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The map label for this gene is yhdN [H]

Identifier: 116249422

GI number: 116249422

Start: 827056

End: 828051

Strand: Direct

Name: yhdN [H]

Synonym: pRL120760

Alternate gene names: 116249422

Gene position: 827056-828051 (Clockwise)

Preceding gene: 116249421

Following gene: 116249423

Centisome position: 95.06

GC content: 64.66

Gene sequence:

>996_bases
ATGAGCGGACAGCAATTGACACGTGAGATCGGCAAATCGGGCGTTTCCGCCTCGGCGGTGGGATTGGGCACCTGGGCGAT
CGGCGGCTGGATGTGGGGCGGAACCGACGAGGCCGAATCCATCGCCGCAATCCGGGCATCGCTCGATGCCGGCGTGACGC
TGATCGACACGGCGCCGGCCTATGGGCTCGGGCGTTCCGAGGAGATCGTCGGCAAGGCGCTGACCGGGCGCCGCGACAAG
GCTGTCATCGCCACCAAATGCGGCCTTGTCTGGCATACGCAGAAGGGCCGTCATTTCTTCGATCAGGACGGCAAGCCGGT
GCACCGTTATCTCGGCCGCGACGCGATCCTGCATGAGGTCGAGGAAAGCCTGAGGCGGCTCGGAACCGACTATATCGACC
TCTACATCACCCATTGGCAGGACCCGACGACCCCTGTCGAGGAAACGATGAGGGCGCTGGAAGACCTGCGTACATCGGGC
AAGATCCGGGCGATCGGCGCAAGCAATGTCAGCCCCGACGACCTCAATGCCTATATCGCTGCCGGTGGTCTCGATGCGAT
CCAGGAGCGGTTCAGCATGATCGACCGGGAGATCGAGGCGGAGCTTCTGCCGCTGACCAAGGCCAACAGCATTGCGACGC
TGAGCTACTCGTCGCTGGCCTTGGGGTTGCTGTCCGGCACCATCGGTCCTGACCGGGTGTTCTCAGGCGACGACCAGCGC
AAGGGCAATCCGCGCTTTTCGGTCGACAACCGCCAGAAGGCAGCGGCGCTGGCCGACGCCATCCGGCCGGTCGCCGAAAA
ACACGGCGCCAGCATCGCCCAGATCGTGATTGCCTGGACGCTGGCGCAGCCGGGCGTCACCTTTGCACTTTGCGGCGCGC
GCAATCCGGTACAAGCGCTCGACAATGCGCGGGCCGGGACCGTCCGGCTGGATGCGGCCGATCTTGCGGCCATCGATACG
GCCATAGCGGCGAAACTGACTGACATGGACAGGTAG

Upstream 100 bases:

>100_bases
TCCTCAGCGTTCTGCGCGGCAATCATCTGGATACGCTGGTGACCGATGAGGCGACGGGTGCGCGGGTGCTGGCACTGGCG
AATGGCGAAGGAAAATGGGC

Downstream 100 bases:

>100_bases
CGGATCGCCATCATGAAACGGCAAGAGATATTGGACGGGCTCCGCCAGAGCCCGAAGGTGGACGTCTGTGTCATCGGCGG
CGGCATCAACGGCATCAGCG

Product: putative aldo-keto reductase protein

Products: NA

Alternate protein names: GSP69; AKR11B [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MSGQQLTREIGKSGVSASAVGLGTWAIGGWMWGGTDEAESIAAIRASLDAGVTLIDTAPAYGLGRSEEIVGKALTGRRDK
AVIATKCGLVWHTQKGRHFFDQDGKPVHRYLGRDAILHEVEESLRRLGTDYIDLYITHWQDPTTPVEETMRALEDLRTSG
KIRAIGASNVSPDDLNAYIAAGGLDAIQERFSMIDREIEAELLPLTKANSIATLSYSSLALGLLSGTIGPDRVFSGDDQR
KGNPRFSVDNRQKAAALADAIRPVAEKHGASIAQIVIAWTLAQPGVTFALCGARNPVQALDNARAGTVRLDAADLAAIDT
AIAAKLTDMDR

Sequences:

>Translated_331_residues
MSGQQLTREIGKSGVSASAVGLGTWAIGGWMWGGTDEAESIAAIRASLDAGVTLIDTAPAYGLGRSEEIVGKALTGRRDK
AVIATKCGLVWHTQKGRHFFDQDGKPVHRYLGRDAILHEVEESLRRLGTDYIDLYITHWQDPTTPVEETMRALEDLRTSG
KIRAIGASNVSPDDLNAYIAAGGLDAIQERFSMIDREIEAELLPLTKANSIATLSYSSLALGLLSGTIGPDRVFSGDDQR
KGNPRFSVDNRQKAAALADAIRPVAEKHGASIAQIVIAWTLAQPGVTFALCGARNPVQALDNARAGTVRLDAADLAAIDT
AIAAKLTDMDR
>Mature_330_residues
SGQQLTREIGKSGVSASAVGLGTWAIGGWMWGGTDEAESIAAIRASLDAGVTLIDTAPAYGLGRSEEIVGKALTGRRDKA
VIATKCGLVWHTQKGRHFFDQDGKPVHRYLGRDAILHEVEESLRRLGTDYIDLYITHWQDPTTPVEETMRALEDLRTSGK
IRAIGASNVSPDDLNAYIAAGGLDAIQERFSMIDREIEAELLPLTKANSIATLSYSSLALGLLSGTIGPDRVFSGDDQRK
GNPRFSVDNRQKAAALADAIRPVAEKHGASIAQIVIAWTLAQPGVTFALCGARNPVQALDNARAGTVRLDAADLAAIDTA
IAAKLTDMDR

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI4504825, Length=341, Percent_Identity=31.3782991202346, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI27436969, Length=340, Percent_Identity=31.1764705882353, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI27436964, Length=313, Percent_Identity=31.629392971246, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI27436966, Length=313, Percent_Identity=31.629392971246, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI27436962, Length=313, Percent_Identity=31.629392971246, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI27436971, Length=311, Percent_Identity=29.5819935691318, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI41152114, Length=200, Percent_Identity=31.5, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI223718702, Length=203, Percent_Identity=32.512315270936, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI41327764, Length=278, Percent_Identity=29.4964028776978, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1788070, Length=312, Percent_Identity=40.7051282051282, Blast_Score=218, Evalue=4e-58,
Organism=Escherichia coli, GI87081735, Length=324, Percent_Identity=31.1728395061728, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1788081, Length=313, Percent_Identity=32.5878594249201, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1789375, Length=343, Percent_Identity=29.4460641399417, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1789199, Length=344, Percent_Identity=28.1976744186047, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI48994888, Length=295, Percent_Identity=26.1016949152542, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082198, Length=311, Percent_Identity=28.2958199356913, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786400, Length=285, Percent_Identity=26.6666666666667, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI212645785, Length=305, Percent_Identity=27.5409836065574, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6325169, Length=296, Percent_Identity=29.3918918918919, Blast_Score=106, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6323998, Length=327, Percent_Identity=25.9938837920489, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6319958, Length=303, Percent_Identity=26.4026402640264, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322615, Length=254, Percent_Identity=24.8031496062992, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319951, Length=294, Percent_Identity=25.1700680272109, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24646155, Length=297, Percent_Identity=29.2929292929293, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24640980, Length=317, Percent_Identity=28.0757097791798, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI45549126, Length=317, Percent_Identity=28.0757097791798, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24646159, Length=298, Percent_Identity=24.496644295302, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 35345; Mature: 35214

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGQQLTREIGKSGVSASAVGLGTWAIGGWMWGGTDEAESIAAIRASLDAGVTLIDTAPA
CCHHHHHHHHHHCCCCCHHEECCHHHHCCEECCCCCHHHHHHHHHHHHHCCEEEEECCCC
YGLGRSEEIVGKALTGRRDKAVIATKCGLVWHTQKGRHFFDQDGKPVHRYLGRDAILHEV
CCCCCCHHHHHHHHCCCCCCEEEEEECCEEEECCCCCCCCCCCCCHHHHHHCHHHHHHHH
EESLRRLGTDYIDLYITHWQDPTTPVEETMRALEDLRTSGKIRAIGASNVSPDDLNAYIA
HHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEE
AGGLDAIQERFSMIDREIEAELLPLTKANSIATLSYSSLALGLLSGTIGPDRVFSGDDQR
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCCCC
KGNPRFSVDNRQKAAALADAIRPVAEKHGASIAQIVIAWTLAQPGVTFALCGARNPVQAL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHH
DNARAGTVRLDAADLAAIDTAIAAKLTDMDR
CCCCCCEEEECHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SGQQLTREIGKSGVSASAVGLGTWAIGGWMWGGTDEAESIAAIRASLDAGVTLIDTAPA
CHHHHHHHHHHCCCCCHHEECCHHHHCCEECCCCCHHHHHHHHHHHHHCCEEEEECCCC
YGLGRSEEIVGKALTGRRDKAVIATKCGLVWHTQKGRHFFDQDGKPVHRYLGRDAILHEV
CCCCCCHHHHHHHHCCCCCCEEEEEECCEEEECCCCCCCCCCCCCHHHHHHCHHHHHHHH
EESLRRLGTDYIDLYITHWQDPTTPVEETMRALEDLRTSGKIRAIGASNVSPDDLNAYIA
HHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEE
AGGLDAIQERFSMIDREIEAELLPLTKANSIATLSYSSLALGLLSGTIGPDRVFSGDDQR
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCCCC
KGNPRFSVDNRQKAAALADAIRPVAEKHGASIAQIVIAWTLAQPGVTFALCGARNPVQAL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHH
DNARAGTVRLDAADLAAIDTAIAAKLTDMDR
CCCCCCEEEECHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 9298659 [H]