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The map label for this gene is ldh [H]

Identifier: 116248901

GI number: 116248901

Start: 241199

End: 242260

Strand: Reverse

Name: ldh [H]

Synonym: pRL120231

Alternate gene names: 116248901

Gene position: 242260-241199 (Counterclockwise)

Preceding gene: 116248902

Following gene: 116248899

Centisome position: 27.85

GC content: 62.99

Gene sequence:

>1062_bases
ATGCCTATGCCGCTGATTGACCGCATTGCCCTGACCCAATTCGCAAAGCAGATATTGACCCGCGCCGGCATGGAGGTCGA
CAAGGCCGAAACGACCGCCGTCGTACTGGTGGAAGGCGACATGATCGGCCACGAAACGCATGGCGTCAGCCTTTTGAACT
GGTATGTCGAGGCATTGGAAGACGGCTCGCTGGCGAAGTCCGGCAGCTATGAGGTCGTCAATGACCGCGGTGCAGCCTTT
GTTTGGGACGGCAAATCCTTGCCCGGCGCATGGCTGCTGACCAAGGCGATCGAGCAGGCCTGCGAACGCGTCGGCGATCA
TGGCGTCGTCACCGCCGCGATCCGCAACTGCCACCATACCTGCGCTCTTTCAGCCTTCATGCGGCAGGTAACCGACCGGG
GCCTGATCGTGCAGCTGTCGGTGTCGCATCCCGCGGCGAGCCGCGTTGCGCCCTATGGCGGCACGAAGCCGCTGCTGACG
CCCAATCCGATGGCGGCCGGATTCCCGACATCTGCGGATCCGATCCTGATCGACGTCTCGGCCTCGATCACCACCACGAC
CATGACGCAAAACCTGGCGAAGGCCGGCAAGAAATTTCCTGAGGCCTGGGCTTTCACCGCCGCAGGTGAGCCGACCGATG
ATCCGCGCGAGGTGACCGAACGGGGCGGGACGATGATGCCTCTTGGCGGCCAGTTGAAGGGGCACAAGGGTTTTGGGCTC
GGGCTGATCGTCGAATTGCTGGGGCAGGGGCTTTCCGGCAAGGGACGGGCCAACGCGCCGTCCGGTGTGTTTTCGCAAAG
CGCTTTCCTTCAGGTCATCGATCCCGCCTTTTTCGCCGGGCTGGATGCCTTTACGGCGCAGTCTGATTTTCTCGCCTCTG
CATGCCGCAGCAATCCTCCTGCGCCCTGGAACAATGGTCCTGTCCGCATGCCGGGCGACAGCGCAGCGCGAAGGCGCCGC
TCGGCGTTGGAAGAGGGCGTGCCGGTCGGCGATGCAACTTGGCAGAAGCTTTGTAAACACGCCGAGATCCTGGGCTTGCC
TATTCCAGACGTCGCTGCGTGA

Upstream 100 bases:

>100_bases
CTGCAGCTGTCGCAGATCCGCTTCAAGTAAACCGGTATGCCGCACTTGAGCACGGGCCGCCGCAAATAGCGGCCCGTGCT
TTCCATGACGTGAGGGAGAA

Downstream 100 bases:

>100_bases
GGAACGCATCTCTGCTTCAAAACTTCTTATCGGCCGCCGCAATGCCCGAGCAGTTGAAATCAAATCGGCCAAACCAACAA
CAGGATCGGCACACTAACGA

Product: putative L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MPMPLIDRIALTQFAKQILTRAGMEVDKAETTAVVLVEGDMIGHETHGVSLLNWYVEALEDGSLAKSGSYEVVNDRGAAF
VWDGKSLPGAWLLTKAIEQACERVGDHGVVTAAIRNCHHTCALSAFMRQVTDRGLIVQLSVSHPAASRVAPYGGTKPLLT
PNPMAAGFPTSADPILIDVSASITTTTMTQNLAKAGKKFPEAWAFTAAGEPTDDPREVTERGGTMMPLGGQLKGHKGFGL
GLIVELLGQGLSGKGRANAPSGVFSQSAFLQVIDPAFFAGLDAFTAQSDFLASACRSNPPAPWNNGPVRMPGDSAARRRR
SALEEGVPVGDATWQKLCKHAEILGLPIPDVAA

Sequences:

>Translated_353_residues
MPMPLIDRIALTQFAKQILTRAGMEVDKAETTAVVLVEGDMIGHETHGVSLLNWYVEALEDGSLAKSGSYEVVNDRGAAF
VWDGKSLPGAWLLTKAIEQACERVGDHGVVTAAIRNCHHTCALSAFMRQVTDRGLIVQLSVSHPAASRVAPYGGTKPLLT
PNPMAAGFPTSADPILIDVSASITTTTMTQNLAKAGKKFPEAWAFTAAGEPTDDPREVTERGGTMMPLGGQLKGHKGFGL
GLIVELLGQGLSGKGRANAPSGVFSQSAFLQVIDPAFFAGLDAFTAQSDFLASACRSNPPAPWNNGPVRMPGDSAARRRR
SALEEGVPVGDATWQKLCKHAEILGLPIPDVAA
>Mature_352_residues
PMPLIDRIALTQFAKQILTRAGMEVDKAETTAVVLVEGDMIGHETHGVSLLNWYVEALEDGSLAKSGSYEVVNDRGAAFV
WDGKSLPGAWLLTKAIEQACERVGDHGVVTAAIRNCHHTCALSAFMRQVTDRGLIVQLSVSHPAASRVAPYGGTKPLLTP
NPMAAGFPTSADPILIDVSASITTTTMTQNLAKAGKKFPEAWAFTAAGEPTDDPREVTERGGTMMPLGGQLKGHKGFGLG
LIVELLGQGLSGKGRANAPSGVFSQSAFLQVIDPAFFAGLDAFTAQSDFLASACRSNPPAPWNNGPVRMPGDSAARRRRS
ALEEGVPVGDATWQKLCKHAEILGLPIPDVAA

Specific function: Unknown

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787020, Length=350, Percent_Identity=26.5714285714286, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1786727, Length=345, Percent_Identity=25.2173913043478, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1790000, Length=334, Percent_Identity=23.6526946107784, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17507179, Length=320, Percent_Identity=27.1875, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17536633, Length=252, Percent_Identity=23.4126984126984, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45553211, Length=301, Percent_Identity=26.2458471760797, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24667912, Length=301, Percent_Identity=26.2458471760797, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24667908, Length=263, Percent_Identity=26.9961977186312, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24667904, Length=301, Percent_Identity=26.2458471760797, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 37236; Mature: 37105

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMPLIDRIALTQFAKQILTRAGMEVDKAETTAVVLVEGDMIGHETHGVSLLNWYVEALE
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCEECCCCCCHHHHHHHHHHHC
DGSLAKSGSYEVVNDRGAAFVWDGKSLPGAWLLTKAIEQACERVGDHGVVTAAIRNCHHT
CCCCCCCCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
CALSAFMRQVTDRGLIVQLSVSHPAASRVAPYGGTKPLLTPNPMAAGFPTSADPILIDVS
HHHHHHHHHHCCCCEEEEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEC
ASITTTTMTQNLAKAGKKFPEAWAFTAAGEPTDDPREVTERGGTMMPLGGQLKGHKGFGL
CCEEHHHHHHHHHHHHHCCCHHEEEECCCCCCCCHHHHHHCCCEECCCCCCCCCCCCCCH
GLIVELLGQGLSGKGRANAPSGVFSQSAFLQVIDPAFFAGLDAFTAQSDFLASACRSNPP
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
APWNNGPVRMPGDSAARRRRSALEEGVPVGDATWQKLCKHAEILGLPIPDVAA
CCCCCCCEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEECCCCCCCCC
>Mature Secondary Structure 
PMPLIDRIALTQFAKQILTRAGMEVDKAETTAVVLVEGDMIGHETHGVSLLNWYVEALE
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCEECCCCCCHHHHHHHHHHHC
DGSLAKSGSYEVVNDRGAAFVWDGKSLPGAWLLTKAIEQACERVGDHGVVTAAIRNCHHT
CCCCCCCCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
CALSAFMRQVTDRGLIVQLSVSHPAASRVAPYGGTKPLLTPNPMAAGFPTSADPILIDVS
HHHHHHHHHHCCCCEEEEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEC
ASITTTTMTQNLAKAGKKFPEAWAFTAAGEPTDDPREVTERGGTMMPLGGQLKGHKGFGL
CCEEHHHHHHHHHHHHHCCCHHEEEECCCCCCCCHHHHHHCCCEECCCCCCCCCCCCCCH
GLIVELLGQGLSGKGRANAPSGVFSQSAFLQVIDPAFFAGLDAFTAQSDFLASACRSNPP
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
APWNNGPVRMPGDSAARRRRSALEEGVPVGDATWQKLCKHAEILGLPIPDVAA
CCCCCCCEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8405966 [H]