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The map label for this gene is acoB [H]

Identifier: 116328022

GI number: 116328022

Start: 1546463

End: 1547437

Strand: Reverse

Name: acoB [H]

Synonym: LBL_1317

Alternate gene names: 116328022

Gene position: 1547437-1546463 (Counterclockwise)

Preceding gene: 116328023

Following gene: 116328021

Centisome position: 42.81

GC content: 50.46

Gene sequence:

>975_bases
ATGGCTATCTTAACATACAGAGAGGCTCTCAACCGCGCGATGTGCGAAGAGATGGATAAGGATCCGAACATCTTTCTCAT
GGGAGAAGAAGTCGGTCACTACGACGGAGCCTACAAAGTTTCGCAAGGGATGCTCGCGAAATACGGAGAAAAAAGAGTCA
TCGATACTCCTATCTCCGAAAACGGTTTTGCCGGAGTGGGAATCGGCGCCGCAATGGTCGGCCTTCGCCCCATTATCGAA
TTTATGACCTGGAATTTTTCTCTCGTGGCGATCGATCAGATCATCAACTCGGCGGCTAAGATGAACTATATGAGCGCGGG
TCAGTTTCCGATTCCGATCGTATTTCGGGGCGCGGGTGGCGCGGGTGGAAGATTGGCGGCTCAACATTCTCAATCGTTTG
AAAGTTGGTATGCGCATATCCCCGGTTTGAAAGTGATCGCGCCTTATACTCCCGCGGACGCTTGCGGACTTTTAAAAACC
GCGATCCGGGACAACAACCCTACGATCTTTATCGAAAGCGAAGTGTTATACGGAAGCAGAGGAGAAGTTCCCGATCAGGA
ATATTCGATTCCCTTCGGAAAGGCGGATCTCAAACGAGAAGGTTCGGATATAACGATTGTTAGCTGGTCGAGAGCCTTGC
AATACGTTCTTCCCGCGGCCGAACGACTTTCGCAGGAAGGAATTTCCGTGGAAGTTTTGGATCTTCGTTCGATCCGACCT
CTGGACGAGGAAGCGATCTACGCTTCCGTTCGTAAAACGAATCGAGCTTTGATCGTGGAAGAAGGCTGGGAAGTGGCCGG
TTTCGGATCGCAAGTCGCTTATCTCATTCAAAAGAATTCCTTCGACGATCTCGACGCACCGGTAGAGCGCATAACGCAGG
AAGACGTTCCGATGCCGTATGCCGCAAATTTGGAAAAGGCCTCTCTTCCGAGTGAAGAAAAAATCATCGCGAAAGTCCGA
GAGATGCTCGAATAA

Upstream 100 bases:

>100_bases
AACTTTCGACGCAAGTGGAAGAATCGATAACGTTTGCGGATCAGAGCGAAGAACCGCCGTTAGGTTGGTTGTATAAAAAC
GTCTACGCGGAGAATGTTTA

Downstream 100 bases:

>100_bases
CGGAGCAAGGAAGATTCAAAATGGCTAAAATTGCAGAGATGACTCAACTCAGTCCCACGATGTCGGAAGGAAAGATCGTC
CGATGGCTCAAACAAAAAGG

Product: pyruvate dehydrogenase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MAILTYREALNRAMCEEMDKDPNIFLMGEEVGHYDGAYKVSQGMLAKYGEKRVIDTPISENGFAGVGIGAAMVGLRPIIE
FMTWNFSLVAIDQIINSAAKMNYMSAGQFPIPIVFRGAGGAGGRLAAQHSQSFESWYAHIPGLKVIAPYTPADACGLLKT
AIRDNNPTIFIESEVLYGSRGEVPDQEYSIPFGKADLKREGSDITIVSWSRALQYVLPAAERLSQEGISVEVLDLRSIRP
LDEEAIYASVRKTNRALIVEEGWEVAGFGSQVAYLIQKNSFDDLDAPVERITQEDVPMPYAANLEKASLPSEEKIIAKVR
EMLE

Sequences:

>Translated_324_residues
MAILTYREALNRAMCEEMDKDPNIFLMGEEVGHYDGAYKVSQGMLAKYGEKRVIDTPISENGFAGVGIGAAMVGLRPIIE
FMTWNFSLVAIDQIINSAAKMNYMSAGQFPIPIVFRGAGGAGGRLAAQHSQSFESWYAHIPGLKVIAPYTPADACGLLKT
AIRDNNPTIFIESEVLYGSRGEVPDQEYSIPFGKADLKREGSDITIVSWSRALQYVLPAAERLSQEGISVEVLDLRSIRP
LDEEAIYASVRKTNRALIVEEGWEVAGFGSQVAYLIQKNSFDDLDAPVERITQEDVPMPYAANLEKASLPSEEKIIAKVR
EMLE
>Mature_323_residues
AILTYREALNRAMCEEMDKDPNIFLMGEEVGHYDGAYKVSQGMLAKYGEKRVIDTPISENGFAGVGIGAAMVGLRPIIEF
MTWNFSLVAIDQIINSAAKMNYMSAGQFPIPIVFRGAGGAGGRLAAQHSQSFESWYAHIPGLKVIAPYTPADACGLLKTA
IRDNNPTIFIESEVLYGSRGEVPDQEYSIPFGKADLKREGSDITIVSWSRALQYVLPAAERLSQEGISVEVLDLRSIRPL
DEEAIYASVRKTNRALIVEEGWEVAGFGSQVAYLIQKNSFDDLDAPVERITQEDVPMPYAANLEKASLPSEEKIIAKVRE
MLE

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156564403, Length=325, Percent_Identity=53.8461538461538, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI291084858, Length=325, Percent_Identity=50.7692307692308, Blast_Score=332, Evalue=2e-91,
Organism=Homo sapiens, GI4557353, Length=319, Percent_Identity=36.9905956112853, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI34101272, Length=319, Percent_Identity=36.9905956112853, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17538422, Length=327, Percent_Identity=55.045871559633, Blast_Score=382, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17506935, Length=318, Percent_Identity=37.7358490566038, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6319698, Length=326, Percent_Identity=51.840490797546, Blast_Score=354, Evalue=1e-98,
Organism=Drosophila melanogaster, GI21358145, Length=325, Percent_Identity=53.5384615384615, Blast_Score=363, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24650940, Length=325, Percent_Identity=53.5384615384615, Blast_Score=363, Evalue=1e-101,
Organism=Drosophila melanogaster, GI160714828, Length=320, Percent_Identity=38.125, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI160714832, Length=320, Percent_Identity=38.125, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24650943, Length=112, Percent_Identity=56.25, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24650945, Length=112, Percent_Identity=56.25, Blast_Score=136, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR000089
- InterPro:   IPR011053
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF00364 Biotin_lipoyl; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35678; Mature: 35547

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILTYREALNRAMCEEMDKDPNIFLMGEEVGHYDGAYKVSQGMLAKYGEKRVIDTPISE
CEEEHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHCHHHHCCCCEEEECCCCC
NGFAGVGIGAAMVGLRPIIEFMTWNFSLVAIDQIINSAAKMNYMSAGQFPIPIVFRGAGG
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCCCCEEEEECCCC
AGGRLAAQHSQSFESWYAHIPGLKVIAPYTPADACGLLKTAIRDNNPTIFIESEVLYGSR
CCCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEEEEEEEECCC
GEVPDQEYSIPFGKADLKREGSDITIVSWSRALQYVLPAAERLSQEGISVEVLDLRSIRP
CCCCCCCCCCCCCCHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCC
LDEEAIYASVRKTNRALIVEEGWEVAGFGSQVAYLIQKNSFDDLDAPVERITQEDVPMPY
CCHHHHHHHHHHCCCEEEEECCCEEECCCHHEEEEEECCCCCCHHHHHHHHHHHCCCCCC
AANLEKASLPSEEKIIAKVREMLE
CCCCHHHCCCCHHHHHHHHHHHHC
>Mature Secondary Structure 
AILTYREALNRAMCEEMDKDPNIFLMGEEVGHYDGAYKVSQGMLAKYGEKRVIDTPISE
EEEHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHCHHHHCCCCEEEECCCCC
NGFAGVGIGAAMVGLRPIIEFMTWNFSLVAIDQIINSAAKMNYMSAGQFPIPIVFRGAGG
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCCCCEEEEECCCC
AGGRLAAQHSQSFESWYAHIPGLKVIAPYTPADACGLLKTAIRDNNPTIFIESEVLYGSR
CCCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEEEEEEEECCC
GEVPDQEYSIPFGKADLKREGSDITIVSWSRALQYVLPAAERLSQEGISVEVLDLRSIRP
CCCCCCCCCCCCCCHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCC
LDEEAIYASVRKTNRALIVEEGWEVAGFGSQVAYLIQKNSFDDLDAPVERITQEDVPMPY
CCHHHHHHHHHHCCCEEEEECCCEEECCCHHEEEEEECCCCCCHHHHHHHHHHHCCCCCC
AANLEKASLPSEEKIIAKVREMLE
CCCCHHHCCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]