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The map label for this gene is trpF

Identifier: 11499194

GI number: 11499194

Start: 1436769

End: 1437368

Strand: Reverse

Name: trpF

Synonym: AF1601

Alternate gene names: 11499194

Gene position: 1437368-1436769 (Counterclockwise)

Preceding gene: 11499195

Following gene: 11499193

Centisome position: 65.98

GC content: 52.0

Gene sequence:

>600_bases
ATGATGGTTAAGGTTTGCGGTGTTAAAAGCCTGAAGGAGCTTGATGCTGTGGAGAGGTATGCAGATTTCACCGGGGTTGT
TGTTAAAAGCGATTCAAAGAGGTGCGTGGAGCTTGATGTGGCTAAAGAGCTTATCGGGAGCTCATCCATTCCGGTTTTTG
CGGTGTCAACTGCAAGCAGCTACGCGGAATGGGAGGAAATTCTCGCAAAGACGGAATGCAGCTTCGCCCAGGTTCACTCC
GAAATGCCGCTGGAGGATTTTGAGAGGCTGAAGGCGGAGGTTAAGGTCATGAAGGCCTTTATTGTTGAAGGCCCGGCTGA
AAAGATCGCTGCCAAGATTGAACTCTACTCCCCTCACCTCATTCTCCTCGATTCGGGGTGCGGGAGCGGAAAAACTCACG
ACTGGAATGTTAGCAAGGCTCTGGCGGAGAGATACGGCGTTTTTCTGGCCGGAGGGCTTAATTTGGACAACGTGAGGGAG
GCGATAAGGTTCGTGAGGCCCATGGGCGTTGACGTCTCGTCCGGAGTGGAGAGAGACGGGCTTAAGGATGAGATGCTGGT
TAGAGAATTTGTCAGGAGGGCGAAAAATGAAGTTCGGTGA

Upstream 100 bases:

>100_bases
GGCTTGAGGAGGGGTAAAATACACGGCGTGCAGTTCCATCCGGAGAGCGTGCTTACAGAGGACGGTGTGAGGATGATTAG
GAACTTCGTGGAGATGTGCC

Downstream 100 bases:

>100_bases
GTTTGGCGGAAGATTTGTTCCGGAGGTTCTTATTCCACCTCTGGAGGAGCTTGAAAAAGCTTATGACAGGTTTAAGGATG
ATGAGGAGTTCAAAGCAAGG

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MMVKVCGVKSLKELDAVERYADFTGVVVKSDSKRCVELDVAKELIGSSSIPVFAVSTASSYAEWEEILAKTECSFAQVHS
EMPLEDFERLKAEVKVMKAFIVEGPAEKIAAKIELYSPHLILLDSGCGSGKTHDWNVSKALAERYGVFLAGGLNLDNVRE
AIRFVRPMGVDVSSGVERDGLKDEMLVREFVRRAKNEVR

Sequences:

>Translated_199_residues
MMVKVCGVKSLKELDAVERYADFTGVVVKSDSKRCVELDVAKELIGSSSIPVFAVSTASSYAEWEEILAKTECSFAQVHS
EMPLEDFERLKAEVKVMKAFIVEGPAEKIAAKIELYSPHLILLDSGCGSGKTHDWNVSKALAERYGVFLAGGLNLDNVRE
AIRFVRPMGVDVSSGVERDGLKDEMLVREFVRRAKNEVR
>Mature_199_residues
MMVKVCGVKSLKELDAVERYADFTGVVVKSDSKRCVELDVAKELIGSSSIPVFAVSTASSYAEWEEILAKTECSFAQVHS
EMPLEDFERLKAEVKVMKAFIVEGPAEKIAAKIELYSPHLILLDSGCGSGKTHDWNVSKALAERYGVFLAGGLNLDNVRE
AIRFVRPMGVDVSSGVERDGLKDEMLVREFVRRAKNEVR

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Saccharomyces cerevisiae, GI6320210, Length=215, Percent_Identity=28.8372093023256, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_ARCFU (O28671)

Other databases:

- EMBL:   AE000782
- PIR:   H69449
- RefSeq:   NP_070430.1
- ProteinModelPortal:   O28671
- SMR:   O28671
- GeneID:   1484827
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF1601
- NMPDR:   fig|224325.1.peg.1591
- TIGR:   AF_1601
- HOGENOM:   HBG554803
- OMA:   TGVILEC
- ProtClustDB:   PRK01222
- BioCyc:   AFUL224325:AF_1601-MONOMER
- BRENDA:   5.3.1.24
- HAMAP:   MF_00135_A
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 22018; Mature: 22018

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMVKVCGVKSLKELDAVERYADFTGVVVKSDSKRCVELDVAKELIGSSSIPVFAVSTASS
CEEEECCCHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCHH
YAEWEEILAKTECSFAQVHSEMPLEDFERLKAEVKVMKAFIVEGPAEKIAAKIELYSPHL
HHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEECCEE
ILLDSGCGSGKTHDWNVSKALAERYGVFLAGGLNLDNVREAIRFVRPMGVDVSSGVERDG
EEEECCCCCCCCCCCHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCCCHHCCCCCCC
LKDEMLVREFVRRAKNEVR
CHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMVKVCGVKSLKELDAVERYADFTGVVVKSDSKRCVELDVAKELIGSSSIPVFAVSTASS
CEEEECCCHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCHH
YAEWEEILAKTECSFAQVHSEMPLEDFERLKAEVKVMKAFIVEGPAEKIAAKIELYSPHL
HHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEECCEE
ILLDSGCGSGKTHDWNVSKALAERYGVFLAGGLNLDNVREAIRFVRPMGVDVSSGVERDG
EEEECCCCCCCCCCCHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCCCHHCCCCCCC
LKDEMLVREFVRRAKNEVR
CHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475