met (Translated Protein) 2.2 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 1.3 %Met (Mature Protein) 2.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MILTEEMERTLKKAWEEAKRRRNEFITLEHILFALTYDTVGKEVLEACGADIERLRKDLI CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH GYLESELETLPESSDDPIYTIGVQHVLQLAEFHVQSTRNKKMDGGDVLAALFREDQSNAV HHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEE YFLGLQDISRLDIVRYISHGIRKDSKNPNKEIQGEENEKISDPLQTFCVDLTARAKEGKL EEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCC DPMVGREEELDRTIHILCRRRKNNPIFVGEAGVGKTSIVEGLAQRVVDGKVPEPLKNLKV CCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCHHCCEE YSLDMGLLLAGTKFRGEFEERLKNVVTQITAQDDHVLFIDEIHTIIGAGAVSGGSLDASN EEECCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCCCCCCCHHH LLKPALSSGELRCIGTTTYKEFKSIFEKDHALSRRFQKVEVGEPSVFETIEILKGLLKKY HHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH ESFHKVKYSSSAVEQAAELSARYILDRKLPDKAIDLLDEAGARVRLREGGKKTVTVREIE HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEECCCCCEEEHHHHH DLVSKIAKVPSVTVKADDREKLKNLDEELKTKIYGQDAAIEQLVQSIRLSISGLSELGKP HHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCC VGCFLFAGPTGVGKTELTRKLAEILGVELVRFDMSEYMEKHTVSRLIGSPPGYVGFEQGG EEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC QLTDAIYRNPHCVLLLDEIEKAHEDIYNILLQIMDHATLTDNNGRKSDFHQVILVMTTNT CHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCEEEEEEEEECC GARERSTNPVGFANDLLEDRSLKAIEKQFSPEFRNRLTAVIEFSSLNQEHVAKVVAKQLA CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH LLQERLNFKQIELEFQDDVLVYIADKAYTPEFGARPVQRWIDTHISKRISEEILFGALKS HHHHHCCCEEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC GGKVKLISGQEGIEMKFTSGKKS CCEEEEEECCCCCEEEECCCCCC >Mature Secondary Structure MILTEEMERTLKKAWEEAKRRRNEFITLEHILFALTYDTVGKEVLEACGADIERLRKDLI CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH GYLESELETLPESSDDPIYTIGVQHVLQLAEFHVQSTRNKKMDGGDVLAALFREDQSNAV HHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEE YFLGLQDISRLDIVRYISHGIRKDSKNPNKEIQGEENEKISDPLQTFCVDLTARAKEGKL EEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCC DPMVGREEELDRTIHILCRRRKNNPIFVGEAGVGKTSIVEGLAQRVVDGKVPEPLKNLKV CCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCHHCCEE YSLDMGLLLAGTKFRGEFEERLKNVVTQITAQDDHVLFIDEIHTIIGAGAVSGGSLDASN EEECCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCCCCCCCHHH LLKPALSSGELRCIGTTTYKEFKSIFEKDHALSRRFQKVEVGEPSVFETIEILKGLLKKY HHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH ESFHKVKYSSSAVEQAAELSARYILDRKLPDKAIDLLDEAGARVRLREGGKKTVTVREIE HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEECCCCCEEEHHHHH DLVSKIAKVPSVTVKADDREKLKNLDEELKTKIYGQDAAIEQLVQSIRLSISGLSELGKP HHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCC VGCFLFAGPTGVGKTELTRKLAEILGVELVRFDMSEYMEKHTVSRLIGSPPGYVGFEQGG EEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC QLTDAIYRNPHCVLLLDEIEKAHEDIYNILLQIMDHATLTDNNGRKSDFHQVILVMTTNT CHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCEEEEEEEEECC GARERSTNPVGFANDLLEDRSLKAIEKQFSPEFRNRLTAVIEFSSLNQEHVAKVVAKQLA CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH LLQERLNFKQIELEFQDDVLVYIADKAYTPEFGARPVQRWIDTHISKRISEEILFGALKS HHHHHCCCEEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC GGKVKLISGQEGIEMKFTSGKKS CCEEEEEECCCCCEEEECCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]