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The map label for this gene is mcpA [H]

Identifier: 116326975

GI number: 116326975

Start: 165220

End: 166788

Strand: Direct

Name: mcpA [H]

Synonym: LBL_0142

Alternate gene names: 116326975

Gene position: 165220-166788 (Clockwise)

Preceding gene: 116326974

Following gene: 116326976

Centisome position: 4.57

GC content: 37.6

Gene sequence:

>1569_bases
ATGTCCAAACAATCTATAGAATCCATTCGTAAGAAAGGAGAAACGCTTACTTATTACGCCAGGATGGGGATCATGATTAT
GATGTTGCTTTCTTTGGCATCGAGTTTTAAAGCTCTTCAGACTCAGATAAGAGTGATTCATACTTGCGGCGCGCTAATTA
TGTTTATTTACTCGATTTTGGGTTTTATACTATATAAAAAATACGAGATTAAACATTGGGTTCATAATTTATTCGTAATA
TTAGATTCTCTTACACTAAGTGTGACGATTTTCTTGGATAGTATGGTTTCTGCGGAAATCATCGCACCCGTTCTCAAAAA
TGCGATTCTCTATTCCGTTTATTATTTTATTATCGCTTATTCCGGTTTGTTAGGAAGGCCCAAGTTTGTGCTGATTACAG
GTTTGATTTCTTCTATAGGTTATGCGATTGCGTTGACGAACGCCGTATTTCACGGTCTCCAATTTTCTGAAGACAACGTG
ATTAATATGAAACCAGGCTATATTAAACTCAGTGCGGAAATCACGAAGGTTGTTTTTATGATGGGAGTGAGTTTTATTCT
TTATCGTTTGATGAAATTGTTTGACGACTTATATCAGGAAGCAACTTCCTATTTCCAGGAAAATAAACAATTCTTAAATA
AGTTGGAGGATAATAGAAAGATAATTCATTCTTCTGCGGAGACATTGGAGATTTCGGTGACGGATTTTTCGGAATTTACG
AGTTTAACCAGTGCAAAAATGGAATCTCAAGCAGCTTCTTTGGAAGAGGTCAATGCAGTGATTGAGTCTTTATCAAAAGC
TTCTGAAAAGAATGTCGACTCGATTCGAATTCAAAACGAGAATCTGATCGAACTCAATCAAAAGTCTCAGGTTCTTTTGG
ATGTAATCGCGAAGATATCGGATTATTCTAAAGGTTTGGATACGAATGCAAAAGAAAGTAAATTGGAAATGGAAGTAGTC
AAGAAGTCCGTTGAAAAGACGAGTGAATTTTTAAAGAGTATTTCGAATTCATTTCAGCGTGTGGATGAGATCAATCGTAT
TCTTGGGGAAATTGCTGACAAAACCAATCTTCTTTCTCTGAACGCTTCGATTGAAGCCGCTCGTGCGGGTGTTGCTGGTC
GTGATTTTGCGGTAGTAGCTCAAGAGGTAAGTAAACTTGCAGAATTTACAGCGACGAATGCGAAGATGATTTCGAAAGTA
GTTCAAGAGTCACTTGAGTTTATTGAAGAGGCGAATTCCGCGTCTCTTGATGCTGGTCATTCGACTGAAAATCAGAGTAT
CAAAATCAATCTAACGGTATCTAAAATAGAAGAGATGAACGGTTTGTATGAACGTGGAACAATGATAGTGAACGATTTTG
TAAGGAATTTGGAGCGAGCGAAGAAGTTATCGGATGAATTATTTTATTCGACTGAAGAACAGATGACTGGTCAGAAAGAG
ATGATGAAGGCGATGCTTGAACTTGAAAAGGAGGTGAACGAGATCACGCGGGAATCCGGAAAAATTCAAGATGGAGTTTT
GAAAATTAAAACTCAATCGAGCGACTTGAAGGCTTTGAGTGTCGTTTAA

Upstream 100 bases:

>100_bases
TTCTAAGTGGTAGTTTGTCCTTTTATAATATGGTCATCGGATTTCCAAAAAGGTTCCTACTTTTCATTTACTTAAATTAA
ATTTTATAAAGGTTTGGCAT

Downstream 100 bases:

>100_bases
TCTGTTTTGTAAGGTACTTCCGATTTACAATTTAGGTCCTCTTTCCAAAACTGTCCTTGAAGAAATCGATAACTTTCTTT
TCTAGGGGAGCGGATTAATG

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: H1 [H]

Number of amino acids: Translated: 522; Mature: 521

Protein sequence:

>522_residues
MSKQSIESIRKKGETLTYYARMGIMIMMLLSLASSFKALQTQIRVIHTCGALIMFIYSILGFILYKKYEIKHWVHNLFVI
LDSLTLSVTIFLDSMVSAEIIAPVLKNAILYSVYYFIIAYSGLLGRPKFVLITGLISSIGYAIALTNAVFHGLQFSEDNV
INMKPGYIKLSAEITKVVFMMGVSFILYRLMKLFDDLYQEATSYFQENKQFLNKLEDNRKIIHSSAETLEISVTDFSEFT
SLTSAKMESQAASLEEVNAVIESLSKASEKNVDSIRIQNENLIELNQKSQVLLDVIAKISDYSKGLDTNAKESKLEMEVV
KKSVEKTSEFLKSISNSFQRVDEINRILGEIADKTNLLSLNASIEAARAGVAGRDFAVVAQEVSKLAEFTATNAKMISKV
VQESLEFIEEANSASLDAGHSTENQSIKINLTVSKIEEMNGLYERGTMIVNDFVRNLERAKKLSDELFYSTEEQMTGQKE
MMKAMLELEKEVNEITRESGKIQDGVLKIKTQSSDLKALSVV

Sequences:

>Translated_522_residues
MSKQSIESIRKKGETLTYYARMGIMIMMLLSLASSFKALQTQIRVIHTCGALIMFIYSILGFILYKKYEIKHWVHNLFVI
LDSLTLSVTIFLDSMVSAEIIAPVLKNAILYSVYYFIIAYSGLLGRPKFVLITGLISSIGYAIALTNAVFHGLQFSEDNV
INMKPGYIKLSAEITKVVFMMGVSFILYRLMKLFDDLYQEATSYFQENKQFLNKLEDNRKIIHSSAETLEISVTDFSEFT
SLTSAKMESQAASLEEVNAVIESLSKASEKNVDSIRIQNENLIELNQKSQVLLDVIAKISDYSKGLDTNAKESKLEMEVV
KKSVEKTSEFLKSISNSFQRVDEINRILGEIADKTNLLSLNASIEAARAGVAGRDFAVVAQEVSKLAEFTATNAKMISKV
VQESLEFIEEANSASLDAGHSTENQSIKINLTVSKIEEMNGLYERGTMIVNDFVRNLERAKKLSDELFYSTEEQMTGQKE
MMKAMLELEKEVNEITRESGKIQDGVLKIKTQSSDLKALSVV
>Mature_521_residues
SKQSIESIRKKGETLTYYARMGIMIMMLLSLASSFKALQTQIRVIHTCGALIMFIYSILGFILYKKYEIKHWVHNLFVIL
DSLTLSVTIFLDSMVSAEIIAPVLKNAILYSVYYFIIAYSGLLGRPKFVLITGLISSIGYAIALTNAVFHGLQFSEDNVI
NMKPGYIKLSAEITKVVFMMGVSFILYRLMKLFDDLYQEATSYFQENKQFLNKLEDNRKIIHSSAETLEISVTDFSEFTS
LTSAKMESQAASLEEVNAVIESLSKASEKNVDSIRIQNENLIELNQKSQVLLDVIAKISDYSKGLDTNAKESKLEMEVVK
KSVEKTSEFLKSISNSFQRVDEINRILGEIADKTNLLSLNASIEAARAGVAGRDFAVVAQEVSKLAEFTATNAKMISKVV
QESLEFIEEANSASLDAGHSTENQSIKINLTVSKIEEMNGLYERGTMIVNDFVRNLERAKKLSDELFYSTEEQMTGQKEM
MKAMLELEKEVNEITRESGKIQDGVLKIKTQSSDLKALSVV

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1788194, Length=291, Percent_Identity=23.7113402061856, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1787690, Length=188, Percent_Identity=29.7872340425532, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI2367378, Length=162, Percent_Identity=33.9506172839506, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788195, Length=267, Percent_Identity=26.9662921348315, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1789453, Length=235, Percent_Identity=27.6595744680851, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 58571; Mature: 58439

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQSIESIRKKGETLTYYARMGIMIMMLLSLASSFKALQTQIRVIHTCGALIMFIYSIL
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFILYKKYEIKHWVHNLFVILDSLTLSVTIFLDSMVSAEIIAPVLKNAILYSVYYFIIAY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLLGRPKFVLITGLISSIGYAIALTNAVFHGLQFSEDNVINMKPGYIKLSAEITKVVFM
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCEEEEHHHHHHHHHH
MGVSFILYRLMKLFDDLYQEATSYFQENKQFLNKLEDNRKIIHSSAETLEISVTDFSEFT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHH
SLTSAKMESQAASLEEVNAVIESLSKASEKNVDSIRIQNENLIELNQKSQVLLDVIAKIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEECCHHHHHHHHHHHHHH
DYSKGLDTNAKESKLEMEVVKKSVEKTSEFLKSISNSFQRVDEINRILGEIADKTNLLSL
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
NASIEAARAGVAGRDFAVVAQEVSKLAEFTATNAKMISKVVQESLEFIEEANSASLDAGH
CCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
STENQSIKINLTVSKIEEMNGLYERGTMIVNDFVRNLERAKKLSDELFYSTEEQMTGQKE
CCCCCEEEEEEEHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHH
MMKAMLELEKEVNEITRESGKIQDGVLKIKTQSSDLKALSVV
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHCCC
>Mature Secondary Structure 
SKQSIESIRKKGETLTYYARMGIMIMMLLSLASSFKALQTQIRVIHTCGALIMFIYSIL
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFILYKKYEIKHWVHNLFVILDSLTLSVTIFLDSMVSAEIIAPVLKNAILYSVYYFIIAY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLLGRPKFVLITGLISSIGYAIALTNAVFHGLQFSEDNVINMKPGYIKLSAEITKVVFM
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCEEEEHHHHHHHHHH
MGVSFILYRLMKLFDDLYQEATSYFQENKQFLNKLEDNRKIIHSSAETLEISVTDFSEFT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHH
SLTSAKMESQAASLEEVNAVIESLSKASEKNVDSIRIQNENLIELNQKSQVLLDVIAKIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEECCHHHHHHHHHHHHHH
DYSKGLDTNAKESKLEMEVVKKSVEKTSEFLKSISNSFQRVDEINRILGEIADKTNLLSL
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
NASIEAARAGVAGRDFAVVAQEVSKLAEFTATNAKMISKVVQESLEFIEEANSASLDAGH
CCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
STENQSIKINLTVSKIEEMNGLYERGTMIVNDFVRNLERAKKLSDELFYSTEEQMTGQKE
CCCCCEEEEEEEHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHH
MMKAMLELEKEVNEITRESGKIQDGVLKIKTQSSDLKALSVV
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]