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Identifier: 11498744

GI number: 11498744

Start: 1018859

End: 1020214

Strand: Reverse

Name: Not Available

Synonym: AF1144

Alternate gene names: 11498744

Gene position: 1020214-1018859 (Counterclockwise)

Preceding gene: 11498745

Following gene: 11498742

Centisome position: 46.83

GC content: 51.77

Gene sequence:

>1356_bases
ATGCAACTGAAAAAGGCAGCTCTGCTGACATCAGGTGTTGCTTCCTTTCTCACCCCCTTCATGGGCTCTTCAACCAACAT
AGCCCTGCCCGCAATAGGCAAAGAATTTCAGATTGACGCCATAACTCTCGGCTGGATTGCCACGGCATATCTTCTCGCAG
CCGGCATGTTTTCCGTCCCCTTCGGCAGGATTGCAGACATAGCGGGAAGGAAGAAGGTTTTTGTGGTTGGACTGCTTGTT
TTCAGTCTCGGCTCCATTCTCTCAGCAATTCCTCCCAATGCGGAGATGCTTATAGCTTTCAGAGTCCTCCAAGGTGTTGG
CGGTGCGATGATTTTCGCCACCTCAGTAGCCATTCTCACTTCGGTTTTCCCTCCCCAGGAAAGGGGGAAGGCCATTGGCA
TCAACACCGGAGCGGTTTACACGGGATTAAGTCTTGGCCCCATAGGTGGAGGGTTTCTGACCCAAAATCTCGGATGGAGG
AGCTTGTTCATCGCCAACGGAGCTTTGGGATTCTTCGCCCTAATCGTTGCATCAGTCTATCTCAGGGGGGAGTGGGCTGA
TGCGAGGGGGGAGAAATTCGACCTTGCCGGTTCCGCAATTTACGCGGCCATGCTCTTCTTCCTGATTTACGGTTTTTCAG
AGTTCTCAGTTGCTTTCATAGTTCTCGGTGCAATCTTGGCCTTAATTTTTGTTGTTTACGAGAACAGGCAAGAGCATCCC
GTTTTTGCTGTAAGGCTTCTTCTGAGCAACCTTACCTTCTCCCTCTCAAGCCTCGCCGCACTGCTCAACTATGCGGCAAC
CTTCGCCGTGGGCTTTTTGATGAGCCTCTACCTCCAGTACGTAAAGGGGTTCGACGCTCAGACGGCTGGCCTCATCCTCG
TATCCCAGCCCGTAGTCATGGCAATCTTCGCCCCCATTGCCGGCTGGATTTCGGATAGAATAGAGCCGAGGGTTGTAGCC
TCAACGGGCATGGCTGTGACAACTCTGTCCTTAATCCTCTTCGCAGGCATCAACGGAGAGACGGCCTTAAGCAACATAAT
CACTTACCTCATGCTCCTCGGTTTTGGAATTGCACTGTTCAGCTCTCCGAACACCAACGCAATCATGAGCTCGGTTGAGA
GAAAATTTTTCGGCATAGCCTCAGCCACAGTTGCAACAATGCGGCTCGTAGGGCAGACTTTGAGCATGGCTCTCGTCATG
CTCGTCTTCTCAATGGTAATTGGAAGGGTTGAGATAACTCCTGAGTACTTCGGCAGGTTCATCGAAAGCTCAAGAATAGC
CTTCTCGATCTTCGCCGCGCTCTGCTTCGTTGGAATCTTCGCATCGCTGGGGAGGGGAAAAATAAAGAGAGGCTAG

Upstream 100 bases:

>100_bases
GGTCTTCTACCGCCGAACTACACAATCCCGGCAGGCAAGCCGGATTACTTGCTCTACAAGAGGGATTAAGTTTTTAAATT
TTTTCGCATAAGGCAAACTC

Downstream 100 bases:

>100_bases
TCGAGCTGCTTTAATGTGTGAAGCATGCGGTGCAGTGTGGTTATAAAGCCGAGCACCGCCACAATCCACAGCGTTGCTGC
ATAAACGCTCACCGCATTAC

Product: multidrug resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MQLKKAALLTSGVASFLTPFMGSSTNIALPAIGKEFQIDAITLGWIATAYLLAAGMFSVPFGRIADIAGRKKVFVVGLLV
FSLGSILSAIPPNAEMLIAFRVLQGVGGAMIFATSVAILTSVFPPQERGKAIGINTGAVYTGLSLGPIGGGFLTQNLGWR
SLFIANGALGFFALIVASVYLRGEWADARGEKFDLAGSAIYAAMLFFLIYGFSEFSVAFIVLGAILALIFVVYENRQEHP
VFAVRLLLSNLTFSLSSLAALLNYAATFAVGFLMSLYLQYVKGFDAQTAGLILVSQPVVMAIFAPIAGWISDRIEPRVVA
STGMAVTTLSLILFAGINGETALSNIITYLMLLGFGIALFSSPNTNAIMSSVERKFFGIASATVATMRLVGQTLSMALVM
LVFSMVIGRVEITPEYFGRFIESSRIAFSIFAALCFVGIFASLGRGKIKRG

Sequences:

>Translated_451_residues
MQLKKAALLTSGVASFLTPFMGSSTNIALPAIGKEFQIDAITLGWIATAYLLAAGMFSVPFGRIADIAGRKKVFVVGLLV
FSLGSILSAIPPNAEMLIAFRVLQGVGGAMIFATSVAILTSVFPPQERGKAIGINTGAVYTGLSLGPIGGGFLTQNLGWR
SLFIANGALGFFALIVASVYLRGEWADARGEKFDLAGSAIYAAMLFFLIYGFSEFSVAFIVLGAILALIFVVYENRQEHP
VFAVRLLLSNLTFSLSSLAALLNYAATFAVGFLMSLYLQYVKGFDAQTAGLILVSQPVVMAIFAPIAGWISDRIEPRVVA
STGMAVTTLSLILFAGINGETALSNIITYLMLLGFGIALFSSPNTNAIMSSVERKFFGIASATVATMRLVGQTLSMALVM
LVFSMVIGRVEITPEYFGRFIESSRIAFSIFAALCFVGIFASLGRGKIKRG
>Mature_451_residues
MQLKKAALLTSGVASFLTPFMGSSTNIALPAIGKEFQIDAITLGWIATAYLLAAGMFSVPFGRIADIAGRKKVFVVGLLV
FSLGSILSAIPPNAEMLIAFRVLQGVGGAMIFATSVAILTSVFPPQERGKAIGINTGAVYTGLSLGPIGGGFLTQNLGWR
SLFIANGALGFFALIVASVYLRGEWADARGEKFDLAGSAIYAAMLFFLIYGFSEFSVAFIVLGAILALIFVVYENRQEHP
VFAVRLLLSNLTFSLSSLAALLNYAATFAVGFLMSLYLQYVKGFDAQTAGLILVSQPVVMAIFAPIAGWISDRIEPRVVA
STGMAVTTLSLILFAGINGETALSNIITYLMLLGFGIALFSSPNTNAIMSSVERKFFGIASATVATMRLVGQTLSMALVM
LVFSMVIGRVEITPEYFGRFIESSRIAFSIFAALCFVGIFASLGRGKIKRG

Specific function: Unknown

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=394, Percent_Identity=29.4416243654822, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI1790195, Length=277, Percent_Identity=27.0758122743682, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788710, Length=413, Percent_Identity=25.181598062954, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789042, Length=394, Percent_Identity=24.6192893401015, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1789312, Length=107, Percent_Identity=35.5140186915888, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI1789515, Length=155, Percent_Identity=30.3225806451613, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6325455, Length=381, Percent_Identity=27.0341207349081, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323735, Length=315, Percent_Identity=23.8095238095238, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324954, Length=396, Percent_Identity=25.7575757575758, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321663, Length=128, Percent_Identity=32.03125, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6322958, Length=141, Percent_Identity=31.2056737588652, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6324264, Length=136, Percent_Identity=29.4117647058824, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47919; Mature: 47919

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLKKAALLTSGVASFLTPFMGSSTNIALPAIGKEFQIDAITLGWIATAYLLAAGMFSVP
CCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHCC
FGRIADIAGRKKVFVVGLLVFSLGSILSAIPPNAEMLIAFRVLQGVGGAMIFATSVAILT
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHH
SVFPPQERGKAIGINTGAVYTGLSLGPIGGGFLTQNLGWRSLFIANGALGFFALIVASVY
HCCCCHHCCCEEEECCCHHEECCEECCCCCCHHHCCCCCCEEEEECCHHHHHHHHHHHHH
LRGEWADARGEKFDLAGSAIYAAMLFFLIYGFSEFSVAFIVLGAILALIFVVYENRQEHP
HCCCCCCCCCCEECCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
VFAVRLLLSNLTFSLSSLAALLNYAATFAVGFLMSLYLQYVKGFDAQTAGLILVSQPVVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHH
AIFAPIAGWISDRIEPRVVASTGMAVTTLSLILFAGINGETALSNIITYLMLLGFGIALF
HHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
SSPNTNAIMSSVERKFFGIASATVATMRLVGQTLSMALVMLVFSMVIGRVEITPEYFGRF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECHHHHHHH
IESSRIAFSIFAALCFVGIFASLGRGKIKRG
HHCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQLKKAALLTSGVASFLTPFMGSSTNIALPAIGKEFQIDAITLGWIATAYLLAAGMFSVP
CCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHCC
FGRIADIAGRKKVFVVGLLVFSLGSILSAIPPNAEMLIAFRVLQGVGGAMIFATSVAILT
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHH
SVFPPQERGKAIGINTGAVYTGLSLGPIGGGFLTQNLGWRSLFIANGALGFFALIVASVY
HCCCCHHCCCEEEECCCHHEECCEECCCCCCHHHCCCCCCEEEEECCHHHHHHHHHHHHH
LRGEWADARGEKFDLAGSAIYAAMLFFLIYGFSEFSVAFIVLGAILALIFVVYENRQEHP
HCCCCCCCCCCEECCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
VFAVRLLLSNLTFSLSSLAALLNYAATFAVGFLMSLYLQYVKGFDAQTAGLILVSQPVVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHH
AIFAPIAGWISDRIEPRVVASTGMAVTTLSLILFAGINGETALSNIITYLMLLGFGIALF
HHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
SSPNTNAIMSSVERKFFGIASATVATMRLVGQTLSMALVMLVFSMVIGRVEITPEYFGRF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECHHHHHHH
IESSRIAFSIFAALCFVGIFASLGRGKIKRG
HHCCHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]