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The map label for this gene is trpG

Identifier: 11499195

GI number: 11499195

Start: 1437358

End: 1437894

Strand: Reverse

Name: trpG

Synonym: AF1602

Alternate gene names: 11499195

Gene position: 1437894-1437358 (Counterclockwise)

Preceding gene: 11499196

Following gene: 11499194

Centisome position: 66.01

GC content: 51.58

Gene sequence:

>537_bases
ATGATAGTCGTTGTTGACTGCAAGGACTCCTTCGTTTACAATCTCGTGGAGTACATCTCTCTGTTCGACAAGGTAAGGGT
TGTTGAGAAGGAGAGTGCTGGATTGCTGAGAAAAATGAGCTTTGACGGTGTGGTGATTTCCCCCGGACCGGGAAAGCCGG
ACAGGAGCCTTGAATTCGTCTTTAAAATGGGCGTTCCTGTGCTCGGCGTCTGCCTCGGCCATCAGATGATTGCGGAGGTT
TTTGGAGGGAAAGTGGGGAGGGTTGAGCCCGTTCACGGCAAAACTTCACTTGTTGAGCATGACGGCAGAGGGATTTTTAA
AGGGGTGAGAAATCCGCTCAGGGCGGGGAGATATCACTCACTCGCCGTTCTTGAACCGCCAGAAGGCTTTGAGGTGTGTG
CAAAAAGTGAAGATGGAGTGGTGATGGGCTTGAGGAGGGGTAAAATACACGGCGTGCAGTTCCATCCGGAGAGCGTGCTT
ACAGAGGACGGTGTGAGGATGATTAGGAACTTCGTGGAGATGTGCCATGATGGTTAA

Upstream 100 bases:

>100_bases
GGATAAGGGCAGGTGCGGGGATAGTTGCGGACTCCGTTCCTGAAAGGGAGTTTTTCGAGACGGAAAACAAGATAGCGAGG
GTTTTGAGGGCGGTTGGGCT

Downstream 100 bases:

>100_bases
GGTTTGCGGTGTTAAAAGCCTGAAGGAGCTTGATGCTGTGGAGAGGTATGCAGATTTCACCGGGGTTGTTGTTAAAAGCG
ATTCAAAGAGGTGCGTGGAG

Product: anthranilate synthase component II (trpG)

Products: NA

Alternate protein names: Anthranilate synthase component II; Glutamine amido-transferase

Number of amino acids: Translated: 178; Mature: 178

Protein sequence:

>178_residues
MIVVVDCKDSFVYNLVEYISLFDKVRVVEKESAGLLRKMSFDGVVISPGPGKPDRSLEFVFKMGVPVLGVCLGHQMIAEV
FGGKVGRVEPVHGKTSLVEHDGRGIFKGVRNPLRAGRYHSLAVLEPPEGFEVCAKSEDGVVMGLRRGKIHGVQFHPESVL
TEDGVRMIRNFVEMCHDG

Sequences:

>Translated_178_residues
MIVVVDCKDSFVYNLVEYISLFDKVRVVEKESAGLLRKMSFDGVVISPGPGKPDRSLEFVFKMGVPVLGVCLGHQMIAEV
FGGKVGRVEPVHGKTSLVEHDGRGIFKGVRNPLRAGRYHSLAVLEPPEGFEVCAKSEDGVVMGLRRGKIHGVQFHPESVL
TEDGVRMIRNFVEMCHDG
>Mature_178_residues
MIVVVDCKDSFVYNLVEYISLFDKVRVVEKESAGLLRKMSFDGVVISPGPGKPDRSLEFVFKMGVPVLGVCLGHQMIAEV
FGGKVGRVEPVHGKTSLVEHDGRGIFKGVRNPLRAGRYHSLAVLEPPEGFEVCAKSEDGVVMGLRRGKIHGVQFHPESVL
TEDGVRMIRNFVEMCHDG

Specific function: Catalyzes The Biosynthesis Of 4-Amino-4-Deoxychorismate (Adc) From Chorismate And Glutamine. [C]

COG id: COG0512

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=148, Percent_Identity=31.7567567567568, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1789760, Length=186, Percent_Identity=44.0860215053763, Blast_Score=142, Evalue=9e-36,
Organism=Escherichia coli, GI1787517, Length=195, Percent_Identity=35.8974358974359, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1788854, Length=158, Percent_Identity=29.746835443038, Blast_Score=65, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322638, Length=187, Percent_Identity=41.7112299465241, Blast_Score=132, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6323873, Length=122, Percent_Identity=32.7868852459016, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPG_ARCFU (O28670)

Other databases:

- EMBL:   AE000782
- PIR:   A69450
- RefSeq:   NP_070431.1
- ProteinModelPortal:   O28670
- SMR:   O28670
- GeneID:   1484828
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF1602
- NMPDR:   fig|224325.1.peg.1592
- TIGR:   AF_1602
- HOGENOM:   HBG292341
- OMA:   SENGHAI
- BioCyc:   AFUL224325:AF_1602-MONOMER
- BRENDA:   4.1.3.27
- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR006221
- PRINTS:   PR00097
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00566

Pfam domain/function: PF00117 GATase

EC number: =4.1.3.27

Molecular weight: Translated: 19593; Mature: 19593

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 71-71 ACT_SITE 155-155 ACT_SITE 157-157

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVVVDCKDSFVYNLVEYISLFDKVRVVEKESAGLLRKMSFDGVVISPGPGKPDRSLEFV
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCEEECCCCCCCCCHHHHH
FKMGVPVLGVCLGHQMIAEVFGGKVGRVEPVHGKTSLVEHDGRGIFKGVRNPLRAGRYHS
HHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCE
LAVLEPPEGFEVCAKSEDGVVMGLRRGKIHGVQFHPESVLTEDGVRMIRNFVEMCHDG
EEEECCCCCHHEECCCCCCEEEEEECCEEECEEECCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIVVVDCKDSFVYNLVEYISLFDKVRVVEKESAGLLRKMSFDGVVISPGPGKPDRSLEFV
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCEEECCCCCCCCCHHHHH
FKMGVPVLGVCLGHQMIAEVFGGKVGRVEPVHGKTSLVEHDGRGIFKGVRNPLRAGRYHS
HHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCE
LAVLEPPEGFEVCAKSEDGVVMGLRRGKIHGVQFHPESVLTEDGVRMIRNFVEMCHDG
EEEECCCCCHHEECCCCCCEEEEEECCEEECEEECCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475