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The map label for this gene is tlpA [H]

Identifier: 116326979

GI number: 116326979

Start: 172868

End: 175273

Strand: Direct

Name: tlpA [H]

Synonym: LBL_0148

Alternate gene names: 116326979

Gene position: 172868-175273 (Clockwise)

Preceding gene: 116326976

Following gene: 116326980

Centisome position: 4.78

GC content: 38.65

Gene sequence:

>2406_bases
ATGGCAGGTTTTCCATTTTACACATCTTGGTCCGTCTTTCATAGATGGGTGGTGATTCCTTCTCCCTTTTTGGGAGTTTT
ATTTCTGATCATGTTCTTTTTTAAATATCCGGAGCCGGTTTCCAAAAAAATAATGATTCCGGCATTTTCAATCGCTTTGT
CGGGAGTGGTCGTTATCTGTGTTTGGTATTTTTACGAATCTTTCTCCGCAAAAAGAGTCTTTTACTTCTCGGGCCATTAT
TGGGACTTTCAAGTTAATTTCTTTTATAAGGTCTATGCCGTAGCTATCATTTTTTATACCTTTCTTTTTGTTGGAATCGG
TATCTGGAGAATGATAACTCTCAAAGGCAAGGACAGAATTATTACCGGAATCGTTTTAATACCCATGGCCTCGATTATTT
TGATTCCGGGAGTGTTCAATGCGATGAGCCGAGACGGAGCGGTTTCCAGAGAATTGTATCAAACGGTTTTGGACATTTCT
CTCGTAACCGGTTTGTTTGTCGTGCTTGTGGGTTATATTAACTATACGAGTGAAAAGACTTCCATTCTTTCCAGAATTAC
CGGAATCACACTCGCTACGTTTTTTCTAATTCTACAGATCGTAAGTATATTTATTTTCAATCAATATGAAGAATCGTACG
ACTTAATTAAAAAAACAGAGGCTAGACTTTCCGCGGCCGGTTTAGAAGTTTCCAAAGATTTGGAATACGTTTTCCAGTAC
GATCCTGGGACGGATTCGGTAACGTCTCTCTTTCCGGGAAATTCTCAACAACCGGACGAATCCACGCTGAGAGAATTCCG
TTTTTTTAAAATAACCCATAATCTTTTCGAACTTCCTTCTCTTCCCAACGAGGAATTTAAACAAAGTGTGGAAGATATAT
TAAAAAATTCTCCCTTCGGTTTCGATGCGTATAAAGCGGGAGTAAAAGAATATCTTTCTTCTAAAAACGAAACTCGACTT
TCGGGGAAGGACATAGAATCGTTTTTTGACGCTTTACAAAACACGTTAGTTGTGCTTAGGAACAAACACTTCCACTTGCC
TCCCAAGGAAAAAAACGATCCGGCTTCCGAAAAAAGAGATAAAATTTTTGATACATTTCTTACACAGATAAGAAAGCAGG
ACGAAAGAACGTACAAAGGGGAAAGAGTTTATGAATTAAACGGTCCGGTTCCCAAACATTACATTTCTTACTTTTACGTA
TCTGGAGGAAAAATTTATGAAGTAGGATTTCGATACGAATCTTTAAGGGAATATCTCCATCCTACCGGTAAAATCCTTTA
TATGTCTGCGATTTGTATTTTGTTTCTTGTTTTATTTGGATTCCGTTTTTTCTTTCAAGGAGCTTTATTGAATCCTCTCG
AGGATGTAGTGGTCGGTTTAAGGGAAGCCAATTCCGGAAACTTAGAATACCGTCTTCAAGTTAAGGTAGAGGATGAAATC
GGATTTATTGCTCGTTCGTTTAACAAAATGGCAAAGTCCATTCAAATGACAAGAAAACGTCTTCATTCTTCTGCGGAGAC
ATTGGAGATTTCGGTGACGGATTTTTCGGAATTTACGAGTTTAACCAGTGCAAAAATGGAATCTCAAGCAGCTTCTTTAG
AAGAGGTCAATGCAGTGATTGAGTCCTTATCAAAAGCTTCTGAAAAGAATGTCGACTCGATTCGAATTCAAAACGAGAAT
CTGATCGAACTCAATCAAAAGTCTCAGGTTCTTTTGGATGTAATCGCGAAGATATCGGACCATTCTAAAGGTTTGGATAC
GAATGCGAAAGAAAGTAAATTGGAAATGGAAGTAGTTAAGAAGTCCGTTGAAAAGACGAGTGAATTTTTAAAGAGTATTT
CGAATTCATTTCAGCGTGTGGATGAGATCAATCGTATTCTTGGGGAAATTGCGAACAAAACCAATCTTCTTTCTCTGAAC
GCTTCGATTGAAGCCGCTCGTGCGGGTATTGCTGGTCGTGGTTTTGCGGTAGTAGCTCAAGAGGTAAGTAAACTTGCAGA
ATTTACAGCGACGAATGCGAAGATGATTTCGAAAGTAGTTCAAGAGTCACTTGAGTTTATTGAAGAGGCGAATTCCGCGT
CTCTTGATGCTGGTCATTCGACTGAAAATCAGAGTATCAAAATCAATCTAACGGTATCTAAAATAGAAGAGATGAACGGT
TTGTATGAACGTGGAACAATGATAGTGAACGATTTTGTAAGGAATTTGGAGCGAGCGAAGAAGTTATCGGATGAATTATT
TTATTCGACTGAAGAACAGATGACTGGTCAGAAAGAGATGATGAAGGCGATGCTTGAACTTGAAAAGGAGGTGAACGAGA
TCACGCGGGAATCCGGAAAAATTCAAGATGGAGTTTTGAAAATTAAAACTCAATCGAGCGACTTGAAGGCTTTGAGTGTC
GTTTAA

Upstream 100 bases:

>100_bases
TTCACTGCGTTCTTTTTTTTTCTCCATTCAAGAAAAGGCATCCGGTACGATTTATCTTAGCGTTGGTCTTTTGTTTCTTG
GAATACTTCACGTCGGTTAT

Downstream 100 bases:

>100_bases
TCGGATACAGTCGCAACTTGAAATCGATTATCGAAACGATTTCTCAGTTCAACGAAACTCTGGATCAAGTATGGACAAGA
TTTGAAAATCTGAATCGATG

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 801; Mature: 800

Protein sequence:

>801_residues
MAGFPFYTSWSVFHRWVVIPSPFLGVLFLIMFFFKYPEPVSKKIMIPAFSIALSGVVVICVWYFYESFSAKRVFYFSGHY
WDFQVNFFYKVYAVAIIFYTFLFVGIGIWRMITLKGKDRIITGIVLIPMASIILIPGVFNAMSRDGAVSRELYQTVLDIS
LVTGLFVVLVGYINYTSEKTSILSRITGITLATFFLILQIVSIFIFNQYEESYDLIKKTEARLSAAGLEVSKDLEYVFQY
DPGTDSVTSLFPGNSQQPDESTLREFRFFKITHNLFELPSLPNEEFKQSVEDILKNSPFGFDAYKAGVKEYLSSKNETRL
SGKDIESFFDALQNTLVVLRNKHFHLPPKEKNDPASEKRDKIFDTFLTQIRKQDERTYKGERVYELNGPVPKHYISYFYV
SGGKIYEVGFRYESLREYLHPTGKILYMSAICILFLVLFGFRFFFQGALLNPLEDVVVGLREANSGNLEYRLQVKVEDEI
GFIARSFNKMAKSIQMTRKRLHSSAETLEISVTDFSEFTSLTSAKMESQAASLEEVNAVIESLSKASEKNVDSIRIQNEN
LIELNQKSQVLLDVIAKISDHSKGLDTNAKESKLEMEVVKKSVEKTSEFLKSISNSFQRVDEINRILGEIANKTNLLSLN
ASIEAARAGIAGRGFAVVAQEVSKLAEFTATNAKMISKVVQESLEFIEEANSASLDAGHSTENQSIKINLTVSKIEEMNG
LYERGTMIVNDFVRNLERAKKLSDELFYSTEEQMTGQKEMMKAMLELEKEVNEITRESGKIQDGVLKIKTQSSDLKALSV
V

Sequences:

>Translated_801_residues
MAGFPFYTSWSVFHRWVVIPSPFLGVLFLIMFFFKYPEPVSKKIMIPAFSIALSGVVVICVWYFYESFSAKRVFYFSGHY
WDFQVNFFYKVYAVAIIFYTFLFVGIGIWRMITLKGKDRIITGIVLIPMASIILIPGVFNAMSRDGAVSRELYQTVLDIS
LVTGLFVVLVGYINYTSEKTSILSRITGITLATFFLILQIVSIFIFNQYEESYDLIKKTEARLSAAGLEVSKDLEYVFQY
DPGTDSVTSLFPGNSQQPDESTLREFRFFKITHNLFELPSLPNEEFKQSVEDILKNSPFGFDAYKAGVKEYLSSKNETRL
SGKDIESFFDALQNTLVVLRNKHFHLPPKEKNDPASEKRDKIFDTFLTQIRKQDERTYKGERVYELNGPVPKHYISYFYV
SGGKIYEVGFRYESLREYLHPTGKILYMSAICILFLVLFGFRFFFQGALLNPLEDVVVGLREANSGNLEYRLQVKVEDEI
GFIARSFNKMAKSIQMTRKRLHSSAETLEISVTDFSEFTSLTSAKMESQAASLEEVNAVIESLSKASEKNVDSIRIQNEN
LIELNQKSQVLLDVIAKISDHSKGLDTNAKESKLEMEVVKKSVEKTSEFLKSISNSFQRVDEINRILGEIANKTNLLSLN
ASIEAARAGIAGRGFAVVAQEVSKLAEFTATNAKMISKVVQESLEFIEEANSASLDAGHSTENQSIKINLTVSKIEEMNG
LYERGTMIVNDFVRNLERAKKLSDELFYSTEEQMTGQKEMMKAMLELEKEVNEITRESGKIQDGVLKIKTQSSDLKALSV
V
>Mature_800_residues
AGFPFYTSWSVFHRWVVIPSPFLGVLFLIMFFFKYPEPVSKKIMIPAFSIALSGVVVICVWYFYESFSAKRVFYFSGHYW
DFQVNFFYKVYAVAIIFYTFLFVGIGIWRMITLKGKDRIITGIVLIPMASIILIPGVFNAMSRDGAVSRELYQTVLDISL
VTGLFVVLVGYINYTSEKTSILSRITGITLATFFLILQIVSIFIFNQYEESYDLIKKTEARLSAAGLEVSKDLEYVFQYD
PGTDSVTSLFPGNSQQPDESTLREFRFFKITHNLFELPSLPNEEFKQSVEDILKNSPFGFDAYKAGVKEYLSSKNETRLS
GKDIESFFDALQNTLVVLRNKHFHLPPKEKNDPASEKRDKIFDTFLTQIRKQDERTYKGERVYELNGPVPKHYISYFYVS
GGKIYEVGFRYESLREYLHPTGKILYMSAICILFLVLFGFRFFFQGALLNPLEDVVVGLREANSGNLEYRLQVKVEDEIG
FIARSFNKMAKSIQMTRKRLHSSAETLEISVTDFSEFTSLTSAKMESQAASLEEVNAVIESLSKASEKNVDSIRIQNENL
IELNQKSQVLLDVIAKISDHSKGLDTNAKESKLEMEVVKKSVEKTSEFLKSISNSFQRVDEINRILGEIANKTNLLSLNA
SIEAARAGIAGRGFAVVAQEVSKLAEFTATNAKMISKVVQESLEFIEEANSASLDAGHSTENQSIKINLTVSKIEEMNGL
YERGTMIVNDFVRNLERAKKLSDELFYSTEEQMTGQKEMMKAMLELEKEVNEITRESGKIQDGVLKIKTQSSDLKALSVV

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1788195, Length=331, Percent_Identity=26.5861027190332, Blast_Score=106, Evalue=6e-24,
Organism=Escherichia coli, GI1787690, Length=281, Percent_Identity=28.1138790035587, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI2367378, Length=275, Percent_Identity=26.9090909090909, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1788194, Length=357, Percent_Identity=23.249299719888, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1789453, Length=361, Percent_Identity=22.7146814404432, Blast_Score=81, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 90994; Mature: 90862

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGFPFYTSWSVFHRWVVIPSPFLGVLFLIMFFFKYPEPVSKKIMIPAFSIALSGVVVIC
CCCCCCCCCHHHHHEEEECCCCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHH
VWYFYESFSAKRVFYFSGHYWDFQVNFFYKVYAVAIIFYTFLFVGIGIWRMITLKGKDRI
HHHHHHCCCCCEEEEEECEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHH
ITGIVLIPMASIILIPGVFNAMSRDGAVSRELYQTVLDISLVTGLFVVLVGYINYTSEKT
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
SILSRITGITLATFFLILQIVSIFIFNQYEESYDLIKKTEARLSAAGLEVSKDLEYVFQY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCEEEEE
DPGTDSVTSLFPGNSQQPDESTLREFRFFKITHNLFELPSLPNEEFKQSVEDILKNSPFG
CCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCC
FDAYKAGVKEYLSSKNETRLSGKDIESFFDALQNTLVVLRNKHFHLPPKEKNDPASEKRD
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
KIFDTFLTQIRKQDERTYKGERVYELNGPVPKHYISYFYVSGGKIYEVGFRYESLREYLH
HHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHEEEEECCCEEEEECCCHHHHHHHHC
PTGKILYMSAICILFLVLFGFRFFFQGALLNPLEDVVVGLREANSGNLEYRLQVKVEDEI
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEEEEEECCHH
GFIARSFNKMAKSIQMTRKRLHSSAETLEISVTDFSEFTSLTSAKMESQAASLEEVNAVI
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
ESLSKASEKNVDSIRIQNENLIELNQKSQVLLDVIAKISDHSKGLDTNAKESKLEMEVVK
HHHHHHHHCCCCEEEECCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
KSVEKTSEFLKSISNSFQRVDEINRILGEIANKTNLLSLNASIEAARAGIAGRGFAVVAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHCCCCCCCHHHHHH
EVSKLAEFTATNAKMISKVVQESLEFIEEANSASLDAGHSTENQSIKINLTVSKIEEMNG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHH
LYERGTMIVNDFVRNLERAKKLSDELFYSTEEQMTGQKEMMKAMLELEKEVNEITRESGK
HHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
IQDGVLKIKTQSSDLKALSVV
CCCCEEEEEECCCCCCHHCCC
>Mature Secondary Structure 
AGFPFYTSWSVFHRWVVIPSPFLGVLFLIMFFFKYPEPVSKKIMIPAFSIALSGVVVIC
CCCCCCCCHHHHHEEEECCCCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHH
VWYFYESFSAKRVFYFSGHYWDFQVNFFYKVYAVAIIFYTFLFVGIGIWRMITLKGKDRI
HHHHHHCCCCCEEEEEECEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHH
ITGIVLIPMASIILIPGVFNAMSRDGAVSRELYQTVLDISLVTGLFVVLVGYINYTSEKT
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
SILSRITGITLATFFLILQIVSIFIFNQYEESYDLIKKTEARLSAAGLEVSKDLEYVFQY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCEEEEE
DPGTDSVTSLFPGNSQQPDESTLREFRFFKITHNLFELPSLPNEEFKQSVEDILKNSPFG
CCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCC
FDAYKAGVKEYLSSKNETRLSGKDIESFFDALQNTLVVLRNKHFHLPPKEKNDPASEKRD
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
KIFDTFLTQIRKQDERTYKGERVYELNGPVPKHYISYFYVSGGKIYEVGFRYESLREYLH
HHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHEEEEECCCEEEEECCCHHHHHHHHC
PTGKILYMSAICILFLVLFGFRFFFQGALLNPLEDVVVGLREANSGNLEYRLQVKVEDEI
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEEEEEECCHH
GFIARSFNKMAKSIQMTRKRLHSSAETLEISVTDFSEFTSLTSAKMESQAASLEEVNAVI
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
ESLSKASEKNVDSIRIQNENLIELNQKSQVLLDVIAKISDHSKGLDTNAKESKLEMEVVK
HHHHHHHHCCCCEEEECCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
KSVEKTSEFLKSISNSFQRVDEINRILGEIANKTNLLSLNASIEAARAGIAGRGFAVVAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHCCCCCCCHHHHHH
EVSKLAEFTATNAKMISKVVQESLEFIEEANSASLDAGHSTENQSIKINLTVSKIEEMNG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHH
LYERGTMIVNDFVRNLERAKKLSDELFYSTEEQMTGQKEMMKAMLELEKEVNEITRESGK
HHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
IQDGVLKIKTQSSDLKALSVV
CCCCEEEEEECCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]