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The map label for this gene is acoA [H]

Identifier: 116328023

GI number: 116328023

Start: 1547437

End: 1548420

Strand: Reverse

Name: acoA [H]

Synonym: LBL_1318

Alternate gene names: 116328023

Gene position: 1548420-1547437 (Counterclockwise)

Preceding gene: 116328031

Following gene: 116328022

Centisome position: 42.84

GC content: 49.19

Gene sequence:

>984_bases
ATGAACAACCATCCCAAAACTAAAAAAGAAACCCAGGACCTGTTCGAACTCTACAAACAAATGCTCCTCATCCGAAGATT
CGAGGAAGGCGCCGCAAAATCCTACAGCACCGGGAAGATCGGCGGATTCTGCCACCTCTACATCGGTCAAGAAGCGGTCG
GAGTCGGATCGATCGCGGCTCTTCAAGAACAAGACTACATCGTATCCACTTACAGAGACCACGGCCACGCACTTGCAAGA
GGTTTGGACCCGAAGGCTTTGATGGCGGAACTCTTCGGAAAAAAAACGGGAATCTCCAGCGGTTACGGAGGTTCGATGCA
CTTCTTTGATAAGAGCAAAAGGTTTATGGGTGGTCATGGAATCGTGGGAGGCCATATCTCTCTCGCCGCCGGAATTGCGT
ATGCGTCCAAATTTAAAAACGAGAACTCGGTCACGATTTGTTTTTTCGGAGAAGGCGCCGCCAACATCGGTTCCTTTCAC
GAAGGAATGAATCTCGCCGCAATCTGGAAACTTCCCCTCGTGATGATCTGCGAAAACAATCACTACGCGATGGGAACTCC
CGAATATCGCGCGTTATCCGTAAAAGACGTTTCGGTTCGTGCAGGCGCCTACGACATCGCAAGAGATCACATCGAGGGAG
ACGAAGTTCGTAAAGTCCGAGATCACGTCAGTGTTGCCGTCGAACGAGCGCGCAGAGGAGAAGGCCCTACTCTTATGGAA
ATTTCCACGTATCGTTTCCGGGGACATTCCATGTCCGATCCCGCAAAATACAGAACCAAGGAAGAATTGGATCGTTACAA
ACAAAGCGATCCTTTGCTCCGAGCCAAACAGGATCTTCTCCATTCGGAATGGACGGAAGAAGAATTAGAAAAACTTGATA
TGGAACTTTCGACGCAAGTGGAAGAATCGATAACGTTTGCGGATCAGAGCGAAGAACCGCCGTTAGGTTGGTTGTATAAA
AACGTCTACGCGGAGAATGTTTAA

Upstream 100 bases:

>100_bases
CAATCCAAATCTTTGGAATTTTTTTTAAGTGGAAACGAAATCGGTTTGCATAAGTCGCTTCTGAAAAGATACTTTGCGAT
TGTTTTCAAAATCTAATTTT

Downstream 100 bases:

>100_bases
TGGCTATCTTAACATACAGAGAGGCTCTCAACCGCGCGATGTGCGAAGAGATGGATAAGGATCCGAACATCTTTCTCATG
GGAGAAGAAGTCGGTCACTA

Product: pyruvate dehydrogenase (lipoamide), alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MNNHPKTKKETQDLFELYKQMLLIRRFEEGAAKSYSTGKIGGFCHLYIGQEAVGVGSIAALQEQDYIVSTYRDHGHALAR
GLDPKALMAELFGKKTGISSGYGGSMHFFDKSKRFMGGHGIVGGHISLAAGIAYASKFKNENSVTICFFGEGAANIGSFH
EGMNLAAIWKLPLVMICENNHYAMGTPEYRALSVKDVSVRAGAYDIARDHIEGDEVRKVRDHVSVAVERARRGEGPTLME
ISTYRFRGHSMSDPAKYRTKEELDRYKQSDPLLRAKQDLLHSEWTEEELEKLDMELSTQVEESITFADQSEEPPLGWLYK
NVYAENV

Sequences:

>Translated_327_residues
MNNHPKTKKETQDLFELYKQMLLIRRFEEGAAKSYSTGKIGGFCHLYIGQEAVGVGSIAALQEQDYIVSTYRDHGHALAR
GLDPKALMAELFGKKTGISSGYGGSMHFFDKSKRFMGGHGIVGGHISLAAGIAYASKFKNENSVTICFFGEGAANIGSFH
EGMNLAAIWKLPLVMICENNHYAMGTPEYRALSVKDVSVRAGAYDIARDHIEGDEVRKVRDHVSVAVERARRGEGPTLME
ISTYRFRGHSMSDPAKYRTKEELDRYKQSDPLLRAKQDLLHSEWTEEELEKLDMELSTQVEESITFADQSEEPPLGWLYK
NVYAENV
>Mature_327_residues
MNNHPKTKKETQDLFELYKQMLLIRRFEEGAAKSYSTGKIGGFCHLYIGQEAVGVGSIAALQEQDYIVSTYRDHGHALAR
GLDPKALMAELFGKKTGISSGYGGSMHFFDKSKRFMGGHGIVGGHISLAAGIAYASKFKNENSVTICFFGEGAANIGSFH
EGMNLAAIWKLPLVMICENNHYAMGTPEYRALSVKDVSVRAGAYDIARDHIEGDEVRKVRDHVSVAVERARRGEGPTLME
ISTYRFRGHSMSDPAKYRTKEELDRYKQSDPLLRAKQDLLHSEWTEEELEKLDMELSTQVEESITFADQSEEPPLGWLYK
NVYAENV

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=315, Percent_Identity=40.3174603174603, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI4505685, Length=318, Percent_Identity=40.8805031446541, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI291084742, Length=318, Percent_Identity=40.8805031446541, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI291084744, Length=325, Percent_Identity=40, Blast_Score=223, Evalue=1e-58,
Organism=Homo sapiens, GI291084757, Length=318, Percent_Identity=36.7924528301887, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI11386135, Length=324, Percent_Identity=32.7160493827161, Blast_Score=148, Evalue=6e-36,
Organism=Homo sapiens, GI258645172, Length=327, Percent_Identity=33.3333333333333, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17536047, Length=328, Percent_Identity=38.719512195122, Blast_Score=230, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI32564172, Length=328, Percent_Identity=38.719512195122, Blast_Score=230, Evalue=9e-61,
Organism=Caenorhabditis elegans, GI86563357, Length=323, Percent_Identity=29.7213622291022, Blast_Score=130, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI86563355, Length=323, Percent_Identity=29.7213622291022, Blast_Score=130, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6321026, Length=325, Percent_Identity=38.7692307692308, Blast_Score=226, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24639748, Length=332, Percent_Identity=40.6626506024096, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24639744, Length=332, Percent_Identity=38.5542168674699, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI28571106, Length=332, Percent_Identity=38.5542168674699, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24639740, Length=332, Percent_Identity=38.5542168674699, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24639746, Length=310, Percent_Identity=39.0322580645161, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI21355903, Length=328, Percent_Identity=26.8292682926829, Blast_Score=129, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 36615; Mature: 36615

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNHPKTKKETQDLFELYKQMLLIRRFEEGAAKSYSTGKIGGFCHLYIGQEAVGVGSIAA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCHHHH
LQEQDYIVSTYRDHGHALARGLDPKALMAELFGKKTGISSGYGGSMHFFDKSKRFMGGHG
HHCCCEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHCCCCC
IVGGHISLAAGIAYASKFKNENSVTICFFGEGAANIGSFHEGMNLAAIWKLPLVMICENN
EECCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHCCCCEEEEECCCEEEEECCC
HYAMGTPEYRALSVKDVSVRAGAYDIARDHIEGDEVRKVRDHVSVAVERARRGEGPTLME
EEECCCCCCEEEEEEEEEEECCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEE
ISTYRFRGHSMSDPAKYRTKEELDRYKQSDPLLRAKQDLLHSEWTEEELEKLDMELSTQV
EEEEEECCCCCCCCHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
EESITFADQSEEPPLGWLYKNVYAENV
HHHHEECCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MNNHPKTKKETQDLFELYKQMLLIRRFEEGAAKSYSTGKIGGFCHLYIGQEAVGVGSIAA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCHHHH
LQEQDYIVSTYRDHGHALARGLDPKALMAELFGKKTGISSGYGGSMHFFDKSKRFMGGHG
HHCCCEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHCCCCC
IVGGHISLAAGIAYASKFKNENSVTICFFGEGAANIGSFHEGMNLAAIWKLPLVMICENN
EECCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHCCCCEEEEECCCEEEEECCC
HYAMGTPEYRALSVKDVSVRAGAYDIARDHIEGDEVRKVRDHVSVAVERARRGEGPTLME
EEECCCCCCEEEEEEEEEEECCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEE
ISTYRFRGHSMSDPAKYRTKEELDRYKQSDPLLRAKQDLLHSEWTEEELEKLDMELSTQV
EEEEEECCCCCCCCHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
EESITFADQSEEPPLGWLYKNVYAENV
HHHHEECCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]