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The map label for this gene is ilvA [H]

Identifier: 115352838

GI number: 115352838

Start: 3074905

End: 3076428

Strand: Direct

Name: ilvA [H]

Synonym: Bamb_2787

Alternate gene names: 115352838

Gene position: 3074905-3076428 (Clockwise)

Preceding gene: 115352820

Following gene: 115352839

Centisome position: 86.46

GC content: 66.8

Gene sequence:

>1524_bases
ATGGCATCCCACGATTACCTGAAGAAAATCCTCACCGCGCGCGTCTACGACGTCGCGCTCGAGACGGAACTCGAACCCGC
CCGCAACCTGTCGGCCCGACTGCGCAACCCCGTTTACCTGAAGCGCGAGGACAACCAGCCGGTGTTCTCGTTCAAGCTGC
GCGGTGCGTACAACAAGATGGCGCACATTCCGGCCGACGCGCTCGCGCGCGGCGTGATCACGGCATCGGCCGGCAATCAT
GCGCAGGGCGTCGCGTTCTCGGCGGCCCGGATGGGCATCAAGGCCGTCATCGTCGTGCCCGTCACGACGCCGCAGGTGAA
GGTCGACGCGGTGCGCGCCCACGGCGGCCCGAGCGTCGAGGTGATCCAGGCGGGCGAGTCGTACAGCGATGCGTATGCGC
ATGCCGTGAAGGTGCAGGCCGAACGCGACCTCACGTTCGTCCACCCGTTCGACGATCCGTACGTGATCGCCGGCCAGGGC
ACGATCGCGATGGAAATCCTGCGGCAGCACCAGGGCCCGATTCACGCGATCTTCGTGCCGATCGGCGGCGGCGGCCTCGC
GGCCGGCGTGGCCGCGTACGTGAAGGCGGTGCGGCCGGAGATCAAGGTGTTCGGCGTGCAGGCCGAGGATTCGTGCGCGA
TGGCGCAGTCGCTGGAAAAAGGCGAGCGCGTCGAGCTGAGCGAAGTCGGGCTGTTTGCGGACGGCACCGCGGTGAAGCTC
GTCGGCGAGGAAACCTTCCGGCTCTGCAGCGAGCTCCTCGACGGCGTCGTGACGGTGGACACCGACGCGCTGTGCGCGGC
GATCAAGGATGTATTCCAGGACACGCGCAGCGTGCTCGAGCCGTCCGGCGCGCTCGCGGTGGCGGGCGCGAAACGCTACG
CGGAACGCGAAGGGATCGAGAACCAGACGCTCGTCGCGGTCACGTCGGGCGCGAACATGAACTTCGACCGGATGCGCTTC
GTTGCCGAACGCGCGGAAGTCGGCGAGGCGCGCGAAGCCGTGTTCGCGGTCACGATCCCCGAGGAGCGCGGCAGCTTCAA
GCGCTTCTGCTCGCTCGTCGGCGAACGCAACGTGACCGAGTTCAACTACCGGATCGCCGATGCGCAGGCCGCGCATATCT
TCGTCGGCGTGCAGATCAAGCGGCGCGGCGAATCGGCGGAGATCGCCGCGAACTTCGAGTCGCACGGCTTCAAGACCGTC
GACCTGACGCACGACGAGCTGTCGAAGGAGCACATCCGCTACATGGTGGGCGGCCGCTCGCCGCTCGCGCTCGACGAACG
CCTGTTCCGCTTCGAATTCCCGGAACGGCCGGGCGCGCTGATGAAGTTCCTGTCGTCGATGGCGCCGGACTGGAACATCA
GCCTGTTCCATTACCGTAACCAGGGTGCGGACTACAGCTCGATCCTCGTCGGGCTGCAGGTGCCGCAGGTCGATCGCGCC
GAGTTCGAACGCTTCCTCGCGGCGCTCGGCTATCCGTATGTCGAAGAGAGCGCCAATCCGGCGTACCGGCTCTTCCTGTC
GTAA

Upstream 100 bases:

>100_bases
TTTCGCGACGGTGCGCCCGGCATGCCGCTTGCGTGCGGGCGGACCCTTGGCGCTATCATTGACGTTTTACCGTCTGCTTC
CGCACCGCACGCGAGCGCCC

Downstream 100 bases:

>100_bases
AGGCTTCGTGCAATGAATCCCGAACATTCCCCGCTCGGCAAGGCCACCGTCTATGCCGCCCAGTACGACGCGTCGCTGCT
GTTCCCGATCCCGCGCGCCG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MASHDYLKKILTARVYDVALETELEPARNLSARLRNPVYLKREDNQPVFSFKLRGAYNKMAHIPADALARGVITASAGNH
AQGVAFSAARMGIKAVIVVPVTTPQVKVDAVRAHGGPSVEVIQAGESYSDAYAHAVKVQAERDLTFVHPFDDPYVIAGQG
TIAMEILRQHQGPIHAIFVPIGGGGLAAGVAAYVKAVRPEIKVFGVQAEDSCAMAQSLEKGERVELSEVGLFADGTAVKL
VGEETFRLCSELLDGVVTVDTDALCAAIKDVFQDTRSVLEPSGALAVAGAKRYAEREGIENQTLVAVTSGANMNFDRMRF
VAERAEVGEAREAVFAVTIPEERGSFKRFCSLVGERNVTEFNYRIADAQAAHIFVGVQIKRRGESAEIAANFESHGFKTV
DLTHDELSKEHIRYMVGGRSPLALDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQVDRA
EFERFLAALGYPYVEESANPAYRLFLS

Sequences:

>Translated_507_residues
MASHDYLKKILTARVYDVALETELEPARNLSARLRNPVYLKREDNQPVFSFKLRGAYNKMAHIPADALARGVITASAGNH
AQGVAFSAARMGIKAVIVVPVTTPQVKVDAVRAHGGPSVEVIQAGESYSDAYAHAVKVQAERDLTFVHPFDDPYVIAGQG
TIAMEILRQHQGPIHAIFVPIGGGGLAAGVAAYVKAVRPEIKVFGVQAEDSCAMAQSLEKGERVELSEVGLFADGTAVKL
VGEETFRLCSELLDGVVTVDTDALCAAIKDVFQDTRSVLEPSGALAVAGAKRYAEREGIENQTLVAVTSGANMNFDRMRF
VAERAEVGEAREAVFAVTIPEERGSFKRFCSLVGERNVTEFNYRIADAQAAHIFVGVQIKRRGESAEIAANFESHGFKTV
DLTHDELSKEHIRYMVGGRSPLALDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQVDRA
EFERFLAALGYPYVEESANPAYRLFLS
>Mature_506_residues
ASHDYLKKILTARVYDVALETELEPARNLSARLRNPVYLKREDNQPVFSFKLRGAYNKMAHIPADALARGVITASAGNHA
QGVAFSAARMGIKAVIVVPVTTPQVKVDAVRAHGGPSVEVIQAGESYSDAYAHAVKVQAERDLTFVHPFDDPYVIAGQGT
IAMEILRQHQGPIHAIFVPIGGGGLAAGVAAYVKAVRPEIKVFGVQAEDSCAMAQSLEKGERVELSEVGLFADGTAVKLV
GEETFRLCSELLDGVVTVDTDALCAAIKDVFQDTRSVLEPSGALAVAGAKRYAEREGIENQTLVAVTSGANMNFDRMRFV
AERAEVGEAREAVFAVTIPEERGSFKRFCSLVGERNVTEFNYRIADAQAAHIFVGVQIKRRGESAEIAANFESHGFKTVD
LTHDELSKEHIRYMVGGRSPLALDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQVDRAE
FERFLAALGYPYVEESANPAYRLFLS

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=298, Percent_Identity=34.8993288590604, Blast_Score=148, Evalue=1e-35,
Organism=Escherichia coli, GI1790207, Length=504, Percent_Identity=53.3730158730159, Blast_Score=512, Evalue=1e-146,
Organism=Escherichia coli, GI1789505, Length=311, Percent_Identity=36.3344051446945, Blast_Score=163, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI71991565, Length=325, Percent_Identity=30.1538461538462, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17537387, Length=342, Percent_Identity=30.9941520467836, Blast_Score=128, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17508781, Length=257, Percent_Identity=30.7392996108949, Blast_Score=118, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6320930, Length=517, Percent_Identity=47.3887814313346, Blast_Score=461, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6322631, Length=304, Percent_Identity=33.2236842105263, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6319788, Length=270, Percent_Identity=25.5555555555556, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21355833, Length=316, Percent_Identity=30.379746835443, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24645328, Length=255, Percent_Identity=29.0196078431373, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 55444; Mature: 55312

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASHDYLKKILTARVYDVALETELEPARNLSARLRNPVYLKREDNQPVFSFKLRGAYNKM
CCCHHHHHHHHHHHHHHHHEECCCCHHHCHHHHHCCCEEEEECCCCCEEEEEECCCHHHH
AHIPADALARGVITASAGNHAQGVAFSAARMGIKAVIVVPVTTPQVKVDAVRAHGGPSVE
HCCCHHHHHCCEEEECCCCCCCCEEEHHHHCCEEEEEEEECCCCCEEEEEEECCCCCCEE
VIQAGESYSDAYAHAVKVQAERDLTFVHPFDDPYVIAGQGTIAMEILRQHQGPIHAIFVP
EEECCCCCCCHHHEEEEEEECCCEEEECCCCCCEEEECCCHHHHHHHHHCCCCEEEEEEE
IGGGGLAAGVAAYVKAVRPEIKVFGVQAEDSCAMAQSLEKGERVELSEVGLFADGTAVKL
ECCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCEEHHHCCEEECCCEEEE
VGEETFRLCSELLDGVVTVDTDALCAAIKDVFQDTRSVLEPSGALAVAGAKRYAEREGIE
ECHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCC
NQTLVAVTSGANMNFDRMRFVAERAEVGEAREAVFAVTIPEERGSFKRFCSLVGERNVTE
CCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHCCCHHHHHHHHCCCCCEE
FNYRIADAQAAHIFVGVQIKRRGESAEIAANFESHGFKTVDLTHDELSKEHIRYMVGGRS
EEEEEECCCEEEEEEEEEEEECCCCCEEEECHHHCCEEEEECCHHHHHHHHHHHEECCCC
PLALDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQVDRA
CCHHHHHHHEECCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHEEEEEECCCCCHH
EFERFLAALGYPYVEESANPAYRLFLS
HHHHHHHHHCCCHHHCCCCCEEEEEEC
>Mature Secondary Structure 
ASHDYLKKILTARVYDVALETELEPARNLSARLRNPVYLKREDNQPVFSFKLRGAYNKM
CCHHHHHHHHHHHHHHHHEECCCCHHHCHHHHHCCCEEEEECCCCCEEEEEECCCHHHH
AHIPADALARGVITASAGNHAQGVAFSAARMGIKAVIVVPVTTPQVKVDAVRAHGGPSVE
HCCCHHHHHCCEEEECCCCCCCCEEEHHHHCCEEEEEEEECCCCCEEEEEEECCCCCCEE
VIQAGESYSDAYAHAVKVQAERDLTFVHPFDDPYVIAGQGTIAMEILRQHQGPIHAIFVP
EEECCCCCCCHHHEEEEEEECCCEEEECCCCCCEEEECCCHHHHHHHHHCCCCEEEEEEE
IGGGGLAAGVAAYVKAVRPEIKVFGVQAEDSCAMAQSLEKGERVELSEVGLFADGTAVKL
ECCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCEEHHHCCEEECCCEEEE
VGEETFRLCSELLDGVVTVDTDALCAAIKDVFQDTRSVLEPSGALAVAGAKRYAEREGIE
ECHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCC
NQTLVAVTSGANMNFDRMRFVAERAEVGEAREAVFAVTIPEERGSFKRFCSLVGERNVTE
CCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHCCCHHHHHHHHCCCCCEE
FNYRIADAQAAHIFVGVQIKRRGESAEIAANFESHGFKTVDLTHDELSKEHIRYMVGGRS
EEEEEECCCEEEEEEEEEEEECCCCCEEEECHHHCCEEEEECCHHHHHHHHHHHEECCCC
PLALDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQVDRA
CCHHHHHHHEECCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHEEEEEECCCCCHH
EFERFLAALGYPYVEESANPAYRLFLS
HHHHHHHHHCCCHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA