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The map label for this gene is dmlR [H]

Identifier: 115351408

GI number: 115351408

Start: 1488058

End: 1488963

Strand: Direct

Name: dmlR [H]

Synonym: Bamb_1355

Alternate gene names: 115351408

Gene position: 1488058-1488963 (Clockwise)

Preceding gene: 115351404

Following gene: 115351409

Centisome position: 41.84

GC content: 69.65

Gene sequence:

>906_bases
ATGCTGATCGACGATCTCCCGGCGCTCGATACCTTCGCGAGGATCGTGTCGGCCGGCAGTCTGTCGGCGGCGGCGCGCGA
GCTGGACTTGTCGCTGTCCGTCGTCAGCAAGCGGCTTGCGCATCTCGAATCGCAGCTCGGCGTGCGTCTGCTGCACCGGA
CGACGCGGCAGCAGACGCTGACCGACGACGGTGCGCAGTTCCACGCGCAGGTGCTGCGCATCCTCGCCGAAGTCGAGCGT
GCCGAAACGCTGATGAGCGATCGCCGCGGCACGGTCGGTGGGGTGCTGCGCGTGACGGCGCCGGGCGAGCTCGGCCGGCT
GCGGATCGCGCCGCTCATCGCGGCGTTTCAGCGGCGGCATCCCGAACTGATCGTGCAACTGATGCTGACCGATGCGATCG
TCGATCTGCTCGCGCACGACATCGATGTCGCCGTGCGGATCGGCAGCCTCGCCGATTCGACGATGATCGCGCGCGAGCTG
GCGCCGAATCATCGCGTGCTTTGCGCGTCGCCGAGCTATGTCGCCGCGCACGGTTTGCCGGCTGAACCGGCCGAGCTTCG
TGCGCACCGATGCATCGTGATGGGCGATCAGCCGCGTGCCGAGTGGCGGTTCGACGGCGCACACGGCACGGTTGCGGTCG
AGGTGACGGCCGCGCTGCTGACGAACGACGGCGGCGCGGCTCGCACGTTGGCGCTGGAGGGCGCGGGCATCGCGCTGAAG
TCGATCTGGGACGTCGGTGCCGATCTCGATGCCGGTCGACTGGTCCGCGTGCTGCCGGCATTCGCGGCGCCGGCGGCGCC
GCTTCATGCGGTTTATCCCGGTGGTCGTCACGTGCCGTTGCGCGTGCGCGCCTTCGTCGATTTCCTGCGCGAGCAGTTGC
GTGGCGCGTGGGGCCGCGGCGACTGA

Upstream 100 bases:

>100_bases
CGGAACAGGTATGGTAGGTTTTCGATTTCCATCTAAATACGGTCGGAAATCGAATGGATTATTCGAAAAAAGGAAAGGTT
CGCGCGGGATCGAGGCCAGG

Downstream 100 bases:

>100_bases
GCGCGCTGCGAGCGATGTGCCGGCGGGGGGGCGTGCGTGACGACCTGCGTTGACGAAGCGGTTTACAATCGTTTGCATCG
GGCGGCGCACGCGTTGCCCG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: D-malate degradation protein R [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MLIDDLPALDTFARIVSAGSLSAAARELDLSLSVVSKRLAHLESQLGVRLLHRTTRQQTLTDDGAQFHAQVLRILAEVER
AETLMSDRRGTVGGVLRVTAPGELGRLRIAPLIAAFQRRHPELIVQLMLTDAIVDLLAHDIDVAVRIGSLADSTMIAREL
APNHRVLCASPSYVAAHGLPAEPAELRAHRCIVMGDQPRAEWRFDGAHGTVAVEVTAALLTNDGGAARTLALEGAGIALK
SIWDVGADLDAGRLVRVLPAFAAPAAPLHAVYPGGRHVPLRVRAFVDFLREQLRGAWGRGD

Sequences:

>Translated_301_residues
MLIDDLPALDTFARIVSAGSLSAAARELDLSLSVVSKRLAHLESQLGVRLLHRTTRQQTLTDDGAQFHAQVLRILAEVER
AETLMSDRRGTVGGVLRVTAPGELGRLRIAPLIAAFQRRHPELIVQLMLTDAIVDLLAHDIDVAVRIGSLADSTMIAREL
APNHRVLCASPSYVAAHGLPAEPAELRAHRCIVMGDQPRAEWRFDGAHGTVAVEVTAALLTNDGGAARTLALEGAGIALK
SIWDVGADLDAGRLVRVLPAFAAPAAPLHAVYPGGRHVPLRVRAFVDFLREQLRGAWGRGD
>Mature_301_residues
MLIDDLPALDTFARIVSAGSLSAAARELDLSLSVVSKRLAHLESQLGVRLLHRTTRQQTLTDDGAQFHAQVLRILAEVER
AETLMSDRRGTVGGVLRVTAPGELGRLRIAPLIAAFQRRHPELIVQLMLTDAIVDLLAHDIDVAVRIGSLADSTMIAREL
APNHRVLCASPSYVAAHGLPAEPAELRAHRCIVMGDQPRAEWRFDGAHGTVAVEVTAALLTNDGGAARTLALEGAGIALK
SIWDVGADLDAGRLVRVLPAFAAPAAPLHAVYPGGRHVPLRVRAFVDFLREQLRGAWGRGD

Specific function: Transcriptional regulator required for the aerobic growth on D-malate as the sole carbon source. Induces the expression of dmlA in response to D-malate or L- or meso-tartrate. Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87081978, Length=296, Percent_Identity=37.1621621621622, Blast_Score=181, Evalue=4e-47,
Organism=Escherichia coli, GI1786401, Length=292, Percent_Identity=35.6164383561644, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI1789440, Length=295, Percent_Identity=33.8983050847458, Blast_Score=160, Evalue=8e-41,
Organism=Escherichia coli, GI1789639, Length=292, Percent_Identity=29.7945205479452, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI1787128, Length=291, Percent_Identity=28.8659793814433, Blast_Score=131, Evalue=5e-32,
Organism=Escherichia coli, GI145693193, Length=291, Percent_Identity=29.8969072164948, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1787589, Length=295, Percent_Identity=26.4406779661017, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788706, Length=300, Percent_Identity=24, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789173, Length=251, Percent_Identity=24.3027888446215, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787601, Length=138, Percent_Identity=27.536231884058, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1788481, Length=176, Percent_Identity=26.1363636363636, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32312; Mature: 32312

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIDDLPALDTFARIVSAGSLSAAARELDLSLSVVSKRLAHLESQLGVRLLHRTTRQQTL
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TDDGAQFHAQVLRILAEVERAETLMSDRRGTVGGVLRVTAPGELGRLRIAPLIAAFQRRH
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCC
PELIVQLMLTDAIVDLLAHDIDVAVRIGSLADSTMIARELAPNHRVLCASPSYVAAHGLP
HHHHHHHHHHHHHHHHHHHCHHHEEEECCHHHHHHHHHHHCCCCEEEEECCCCCEECCCC
AEPAELRAHRCIVMGDQPRAEWRFDGAHGTVAVEVTAALLTNDGGAARTLALEGAGIALK
CCHHHHHHCEEEEECCCCCCCEEECCCCCEEEEEEEEEEEECCCCCEEEEEECCCCCHHH
SIWDVGADLDAGRLVRVLPAFAAPAAPLHAVYPGGRHVPLRVRAFVDFLREQLRGAWGRG
HHHHCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCC
D
C
>Mature Secondary Structure
MLIDDLPALDTFARIVSAGSLSAAARELDLSLSVVSKRLAHLESQLGVRLLHRTTRQQTL
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TDDGAQFHAQVLRILAEVERAETLMSDRRGTVGGVLRVTAPGELGRLRIAPLIAAFQRRH
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCC
PELIVQLMLTDAIVDLLAHDIDVAVRIGSLADSTMIARELAPNHRVLCASPSYVAAHGLP
HHHHHHHHHHHHHHHHHHHCHHHEEEECCHHHHHHHHHHHCCCCEEEEECCCCCEECCCC
AEPAELRAHRCIVMGDQPRAEWRFDGAHGTVAVEVTAALLTNDGGAARTLALEGAGIALK
CCHHHHHHCEEEEECCCCCCCEEECCCCCEEEEEEEEEEEECCCCCEEEEEECCCCCHHH
SIWDVGADLDAGRLVRVLPAFAAPAAPLHAVYPGGRHVPLRVRAFVDFLREQLRGAWGRG
HHHHCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCC
D
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]