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The map label for this gene is dnaX-2 [H]

Identifier: 116326905

GI number: 116326905

Start: 72649

End: 74112

Strand: Direct

Name: dnaX-2 [H]

Synonym: LBL_0064

Alternate gene names: 116326905

Gene position: 72649-74112 (Clockwise)

Preceding gene: 116326904

Following gene: 116326906

Centisome position: 2.01

GC content: 38.18

Gene sequence:

>1464_bases
ATGACAGGAACTCACGAAGTCCTTTCTCGGAAATACCGCCCGCAAATATTTCGGGACGTAATTCATCAAGACCTTGCCAT
AGGCGCTCTTCAAAACGCACTTAAATCCGGAAAAATCGGTCATGCATATATTTTCTTCGGTCCTAGAGGAGTCGGTAAAA
CGACGATCGCGAGAATTCTTGCAAAACGATTGAATTGCCGAAATCCGATCAATAATGAACCTTGCAACGAATGTAGTTCT
TGTACCGAAATCACTCAGGGGATTTCGAGCGACGTTCTTGAAATCGATGCCGCGAGCAATCGAGGAATCGAAAATATTCG
TGAACTCAGAGACAATGTTAAATTCGCCCCCATGGGCGGAAAATATAAAGTTTATATAATAGACGAAGTCCACATGTTGA
CGGATCAGTCCTTCAACGCTCTTCTAAAAACTTTGGAAGAACCCCCAGCTCACATTGTTTTTATTTTGGCCACAACTGAG
TTTCATAAAATTCCAGAGACCATTCTTTCCAGATGTCAGGATTTTATCTTTAAAAAAGTACCCTTGTCCGTTTTACAGGA
TTATTCCGAAAAACTTTGTAAGATCGAAAATGTCCAATACGATCAAGAAGGACTTTTCTGGATTGCGAAAAAAGGCGACG
GTTCCGTAAGAGACATGCTTTCTTTTATGGAACAGGCGATCGTATTTACGGATTCCAAATTGTCAGGAACCGGAATCCGC
AAGATGATCGGTTATCACGGAATTGAATTTTTAACTTCGTTCATCAAAAGTCTTATCGATCCCGACAATCATTCAAAAAG
TTTGGAAATCCTCGAATCCCTCTATCAAGAAGGTCAAGATATCTACAAATTTTTATGGGATTCCATAGAATTTACTCACA
CTCTTAACTTGATCCGCGATTCCCTTGCCGATTCCGAATCCGTTAATTTTCCCAAAGAAGATCTGGCAAAAATGAAATCT
GATTTTGAAAATGTGGATTCTTCAAAATTGAATTTTCTTTCCGGAAAACTTTTTGAAATTTACGAAAAAATCAAAACGAT
TCGTTTGAGAAACTCTTTTGAGATTAAAGTATTCACAGAAATTCAAATCAAAAAACTCGTGGAAGAACTTACCTATCCGA
GTTTGGCCGGTTTGGTAGATCGAATCAATCATCTGATTCTTATGATGCAAGGTTCTAAAAATTCCACTCTCGATACGGAA
CACGCTAAATCACTTCCTATACCCAAAAGTGTGGCACAAGAAGAATCTTCTAAAAAAAAAGATAATTCGTTTTCCGACAT
CTCTTTAGGATCCCGCTTCGAGTCTAATCAGCAGGATTCTTCTTTGAGAAACGATTCCTTGGAAACAAAATCGACTATAA
CTTCCGAACCAAATTTGCAAAAATTCGATACGAGTACCGAAATAAAGAAAAAATTTCTCGGAACCGAAGTAGATCAAAGT
AAAATCCCTAAATTGGATTCTTAA

Upstream 100 bases:

>100_bases
GCTACAGGAGAAGTGTCAGAGTGGTCTATTGTGCATGCTTGGAAAGCATGTGTGCCAAAAGCACCCCGGGTTCGAATCCC
GGCTTCTCCGACTCCGTATT

Downstream 100 bases:

>100_bases
CGTTATGCTTGATAAAATAAAAAACCTGTCGGAACTTCTCTCCAACATGGGAGCCCTCCGAGAAAAAATGGAAGACGTAA
AAAAACGCATCGCCTCCATT

Product: DNA polymerase III, gamma and tau subunits

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MTGTHEVLSRKYRPQIFRDVIHQDLAIGALQNALKSGKIGHAYIFFGPRGVGKTTIARILAKRLNCRNPINNEPCNECSS
CTEITQGISSDVLEIDAASNRGIENIRELRDNVKFAPMGGKYKVYIIDEVHMLTDQSFNALLKTLEEPPAHIVFILATTE
FHKIPETILSRCQDFIFKKVPLSVLQDYSEKLCKIENVQYDQEGLFWIAKKGDGSVRDMLSFMEQAIVFTDSKLSGTGIR
KMIGYHGIEFLTSFIKSLIDPDNHSKSLEILESLYQEGQDIYKFLWDSIEFTHTLNLIRDSLADSESVNFPKEDLAKMKS
DFENVDSSKLNFLSGKLFEIYEKIKTIRLRNSFEIKVFTEIQIKKLVEELTYPSLAGLVDRINHLILMMQGSKNSTLDTE
HAKSLPIPKSVAQEESSKKKDNSFSDISLGSRFESNQQDSSLRNDSLETKSTITSEPNLQKFDTSTEIKKKFLGTEVDQS
KIPKLDS

Sequences:

>Translated_487_residues
MTGTHEVLSRKYRPQIFRDVIHQDLAIGALQNALKSGKIGHAYIFFGPRGVGKTTIARILAKRLNCRNPINNEPCNECSS
CTEITQGISSDVLEIDAASNRGIENIRELRDNVKFAPMGGKYKVYIIDEVHMLTDQSFNALLKTLEEPPAHIVFILATTE
FHKIPETILSRCQDFIFKKVPLSVLQDYSEKLCKIENVQYDQEGLFWIAKKGDGSVRDMLSFMEQAIVFTDSKLSGTGIR
KMIGYHGIEFLTSFIKSLIDPDNHSKSLEILESLYQEGQDIYKFLWDSIEFTHTLNLIRDSLADSESVNFPKEDLAKMKS
DFENVDSSKLNFLSGKLFEIYEKIKTIRLRNSFEIKVFTEIQIKKLVEELTYPSLAGLVDRINHLILMMQGSKNSTLDTE
HAKSLPIPKSVAQEESSKKKDNSFSDISLGSRFESNQQDSSLRNDSLETKSTITSEPNLQKFDTSTEIKKKFLGTEVDQS
KIPKLDS
>Mature_486_residues
TGTHEVLSRKYRPQIFRDVIHQDLAIGALQNALKSGKIGHAYIFFGPRGVGKTTIARILAKRLNCRNPINNEPCNECSSC
TEITQGISSDVLEIDAASNRGIENIRELRDNVKFAPMGGKYKVYIIDEVHMLTDQSFNALLKTLEEPPAHIVFILATTEF
HKIPETILSRCQDFIFKKVPLSVLQDYSEKLCKIENVQYDQEGLFWIAKKGDGSVRDMLSFMEQAIVFTDSKLSGTGIRK
MIGYHGIEFLTSFIKSLIDPDNHSKSLEILESLYQEGQDIYKFLWDSIEFTHTLNLIRDSLADSESVNFPKEDLAKMKSD
FENVDSSKLNFLSGKLFEIYEKIKTIRLRNSFEIKVFTEIQIKKLVEELTYPSLAGLVDRINHLILMMQGSKNSTLDTEH
AKSLPIPKSVAQEESSKKKDNSFSDISLGSRFESNQQDSSLRNDSLETKSTITSEPNLQKFDTSTEIKKKFLGTEVDQSK
IPKLDS

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=232, Percent_Identity=27.1551724137931, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI31881687, Length=232, Percent_Identity=27.1551724137931, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI6677723, Length=219, Percent_Identity=26.9406392694064, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI194306571, Length=219, Percent_Identity=26.9406392694064, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI194306567, Length=219, Percent_Identity=26.9406392694064, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI31563534, Length=221, Percent_Identity=27.1493212669683, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI1786676, Length=318, Percent_Identity=40.251572327044, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1787341, Length=151, Percent_Identity=31.1258278145695, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17554730, Length=223, Percent_Identity=23.7668161434978, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17541988, Length=221, Percent_Identity=28.0542986425339, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71986063, Length=312, Percent_Identity=23.0769230769231, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324478, Length=299, Percent_Identity=25.4180602006689, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324039, Length=258, Percent_Identity=24.031007751938, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322528, Length=230, Percent_Identity=28.2608695652174, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324111, Length=426, Percent_Identity=23.7089201877934, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI19921076, Length=273, Percent_Identity=24.1758241758242, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17647857, Length=272, Percent_Identity=26.4705882352941, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI18859927, Length=229, Percent_Identity=24.8908296943231, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 55238; Mature: 55106

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGTHEVLSRKYRPQIFRDVIHQDLAIGALQNALKSGKIGHAYIFFGPRGVGKTTIARIL
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHH
AKRLNCRNPINNEPCNECSSCTEITQGISSDVLEIDAASNRGIENIRELRDNVKFAPMGG
HHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHEEEECCCCCCHHHHHHHHHCCEEEECCC
KYKVYIIDEVHMLTDQSFNALLKTLEEPPAHIVFILATTEFHKIPETILSRCQDFIFKKV
CEEEEEEECHHHHHHHHHHHHHHHHCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHC
PLSVLQDYSEKLCKIENVQYDQEGLFWIAKKGDGSVRDMLSFMEQAIVFTDSKLSGTGIR
CHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCHHH
KMIGYHGIEFLTSFIKSLIDPDNHSKSLEILESLYQEGQDIYKFLWDSIEFTHTLNLIRD
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLADSESVNFPKEDLAKMKSDFENVDSSKLNFLSGKLFEIYEKIKTIRLRNSFEIKVFTE
HHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHH
IQIKKLVEELTYPSLAGLVDRINHLILMMQGSKNSTLDTEHAKSLPIPKSVAQEESSKKK
HHHHHHHHHHCCCHHHHHHHHHHHEEEEEECCCCCCCCCHHHCCCCCCHHHHHHHHHHHC
DNSFSDISLGSRFESNQQDSSLRNDSLETKSTITSEPNLQKFDTSTEIKKKFLGTEVDQS
CCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHCCCCCCCHHCCCHHHHHHHHHCCCCCHH
KIPKLDS
CCCCCCC
>Mature Secondary Structure 
TGTHEVLSRKYRPQIFRDVIHQDLAIGALQNALKSGKIGHAYIFFGPRGVGKTTIARIL
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHH
AKRLNCRNPINNEPCNECSSCTEITQGISSDVLEIDAASNRGIENIRELRDNVKFAPMGG
HHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHEEEECCCCCCHHHHHHHHHCCEEEECCC
KYKVYIIDEVHMLTDQSFNALLKTLEEPPAHIVFILATTEFHKIPETILSRCQDFIFKKV
CEEEEEEECHHHHHHHHHHHHHHHHCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHC
PLSVLQDYSEKLCKIENVQYDQEGLFWIAKKGDGSVRDMLSFMEQAIVFTDSKLSGTGIR
CHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCHHH
KMIGYHGIEFLTSFIKSLIDPDNHSKSLEILESLYQEGQDIYKFLWDSIEFTHTLNLIRD
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLADSESVNFPKEDLAKMKSDFENVDSSKLNFLSGKLFEIYEKIKTIRLRNSFEIKVFTE
HHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHH
IQIKKLVEELTYPSLAGLVDRINHLILMMQGSKNSTLDTEHAKSLPIPKSVAQEESSKKK
HHHHHHHHHHCCCHHHHHHHHHHHEEEEEECCCCCCCCCHHHCCCCCCHHHHHHHHHHHC
DNSFSDISLGSRFESNQQDSSLRNDSLETKSTITSEPNLQKFDTSTEIKKKFLGTEVDQS
CCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHCCCCCCCHHCCCHHHHHHHHHCCCCCHH
KIPKLDS
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]