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The map label for this gene is ubiB [C]

Identifier: 116327612

GI number: 116327612

Start: 980000

End: 981706

Strand: Direct

Name: ubiB [C]

Synonym: LBL_0844

Alternate gene names: 116327612

Gene position: 980000-981706 (Clockwise)

Preceding gene: 116327611

Following gene: 116327613

Centisome position: 27.11

GC content: 42.36

Gene sequence:

>1707_bases
ATGCTCGTTTCTTCCGCAGCCGAACCTCAGGAAATCCAGTCATACAAACGACACGGTAGTTCCTGGAGATTTTGGAATGC
GAGTTCTTTCGTCTGGAAAAAGATATGGTCTATATTCTGGTTTTTTAAACTGGGAAAAATCTTTTTTCCTTCCTATAGGG
ATAGGGTCGTTCAGGAAAAATTCTTTCGTACATTAGGAGAGGATTGCCGTAATTTTTTCTTATCCATGGGGGGAGTTTAT
ATCAAGCTCGGTCAGTATCTCGGAAACCTCTCCCATGTTTTTCCGGATTCGTTTACCGAATCTCTTCAAGATCTTCAGGA
CAGAGTTCCTCCTCATCCCTTTTCGGAAATCGAAGAACGTTTCCGTTTGGAATTCGGGAAAGAAATCACGAAAGTTTTTC
CGGACATTCTAAGCGTTCCCGAGGCGAGCGCGTCCACGGCTCAGGTCCACGTCGCTTCCATCGGGGGTCAGAAGGTTGCG
GTAAAAGTTTTATATCCCGGAATCGAGACCTTGATTGCGGACGATTTGAGGAATATTCGCTCTTTTTTGAAAAGAATCAA
TCGTTATTTATTTCGTTTCGAATACAAAAAAATCCACGATGAAATCACCCATCTTATAACCAGAGAAACCAACCTTCAAT
TGGAAGCGGATTCTTATGATCGGATGAGACAACTTTTCGCTGAAGAACCGGATTACGTATTTCCGAAAGTGATCCGCCCA
TTTTTAGGTAAAAGTGTTTTGGTTACGGAATTTATAGAAGGGGTTAAGATTACAAGAGCGGTTCCCGTACTCAAAGGTCA
GGCCAAGTCCAGGCCTGTGGAACTTCTTGTTCGTGCCTATGTGTTGATGATTTTTCAGTACCGTTTTTATCATGCGGACC
CGCATCCCGGAAATTTAATTTACACGAAAGATGAAAAACTTTGTTTCATCGATTTCGGAGCTGTGGGAGAAATGAATGCG
AATAGGGCTTTTGCTCTGAAACAAATCTTTCTCTGTGCAATTGTCAAAGATTATTACGGAGTCGTTTCCGGTCTGGACGA
CATAGGCGCATTATCCGTTTCTGCGGATCGGGATAAACTCGAAGAGGTTGTTCGTTACTCTTTGGAAAAGTTGGGAAGGT
TTATCGCGGACACGGATTACTTCCGGAATCTTTCTCTGGAACAGATTCATACTAGGGAGGATCGACTTTTCTTAAAGGAG
ATCAATTCCAGTCTGAAGGAAATTTTTAGAATGATTCAGATGCCGGAAAATTTTATTTTCTTAGAACGTGTTCTGGGATT
ACTGGTAGGGATTACCGCGATTTTGGATCCTTATAGAACCGTTTTGGACTACGGGGAAAAACCGTTCCGGGCCGTCGCCA
CCGGAAAAGAAGGCGGACTGGAGTTTTCTTTGTTAAACGAAGATAAGAATCTTTTAAGCCATGCCCTTTCCATTCCGGGG
GAATTTTATAAAGTACTTCAGAACATCAATCGGGGAAGACTTCAACTCCGAGAGGTGGAGCAACACACTCGGAAGATGTA
TGTTCTGGGACATCAGTTTTTATATTCCGGATTCCTGGTTGCGGGAATTCATTTCGGAAATTATTATCTCGAAAGAGGAA
TGGAAATTCAAGGTTGGGGATTTTGGGGAATCTCCGGATTTTTTGGACTGTTAGTTATTTATTCATTTTGGAAACACAAA
CTTAAAAAGAAAGGAACTCTCTCGTGA

Upstream 100 bases:

>100_bases
TCACCGGGGATATGGAGGAGAATCTTCAAATTCTCACCTTACTGGATACGATCCGGAGAAGAGCCGAAAAAAGATTCCTG
GGGGTTTAGAAGTTTCACGT

Downstream 100 bases:

>100_bases
AATATTTTGAAAAACGATTTTTAGACGTCTATCGCCCTCTTTATATAGGCGTTATCTTTCTCGGGATCATATTGGATCTT
GTGACTAAGTTTCTCGTCAT

Product: protein kinase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 568; Mature: 568

Protein sequence:

>568_residues
MLVSSAAEPQEIQSYKRHGSSWRFWNASSFVWKKIWSIFWFFKLGKIFFPSYRDRVVQEKFFRTLGEDCRNFFLSMGGVY
IKLGQYLGNLSHVFPDSFTESLQDLQDRVPPHPFSEIEERFRLEFGKEITKVFPDILSVPEASASTAQVHVASIGGQKVA
VKVLYPGIETLIADDLRNIRSFLKRINRYLFRFEYKKIHDEITHLITRETNLQLEADSYDRMRQLFAEEPDYVFPKVIRP
FLGKSVLVTEFIEGVKITRAVPVLKGQAKSRPVELLVRAYVLMIFQYRFYHADPHPGNLIYTKDEKLCFIDFGAVGEMNA
NRAFALKQIFLCAIVKDYYGVVSGLDDIGALSVSADRDKLEEVVRYSLEKLGRFIADTDYFRNLSLEQIHTREDRLFLKE
INSSLKEIFRMIQMPENFIFLERVLGLLVGITAILDPYRTVLDYGEKPFRAVATGKEGGLEFSLLNEDKNLLSHALSIPG
EFYKVLQNINRGRLQLREVEQHTRKMYVLGHQFLYSGFLVAGIHFGNYYLERGMEIQGWGFWGISGFFGLLVIYSFWKHK
LKKKGTLS

Sequences:

>Translated_568_residues
MLVSSAAEPQEIQSYKRHGSSWRFWNASSFVWKKIWSIFWFFKLGKIFFPSYRDRVVQEKFFRTLGEDCRNFFLSMGGVY
IKLGQYLGNLSHVFPDSFTESLQDLQDRVPPHPFSEIEERFRLEFGKEITKVFPDILSVPEASASTAQVHVASIGGQKVA
VKVLYPGIETLIADDLRNIRSFLKRINRYLFRFEYKKIHDEITHLITRETNLQLEADSYDRMRQLFAEEPDYVFPKVIRP
FLGKSVLVTEFIEGVKITRAVPVLKGQAKSRPVELLVRAYVLMIFQYRFYHADPHPGNLIYTKDEKLCFIDFGAVGEMNA
NRAFALKQIFLCAIVKDYYGVVSGLDDIGALSVSADRDKLEEVVRYSLEKLGRFIADTDYFRNLSLEQIHTREDRLFLKE
INSSLKEIFRMIQMPENFIFLERVLGLLVGITAILDPYRTVLDYGEKPFRAVATGKEGGLEFSLLNEDKNLLSHALSIPG
EFYKVLQNINRGRLQLREVEQHTRKMYVLGHQFLYSGFLVAGIHFGNYYLERGMEIQGWGFWGISGFFGLLVIYSFWKHK
LKKKGTLS
>Mature_568_residues
MLVSSAAEPQEIQSYKRHGSSWRFWNASSFVWKKIWSIFWFFKLGKIFFPSYRDRVVQEKFFRTLGEDCRNFFLSMGGVY
IKLGQYLGNLSHVFPDSFTESLQDLQDRVPPHPFSEIEERFRLEFGKEITKVFPDILSVPEASASTAQVHVASIGGQKVA
VKVLYPGIETLIADDLRNIRSFLKRINRYLFRFEYKKIHDEITHLITRETNLQLEADSYDRMRQLFAEEPDYVFPKVIRP
FLGKSVLVTEFIEGVKITRAVPVLKGQAKSRPVELLVRAYVLMIFQYRFYHADPHPGNLIYTKDEKLCFIDFGAVGEMNA
NRAFALKQIFLCAIVKDYYGVVSGLDDIGALSVSADRDKLEEVVRYSLEKLGRFIADTDYFRNLSLEQIHTREDRLFLKE
INSSLKEIFRMIQMPENFIFLERVLGLLVGITAILDPYRTVLDYGEKPFRAVATGKEGGLEFSLLNEDKNLLSHALSIPG
EFYKVLQNINRGRLQLREVEQHTRKMYVLGHQFLYSGFLVAGIHFGNYYLERGMEIQGWGFWGISGFFGLLVIYSFWKHK
LKKKGTLS

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=270, Percent_Identity=29.2592592592593, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI40254938, Length=243, Percent_Identity=27.9835390946502, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI27363457, Length=256, Percent_Identity=25.78125, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI34147522, Length=203, Percent_Identity=27.5862068965517, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI217416386, Length=199, Percent_Identity=27.6381909547739, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI2367309, Length=320, Percent_Identity=27.8125, Blast_Score=113, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17559152, Length=283, Percent_Identity=26.1484098939929, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI32565180, Length=275, Percent_Identity=26.5454545454545, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323282, Length=273, Percent_Identity=28.2051282051282, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6321319, Length=276, Percent_Identity=26.0869565217391, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6325148, Length=251, Percent_Identity=25.0996015936255, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24662575, Length=311, Percent_Identity=28.6173633440514, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI22024280, Length=225, Percent_Identity=27.1111111111111, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI18859849, Length=325, Percent_Identity=24.3076923076923, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 65911; Mature: 65911

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVSSAAEPQEIQSYKRHGSSWRFWNASSFVWKKIWSIFWFFKLGKIFFPSYRDRVVQEK
CCCCCCCCHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
FFRTLGEDCRNFFLSMGGVYIKLGQYLGNLSHVFPDSFTESLQDLQDRVPPHPFSEIEER
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHH
FRLEFGKEITKVFPDILSVPEASASTAQVHVASIGGQKVAVKVLYPGIETLIADDLRNIR
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHH
SFLKRINRYLFRFEYKKIHDEITHLITRETNLQLEADSYDRMRQLFAEEPDYVFPKVIRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHCCCCCCCHHHHHH
FLGKSVLVTEFIEGVKITRAVPVLKGQAKSRPVELLVRAYVLMIFQYRFYHADPHPGNLI
HHCCHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
YTKDEKLCFIDFGAVGEMNANRAFALKQIFLCAIVKDYYGVVSGLDDIGALSVSADRDKL
EECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCEECCCCHHHH
EEVVRYSLEKLGRFIADTDYFRNLSLEQIHTREDRLFLKEINSSLKEIFRMIQMPENFIF
HHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LERVLGLLVGITAILDPYRTVLDYGEKPFRAVATGKEGGLEFSLLNEDKNLLSHALSIPG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCEEEEEECCHHHHHHHHHHCCH
EFYKVLQNINRGRLQLREVEQHTRKMYVLGHQFLYSGFLVAGIHFGNYYLERGMEIQGWG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
FWGISGFFGLLVIYSFWKHKLKKKGTLS
CHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLVSSAAEPQEIQSYKRHGSSWRFWNASSFVWKKIWSIFWFFKLGKIFFPSYRDRVVQEK
CCCCCCCCHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
FFRTLGEDCRNFFLSMGGVYIKLGQYLGNLSHVFPDSFTESLQDLQDRVPPHPFSEIEER
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHH
FRLEFGKEITKVFPDILSVPEASASTAQVHVASIGGQKVAVKVLYPGIETLIADDLRNIR
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHH
SFLKRINRYLFRFEYKKIHDEITHLITRETNLQLEADSYDRMRQLFAEEPDYVFPKVIRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHCCCCCCCHHHHHH
FLGKSVLVTEFIEGVKITRAVPVLKGQAKSRPVELLVRAYVLMIFQYRFYHADPHPGNLI
HHCCHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
YTKDEKLCFIDFGAVGEMNANRAFALKQIFLCAIVKDYYGVVSGLDDIGALSVSADRDKL
EECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCEECCCCHHHH
EEVVRYSLEKLGRFIADTDYFRNLSLEQIHTREDRLFLKEINSSLKEIFRMIQMPENFIF
HHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LERVLGLLVGITAILDPYRTVLDYGEKPFRAVATGKEGGLEFSLLNEDKNLLSHALSIPG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCEEEEEECCHHHHHHHHHHCCH
EFYKVLQNINRGRLQLREVEQHTRKMYVLGHQFLYSGFLVAGIHFGNYYLERGMEIQGWG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
FWGISGFFGLLVIYSFWKHKLKKKGTLS
CHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]