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The map label for this gene is idnD [H]

Identifier: 116249069

GI number: 116249069

Start: 435712

End: 436746

Strand: Direct

Name: idnD [H]

Synonym: pRL120403

Alternate gene names: 116249069

Gene position: 435712-436746 (Clockwise)

Preceding gene: 116249068

Following gene: 116249070

Centisome position: 50.08

GC content: 65.12

Gene sequence:

>1035_bases
ATGCGGACACGTGTGGCACGGCTTTACCAAAAGGGCGACCTCAGGATCGAGACCGCCGCGGTTGCGGCCCCTGGTCCCGG
GGAGGTGCTTCTCAAAATGGCGGCCGCAGGGATTTGCGGCTCCGACCTGCATTATTATCAGGACGGCGGCTTCGGGCCTG
TCCGGGTTCGCGAGCCGATCATACCCGGCCACGAGGCCTCGGGGACCGTGAGCCAAGCGGGCGAGGGCGTCGATCTGAAG
GCTGGCACGCTGGTGGCGGTCAATCCCAGCCAACCCTGCGGGCATTGCGAATATTGCCAGAAAAACATGCCGATCCACTG
CCTGGACATGCGCTTCATGGGCAGTGCGATGCGCCTGCCGCATGAGCAGGGCATGTTCCGGGAATGGCTGGTGGTGCCGG
CCAAGCAATGCTTTGCGGTCGGAGCTGCGACAACCGCCGCGGAAGCGGCCTGCAGCGAGCCGCTCTCCGTCTGCCTGCAC
GCGGCATCGCGCGCAGGAGATATCACAGGCAAACGCGTGCTGGTCACCGGAGCCGGCCCGATCGGCGCCCTGATGGTTGC
CGTCGCCTCCTATCACCATGCAAGCGAGATCGTGGTGACAGATCTCGCGGACGCGGCGCTGGACCGGGCCAAAGCGATGG
GCGCCAGCCGCACGATCAATGTTTCCAAAAACGCCCAGGCGCTTGCCGAATTCGAGGCGGGAAAGGGCTATTTCGATCTC
GTCTTCGAATGCTCGGCCGCCGCCCCGGCCATCCGCGGCGCAATTGCCGCCATCAGGCCGCGCGGAACGATCGTGCAGGT
CGGCGTCACAGGAGACGTCCCGATCCCGCTCAACGCCATCGTCGGCAAGGAGCTTCAACTCCACGGAACGCAGCGCTTCC
ACGAGGAGTTCGGTACTGCCGTCGAGCTGATCTCCAGCCGCAAGATCGATGTGCGGCCGATCATCAGTCACAGCCTGCCG
CTCGAAGAAGCCACCGCAGCCTTCACCCTCGCCGGCGACCGCGCGGCCGCCTGCAAGGTGCAACTGACTTTTTAG

Upstream 100 bases:

>100_bases
GCTGGTGCCGCTCTTCCTGGCGCTGATCCTGATCACCTTCGTGCCCGCCATATCGCTGTGGCTGCCGCAGCAACTCGGGC
TGCTGAGATAGGAGTGGAAG

Downstream 100 bases:

>100_bases
AGCGCGTCGCCGAACTCACGCCTGTGCTCGGCGGGGCGATGAGCAATCGAATCCGCCCGGCCGACGCGTCTACGCGCGCC
TGGCTGCCCCGACGGTATTG

Product: putative dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MRTRVARLYQKGDLRIETAAVAAPGPGEVLLKMAAAGICGSDLHYYQDGGFGPVRVREPIIPGHEASGTVSQAGEGVDLK
AGTLVAVNPSQPCGHCEYCQKNMPIHCLDMRFMGSAMRLPHEQGMFREWLVVPAKQCFAVGAATTAAEAACSEPLSVCLH
AASRAGDITGKRVLVTGAGPIGALMVAVASYHHASEIVVTDLADAALDRAKAMGASRTINVSKNAQALAEFEAGKGYFDL
VFECSAAAPAIRGAIAAIRPRGTIVQVGVTGDVPIPLNAIVGKELQLHGTQRFHEEFGTAVELISSRKIDVRPIISHSLP
LEEATAAFTLAGDRAAACKVQLTF

Sequences:

>Translated_344_residues
MRTRVARLYQKGDLRIETAAVAAPGPGEVLLKMAAAGICGSDLHYYQDGGFGPVRVREPIIPGHEASGTVSQAGEGVDLK
AGTLVAVNPSQPCGHCEYCQKNMPIHCLDMRFMGSAMRLPHEQGMFREWLVVPAKQCFAVGAATTAAEAACSEPLSVCLH
AASRAGDITGKRVLVTGAGPIGALMVAVASYHHASEIVVTDLADAALDRAKAMGASRTINVSKNAQALAEFEAGKGYFDL
VFECSAAAPAIRGAIAAIRPRGTIVQVGVTGDVPIPLNAIVGKELQLHGTQRFHEEFGTAVELISSRKIDVRPIISHSLP
LEEATAAFTLAGDRAAACKVQLTF
>Mature_344_residues
MRTRVARLYQKGDLRIETAAVAAPGPGEVLLKMAAAGICGSDLHYYQDGGFGPVRVREPIIPGHEASGTVSQAGEGVDLK
AGTLVAVNPSQPCGHCEYCQKNMPIHCLDMRFMGSAMRLPHEQGMFREWLVVPAKQCFAVGAATTAAEAACSEPLSVCLH
AASRAGDITGKRVLVTGAGPIGALMVAVASYHHASEIVVTDLADAALDRAKAMGASRTINVSKNAQALAEFEAGKGYFDL
VFECSAAAPAIRGAIAAIRPRGTIVQVGVTGDVPIPLNAIVGKELQLHGTQRFHEEFGTAVELISSRKIDVRPIISHSLP
LEEATAAFTLAGDRAAACKVQLTF

Specific function: Catalyzes the NADH/NADPH-dependent oxidation of L- idonate to 5-ketogluconate (5KG) [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=322, Percent_Identity=36.6459627329193, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI4501933, Length=360, Percent_Identity=27.2222222222222, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI34577061, Length=360, Percent_Identity=26.6666666666667, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4501929, Length=359, Percent_Identity=25.6267409470752, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1790718, Length=316, Percent_Identity=40.1898734177215, Blast_Score=248, Evalue=5e-67,
Organism=Escherichia coli, GI1788073, Length=333, Percent_Identity=31.5315315315315, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI1787863, Length=342, Percent_Identity=30.9941520467836, Blast_Score=141, Evalue=8e-35,
Organism=Escherichia coli, GI1790045, Length=330, Percent_Identity=29.6969696969697, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1788407, Length=310, Percent_Identity=30.6451612903226, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1788075, Length=341, Percent_Identity=29.6187683284457, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI226510992, Length=330, Percent_Identity=29.6969696969697, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI87082125, Length=350, Percent_Identity=27.7142857142857, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI87081918, Length=297, Percent_Identity=30.3030303030303, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786552, Length=362, Percent_Identity=27.3480662983425, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1786518, Length=260, Percent_Identity=27.3076923076923, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=329, Percent_Identity=39.209726443769, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17562878, Length=336, Percent_Identity=38.0952380952381, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17562584, Length=357, Percent_Identity=25.4901960784314, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=310, Percent_Identity=27.0967741935484, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322619, Length=332, Percent_Identity=34.6385542168675, Blast_Score=179, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6319955, Length=332, Percent_Identity=34.6385542168675, Blast_Score=179, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6323099, Length=325, Percent_Identity=33.2307692307692, Blast_Score=164, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6319258, Length=308, Percent_Identity=30.1948051948052, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319257, Length=383, Percent_Identity=27.154046997389, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6323729, Length=284, Percent_Identity=28.169014084507, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319621, Length=263, Percent_Identity=27.3764258555133, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324486, Length=263, Percent_Identity=25.0950570342205, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=265, Percent_Identity=24.9056603773585, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737897, Length=329, Percent_Identity=34.6504559270517, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI17137530, Length=323, Percent_Identity=34.3653250773994, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI17737895, Length=354, Percent_Identity=26.8361581920904, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI45551930, Length=315, Percent_Identity=23.8095238095238, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45550770, Length=315, Percent_Identity=23.8095238095238, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221457811, Length=315, Percent_Identity=23.8095238095238, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.264 [H]

Molecular weight: Translated: 36078; Mature: 36078

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTRVARLYQKGDLRIETAAVAAPGPGEVLLKMAAAGICGSDLHYYQDGGFGPVRVREPI
CCCHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHCCCCCCCCEEEECCCCCCEEEECCC
IPGHEASGTVSQAGEGVDLKAGTLVAVNPSQPCGHCEYCQKNMPIHCLDMRFMGSAMRLP
CCCCCCCCCHHHCCCCCEECCCEEEEECCCCCCCCHHHHHCCCCEEEECHHHHHHHHCCC
HEQGMFREWLVVPAKQCFAVGAATTAAEAACSEPLSVCLHAASRAGDITGKRVLVTGAGP
CCCCHHHHHHHCCCHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEECCCH
IGALMVAVASYHHASEIVVTDLADAALDRAKAMGASRTINVSKNAQALAEFEAGKGYFDL
HHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCEEEE
VFECSAAAPAIRGAIAAIRPRGTIVQVGVTGDVPIPLNAIVGKELQLHGTQRFHEEFGTA
EEECCCCCHHHHHHHHEECCCCCEEEEEECCCCCCCHHHHHCCEEEECCHHHHHHHHHHH
VELISSRKIDVRPIISHSLPLEEATAAFTLAGDRAAACKVQLTF
HHHHHCCCCCEEEHHCCCCCHHHHCEEEEEECCCCEEEEEEEEC
>Mature Secondary Structure
MRTRVARLYQKGDLRIETAAVAAPGPGEVLLKMAAAGICGSDLHYYQDGGFGPVRVREPI
CCCHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHCCCCCCCCEEEECCCCCCEEEECCC
IPGHEASGTVSQAGEGVDLKAGTLVAVNPSQPCGHCEYCQKNMPIHCLDMRFMGSAMRLP
CCCCCCCCCHHHCCCCCEECCCEEEEECCCCCCCCHHHHHCCCCEEEECHHHHHHHHCCC
HEQGMFREWLVVPAKQCFAVGAATTAAEAACSEPLSVCLHAASRAGDITGKRVLVTGAGP
CCCCHHHHHHHCCCHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEECCCH
IGALMVAVASYHHASEIVVTDLADAALDRAKAMGASRTINVSKNAQALAEFEAGKGYFDL
HHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCEEEE
VFECSAAAPAIRGAIAAIRPRGTIVQVGVTGDVPIPLNAIVGKELQLHGTQRFHEEFGTA
EEECCCCCHHHHHHHHEECCCCCEEEEEECCCCCCCHHHHHCCEEEECCHHHHHHHHHHH
VELISSRKIDVRPIISHSLPLEEATAAFTLAGDRAAACKVQLTF
HHHHHCCCCCEEEHHCCCCCHHHHCEEEEEECCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 9658018 [H]