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The map label for this gene is mdtA [H]

Identifier: 116249359

GI number: 116249359

Start: 752595

End: 753668

Strand: Direct

Name: mdtA [H]

Synonym: pRL120696

Alternate gene names: 116249359

Gene position: 752595-753668 (Clockwise)

Preceding gene: 116249356

Following gene: 116249360

Centisome position: 86.5

GC content: 63.69

Gene sequence:

>1074_bases
ATGAGAACCATTCTGGTCGCCACAGCGATCGTATGCGCCGTCGGTCTCGGATCATGCAGCGATGAGCGCGGGCCGACTGA
GCCAACCGCACGGCAGGTCGGTGTCGTCGTCGCCAAGCCTGAGCCGCTGGTCCAAGGTGGCGCGGTCACCGGCGAAGTCC
GCGCCCGTGTCCAGACCGATCTGTCCTTCCGCGTCAGCGGCAAGATCGTCGAGCGGCTGGTGGAAGTCGGACAGTCCGTG
AAGGCGGGGCAGCTCCTCGCGCGGATCGATCCCGAAGAGCAGAAGGCCGAGCTGGATGTGGCAGCTGCCAATCTTCAGTC
GGCTGAGGCGCAGCAAACCCAGGCGCAGCTCGCATACGACCGCCAGCAGAGCCTGTTTCGAACGCAGGTTACGACGCGTG
CGGCACTCGACCAGGCGCAGGAGGCGCTTCTGACCGCACAGGCATCGACGAAGTCGGCGCAGGCGCTGTTGGAAACCGCT
CAGGATACTCTGTCCTACACAGAGCTGAAGGCGGACGCCGACGGGATGATCACCGCCCGCAATGCCGAGGTCGGGCAGGT
GGCGCAGGCCGCCCAGGTCGTCTTCACGCTTGCCCATGACGGCGACCGGGATGCCGTCTTTGAAGTGGTCGAAAGCGCGT
TCCTGCGGCCGATCGACGGCGACGGGACCGTGGCCCTTCTGTCGAACCCCTCGCAGAAGATCGCGGCGAAGGTTCGCGAG
ATTTCGCCGACGATCGATTCCTCCACCGGAACCATCAAGGTCAAGGTCGCGATATCGAGCGACGCTGCGATCCCTCTCGG
CGCTCCCGTCGTCGGAAGATTCAATTATGTCTCGCAGGACGTCATCCAGCTTCCCTGGTCCGCCATGACATCCAAGGACG
GCAAGCCGGCCGTCTGGATTGTCGATCCCGCATCGTCTGCGGTTTCGGCAAGGGCAGTGGATGTCTCCGGCTACGAGACC
GGCAGCTTCATCGTCAAGTCAGGCGTGTCGGACGGAGAGGTCGTGGTGGCCGACGGAACCAAGTTCCTCAGGCCGGGTGA
AATCGTGTCTTATGTCAAGGAAGCTTCCAAGTGA

Upstream 100 bases:

>100_bases
CCCTTGTTGCGCACGCCCTCGTCCCTGCGGGCGCAAAGCTTCATTGACTAATGGGTCAGTCAATTATATAGCAGCTGCCG
TTGAGAGCAAGAGGTCAACT

Downstream 100 bases:

>100_bases
TTATTCGTCCCAAGATAGTCGCACTGATGATGGGTACGGCCCTGATCTCCTCCTGCACGCCGCAGGAGGAAAGCAAGGAG
GAAGCGCCCCGTCCCGTGCT

Product: HlyD family secretion protein

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MRTILVATAIVCAVGLGSCSDERGPTEPTARQVGVVVAKPEPLVQGGAVTGEVRARVQTDLSFRVSGKIVERLVEVGQSV
KAGQLLARIDPEEQKAELDVAAANLQSAEAQQTQAQLAYDRQQSLFRTQVTTRAALDQAQEALLTAQASTKSAQALLETA
QDTLSYTELKADADGMITARNAEVGQVAQAAQVVFTLAHDGDRDAVFEVVESAFLRPIDGDGTVALLSNPSQKIAAKVRE
ISPTIDSSTGTIKVKVAISSDAAIPLGAPVVGRFNYVSQDVIQLPWSAMTSKDGKPAVWIVDPASSAVSARAVDVSGYET
GSFIVKSGVSDGEVVVADGTKFLRPGEIVSYVKEASK

Sequences:

>Translated_357_residues
MRTILVATAIVCAVGLGSCSDERGPTEPTARQVGVVVAKPEPLVQGGAVTGEVRARVQTDLSFRVSGKIVERLVEVGQSV
KAGQLLARIDPEEQKAELDVAAANLQSAEAQQTQAQLAYDRQQSLFRTQVTTRAALDQAQEALLTAQASTKSAQALLETA
QDTLSYTELKADADGMITARNAEVGQVAQAAQVVFTLAHDGDRDAVFEVVESAFLRPIDGDGTVALLSNPSQKIAAKVRE
ISPTIDSSTGTIKVKVAISSDAAIPLGAPVVGRFNYVSQDVIQLPWSAMTSKDGKPAVWIVDPASSAVSARAVDVSGYET
GSFIVKSGVSDGEVVVADGTKFLRPGEIVSYVKEASK
>Mature_357_residues
MRTILVATAIVCAVGLGSCSDERGPTEPTARQVGVVVAKPEPLVQGGAVTGEVRARVQTDLSFRVSGKIVERLVEVGQSV
KAGQLLARIDPEEQKAELDVAAANLQSAEAQQTQAQLAYDRQQSLFRTQVTTRAALDQAQEALLTAQASTKSAQALLETA
QDTLSYTELKADADGMITARNAEVGQVAQAAQVVFTLAHDGDRDAVFEVVESAFLRPIDGDGTVALLSNPSQKIAAKVRE
ISPTIDSSTGTIKVKVAISSDAAIPLGAPVVGRFNYVSQDVIQLPWSAMTSKDGKPAVWIVDPASSAVSARAVDVSGYET
GSFIVKSGVSDGEVVVADGTKFLRPGEIVSYVKEASK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=347, Percent_Identity=27.3775216138329, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1789929, Length=371, Percent_Identity=25.0673854447439, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1786668, Length=356, Percent_Identity=28.3707865168539, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87081796, Length=227, Percent_Identity=29.0748898678414, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789665, Length=371, Percent_Identity=26.4150943396226, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI87081951, Length=169, Percent_Identity=33.7278106508876, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 37437; Mature: 37437

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTILVATAIVCAVGLGSCSDERGPTEPTARQVGVVVAKPEPLVQGGAVTGEVRARVQTD
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCEEEECCCCCCCCCCEEHHHHEEEEEC
LSFRVSGKIVERLVEVGQSVKAGQLLARIDPEEQKAELDVAAANLQSAEAQQTQAQLAYD
CEEEECHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQQSLFRTQVTTRAALDQAQEALLTAQASTKSAQALLETAQDTLSYTELKADADGMITAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEC
NAEVGQVAQAAQVVFTLAHDGDRDAVFEVVESAFLRPIDGDGTVALLSNPSQKIAAKVRE
CCCHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHH
ISPTIDSSTGTIKVKVAISSDAAIPLGAPVVGRFNYVSQDVIQLPWSAMTSKDGKPAVWI
CCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHCCCCCCCEEEE
VDPASSAVSARAVDVSGYETGSFIVKSGVSDGEVVVADGTKFLRPGEIVSYVKEASK
ECCCCCCCEEEEEEECCCCCCCEEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MRTILVATAIVCAVGLGSCSDERGPTEPTARQVGVVVAKPEPLVQGGAVTGEVRARVQTD
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCEEEECCCCCCCCCCEEHHHHEEEEEC
LSFRVSGKIVERLVEVGQSVKAGQLLARIDPEEQKAELDVAAANLQSAEAQQTQAQLAYD
CEEEECHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQQSLFRTQVTTRAALDQAQEALLTAQASTKSAQALLETAQDTLSYTELKADADGMITAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEC
NAEVGQVAQAAQVVFTLAHDGDRDAVFEVVESAFLRPIDGDGTVALLSNPSQKIAAKVRE
CCCHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHH
ISPTIDSSTGTIKVKVAISSDAAIPLGAPVVGRFNYVSQDVIQLPWSAMTSKDGKPAVWI
CCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHCCCCCCCEEEE
VDPASSAVSARAVDVSGYETGSFIVKSGVSDGEVVVADGTKFLRPGEIVSYVKEASK
ECCCCCCCEEEEEEECCCCCCCEEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]