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The map label for this gene is mtnP [H]

Identifier: 116326976

GI number: 116326976

Start: 166886

End: 167749

Strand: Direct

Name: mtnP [H]

Synonym: LBL_0143

Alternate gene names: 116326976

Gene position: 166886-167749 (Clockwise)

Preceding gene: 116326975

Following gene: 116326979

Centisome position: 4.62

GC content: 41.55

Gene sequence:

>864_bases
ATGTCACGTAACGTAAAAGCGGCCATCATAGGTGGAACGGGACTTTATAGTTTGGATGGAATGGAATTGATAGAGGAAAT
TTATCCCGATACTCCCTGGGGAAAACCTTCCGATAAAATCAAAATCGGGAAGTACAAAGAAAAACTAATCGCGTTTTTAC
CGAGACACGGAATCGGACATTTTCTTTCGCCACCCGAAATCCCGAATCATGCGAATATTTGTGCACTCAAACAACTTGGC
GTGGAAGAGATTGTCGCCTTTAGCTCGGTTGGAAGTTTGAGAGAAGAAATCAAACCTCTCGATTTTGTTTTACCTTCTCA
AATCATTGATCGTACCCATTTAAGGGATTCCACGTATTTTGGAAACGGAATAGTTGCCCATGCTCCATTCGCGGAGCCAT
TTTCTCAAAACTTGGGTAAAAGAATTGAACAAACCGCTGAAAAGATCGGCTTAAAAATTCATACGGGCAAAACATTGATT
TGTATGGAAGGGCCTCTTTTTTCTACAAAGGCCGAATCTCATCTTTATCGTTCTTGGGGTGCGGATATTATCAATATGAC
TGTACTTCCGGAAGCGAAGCTTGCTCGAGAAGCCGAGATTTCATACCAGATGATTTGTATGTCTACGGATTATGACTGTT
GGAGAGAAGGGGAAGAGTCCGTCACCGTTGAGATGGTGATCGCAAATCTTACGAAGAATGCGGAAACCGCTAAAAAACTA
CTTTCCGAACTAATTCATGTGATTGGAAACGGGGACGACCTATCTTTAAAAAACAGTACCCGATATTCGATCATCACGGC
GCCTGAAAAAAGAAATCCGGAAACCGTAAAAAAACTCAAAGTTCTTTTCCCAGAATACTTTTAA

Upstream 100 bases:

>100_bases
TAATCTGTTTTGTAAGGTACTTCCGATTTACAATTTAGGTCCTCTTTCCAAAACTGTCCTTGAAGAAATCGATAACTTTC
TTTTCTAGGGGAGCGGATTA

Downstream 100 bases:

>100_bases
ATCGATCTTTTATCGGATCTCATCTAGACTTTTTTTCAATGCCCGGCGATATTCCGGATAAAGAGCAAGGTCGTTATGCG
AGCCGTTTGGGATCGTAAAA

Product: purine-nucleoside phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MSRNVKAAIIGGTGLYSLDGMELIEEIYPDTPWGKPSDKIKIGKYKEKLIAFLPRHGIGHFLSPPEIPNHANICALKQLG
VEEIVAFSSVGSLREEIKPLDFVLPSQIIDRTHLRDSTYFGNGIVAHAPFAEPFSQNLGKRIEQTAEKIGLKIHTGKTLI
CMEGPLFSTKAESHLYRSWGADIINMTVLPEAKLAREAEISYQMICMSTDYDCWREGEESVTVEMVIANLTKNAETAKKL
LSELIHVIGNGDDLSLKNSTRYSIITAPEKRNPETVKKLKVLFPEYF

Sequences:

>Translated_287_residues
MSRNVKAAIIGGTGLYSLDGMELIEEIYPDTPWGKPSDKIKIGKYKEKLIAFLPRHGIGHFLSPPEIPNHANICALKQLG
VEEIVAFSSVGSLREEIKPLDFVLPSQIIDRTHLRDSTYFGNGIVAHAPFAEPFSQNLGKRIEQTAEKIGLKIHTGKTLI
CMEGPLFSTKAESHLYRSWGADIINMTVLPEAKLAREAEISYQMICMSTDYDCWREGEESVTVEMVIANLTKNAETAKKL
LSELIHVIGNGDDLSLKNSTRYSIITAPEKRNPETVKKLKVLFPEYF
>Mature_286_residues
SRNVKAAIIGGTGLYSLDGMELIEEIYPDTPWGKPSDKIKIGKYKEKLIAFLPRHGIGHFLSPPEIPNHANICALKQLGV
EEIVAFSSVGSLREEIKPLDFVLPSQIIDRTHLRDSTYFGNGIVAHAPFAEPFSQNLGKRIEQTAEKIGLKIHTGKTLIC
MEGPLFSTKAESHLYRSWGADIINMTVLPEAKLAREAEISYQMICMSTDYDCWREGEESVTVEMVIANLTKNAETAKKLL
SELIHVIGNGDDLSLKNSTRYSIITAPEKRNPETVKKLKVLFPEYF

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=270, Percent_Identity=44.4444444444444, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI71980569, Length=274, Percent_Identity=37.2262773722628, Blast_Score=176, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6323045, Length=307, Percent_Identity=46.9055374592834, Blast_Score=258, Evalue=6e-70,
Organism=Drosophila melanogaster, GI20130079, Length=253, Percent_Identity=38.3399209486166, Blast_Score=185, Evalue=3e-47,
Organism=Drosophila melanogaster, GI221459247, Length=227, Percent_Identity=32.15859030837, Blast_Score=143, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 32047; Mature: 31916

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRNVKAAIIGGTGLYSLDGMELIEEIYPDTPWGKPSDKIKIGKYKEKLIAFLPRHGIGH
CCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCC
FLSPPEIPNHANICALKQLGVEEIVAFSSVGSLREEIKPLDFVLPSQIIDRTHLRDSTYF
CCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHCCCCCEE
GNGIVAHAPFAEPFSQNLGKRIEQTAEKIGLKIHTGKTLICMEGPLFSTKAESHLYRSWG
CCCEEEECCCCCHHHHHHHHHHHHHHHHHCEEEECCCEEEEECCCCCCCHHHHHHHHHHC
ADIINMTVLPEAKLAREAEISYQMICMSTDYDCWREGEESVTVEMVIANLTKNAETAKKL
CCEEEEEECCCHHHHHHHCCCEEEEEEECCCHHHHCCCCCEEEEEEEHHHHCCHHHHHHH
LSELIHVIGNGDDLSLKNSTRYSIITAPEKRNPETVKKLKVLFPEYF
HHHHHHHHCCCCCEEECCCCCEEEEECCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SRNVKAAIIGGTGLYSLDGMELIEEIYPDTPWGKPSDKIKIGKYKEKLIAFLPRHGIGH
CCCEEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCC
FLSPPEIPNHANICALKQLGVEEIVAFSSVGSLREEIKPLDFVLPSQIIDRTHLRDSTYF
CCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHCCCCCEE
GNGIVAHAPFAEPFSQNLGKRIEQTAEKIGLKIHTGKTLICMEGPLFSTKAESHLYRSWG
CCCEEEECCCCCHHHHHHHHHHHHHHHHHCEEEECCCEEEEECCCCCCCHHHHHHHHHHC
ADIINMTVLPEAKLAREAEISYQMICMSTDYDCWREGEESVTVEMVIANLTKNAETAKKL
CCEEEEEECCCHHHHHHHCCCEEEEEEECCCHHHHCCCCCEEEEEEEHHHHCCHHHHHHH
LSELIHVIGNGDDLSLKNSTRYSIITAPEKRNPETVKKLKVLFPEYF
HHHHHHHHCCCCCEEECCCCCEEEEECCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA