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The map label for this gene is gyrA [H]

Identifier: 115350970

GI number: 115350970

Start: 1006639

End: 1009242

Strand: Direct

Name: gyrA [H]

Synonym: Bamb_0916

Alternate gene names: 115350970

Gene position: 1006639-1009242 (Clockwise)

Preceding gene: 115350963

Following gene: 115350971

Centisome position: 28.3

GC content: 64.48

Gene sequence:

>2604_bases
ATGGATCAATTCGCCAAAGAGACCCTGCCCACCTCCCTTGAGGAGGAAATGCGCCGTTCGTATCTCGATTACGCGATGAG
CGTGATCGTCGGACGTGCCCTTCCGGATGTCCGCGATGGCCTGAAGCCCGTGCACCGGCGCGTACTGTTCGCGATGCACG
AACTGAACAACGACTGGAACCGCGCGTACAAGAAATCGGCGCGTATCGTCGGTGACGTGATCGGTAAGTATCACCCGCAC
GGCGATACCGCGGTGTACGACACGATCGTCCGGATGGCGCAGGACTTCTCGCTGCGCTACATGCTGATCGACGGGCAGGG
CAACTTCGGCTCGATCGACGGCGACAATGCCGCGGCGATGCGTTACACCGAAATTCGCATGGCGAAGATCGGTCACGAGC
TGCTCGCCGACATCGACAAGGAAACGGTCGACTTCGAGCCGAACTACGACGGCAACGAAATGCAGCCGGCGGTCCTGCCG
TCGCGCATTCCGAACCTGCTGATCAACGGCTCGTCGGGCATCGCGGTCGGCATGGCGACCAACATCCCGCCGCACAACCT
GAACGAAGTCGTCGACGCTTGTCAGCACCTGCTGAACAACTCCGAAGCGACGATCGACGAGCTGATCGAGATCATCCCGG
CCCCGGACTTCCCGACGGCCGGCATCATCTACGGCGTCGCCGGCGTGCGCGACGGCTATCGCACCGGCCGTGGCCGCGTC
GTGATGCGCGCCACCACGCACTTCGAGGAGATCGACCGCGGCCAGCGGATGGCGATCATCGTCGACGAGCTGCCGTACCA
GGTGAACAAGCGCTCGCTGCTCGAGCGGATCGCCGAGCTCGTCAACGAGAAGAAGCTCGAGGGCATCTCCGACATCCGCG
ACGAGTCCGACAAGAGCGGCATGCGTGTCGTGATCGAGCTCAAGCGCGGCGAAGTGCCGGAAGTGGTGCTGAACAACCTG
TACAAGGCGACGCAGCTGCAGGACACGTTCGGCATGAACATGGTCGCGCTGGTCGACGGCCAGCCGAAGCTGCTGAACCT
GAAGGAAATCCTGCAGTGCTTCCTGTCGCACCGACGCGAAGTGCTGACGCGCCGCACGATCTACGAACTGCGCAAGGCCC
GCGAACGCGGCCACGTGCTCGAAGGTCTCGCGGTCGCGCTCGCGAACATCGACGAGTTCATCGCGATCATCAAGGCCGCG
CCGACGCCGCCGATCGCGAAGCAGGAGCTGATGGCGAAGCCGTGGGATTCGTCGCTCGTGCGCGAGATGCTCACGCGCGC
CGAGACCGAGAACGCATCGGCGGGCGGCCGCTCCGCGTATCGTCCGGAAGGCCTGAACCCCGCGTTCGGGATGCAGACCG
ACGGGCTGTACCGTCTGTCCGACACGCAGGCGCAGGAAATCCTGCAGATGCGTCTGCAACGCCTGACCGGTCTCGAGCAG
GACAAGATCATCGGCGAGTACCGCGAAGTGATGGCACAGATCGCCGACCTGCTGGACATCCTCGCGCGCCCGGAGCGGAT
CACGACGATGATCGGCGACGAGCTGACGTCGGTGAAGGCCGAATTCGGCGACGCACGCCGCTCGCGCATCGAGCTGAACG
CGACCGAACTGAATACGGAAGACCTGATCACGCCGCAGGACATGGTCGTCACGATGTCGCACGCGGGCTACGTGAAGTCG
CAGCCGCTGTCCGAGTATCGCGCGCAGAAGCGCGGCGGTCGCGGCAAGCAGGCGACGCAGATGAAGGAAGACGACTGGAT
CGAGACGCTGTTCATCGCGAACACGCACGATTACATCCTGTGCTTCTCGAACCGCGGCCGCGTGTACTGGGTCAAGGTCT
ATGAAGTGCCGCAGGGCTCGCGCAACTCGCGCGGCCGCCCGATCGTCAACATGTTCCCGCTGCAGGAAGGCGAGAAGATC
AACGTCGTGCTGCCGGTCAAGGAATTCTCGGCCGACAAGTTCGTGTTCATGGCGACGTCGCTCGGCACCGTGAAGAAGAC
GCCGCTCGAGGCATTCAGCCGCCCGATGAAGAAGGGCATCATCGCGGTCGGCCTCGACGAGGGCGACTATCTGATCGGCG
CGTCGATCACCGACGGCGCGCACGACGTGATGCTGTTCTCCGACTCCGGCAAGGCCGTGCGCTTCGACGAGAACGACGTG
CGCCCGATGGGGCGCGAGGCGCGCGGCGTGCGCGGCATGCAGCTGGAGGACGGCCAGCAGGTCATCGCGCTGCTGGTCGC
CGGCAGCGAGGAGCAGACCGTGCTCACCGCGACCGAGAACGGCTATGGCAAGCGCACGCCGATCGCCGAGTACACGCGTC
ACGGCCGCGGCACGAAGGGGATGATCGCGATCCAGACGTCCGAGCGCAACGGCAAGGTCGTGGCCGCGACGCTCGTCGAC
GCCGAGGATCAGATCATGCTGATCACGACCGCCGGCGTGTTGATTCGTACCCGCGTTTCCGAGATACGCGAGATGGGGCG
CGCTACGCAAGGTGTTACACTCATCAGTCTCGATGAGGGTACCAAGCTCTCCGGCCTGCAGCAGGTCGCGGAAGCCGAAG
AGGGCGAAGGCGAGGCCGACGAGGCGTCGGACGGCGAAGCCTGA

Upstream 100 bases:

>100_bases
TGGCCGCCGATGGGCGCATGTTAGAATCTCGCGTTGCGTTGCGCATGCAGCGCCCACGCGAAAGGCGGTCGCCGTCTTCG
CTCCGAAACGATACGGATAC

Downstream 100 bases:

>100_bases
ATAACGGATGAGACTCGAGCCGCCGCGGGCGCCATGCGCCGCGGTCGGCGAGCAACCATTCATATTTCCAAAAGGGAGTG
ATGATGCAAAAGCAATTCAA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 867; Mature: 867

Protein sequence:

>867_residues
MDQFAKETLPTSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWNRAYKKSARIVGDVIGKYHPH
GDTAVYDTIVRMAQDFSLRYMLIDGQGNFGSIDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFEPNYDGNEMQPAVLP
SRIPNLLINGSSGIAVGMATNIPPHNLNEVVDACQHLLNNSEATIDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV
VMRATTHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNL
YKATQLQDTFGMNMVALVDGQPKLLNLKEILQCFLSHRREVLTRRTIYELRKARERGHVLEGLAVALANIDEFIAIIKAA
PTPPIAKQELMAKPWDSSLVREMLTRAETENASAGGRSAYRPEGLNPAFGMQTDGLYRLSDTQAQEILQMRLQRLTGLEQ
DKIIGEYREVMAQIADLLDILARPERITTMIGDELTSVKAEFGDARRSRIELNATELNTEDLITPQDMVVTMSHAGYVKS
QPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYILCFSNRGRVYWVKVYEVPQGSRNSRGRPIVNMFPLQEGEKI
NVVLPVKEFSADKFVFMATSLGTVKKTPLEAFSRPMKKGIIAVGLDEGDYLIGASITDGAHDVMLFSDSGKAVRFDENDV
RPMGREARGVRGMQLEDGQQVIALLVAGSEEQTVLTATENGYGKRTPIAEYTRHGRGTKGMIAIQTSERNGKVVAATLVD
AEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEGTKLSGLQQVAEAEEGEGEADEASDGEA

Sequences:

>Translated_867_residues
MDQFAKETLPTSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWNRAYKKSARIVGDVIGKYHPH
GDTAVYDTIVRMAQDFSLRYMLIDGQGNFGSIDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFEPNYDGNEMQPAVLP
SRIPNLLINGSSGIAVGMATNIPPHNLNEVVDACQHLLNNSEATIDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV
VMRATTHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNL
YKATQLQDTFGMNMVALVDGQPKLLNLKEILQCFLSHRREVLTRRTIYELRKARERGHVLEGLAVALANIDEFIAIIKAA
PTPPIAKQELMAKPWDSSLVREMLTRAETENASAGGRSAYRPEGLNPAFGMQTDGLYRLSDTQAQEILQMRLQRLTGLEQ
DKIIGEYREVMAQIADLLDILARPERITTMIGDELTSVKAEFGDARRSRIELNATELNTEDLITPQDMVVTMSHAGYVKS
QPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYILCFSNRGRVYWVKVYEVPQGSRNSRGRPIVNMFPLQEGEKI
NVVLPVKEFSADKFVFMATSLGTVKKTPLEAFSRPMKKGIIAVGLDEGDYLIGASITDGAHDVMLFSDSGKAVRFDENDV
RPMGREARGVRGMQLEDGQQVIALLVAGSEEQTVLTATENGYGKRTPIAEYTRHGRGTKGMIAIQTSERNGKVVAATLVD
AEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEGTKLSGLQQVAEAEEGEGEADEASDGEA
>Mature_867_residues
MDQFAKETLPTSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWNRAYKKSARIVGDVIGKYHPH
GDTAVYDTIVRMAQDFSLRYMLIDGQGNFGSIDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFEPNYDGNEMQPAVLP
SRIPNLLINGSSGIAVGMATNIPPHNLNEVVDACQHLLNNSEATIDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV
VMRATTHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNL
YKATQLQDTFGMNMVALVDGQPKLLNLKEILQCFLSHRREVLTRRTIYELRKARERGHVLEGLAVALANIDEFIAIIKAA
PTPPIAKQELMAKPWDSSLVREMLTRAETENASAGGRSAYRPEGLNPAFGMQTDGLYRLSDTQAQEILQMRLQRLTGLEQ
DKIIGEYREVMAQIADLLDILARPERITTMIGDELTSVKAEFGDARRSRIELNATELNTEDLITPQDMVVTMSHAGYVKS
QPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYILCFSNRGRVYWVKVYEVPQGSRNSRGRPIVNMFPLQEGEKI
NVVLPVKEFSADKFVFMATSLGTVKKTPLEAFSRPMKKGIIAVGLDEGDYLIGASITDGAHDVMLFSDSGKAVRFDENDV
RPMGREARGVRGMQLEDGQQVIALLVAGSEEQTVLTATENGYGKRTPIAEYTRHGRGTKGMIAIQTSERNGKVVAATLVD
AEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEGTKLSGLQQVAEAEEGEGEADEASDGEA

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=321, Percent_Identity=26.4797507788162, Blast_Score=95, Evalue=3e-19,
Organism=Homo sapiens, GI19913408, Length=379, Percent_Identity=26.1213720316623, Blast_Score=94, Evalue=7e-19,
Organism=Escherichia coli, GI1788562, Length=851, Percent_Identity=61.1045828437133, Blast_Score=1053, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=718, Percent_Identity=34.958217270195, Blast_Score=389, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17535065, Length=494, Percent_Identity=26.1133603238866, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI212645657, Length=379, Percent_Identity=26.1213720316623, Blast_Score=83, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI212645845, Length=172, Percent_Identity=31.9767441860465, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=352, Percent_Identity=26.9886363636364, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136538, Length=349, Percent_Identity=26.647564469914, Blast_Score=94, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 96389; Mature: 96389

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQFAKETLPTSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWN
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHH
RAYKKSARIVGDVIGKYHPHGDTAVYDTIVRMAQDFSLRYMLIDGQGNFGSIDGDNAAAM
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEE
RYTEIRMAKIGHELLADIDKETVDFEPNYDGNEMQPAVLPSRIPNLLINGSSGIAVGMAT
EHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEECCCCEEEEEEC
NIPPHNLNEVVDACQHLLNNSEATIDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCE
VMRATTHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSG
EEEEHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
MRVVIELKRGEVPEVVLNNLYKATQLQDTFGMNMVALVDGQPKLLNLKEILQCFLSHRRE
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECHHHHHHHHHHHHHH
VLTRRTIYELRKARERGHVLEGLAVALANIDEFIAIIKAAPTPPIAKQELMAKPWDSSLV
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCHHHH
REMLTRAETENASAGGRSAYRPEGLNPAFGMQTDGLYRLSDTQAQEILQMRLQRLTGLEQ
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCH
DKIIGEYREVMAQIADLLDILARPERITTMIGDELTSVKAEFGDARRSRIELNATELNTE
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHCEEEEEHEECCHH
DLITPQDMVVTMSHAGYVKSQPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYIL
HCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEE
CFSNRGRVYWVKVYEVPQGSRNSRGRPIVNMFPLQEGEKINVVLPVKEFSADKFVFMATS
EECCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEEEHHHCCCCCEEEEEEC
LGTVKKTPLEAFSRPMKKGIIAVGLDEGDYLIGASITDGAHDVMLFSDSGKAVRFDENDV
CCCCCCCCHHHHHHHHHCCEEEEEECCCCEEEEEEECCCCCEEEEECCCCCEEEECCCCC
RPMGREARGVRGMQLEDGQQVIALLVAGSEEQTVLTATENGYGKRTPIAEYTRHGRGTKG
CCCCHHHCCCCCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCC
MIAIQTSERNGKVVAATLVDAEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEG
EEEEEECCCCCCEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHCCHHCCEEEEEECCC
TKLSGLQQVAEAEEGEGEADEASDGEA
CCHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MDQFAKETLPTSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWN
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHH
RAYKKSARIVGDVIGKYHPHGDTAVYDTIVRMAQDFSLRYMLIDGQGNFGSIDGDNAAAM
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEE
RYTEIRMAKIGHELLADIDKETVDFEPNYDGNEMQPAVLPSRIPNLLINGSSGIAVGMAT
EHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEECCCCEEEEEEC
NIPPHNLNEVVDACQHLLNNSEATIDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCE
VMRATTHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSG
EEEEHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
MRVVIELKRGEVPEVVLNNLYKATQLQDTFGMNMVALVDGQPKLLNLKEILQCFLSHRRE
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECHHHHHHHHHHHHHH
VLTRRTIYELRKARERGHVLEGLAVALANIDEFIAIIKAAPTPPIAKQELMAKPWDSSLV
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCHHHH
REMLTRAETENASAGGRSAYRPEGLNPAFGMQTDGLYRLSDTQAQEILQMRLQRLTGLEQ
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCH
DKIIGEYREVMAQIADLLDILARPERITTMIGDELTSVKAEFGDARRSRIELNATELNTE
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHCEEEEEHEECCHH
DLITPQDMVVTMSHAGYVKSQPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYIL
HCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEE
CFSNRGRVYWVKVYEVPQGSRNSRGRPIVNMFPLQEGEKINVVLPVKEFSADKFVFMATS
EECCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEEEHHHCCCCCEEEEEEC
LGTVKKTPLEAFSRPMKKGIIAVGLDEGDYLIGASITDGAHDVMLFSDSGKAVRFDENDV
CCCCCCCCHHHHHHHHHCCEEEEEECCCCEEEEEEECCCCCEEEEECCCCCEEEECCCCC
RPMGREARGVRGMQLEDGQQVIALLVAGSEEQTVLTATENGYGKRTPIAEYTRHGRGTKG
CCCCHHHCCCCCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCC
MIAIQTSERNGKVVAATLVDAEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEG
EEEEEECCCCCCEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHCCHHCCEEEEEECCC
TKLSGLQQVAEAEEGEGEADEASDGEA
CCHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7811002; 10984043 [H]