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The map label for this gene is norM [H]

Identifier: 115351824

GI number: 115351824

Start: 1960559

End: 1961914

Strand: Direct

Name: norM [H]

Synonym: Bamb_1773

Alternate gene names: 115351824

Gene position: 1960559-1961914 (Clockwise)

Preceding gene: 115351823

Following gene: 115351831

Centisome position: 55.13

GC content: 68.95

Gene sequence:

>1356_bases
ATGTTCGCCGACATCCGCCGGATCGTCGGTCTCGCGTGGCCGGTGCTCGTCGGCCAGCTCGCGATCATCGCGTTCGGCGT
GATCGACACGGCGATGGTCGGCCGCTACTCGGCCATCGACCTGGCCGCGCTCGGGCTCGGTTCGTCGATCTACGTGTCGA
TCTACATCGGGATGACGGGCATCCTGTCCGCGCTGCAGCCGATCACCGGGCAGCTGTACGGCGCCCGGCGCTACGCCGAG
ATCGGCGAGGAAGTCCGCCAGGCGCTGTGGCTCGCGCTGATGCTCGCGGTGCCCGGCTTCCTGCTGCTGCATTTTCCCGA
ACCGCTGCTGCACATCGCCCACGCGCCGCCCGCGCTGCACGAGCGCACCGTCGATTACCTGCGCATCCTGTCGTACGGGC
TGCCTGCGAGCCTCGTGTTCCGGATCTACAACGCGCTGACCAATGCGGCCGGCAAGCCGCGCCTCGCGATGATCCTGCAG
ATCGGCGCGCTGCTGCTCAAATTTCCGCTCAACGTGTGGTTCATCTTCGGCGGGTTCGGCATGCCGGCGCTCGGCGGCCC
CGGTTGCGGGCTCGCGAGCACGCTGATCAACTGGGCGCTCGCGCTGATCGGCTTCACGCTCCTCGCGAAGCTCGACGTGT
TCACGCCGCTCGCGATCTTCTCGCGCTTTTGCTGGCCCGTCTGGTGGCGCCAGAAGGCGATTCTCAAGCTCGGCGTGCCG
ATGGGCCTGTCGTACCTGATCGAGGTCACGTCGTTCACGTGCATGGCGCTCTTCATCGCGCAGTTCGGCACGACGACGCT
CGCCGGCCACCAGATCGCCGGCAACATCAGCGCGGTGCTGTACATGACGCCGCTGTCGATCGGCGTCGCGGCATCGACGC
TCGTCGCGCGCGCGCTCGGTGCCGGCCGTCCGGACGAGGCGCGCCTGCTCGGCCGGCACAGCGTGATGCTCGCGTGCGGG
ATCGCGGCCGCGTATGGCGTGCTGGTGTTCACGCTGCGTCCGCTGATCGTCAGCGGCTACACGCCGAACCCGGCCGTGGT
GGCCGCGGCGCTGCCGCTGGTCGCGATCGTCACCTGCTATCACTTCTTCGATGCGCTGCAGATCACGTCGGCATTCGTGC
TGCGCGCGTACAAGGTTGCCGTCGTGCCGACCGTGATCTACGCGGTCGCGCTGTGGGGCGTCGGGCTCGGCGGTGGCTAC
GTGCTCGGCTTCGACATCGGCGGCATCGCGCCGGCATGGCTGACCGGCGCGCGCGGCTTCTGGTTCGCGAACACGATCAG
CCTGATGCTCGCCGGTGCAGGACTCGCCCTCTACCTGCGCCGCGTCAGCCGCGCGGCGCTGTCCGTCGGCGCCTGA

Upstream 100 bases:

>100_bases
TGGCCGACCGCGACGAGCGCTTCCGCCTGTACGAGCGCATCGAGCGGCCGACGACGCCCGTCAAGCGCCGTGGCCCGCGC
CGCCGGACGGTCGATTGACG

Downstream 100 bases:

>100_bases
CCCGCTGTCAGCAGCCTACGCGTCCTCCAGCACGTCGGCCGCGTGATACGACGACCGCACGAGCGGGCCGGCCACGACTT
CCCTGAAACCGAGCGCCAGC

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MFADIRRIVGLAWPVLVGQLAIIAFGVIDTAMVGRYSAIDLAALGLGSSIYVSIYIGMTGILSALQPITGQLYGARRYAE
IGEEVRQALWLALMLAVPGFLLLHFPEPLLHIAHAPPALHERTVDYLRILSYGLPASLVFRIYNALTNAAGKPRLAMILQ
IGALLLKFPLNVWFIFGGFGMPALGGPGCGLASTLINWALALIGFTLLAKLDVFTPLAIFSRFCWPVWWRQKAILKLGVP
MGLSYLIEVTSFTCMALFIAQFGTTTLAGHQIAGNISAVLYMTPLSIGVAASTLVARALGAGRPDEARLLGRHSVMLACG
IAAAYGVLVFTLRPLIVSGYTPNPAVVAAALPLVAIVTCYHFFDALQITSAFVLRAYKVAVVPTVIYAVALWGVGLGGGY
VLGFDIGGIAPAWLTGARGFWFANTISLMLAGAGLALYLRRVSRAALSVGA

Sequences:

>Translated_451_residues
MFADIRRIVGLAWPVLVGQLAIIAFGVIDTAMVGRYSAIDLAALGLGSSIYVSIYIGMTGILSALQPITGQLYGARRYAE
IGEEVRQALWLALMLAVPGFLLLHFPEPLLHIAHAPPALHERTVDYLRILSYGLPASLVFRIYNALTNAAGKPRLAMILQ
IGALLLKFPLNVWFIFGGFGMPALGGPGCGLASTLINWALALIGFTLLAKLDVFTPLAIFSRFCWPVWWRQKAILKLGVP
MGLSYLIEVTSFTCMALFIAQFGTTTLAGHQIAGNISAVLYMTPLSIGVAASTLVARALGAGRPDEARLLGRHSVMLACG
IAAAYGVLVFTLRPLIVSGYTPNPAVVAAALPLVAIVTCYHFFDALQITSAFVLRAYKVAVVPTVIYAVALWGVGLGGGY
VLGFDIGGIAPAWLTGARGFWFANTISLMLAGAGLALYLRRVSRAALSVGA
>Mature_451_residues
MFADIRRIVGLAWPVLVGQLAIIAFGVIDTAMVGRYSAIDLAALGLGSSIYVSIYIGMTGILSALQPITGQLYGARRYAE
IGEEVRQALWLALMLAVPGFLLLHFPEPLLHIAHAPPALHERTVDYLRILSYGLPASLVFRIYNALTNAAGKPRLAMILQ
IGALLLKFPLNVWFIFGGFGMPALGGPGCGLASTLINWALALIGFTLLAKLDVFTPLAIFSRFCWPVWWRQKAILKLGVP
MGLSYLIEVTSFTCMALFIAQFGTTTLAGHQIAGNISAVLYMTPLSIGVAASTLVARALGAGRPDEARLLGRHSVMLACG
IAAAYGVLVFTLRPLIVSGYTPNPAVVAAALPLVAIVTCYHFFDALQITSAFVLRAYKVAVVPTVIYAVALWGVGLGGGY
VLGFDIGGIAPAWLTGARGFWFANTISLMLAGAGLALYLRRVSRAALSVGA

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=423, Percent_Identity=23.8770685579196, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI48994890, Length=443, Percent_Identity=32.2799097065463, Blast_Score=215, Evalue=4e-57,
Organism=Escherichia coli, GI226510954, Length=431, Percent_Identity=24.1299303944316, Blast_Score=76, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320545, Length=412, Percent_Identity=26.4563106796117, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321821, Length=335, Percent_Identity=22.9850746268657, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 47907; Mature: 47907

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFADIRRIVGLAWPVLVGQLAIIAFGVIDTAMVGRYSAIDLAALGLGSSIYVSIYIGMTG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEEHHHHH
ILSALQPITGQLYGARRYAEIGEEVRQALWLALMLAVPGFLLLHFPEPLLHIAHAPPALH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHH
ERTVDYLRILSYGLPASLVFRIYNALTNAAGKPRLAMILQIGALLLKFPLNVWFIFGGFG
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCC
MPALGGPGCGLASTLINWALALIGFTLLAKLDVFTPLAIFSRFCWPVWWRQKAILKLGVP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MGLSYLIEVTSFTCMALFIAQFGTTTLAGHQIAGNISAVLYMTPLSIGVAASTLVARALG
HHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHCCCEEEEEECCHHHHHHHHHHHHHHHC
AGRPDEARLLGRHSVMLACGIAAAYGVLVFTLRPLIVSGYTPNPAVVAAALPLVAIVTCY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
HFFDALQITSAFVLRAYKVAVVPTVIYAVALWGVGLGGGYVLGFDIGGIAPAWLTGARGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHCCCCH
WFANTISLMLAGAGLALYLRRVSRAALSVGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFADIRRIVGLAWPVLVGQLAIIAFGVIDTAMVGRYSAIDLAALGLGSSIYVSIYIGMTG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEEHHHHH
ILSALQPITGQLYGARRYAEIGEEVRQALWLALMLAVPGFLLLHFPEPLLHIAHAPPALH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHH
ERTVDYLRILSYGLPASLVFRIYNALTNAAGKPRLAMILQIGALLLKFPLNVWFIFGGFG
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCC
MPALGGPGCGLASTLINWALALIGFTLLAKLDVFTPLAIFSRFCWPVWWRQKAILKLGVP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MGLSYLIEVTSFTCMALFIAQFGTTTLAGHQIAGNISAVLYMTPLSIGVAASTLVARALG
HHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHCCCEEEEEECCHHHHHHHHHHHHHHHC
AGRPDEARLLGRHSVMLACGIAAAYGVLVFTLRPLIVSGYTPNPAVVAAALPLVAIVTCY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
HFFDALQITSAFVLRAYKVAVVPTVIYAVALWGVGLGGGYVLGFDIGGIAPAWLTGARGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHCCCCH
WFANTISLMLAGAGLALYLRRVSRAALSVGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA