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The map label for this gene is ilvC

Identifier: 116326980

GI number: 116326980

Start: 175773

End: 176774

Strand: Direct

Name: ilvC

Synonym: LBL_0149

Alternate gene names: 116326980

Gene position: 175773-176774 (Clockwise)

Preceding gene: 116326979

Following gene: 116326981

Centisome position: 4.86

GC content: 43.51

Gene sequence:

>1002_bases
ATGGCAAATATCTATTACGACGCCGATTGTGATTTAAGCTCTCTAAAAGGAAAAACCATCGCAGTAATCGGTTACGGAAG
TCAGGGACATGCTCAGGCTCAAAATATGAAAGATTCCGGGCTTAAAGTTATCATTGGTTTAAAAGAAGGATCCAAATCAA
TTCAAGATGCCAAGAATGCAGGCTTTGAAGTATACAGTGTTGCCGAAGCTTCTCAAAAAGCGGATGTCATACAAATTCTC
GCCCCGGATACGATTCAAGCGGATCTTTATAAAAAAGATATTGAACCGAATCTGAAAAAAGGGAATGCACTCGTTTTTTC
TCACGGATTCAACATTCACTACGATTTCATCAAACCTCCTGAAGAGGTGGATGTTTATATGGTTGCTCCTAAAGGTCCGG
GCCATCTTGTTCGTAGAGTTTATACGGAAGGCGGGGGAGTTCCATGTTTGATTGCGGTTCATCAGGATTCAACTGGCGAG
GCTAAAAAAAGGGCGCTTGCTCATGCCGCCGGTGTCGGAGGCGGTCGTGCAGGAATTTTGGAAACATCTTTTCGTGAAGA
AACCGAAACGGACTTATTCGGAGAACAGGTTGTTCTTTGCGGCGGTCTTTCCAATCTAATCATGGCCGGGTTTGAAACTT
TAACCGAAGCAGGTTATGATCCTGAAATCGCGTACTTCGAGTGTCTTCATGAAGTGAAACTCATCACCGATCTCATCTAC
GAAGGCGGATTGGCAAGAATGAGGTTTTCTATTTCCGATACCGCGGAATACGGCGATTACGTAAGCGGCCCGCGCGTAAT
TGACCCAGGTGTAAAACAAAGAATGAAAGAAGTTCTGAACGATATTCAGAAAGATAAGGGAGCAAAATTCGCAACCAACT
GGATGGCTGAAACGAAAGCCGGTTACCCAAACTTTAAAAATATGAGAGATAAGAACGCGGCTCATCCGATCGAATCGGTT
GGTAAAAAACTGAGAAGTATGATGAAGTGGTTATCTAAGTAA

Upstream 100 bases:

>100_bases
CTGTGTTTCATAAAACAATACAACTTATAGGTTGTATTAAAGTTGTCATTCTATCCTTTTTTAAATGTTTTGTAAAAAGG
AACATTCAAGGAAAAGAAAA

Downstream 100 bases:

>100_bases
ACGGATAATTTCGTTTCAAAGTCTTTTTTTGATGAAAAGCCCGGCGGACTTTTTAGTTCTCCGGGTTTTTTATGTGCTTA
GCGAATATTGTAAAACAAGT

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MANIYYDADCDLSSLKGKTIAVIGYGSQGHAQAQNMKDSGLKVIIGLKEGSKSIQDAKNAGFEVYSVAEASQKADVIQIL
APDTIQADLYKKDIEPNLKKGNALVFSHGFNIHYDFIKPPEEVDVYMVAPKGPGHLVRRVYTEGGGVPCLIAVHQDSTGE
AKKRALAHAAGVGGGRAGILETSFREETETDLFGEQVVLCGGLSNLIMAGFETLTEAGYDPEIAYFECLHEVKLITDLIY
EGGLARMRFSISDTAEYGDYVSGPRVIDPGVKQRMKEVLNDIQKDKGAKFATNWMAETKAGYPNFKNMRDKNAAHPIESV
GKKLRSMMKWLSK

Sequences:

>Translated_333_residues
MANIYYDADCDLSSLKGKTIAVIGYGSQGHAQAQNMKDSGLKVIIGLKEGSKSIQDAKNAGFEVYSVAEASQKADVIQIL
APDTIQADLYKKDIEPNLKKGNALVFSHGFNIHYDFIKPPEEVDVYMVAPKGPGHLVRRVYTEGGGVPCLIAVHQDSTGE
AKKRALAHAAGVGGGRAGILETSFREETETDLFGEQVVLCGGLSNLIMAGFETLTEAGYDPEIAYFECLHEVKLITDLIY
EGGLARMRFSISDTAEYGDYVSGPRVIDPGVKQRMKEVLNDIQKDKGAKFATNWMAETKAGYPNFKNMRDKNAAHPIESV
GKKLRSMMKWLSK
>Mature_332_residues
ANIYYDADCDLSSLKGKTIAVIGYGSQGHAQAQNMKDSGLKVIIGLKEGSKSIQDAKNAGFEVYSVAEASQKADVIQILA
PDTIQADLYKKDIEPNLKKGNALVFSHGFNIHYDFIKPPEEVDVYMVAPKGPGHLVRRVYTEGGGVPCLIAVHQDSTGEA
KKRALAHAAGVGGGRAGILETSFREETETDLFGEQVVLCGGLSNLIMAGFETLTEAGYDPEIAYFECLHEVKLITDLIYE
GGLARMRFSISDTAEYGDYVSGPRVIDPGVKQRMKEVLNDIQKDKGAKFATNWMAETKAGYPNFKNMRDKNAAHPIESVG
KKLRSMMKWLSK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=297, Percent_Identity=36.7003367003367, Blast_Score=155, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6323387, Length=281, Percent_Identity=35.2313167259786, Blast_Score=137, Evalue=2e-33,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_LEPBJ (Q04P56)

Other databases:

- EMBL:   CP000350
- RefSeq:   YP_802072.1
- ProteinModelPortal:   Q04P56
- SMR:   Q04P56
- STRING:   Q04P56
- GeneID:   4411841
- GenomeReviews:   CP000350_GR
- KEGG:   lbj:LBJ_2914
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- PhylomeDB:   Q04P56
- ProtClustDB:   PRK05479
- BioCyc:   LBOR355277:LBJ_2914-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36364; Mature: 36233

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANIYYDADCDLSSLKGKTIAVIGYGSQGHAQAQNMKDSGLKVIIGLKEGSKSIQDAKNA
CCCEEECCCCCHHHCCCCEEEEEEECCCCCHHHHCCCCCCCEEEEEECCCCHHHHHHHHC
GFEVYSVAEASQKADVIQILAPDTIQADLYKKDIEPNLKKGNALVFSHGFNIHYDFIKPP
CEEEEEEHHHHCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCEEEEECCCEEEECCCCCC
EEVDVYMVAPKGPGHLVRRVYTEGGGVPCLIAVHQDSTGEAKKRALAHAAGVGGGRAGIL
CCCEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCE
ETSFREETETDLFGEQVVLCGGLSNLIMAGFETLTEAGYDPEIAYFECLHEVKLITDLIY
ECHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGLARMRFSISDTAEYGDYVSGPRVIDPGVKQRMKEVLNDIQKDKGAKFATNWMAETKA
HCCCEEEEEECCCHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
GYPNFKNMRDKNAAHPIESVGKKLRSMMKWLSK
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ANIYYDADCDLSSLKGKTIAVIGYGSQGHAQAQNMKDSGLKVIIGLKEGSKSIQDAKNA
CCEEECCCCCHHHCCCCEEEEEEECCCCCHHHHCCCCCCCEEEEEECCCCHHHHHHHHC
GFEVYSVAEASQKADVIQILAPDTIQADLYKKDIEPNLKKGNALVFSHGFNIHYDFIKPP
CEEEEEEHHHHCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCEEEEECCCEEEECCCCCC
EEVDVYMVAPKGPGHLVRRVYTEGGGVPCLIAVHQDSTGEAKKRALAHAAGVGGGRAGIL
CCCEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCE
ETSFREETETDLFGEQVVLCGGLSNLIMAGFETLTEAGYDPEIAYFECLHEVKLITDLIY
ECHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGLARMRFSISDTAEYGDYVSGPRVIDPGVKQRMKEVLNDIQKDKGAKFATNWMAETKA
HCCCEEEEEECCCHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
GYPNFKNMRDKNAAHPIESVGKKLRSMMKWLSK
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA